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Zika Virus Outbreaks: a Narrative Review 寨卡病毒爆发:叙事回顾
IF 5.4 Q1 Medicine Pub Date : 2023-11-17 DOI: 10.1007/s40475-023-00307-7
Hariharan Seshadri, Himanshu Jindal, Hritik Madan, Amogh Verma, Efa Khan, Novonil Deb, Ambika Walecha, Vinay Suresh
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引用次数: 0
CNS Infections in Patients Living with HIV/AIDS 艾滋病毒/艾滋病患者的中枢神经系统感染
Q1 Medicine Pub Date : 2023-11-11 DOI: 10.1007/s40475-023-00301-z
Héctor Rivera-Villegas, María Fernanda Vargas-Morales, Juan Sierra-Madero
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引用次数: 0
A Fungus for Our Time: Candida auris Emerges into the Anthropocene 我们时代的真菌:金黄色念珠菌出现在人类世
Q1 Medicine Pub Date : 2023-11-03 DOI: 10.1007/s40475-023-00293-w
Juliet C. Stephenson, Dominic R. Garza, Tejas Bouklas
Abstract Purpose of Review Candida auris is a multi-drug-resistant pathogen with many phenotypic variations that contribute to its pathogenicity. This review aims to characterize its phenotypic heterogeneity while highlighting the variants that should be prioritized in future research to advance therapies against C. auris . Recent Findings As the Earth warms, fungi like Candida experience selective pressure to tolerate these higher temperatures and become the few fungal species capable of successfully colonizing the host. The most recent of these is C. auris , which has become an acute concern due to its rapid emergence, high mortality rate, and resistance to all known classes of antifungals. Summary Several studies have contributed rapidly to our general understanding of C. auris , but not enough has been experimentally verified on its morphological variation and its ability to maintain a successful commensal lifestyle on the human skin. Because of its distinct phenotypic variations compared to other fungal species, especially under the selective pressures of its host, C. auris presents a unique opportunity to identify unique targets and strategies to contribute to the antifungal pipeline and control emergent pathogens.
摘要耳念珠菌是一种多重耐药病原菌,具有多种表型变异,导致其致病性。本综述旨在描述其表型异质性,同时强调在未来研究中应该优先考虑的变异,以推进针对金黄色葡萄球菌的治疗。随着地球变暖,像念珠菌这样的真菌经历了忍受高温的选择压力,成为少数能够成功殖民宿主的真菌物种。其中最近的是金黄色葡萄球菌,由于其出现迅速、死亡率高以及对所有已知种类的抗真菌药物具有耐药性,已成为一个严重问题。几项研究迅速使我们对金黄色葡萄球菌有了大致的了解,但对其形态变异及其在人类皮肤上维持成功共生生活方式的能力的实验验证还不够。由于其与其他真菌物种相比具有明显的表型变异,特别是在其宿主的选择压力下,金黄色葡萄球菌提供了一个独特的机会来确定独特的靶点和策略,以促进抗真菌管道和控制突发病原体。
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引用次数: 1
An Overview of Hookworm Virulence Mechanisms 钩虫毒力机制综述
Q1 Medicine Pub Date : 2023-11-02 DOI: 10.1007/s40475-023-00305-9
Margaret Cassar, Darian Dagenais
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引用次数: 0
Immunomodulation of Macrophages May Benefit Cutaneous Leishmaniasis Outcome 巨噬细胞的免疫调节可能有利于皮肤利什曼病的预后
Q1 Medicine Pub Date : 2023-11-01 DOI: 10.1007/s40475-023-00303-x
Lucas Bonatto de Souza Lima, Rafael Andrade Menolli, Thais Soprani Ayala
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引用次数: 0
Brain Abscesses in the Tropics 热带地区的脑脓肿
Q1 Medicine Pub Date : 2023-11-01 DOI: 10.1007/s40475-023-00306-8
Michaele Francesco Corbisiero, Rebecca A. Ripperton, Elizabeth Garcia Creighton, Anthony M. Smyth, J. David Beckham, Andres F. Henao-Martínez
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引用次数: 0
Human African Trypanosomiasis (Sleeping Sickness)—Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention 非洲人类锥虫病(昏睡病)——流行病学、临床表现、诊断、治疗和预防
Q1 Medicine Pub Date : 2023-10-25 DOI: 10.1007/s40475-023-00304-w
Yeimer Ortiz-Martínez, Menan Gérard Kouamé, Felix Bongomin, Sulaiman Lakoh, Andrés F. Henao-Martínez
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引用次数: 0
Effectiveness of Essential Oils and Their Components Against Triatoma infestans (Hemiptera: Reduviidae) 精油及其成分对红眼虫的防治效果研究
Q1 Medicine Pub Date : 2023-10-03 DOI: 10.1007/s40475-023-00295-8
E. Sosa, V. Quiroga, A.C. Toloza
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引用次数: 0
Implications of Climate Change and Anopheles stephensi Liston in Africa: Knowledge Gaps and Lessons from History 气候变化和非洲斯氏按蚊的影响:知识缺口和历史教训
Q1 Medicine Pub Date : 2023-09-29 DOI: 10.1007/s40475-023-00296-7
David B. Pecor, Alexander M. Potter, Yvonne-Marie Linton
Abstract Purpose of Review The invasive Asian mosquito vector— Anopheles stephensi Liston, 1901—is poised to greatly complicate malaria eradication efforts across Africa. This species has been reported in an increasing number of African nations and has the potential to introduce malaria into most of Africa’s largest cities. Climate change is a dominant force changing population dynamics across the continent and driving human populations to migrate to urban centers. Recent Findings This work presents all high-quality surveillance data documenting An . stephensi to date, including an overlooked report of the species collected in Egypt in 1966. Finally, we provide detailed images of adult and larval morphology and bionomics descriptions. Summary Based on our current knowledge of Anopheles stephensi , we explore how climate change may impact its distribution and malaria rates in the coming decades. We also identify key knowledge gaps related to this species invasion including the most up-to-date information on the taxonomy, morphological characters, and bionomics of An . stephensi . Tools that are publicly available via VectorMap are also presented along with guidance on strengthening surveillance programs targeting An . stephensi using these tools.
入侵性的亚洲蚊媒——斯氏按蚊(Anopheles stephensi Liston, 1901)将极大地复杂化整个非洲的疟疾根除工作。据报道,在越来越多的非洲国家发现了这一物种,并有可能将疟疾引入非洲大多数大城市。气候变化是改变整个非洲大陆人口动态的主导力量,并推动人口向城市中心迁移。这项工作提供了所有高质量的监测数据,记录了安。包括1966年在埃及收集的一份被忽视的物种报告。最后,我们提供了详细的成虫和幼虫的形态和生物学描述图像。基于我们目前对斯氏按蚊的了解,我们探讨了气候变化如何影响其分布和未来几十年的疟疾发病率。我们还确定了与该物种入侵有关的关键知识空白,包括最新的分类、形态特征和生物学信息。stephensi。报告还介绍了通过VectorMap公开提供的工具,以及关于加强针对艾滋病的监测项目的指导。Stephensi使用这些工具。
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引用次数: 0
A Systematic Review of Disparities in Risk for Neglected Infections of Poverty in the United States 对美国被忽视的贫困感染风险差异的系统回顾
Q1 Medicine Pub Date : 2023-09-29 DOI: 10.1007/s40475-023-00298-5
Rachael Singer, Rachel Radcliffe
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引用次数: 0
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Current Tropical Medicine Reports
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