E. F. Augustina, Nur Riflianty Rivai, Haykal Miftah Gifary
Objective: inflammation may play a role in bone loss by altering the bone remodelling process, favouring bone resorption by osteoclasts over bone synthesis by osteoblasts. Matrix metalloproteinase 13 (MMP-13) has the ability to activate osteoclasts, leading to bone resorption. Regenerative treatments have been widely used in periodontology. When combined with Platelet-rich fibrin (PRF), xenografts will give better results in bone regeneration. The aim of this study was to evaluate the effect of xenograft combined with PRF on MMP-13 expression in a bone defect using an experimentally created bone defect. Material and Methods: eighteen New Zealand rabbits were assigned to three groups. Each group consisted of six New Zealand rabbits. A critical bone defect with a diameter size of 5 mm was created in the right tibia of each rabbit in group 1 (application: xenograft), group 2 (application: PRF), and group 3 (application: xenograft and PRF). The PRF was produced from 5 ml of blood taken from each rabbit’s ears. After 30 days, the rabbits were euthanized. The tissue samples were evaluated by immunohistochemical staining. Results: group 3 showed the lowest mean expression of MMP-13 (4.50) compared to group 1 (20.50) and group 2 (11.70). Group 3 showed a significant difference in the MMP-13 expression compared to group 1 and group 2 (P = 0.000) (P < 0.05). Conclusion: this research showed that the combination of xenograft and PRF had the lowest expression of MMP-13. The application of a xenograft and PRF has better osteogenesis ability in bone regeneration.
{"title":"The expression of matrix metalloproteinase-13 (MMP-13) on xenograft and PRF in bone regeneration","authors":"E. F. Augustina, Nur Riflianty Rivai, Haykal Miftah Gifary","doi":"10.4322/bds.2023.e3366","DOIUrl":"https://doi.org/10.4322/bds.2023.e3366","url":null,"abstract":"Objective: inflammation may play a role in bone loss by altering the bone remodelling process, favouring bone resorption by osteoclasts over bone synthesis by osteoblasts. Matrix metalloproteinase 13 (MMP-13) has the ability to activate osteoclasts, leading to bone resorption. Regenerative treatments have been widely used in periodontology. When combined with Platelet-rich fibrin (PRF), xenografts will give better results in bone regeneration. The aim of this study was to evaluate the effect of xenograft combined with PRF on MMP-13 expression in a bone defect using an experimentally created bone defect. Material and Methods: eighteen New Zealand rabbits were assigned to three groups. Each group consisted of six New Zealand rabbits. A critical bone defect with a diameter size of 5 mm was created in the right tibia of each rabbit in group 1 (application: xenograft), group 2 (application: PRF), and group 3 (application: xenograft and PRF). The PRF was produced from 5 ml of blood taken from each rabbit’s ears. After 30 days, the rabbits were euthanized. The tissue samples were evaluated by immunohistochemical staining. Results: group 3 showed the lowest mean expression of MMP-13 (4.50) compared to group 1 (20.50) and group 2 (11.70). Group 3 showed a significant difference in the MMP-13 expression compared to group 1 and group 2 (P = 0.000) (P < 0.05). Conclusion: this research showed that the combination of xenograft and PRF had the lowest expression of MMP-13. The application of a xenograft and PRF has better osteogenesis ability in bone regeneration.","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90464824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bethania Paludo Oliveira, M. Buzalaf, N. M. Santos, N. C. Silva, T. M. Ventura, J. A. Rodrigues
{"title":"Knowledge and attitudes related to erosive tooth wear of professional wine tasters: a cross-sectional study","authors":"Bethania Paludo Oliveira, M. Buzalaf, N. M. Santos, N. C. Silva, T. M. Ventura, J. A. Rodrigues","doi":"10.4322/bds.2023.e3517","DOIUrl":"https://doi.org/10.4322/bds.2023.e3517","url":null,"abstract":"","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84501668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. C. Ramos, M. G. Augusto, L. M. M. Alves, C. Kleverlaan, A. D. Piva
{"title":"Wear of dental ceramics","authors":"N. C. Ramos, M. G. Augusto, L. M. M. Alves, C. Kleverlaan, A. D. Piva","doi":"10.4322/bds.2023.e3638","DOIUrl":"https://doi.org/10.4322/bds.2023.e3638","url":null,"abstract":"","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87851757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karolina Aparecida Castilho Fadim, Sérgio Eduardo de Paiva Gonçalves, João Paulo Mendes Tribst
The integration of artificial intelligence (AI) text generators in scientific reports demands careful evaluation of specific ethical considerations. While these AI technologies offer text generation support, addressing the ethical implications is vital. This editorial highlights the need for a thoughtful and responsible approach, emphasizing the establishment of guidelines and best practices by researchers and scientific communities. Collaborative efforts between AI developers, researchers, and ethical committees can ensure the seamless integration of AI technologies while upholding the integrity, quality, and ethical standards of scientific reporting. This text comprehensively summarizes the key considerations to be followed when utilizing artificial intelligence text generators in scientific reports. KEYWORDS Artificial intelligence; Dental society; Ethics; Forecasting; Scientific society.
