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A comparative study for assessment of post-operative sequelae following mandibular transalveolar molar extractions using ozone and dexamethasone 臭氧与地塞米松对下颌经牙槽磨牙拔除术后后遗症的比较研究
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023011
V. Poddar, Mehak Juneja, S. Arora, S. Ganguly, S. Jain, Ankita Pati Upadhyay
Objectives: Trans-alveolar extractions involve surgical removal of tooth that has its own postoperative sequelae, most commonly manifested as pain and swelling. This study aims to compare the efficacy of topical ozone and dexamethasone in management of post-operative sequelae after mandibular trans-alveolar molar extractions. Materials and Methods: Sixty patients requiring surgical removal of mandibular molars under local anesthesia were randomly allocated into two groups, each group consisting of 30 patients. Group 1 received Topical Ozonated Oil in the extraction socket post-operatively, while Group 2 was administered 8 mg dexamethasone injection post-operatively. The patients were checked for postoperative wound healing, pain and swelling on 1st, 3rd and 7th day. Results: The results showed comparatively similar results for the pain severity and swelling score at the 1st and 7th postoperative day in both the groups. A greater reduction of pain was noticed in Group 1 on 3rd postoperative day. Wound Healing was noted to be better in Group 1 at 3rd and 7th post-operative day. Conclusion: In conclusion, topical ozone therapy can be used as an effective alternative treatment modality, when compared to dexamethasone for better management of post-operative sequelae following mandibular trans-alveolar molar extractions.
目的:经牙槽拔牙是一种手术拔牙,其术后后遗症主要表现为疼痛和肿胀。本研究旨在比较局部臭氧和地塞米松治疗下颌经牙槽磨牙拔牙术后后遗症的疗效。材料与方法:选择60例局部麻醉下行下颌磨牙切除手术的患者,随机分为两组,每组30例。组1术后给予局部臭氧化油于拔牙槽内,组2术后给予地塞米松注射液8 mg。术后第1天、第3天、第7天检查患者伤口愈合、疼痛和肿胀情况。结果:两组术后第1天和第7天疼痛程度和肿胀评分比较相似。第1组术后第3天疼痛明显减轻。第1组术后第3、7天伤口愈合较好。结论:与地塞米松相比,局部臭氧治疗可以作为一种有效的替代治疗方式,更好地治疗下颌经牙槽磨牙拔牙术后的后遗症。
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引用次数: 0
Acute periapical dental abscesses and increased risk for extracranial carotid artery aneurysms 急性牙根尖周脓肿和颅内外颈动脉动脉瘤的风险增加
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2022035
J. Katz, I. Rotstein
Aim: To assess the prevalence of acute periapical abscesses (PAs) in patients with a history of extracranial carotid artery aneurysms (ECAA). Materials and methods: History of acute PAs and ECAA diagnosis was retrieved by searching the appropriate query in the database. All cases were diagnosed for acute PAs by calibrated dentists for patients admitted to urgent care. The odds ratio (OR) for the prevalence of acute PAs and its association with history of ECAA were then calculated. Results: The prevalence of acute PAs in patients with a history ECAA was significantly higher as compared to the general hospital patient population (p < 0.0001). The OR was 5.5. Females were more affected than males by 1.7 folds (p < 0.001). Whites were more affected than African Americans by 1.6 folds (p < 0.00001). Conclusions: The high prevalence of acute PAs in patients with a history of ECAA may suggest an association between these two conditions warranting a thorough medical examination.
目的:评估有颅外颈动脉动脉瘤(ECAA)病史的患者急性根尖周围脓肿(PAs)的发生率。材料与方法:在数据库中检索合适的查询,检索急性PAs病史和ECAA诊断。所有病例均由接受紧急护理的患者的校准牙医诊断为急性PAs。然后计算急性PAs患病率及其与ECAA病史的比值比(OR)。结果:有ECAA病史的患者的急性PAs患病率明显高于普通医院患者(p < 0.0001)。OR为5.5。女性比男性多1.7倍(p < 0.001)。白人比非裔美国人受影响多1.6倍(p < 0.00001)。结论:有ECAA病史的患者中急性PAs的高患病率可能表明这两种情况之间存在关联,需要进行彻底的医学检查。
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引用次数: 0
Early lingual nerve suture under local anesthesia after wisdom tooth extraction: a case report 智齿拔除后局部麻醉下早期舌神经缝合1例
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2022036
Aurélie Godard, G. Millot
Introduction: Lingual nerve injury is one of the operative risks of mandibular wisdom tooth avulsion surgery. The anatomical relationship of the nerve to the medial side of the socket of the mandibular third molar must be known when performing the procedure. When a lesion occurs, the diagnosis may be delayed by the effect of anesthesia. In the case of a complete section, repair can be considered by direct suture of the nerve margins. It is recommended to perform this suture as soon as possible. In most cases, the lingual nerve suture is performed remotely and under general anesthesia. Observation: The case presented here describes the early repair of a lingual nerve transection after avulsion of a mandibular third molar. The procedure has been performed under local anesthesia one day after surgery and consisted of a direct suture using the previous surgical approach. Conclusion: This allows for a simplified treatment of this complication, thus shortening the management time.
