{"title":"Assessment of Endocrine Disruption Potential of Chemicals Using Combined Quantitative Structure-Activity Relationship Modeling of In Vitro and In Vivo Assays","authors":"M. Girireddy, R. Saiakhov, S. Chakravarti","doi":"10.1089/aivt.2022.0015","DOIUrl":"https://doi.org/10.1089/aivt.2022.0015","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47043250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judy Strickland, David G Allen, Dori Germolec, Nicole Kleinstreuer, Victor J Johnson, Travis Gulledge, Jim Truax, Anna Lowit, Timothy Dole, Timothy McMahon, Melissa Panger, Judy Facey, Stephen Savage
Introduction: Isothiazolinones (ITs) are widely used as antimicrobial preservatives in cosmetics and as additives for preservation of consumer and industrial products to control bacteria, fungi, and algae. Although they are effective biocides, they have the potential to produce skin irritation and sensitization, which poses a human health hazard. In this project, we evaluated nonanimal defined approaches (DAs) for skin sensitization that can provide point-of-departure estimates for use in quantitative risk assessment for ITs.
Materials and methods: The skin sensitization potential of six ITs was evaluated using three internationally harmonized nonanimal test methods: the direct peptide reactivity assay, KeratinoSens™, and the human cell line activation test. Results from these test methods were then applied to two versions of the Shiseido Artificial Neural Network DA.
Results: Sensitization hazard or potency predictions were compared with those of the in vivo murine local lymph node assay (LLNA). The nonanimal methods produced skin sensitization hazard and potency classifications concordant with those of the LLNA. EC3 values (the estimated concentration needed to produce a stimulation index of three, the threshold positive response) generated by the DAs had less variability than LLNA EC3 values, and confidence limits from the DAs overlapped those of the LLNA EC3 for most substances.
Conclusion: The application of in silico models to in chemico and in vitro skin sensitization data is a promising data integration procedure for DAs to support hazard and potency classification and quantitative risk assessment.
{"title":"Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds.","authors":"Judy Strickland, David G Allen, Dori Germolec, Nicole Kleinstreuer, Victor J Johnson, Travis Gulledge, Jim Truax, Anna Lowit, Timothy Dole, Timothy McMahon, Melissa Panger, Judy Facey, Stephen Savage","doi":"10.1089/aivt.2022.0014","DOIUrl":"https://doi.org/10.1089/aivt.2022.0014","url":null,"abstract":"<p><strong>Introduction: </strong>Isothiazolinones (ITs) are widely used as antimicrobial preservatives in cosmetics and as additives for preservation of consumer and industrial products to control bacteria, fungi, and algae. Although they are effective biocides, they have the potential to produce skin irritation and sensitization, which poses a human health hazard. In this project, we evaluated nonanimal defined approaches (DAs) for skin sensitization that can provide point-of-departure estimates for use in quantitative risk assessment for ITs.</p><p><strong>Materials and methods: </strong>The skin sensitization potential of six ITs was evaluated using three internationally harmonized nonanimal test methods: the direct peptide reactivity assay, KeratinoSens™, and the human cell line activation test. Results from these test methods were then applied to two versions of the Shiseido Artificial Neural Network DA.</p><p><strong>Results: </strong>Sensitization hazard or potency predictions were compared with those of the in vivo murine local lymph node assay (LLNA). The nonanimal methods produced skin sensitization hazard and potency classifications concordant with those of the LLNA. EC3 values (the estimated concentration needed to produce a stimulation index of three, the threshold positive response) generated by the DAs had less variability than LLNA EC3 values, and confidence limits from the DAs overlapped those of the LLNA EC3 for most substances.</p><p><strong>Conclusion: </strong>The application of <i>in silico</i> models to <i>in chemico</i> and in vitro skin sensitization data is a promising data integration procedure for DAs to support hazard and potency classification and quantitative risk assessment.</p>","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":"8 4","pages":"117-128"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1089/aivt.2022.29031.editorial