{"title":"Scientific writing with artificial intelligence: key considerations and alerts","authors":"Karolina Aparecida Castilho Fadim, Sérgio Eduardo de Paiva Gonçalves, João Paulo Mendes Tribst","doi":"10.4322/bds.2023.e3988","DOIUrl":"https://doi.org/10.4322/bds.2023.e3988","url":null,"abstract":"The integration of artificial intelligence (AI) text generators in scientific reports demands careful evaluation of specific ethical considerations. While these AI technologies offer text generation support, addressing the ethical implications is vital. This editorial highlights the need for a thoughtful and responsible approach, emphasizing the establishment of guidelines and best practices by researchers and scientific communities. Collaborative efforts between AI developers, researchers, and ethical committees can ensure the seamless integration of AI technologies while upholding the integrity, quality, and ethical standards of scientific reporting. This text comprehensively summarizes the key considerations to be followed when utilizing artificial intelligence text generators in scientific reports. KEYWORDS Artificial intelligence; Dental society; Ethics; Forecasting; Scientific society.","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lorena Vieira SACRAMENTO, Ianna Josefa Valeska de Aniz CASTRO, Leonardo M. G. FIGUEIREDO, Braúlio CARNEIRO, Jean Nunes dos SANTOS, Águida Cristina Gomes HENRIQUES
Odontogenic lesions are a heterogeneous group of diseases that presents differences in their biological behavior and the occurrence of variable inductive interactions. Calcifying odontogenic cyst (COC), or Gorlin’s cyst, is a well-recognized example of these lesions. We describe a case of COC with AOT-like areas and highlights its morphological diversity. A 60-year-old pheoderma man presented with a large swelling in the anterior buccal region of the mandible. Panoramic radiography revealed a well-defined, unilocular, radiolucent lesion associated with important root resorption. Complete enucleation of the lesion was performed and the histopathological findings met the criteria for the diagnosis of COC, although the cyst exhibited unusual AOT-like features. The patient has been recurrence free for 6 months after surgery. COCs with AOT-like features are rare, and reflect the multipotentiality and complexity of the inductive effects of the odontogenic epithelium with the ectomesenchyme. Enucleation seems to be the most indicated treatment, similar to classical COC. KEYWORDS Adenomatoid odontogenic tumor; Calcifying odontogenic cyst; Odontogenic cysts; Oral pathology; Oral surgery.