舌神经损伤是下颌智齿撕脱术的手术风险之一。神经与下颌第三磨牙窝内侧的解剖关系在进行手术时必须知道。当病变发生时,由于麻醉的作用,诊断可能会延迟。在神经切面完整的情况下,可以考虑直接缝合神经边缘进行修复。建议尽快进行缝合。在大多数情况下,舌神经缝合是在全身麻醉下远程进行的。观察:这个病例描述了下颌第三磨牙撕脱后舌神经断裂的早期修复。该手术在手术后一天局部麻醉下进行,包括使用先前手术入路直接缝合。结论:该方法简化了该并发症的治疗,缩短了治疗时间。
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引用次数: 0
Regional odontodysplasia "ghost teeth": a rare developmental anomaly 局部牙发育不良“鬼牙”:一种罕见的发育异常
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023019
Sarah Tabbai, Hind Ramdi
Regional odontodysplasia (RO) is a rare developmental anomaly characterized by hypoplasia
局部牙发育不良是一种罕见的发育异常,其特征是发育不全
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引用次数: 0
Management of biologics in oral surgery 口腔外科生物制剂的管理
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023025
S. Mills, Patrick Ryan, K. Gaffney
Biologics have revolutionised the management of immune-mediated inflammatory disorders, and their growing use has resulted in increasing numbers of these patients presenting in oral surgery settings. While the efficacy of biologics has been well established, they are associated with numerous adverse effects. Several professional bodies have published recommendations on perioperative management of these agents to reduce complications. Currently no specific dental or oral surgery guidance exists. The aim of this paper is to review the current literature and guidance regarding the use of biologics in the perioperative period.
生物制剂已经彻底改变了免疫介导的炎症性疾病的治疗,它们越来越多的使用导致越来越多的这些患者出现在口腔手术环境中。虽然生物制剂的功效已经得到了很好的证实,但它们与许多不良反应有关。一些专业机构已经发表了关于这些药物的围手术期管理以减少并发症的建议。目前还没有专门的牙科或口腔手术指南。本文的目的是回顾目前的文献和指南关于生物制剂在围手术期的使用。
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引用次数: 0
Evaluation of differential white blood cell count and cheek pouch epithelium in 7,12-dimethylbenza[a]anthracene hamster carcinogenesis model, managed with three phytochemicals 用三种植物化学物质处理的7,12-二甲基苯[a]蒽仓鼠癌变模型中白细胞计数和颊袋上皮的差异评价
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023005
Mahmoud H. Darwish, M. Hassan, Ola M. Maria
Objectives: Nigella sativa (NS), thymoquinone (TQ), and epigallocatechin-3-gallate (EGCG) are phytochemicals that might have antioxidant protective potentials on the hamster cheek pouch epithelium (HCPE). We aimed at evaluating and comparing the potential therapeutic outcomes of these 3 phytochemicals by analysis of peripheral white blood cells (WBCs) counts. Materials and Methods: NS whole oil, TQ and EGCG were administered before, with or after 7,12-dimethylbenza[a]anthracene (DMBA) painting the hamster left cheek pouch. Before sacrificing each animal, 2 ml of blood was withdrawn into a fine heparin-containing tube to estimate the total WBCs, lymphocytes, MID cells, and granulocytes counts by an automatic count system. All cheek pouches were surgically excised and examined with light microscope. Results: Severe epithelial dysplasia was evident after 6 weeks of DMBA administration, and when NS was given for 2 weeks followed by DMBA for 6 weeks. When NS or EGCG were given for 2 weeks then continued with DMBA for 6 weeks, mild dysplasia was seen. When DMBA was given for 6 weeks followed by NS or TQ for 6 weeks, mild dysplasia was noted. Administration of DMBA for 6 weeks resulted in significant reduction in total WBCs and lymphocytes counts compared to healthy controls. Administration of NS or TQ for 2 weeks resulted in significant elevation in lymphocytes count compared to healthy controls. Significant elevation in total WBCS and lymphocytes counts was noted when EGCG was given for 2 weeks and continued with DMBA for other 6 weeks. Similar results were noted when DMBA was given for 6 weeks followed by TQ for 6 weeks when compared to NS, DMBA or healthy controls. Discussion: The three phytochemicals showed different levels of protection against DMBA carcinogenic activity, more specifically, TQ and NS had higher therapeutic potential and might be used for treatment and/or preventive management of oral cancer in the future. Conclusion: However, further investigations are required to address the mechanism of action and feasibility of clinical application of each phytochemical.