B. Lidbury
{"title":"Machine Learning and In Vitro Toxicology","authors":"B. Lidbury","doi":"10.1089/aivt.2022.29031.editorial","DOIUrl":"https://doi.org/10.1089/aivt.2022.29031.editorial","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47858404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Motafeghi, B. Khayambashi, P. Mortazavi, M. Eghbali, Amirhossein Salmanmahiny, Romina Shahsavari, M. Shokrzadeh
{"title":"Synergistic Effect of Selenium/Zinc with Sulfasalazine on the Human Colorectal Cancer Cell Line (HT-29)","authors":"F. Motafeghi, B. Khayambashi, P. Mortazavi, M. Eghbali, Amirhossein Salmanmahiny, Romina Shahsavari, M. Shokrzadeh","doi":"10.1089/aivt.2022.0007","DOIUrl":"https://doi.org/10.1089/aivt.2022.0007","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47501993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanjeeva J. Wijeyesakere, Daniel M. Wilson, T. Auernhammer, Amanda K. Parks, S. Marty
{"title":"Machine-Learning Model Predicts Interaction with γ-Amino Butyric Acid (GABA)ergic Neurotransmission","authors":"Sanjeeva J. Wijeyesakere, Daniel M. Wilson, T. Auernhammer, Amanda K. Parks, S. Marty","doi":"10.1089/aivt.2021.0028","DOIUrl":"https://doi.org/10.1089/aivt.2021.0028","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48964158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Weber, B. Birk, Chantal Herrmann, H. Huener, K. Renko, S. Coecke, S. Schneider, D. Funk-Weyer, R. Landsiedel
{"title":"A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes","authors":"A. Weber, B. Birk, Chantal Herrmann, H. Huener, K. Renko, S. Coecke, S. Schneider, D. Funk-Weyer, R. Landsiedel","doi":"10.1089/aivt.2022.0010","DOIUrl":"https://doi.org/10.1089/aivt.2022.0010","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44479659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterizing Local Acute Irritation Properties of Captan and Folpet with New Approach Methods","authors":"F. Kluxen, C. Roper, Signe M. Jensen, C. Koenig","doi":"10.1089/aivt.2022.0004","DOIUrl":"https://doi.org/10.1089/aivt.2022.0004","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44251101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Misurale, Cristina Scarone, L. Pezzolesi, R. Pistocchi, A. Bassi, A. Novellino, Matilde Calderoni, A. Pagano, Valentina Giussani, S. Alloisio
{"title":"An Integrated In Vitro Approach for Human Health and Environmental Risk Assessment of Mediterranean Ostreopsis cf. ovata, Prorocentrum lima, and Coolia monotis Strains","authors":"Francesco Misurale, Cristina Scarone, L. Pezzolesi, R. Pistocchi, A. Bassi, A. Novellino, Matilde Calderoni, A. Pagano, Valentina Giussani, S. Alloisio","doi":"10.1089/aivt.2022.0008","DOIUrl":"https://doi.org/10.1089/aivt.2022.0008","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45436707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1089/aivt.2022.29030.editorial
Andrew Gow
{"title":"Scientific Usefulness of New Approach Methodologies","authors":"Andrew Gow","doi":"10.1089/aivt.2022.29030.editorial","DOIUrl":"https://doi.org/10.1089/aivt.2022.29030.editorial","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45592635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Keyser, R. Leverette, M. Hollings, Adam Seymour, Randy J. Weidman, Carlton J. Bequette, Kristen G. Jordan
{"title":"Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48","authors":"B. Keyser, R. Leverette, M. Hollings, Adam Seymour, Randy J. Weidman, Carlton J. Bequette, Kristen G. Jordan","doi":"10.1089/aivt.2022.0001","DOIUrl":"https://doi.org/10.1089/aivt.2022.0001","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41815192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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