{"title":"Calcifying odontogenic cyst with AOT-like features: a case report and literature review","authors":"Lorena Vieira SACRAMENTO, Ianna Josefa Valeska de Aniz CASTRO, Leonardo M. G. FIGUEIREDO, Braúlio CARNEIRO, Jean Nunes dos SANTOS, Águida Cristina Gomes HENRIQUES","doi":"10.4322/bds.2023.e3823","DOIUrl":"https://doi.org/10.4322/bds.2023.e3823","url":null,"abstract":"Odontogenic lesions are a heterogeneous group of diseases that presents differences in their biological behavior and the occurrence of variable inductive interactions. Calcifying odontogenic cyst (COC), or Gorlin’s cyst, is a well-recognized example of these lesions. We describe a case of COC with AOT-like areas and highlights its morphological diversity. A 60-year-old pheoderma man presented with a large swelling in the anterior buccal region of the mandible. Panoramic radiography revealed a well-defined, unilocular, radiolucent lesion associated with important root resorption. Complete enucleation of the lesion was performed and the histopathological findings met the criteria for the diagnosis of COC, although the cyst exhibited unusual AOT-like features. The patient has been recurrence free for 6 months after surgery. COCs with AOT-like features are rare, and reflect the multipotentiality and complexity of the inductive effects of the odontogenic epithelium with the ectomesenchyme. Enucleation seems to be the most indicated treatment, similar to classical COC. KEYWORDS Adenomatoid odontogenic tumor; Calcifying odontogenic cyst; Odontogenic cysts; Oral pathology; Oral surgery.","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ellen Eduarda Fernandes, Daniela Fernandes Lobo Molica Oliveira, R. P. Jóias, P. A. Diniz, P. P. Barros, A. O. C. Jorge, W. Oliveira, S. Rode
{"title":"Analysis of biofilm formation by Candida albicans in different types of orthodontic fixed appliances and devices","authors":"Ellen Eduarda Fernandes, Daniela Fernandes Lobo Molica Oliveira, R. P. Jóias, P. A. Diniz, P. P. Barros, A. O. C. Jorge, W. Oliveira, S. Rode","doi":"10.4322/bds.2023.e3440","DOIUrl":"https://doi.org/10.4322/bds.2023.e3440","url":null,"abstract":"","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75161101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. L. F. Ricardo, Rosemeire-Arai Yoshida, R. Guaré, C. Cardoso, S. Lopes, K. Fardim, A. Costa, Maria Teresa Santos
{"title":"Dental care for patients with special needs at a private higher education institute","authors":"A. L. F. Ricardo, Rosemeire-Arai Yoshida, R. Guaré, C. Cardoso, S. Lopes, K. Fardim, A. Costa, Maria Teresa Santos","doi":"10.4322/bds.2023.e3646","DOIUrl":"https://doi.org/10.4322/bds.2023.e3646","url":null,"abstract":"","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86486501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: to compare the quality of obturation, instrumentation time and post-operative pain after pulpectomy in primary molars using manual K-files, Kedo-S and Kedo-S Square rotary file systems. Material and Methods: a double blinded randomized control trial was conducted in 45 children, who were indicated for pulpectomy in any one of the primary mandibular molars. The canal preparation was done using either hand K-files, Kedo-S files, or Kedo-S Square files based on the groups assigned. The time taken for instrumentation was recorded using a stopwatch. The quality of obturation was evaluated using post-operative radiograph and post-operative pain was assessed with modified Wong-Baker Faces Pain scale. Results: instrumentation time was minimum in rotary Kedo-S Square files (53.23 ± 9.60 seconds) followed by Kedo-S files (82.70 ± 11.86 seconds). The preparation time was maximum with manual K-files (121.43 ± 20.18 seconds). Kedo-S square files provided a higher number of optimally filled canals (66.4%). All the three instrumentations equally showed the tendency to produce voids in the obturation. Rotary files Kedo-S Square followed by Kedo-S showed less post-operative pain compared to K-files. Conclusion: the use of pediatric rotary instruments for canal preparation during pulpectomy will result in better quality of obturation in reduced time with least post-operative pain.