目的:黑草(NS)、百里醌(TQ)和没食子儿茶素-3-没食子酸酯(EGCG)是一种可能对仓鼠颊袋上皮(HCPE)具有抗氧化保护作用的植物化学物质。我们旨在通过分析外周血细胞(wbc)计数来评估和比较这3种植物化学物质的潜在治疗效果。材料与方法:在7,12-二甲基苯并[a]蒽(DMBA)涂敷仓鼠左颊袋之前、之后分别给予NS全油、TQ和EGCG。在牺牲每只动物之前,将2ml血液抽入含有肝素的细管中,通过自动计数系统估计白细胞、淋巴细胞、MID细胞和粒细胞的总数。手术切除所有颊袋,光镜下检查。结果:DMBA给药6周后出现严重上皮异常增生,NS给药2周后再给DMBA给药6周。给予NS或EGCG 2周后继续给予DMBA 6周,轻度发育不良。当给予DMBA 6周,然后给予NS或TQ 6周时,注意到轻度发育不良。与健康对照组相比,服用DMBA 6周导致白细胞总数和淋巴细胞计数显著减少。与健康对照组相比,给予NS或TQ治疗2周导致淋巴细胞计数显著升高。当给予EGCG 2周并继续给予DMBA 6周时,发现总白细胞计数和淋巴细胞计数明显升高。与NS、DMBA或健康对照组相比,服用DMBA 6周后再服用TQ 6周的结果相似。讨论:三种植物化学物质对DMBA的致癌活性表现出不同程度的保护,更具体地说,TQ和NS具有更高的治疗潜力,未来可能用于口腔癌的治疗和/或预防性管理。结论:每种植物化学物质的作用机制和临床应用的可行性有待进一步研究。
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引用次数: 0
Reply to “A modified sagittal split osteotomy: description of technique” 回复“改良矢状面劈开截骨术:技术描述”
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023013
H. Bertin, J. Perrin, P. Corre
A modi fi ed sagittal split osteotomy: description of technique ”
改良矢状面劈裂截骨术:技术描述
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引用次数: 0
The impact of Lidocaine gel on TNF-α expression in surgically induced oral mucosal ulcers: an immunohistochemical analysis in rabbits 利多卡因凝胶对兔手术性口腔粘膜溃疡中TNF-α表达的影响:免疫组织化学分析
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023001
R. S. Hamed, Alyaa I. Naser, L. Al-Allaf, G. Taqa
Background: Besides being a local anesthetic agent lidocaine is a promising anti-inflammatory agent with limited studies on its effect on the mucosa. Aim: Assess the anti-inflammatory effect of lidocaine following surgical induction wound in the oral mucosa as assessed by tumor necrosis factor-α (TNF-α) expression. Materials and methods: The study was conducted on 32 albino rabbits that were categorized into 2 equal groups of 16 rabbits: In the control group an oral wound was surgically induced and left without treatment and in the treatment group an oral wound was surgically induced and received topical Lidocaine gel. Euthanasia of animals was carried out on days 1, 3, 7, and 10, and sample sites were processed for histopathological and immunohistochemical staining for TNF-α. Results: In the histological observations, it was noticed that the healing process was more rapid and convenient in the test group compared to the control group. For Immunohistochemical assessment, the TNF-α started to express clearly at 1 day and gradually decreased and disappeared at 10 days with a superior effect of the lidocaine group over the control group. Conclusion: Lidocaine seems to have anti-inflammatory reactions by lowering TNF-α levels and preventing the production of pro-inflammatory cytokines.