{"title":"Comparison of obturation quality, instrumentation time and post-operative pain\u0000 using manual K-files and pediatric rotary files in primary molars a double blinded\u0000 randomised clinical trial","authors":"L. Lakshmanan, M. Ramakrishnan, G. Jeevanandan","doi":"10.4322/bds.2023.e3497","DOIUrl":"https://doi.org/10.4322/bds.2023.e3497","url":null,"abstract":"Objective: to compare the quality of obturation, instrumentation time and post-operative pain after pulpectomy in primary molars using manual K-files, Kedo-S and Kedo-S Square rotary file systems. Material and Methods: a double blinded randomized control trial was conducted in 45 children, who were indicated for pulpectomy in any one of the primary mandibular molars. The canal preparation was done using either hand K-files, Kedo-S files, or Kedo-S Square files based on the groups assigned. The time taken for instrumentation was recorded using a stopwatch. The quality of obturation was evaluated using post-operative radiograph and post-operative pain was assessed with modified Wong-Baker Faces Pain scale. Results: instrumentation time was minimum in rotary Kedo-S Square files (53.23 ± 9.60 seconds) followed by Kedo-S files (82.70 ± 11.86 seconds). The preparation time was maximum with manual K-files (121.43 ± 20.18 seconds). Kedo-S square files provided a higher number of optimally filled canals (66.4%). All the three instrumentations equally showed the tendency to produce voids in the obturation. Rotary files Kedo-S Square followed by Kedo-S showed less post-operative pain compared to K-files. Conclusion: the use of pediatric rotary instruments for canal preparation during pulpectomy will result in better quality of obturation in reduced time with least post-operative pain.","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87574772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Pax-7 and Myo-D regulate satellite cells’ activation and differentiation, thus muscle regeneration following damage. This research aimed to investigate the effect of Thymoquinone (TQ) on skeletal muscle regeneration following 7,12-dimethylbenz-(a)-anthracene (DMBA)-induced injury in the hamster buccal pouch via immunohistochemical assessment of Pax-7 and Myo-D expression. Material and Methods: 65 male golden Syrian hamsters were divided into 3 groups: Group 1: (n=5) received no treatment. Group 2: (n=20) served as a positive control. The left buccal pouches were painted with the carcinogen 3/week/ 6weeks. Group 3: (n=40) were subdivided into two equal sub-groups as follows: Group 3a: (n=20) were given one i.p. TQ injection. Group 3b: (n=20) were given two i.p. TQ injections. Five animals from each group (2 and 3) were euthanized at 24, 48 hrs, one, and two weeks after the last injection. A blood sample (2 ml) was withdrawn for assessment of TNF-α levels in serum. Serial sections of the pouches were examined histologically (H&E), and immunohistochemically (IHC) for the detection of Pax-7 and Myo-D proteins. Results: double i.p injections of TQ resulted in a significant elevation in the level of TNF-α from the second-day post-injection with a progressive formation of the muscle fibers (MFs) and mononuclear cells (MNCs) around the deeper blood vessels. At 14 days, no statistically significant difference was found between this group and group ‘2’, while the difference remained significant compared to groups ‘1’ and ‘3a’. The muscle fibers were more mature and compact. IHC results showed positive expression of the perivascular mononuclear cells (MNCs) to both Pax-7 and Myo-D with positive reactivity of the peripheral nuclei of muscle fibers to Pax-7 compared to the negative reaction in the positive control group. Conclusion: early and two TQ injections had a promising effect on the induction of striated muscle regeneration, mainly by non-myogenic stem cells.
{"title":"Effect of Thymoquinone on skeletal muscle regeneration via assessment of Pax-7 and\u0000 Myo-D expression in the DMBA-treated hamster pouch","authors":"Sara A Swidan, Samia Elazab, M. Hassan","doi":"10.4322/bds.2023.e3620","DOIUrl":"https://doi.org/10.4322/bds.2023.e3620","url":null,"abstract":"Objective: Pax-7 and Myo-D regulate satellite cells’ activation and differentiation, thus muscle regeneration following damage. This research aimed to investigate the effect of Thymoquinone (TQ) on skeletal muscle regeneration following 7,12-dimethylbenz-(a)-anthracene (DMBA)-induced injury in the hamster buccal pouch via immunohistochemical assessment of Pax-7 and Myo-D expression. Material and Methods: 65 male golden Syrian hamsters were divided into 3 groups: Group 1: (n=5) received no treatment. Group 2: (n=20) served as a positive control. The left buccal pouches were painted with the carcinogen 3/week/ 6weeks. Group 3: (n=40) were subdivided into two equal sub-groups as follows: Group 3a: (n=20) were given one i.p. TQ injection. Group 3b: (n=20) were given two i.p. TQ injections. Five animals from each group (2 and 3) were euthanized at 24, 48 hrs, one, and two weeks after the last injection. A blood sample (2 ml) was withdrawn for assessment of TNF-α levels in serum. Serial sections of the pouches were examined histologically (H&E), and immunohistochemically (IHC) for the detection of Pax-7 and Myo-D proteins. Results: double i.p injections of TQ resulted in a significant elevation in the level of TNF-α from the second-day post-injection with a progressive formation of the muscle fibers (MFs) and mononuclear cells (MNCs) around the deeper blood vessels. At 14 days, no statistically significant difference was found between this group and group ‘2’, while the difference remained significant compared to groups ‘1’ and ‘3a’. The muscle fibers were more mature and compact. IHC results showed positive expression of the perivascular mononuclear cells (MNCs) to both Pax-7 and Myo-D with positive reactivity of the peripheral nuclei of muscle fibers to Pax-7 compared to the negative reaction in the positive control group. Conclusion: early and two TQ injections had a promising effect on the induction of striated muscle regeneration, mainly by non-myogenic stem cells.","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87759937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yusra Hameed AL-MUKHTAR, Zaid Hazim DELEME, Ahmed Salih KHUDHUR
Etoricoxib, a new cyclooxygenase-2-selective inhibitor has demonstrated a rapid onset analgesic effect for relieving acute pain especially when prescribed as a pre-emptive medication. On these bases, this study may provide useful information and guidance for clinicians working in the field of oral surgery, as regards handling odontogenic pain and postoperative pain precisely with cyclooxygenase-2 inhibitors. Objective: the study aimed to measure the quantifiable efficacy of Etoricoxib in reducing post-extraction pain in subjects undergoing minor oral surgical intervention as compared to Naproxen (a traditional NSAID) which is commonly used to control postoperative pain. Material and Methods: a 120 mg film-coated tablet of Etoricoxib was given to each of the twenty patients representing the study group, and a 500 mg tablet of Naproxen was given to each of the other twenty subjects representing the positive control group. According to manufacturer instructions, the tablets were given to the subjects 30 minutes pre-operatively (before dental extraction). Post-operative pain was assessed for each subject using eleven points from zero to ten, visual analog scale. Results: showed no statistically significant difference between Etoricoxib and Naproxen in decreasing post-extraction odontogenic pain, suggesting that Etoricoxib is as efficient as Naproxen in the control of discomfort with dental origin taking into consideration the patient’s status when prescribing the medication. Conclusion: this study suggests that Etoricoxib can be handled as a pre-emptive medication to reduce post-operative pain for subjects seeking traditional or surgical extraction of any of their teeth. KEYWORDS Etoricoxib; Pain; Oral surgery; Clinical Trial
{"title":"Evaluating the efficacy of Etoricoxib in reducing post-operative pain associated with minor oral surgery. A randomized clinical trial","authors":"Yusra Hameed AL-MUKHTAR, Zaid Hazim DELEME, Ahmed Salih KHUDHUR","doi":"10.4322/bds.2023.e3854","DOIUrl":"https://doi.org/10.4322/bds.2023.e3854","url":null,"abstract":"Etoricoxib, a new cyclooxygenase-2-selective inhibitor has demonstrated a rapid onset analgesic effect for relieving acute pain especially when prescribed as a pre-emptive medication. On these bases, this study may provide useful information and guidance for clinicians working in the field of oral surgery, as regards handling odontogenic pain and postoperative pain precisely with cyclooxygenase-2 inhibitors. Objective: the study aimed to measure the quantifiable efficacy of Etoricoxib in reducing post-extraction pain in subjects undergoing minor oral surgical intervention as compared to Naproxen (a traditional NSAID) which is commonly used to control postoperative pain. Material and Methods: a 120 mg film-coated tablet of Etoricoxib was given to each of the twenty patients representing the study group, and a 500 mg tablet of Naproxen was given to each of the other twenty subjects representing the positive control group. According to manufacturer instructions, the tablets were given to the subjects 30 minutes pre-operatively (before dental extraction). Post-operative pain was assessed for each subject using eleven points from zero to ten, visual analog scale. Results: showed no statistically significant difference between Etoricoxib and Naproxen in decreasing post-extraction odontogenic pain, suggesting that Etoricoxib is as efficient as Naproxen in the control of discomfort with dental origin taking into consideration the patient’s status when prescribing the medication. Conclusion: this study suggests that Etoricoxib can be handled as a pre-emptive medication to reduce post-operative pain for subjects seeking traditional or surgical extraction of any of their teeth. KEYWORDS Etoricoxib; Pain; Oral surgery; Clinical Trial","PeriodicalId":37577,"journal":{"name":"Brazilian Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135910401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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