背景:利多卡因除了是一种局部麻醉剂外,也是一种很有前途的抗炎药,但对其粘膜作用的研究有限。目的:通过观察肿瘤坏死因子-α (TNF-α)的表达,评价利多卡因在口腔粘膜手术诱导创面后的抗炎作用。材料和方法:将32只白化兔分为2组,每组16只,对照组手术创面不处理,治疗组手术创面外用利多卡因凝胶。分别于第1、3、7、10天对动物进行安乐死,并对样本部位进行组织病理学和免疫组化TNF-α染色。结果:在组织学观察中,实验组的愈合过程比对照组更快、更方便。免疫组化评价,TNF-α在第1天开始清晰表达,第10天逐渐降低消失,利多卡因组效果优于对照组。结论:利多卡因可能通过降低TNF-α水平和抑制促炎细胞因子的产生而具有抗炎作用。
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引用次数: 0
Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus 口腔扁平苔藓患者唾液皮质醇、焦虑、抑郁水平的比较评价
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023009
S. Jafari, M. Baharvand, Maryam Jarahzade, M. Namdari, Pardis Hojjat, M. Alimohammadi
Oral lichen planus (OLP) is an inflammatory condition of oral mucosa and skin. The present study compared salivary cortisol, depression and anxiety levels of patients with erosive and reticular OLP and healthy controls. In this case-control trial, 69 individuals (23 healthy, 23 erosive OLP and 23 reticular OLP patients) were selected. The participants completed the hospital anxiety and depression scale (HADS) and 5 mL of their unstimulated saliva were collected. Salivary cortisol levels were measured by enzyme-linked immunosorbent assay(ELISA). The comparison of anxiety and depression scores as well as salivary cortisol levels was done one-way analysis of variance (ANOVA) test while the paired comparisons were done by Turkey post hoc test. The mean anxiety score in erosive OLP patients was significantly higher than that in the control and reticular OLP groups. The reticular OLP and control groups had no significant difference in this respect. The three groups were not significantly different regarding the depression score or salivary level of cortisol. The correlation between depression and anxiety was significant but salivary level of cortisol had no correlation with anxiety or depression. This study showed that anxiety control may aid in control of erosive OLP, although further investigations are required.
口腔扁平苔藓(OLP)是口腔黏膜和皮肤的一种炎症性疾病。本研究比较了糜烂性和网状OLP患者与健康对照者的唾液皮质醇、抑郁和焦虑水平。本病例对照试验共纳入69例患者(23例健康、23例糜烂性OLP和23例网状OLP)。参与者完成了医院焦虑和抑郁量表(HADS),并收集了5 mL未受刺激的唾液。采用酶联免疫吸附试验(ELISA)测定唾液皮质醇水平。焦虑、抑郁评分及唾液皮质醇水平的比较采用单因素方差分析(ANOVA)检验,配对比较采用土耳其事后检验。糜烂性OLP患者的平均焦虑评分明显高于对照组和网状OLP组。网状OLP组与对照组在这方面无显著差异。这三组在抑郁评分或唾液皮质醇水平上没有显著差异。抑郁和焦虑之间的相关性显著,但唾液皮质醇水平与焦虑或抑郁无关。本研究表明,控制焦虑可能有助于控制糜烂性OLP,尽管还需要进一步的研究。
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引用次数: 1
Interest of pharyngeal packing in head and neck surgery: a meta-analysis 头颈部手术对咽填塞的兴趣:一项荟萃分析
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023012
Théo Casenave, Natacha Raynaud, Florent Geoffroy, J. Torres
Introduction: There is controversy regarding the use of pharyngeal packing in oral and nasal surgery. The primary objective of this study was to examine the association between pharyngeal packing, throat pain, and postoperative nausea and vomiting (PONV) in head and neck surgery. Material and methods: A systematic review of clinical studies published from January 2000 to August 2020 concerning the use of pharyngeal packing in head and neck surgery was conducted in the Medline, ScienceDirect and Cochrane Library databases. Throat pain and PONV were collected in each article, and a meta-analysis was performed. Results: A total of 10 clinical trials involving 877 patients were included in the meta-analysis. Pharyngeal packing did not significantly decrease PONV score either during the immediate (OR = 0.90, 95% CI: 0.59 to 1.38, p = 0.52, I2 = 0%) or the delayed postoperative period (OR = 0.88, 95% CI: 0.54 to 1.43, p = 0.28, I2 = 21%), but significantly increased the immediate postoperative throat pain score (MD = 0.68, 95% CI: 0.21 to 1.16, p = 0.19, I2 = 35%). Conclusion: This study suggests that the use of a pharyngeal packing to improve the preoperative aftermath in head and neck surgery should not be recommended.
关于咽填充物在口腔和鼻腔手术中的使用存在争议。本研究的主要目的是探讨头颈部手术中咽部填塞、咽喉疼痛和术后恶心呕吐(PONV)之间的关系。材料和方法:在Medline、ScienceDirect和Cochrane图书馆数据库中对2000年1月至2020年8月发表的有关头颈部手术中咽填充物使用的临床研究进行系统回顾。每篇文章收集咽喉疼痛和PONV,并进行meta分析。结果:meta分析共纳入10项临床试验,涉及877例患者。咽填塞在术后即刻(OR = 0.90, 95% CI: 0.59 ~ 1.38, p = 0.52, I2 = 0%)或术后延迟(OR = 0.88, 95% CI: 0.54 ~ 1.43, p = 0.28, I2 = 21%)均未显著降低PONV评分,但显著增加了术后即刻咽喉疼痛评分(MD = 0.68, 95% CI: 0.21 ~ 1.16, p = 0.19, I2 = 35%)。结论:本研究提示不推荐使用咽填充物来改善头颈部手术的术前后遗症。
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引用次数: 0
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Journal of Oral Medicine and Oral Surgery
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