Revista Colombiana de Reumatologia最新文献

{"title":"Efectividad del uso del parche de trinitrato de glicerilo en el fenómeno de Raynaud secundario","authors":"Silvia Méndez-Flores ,&nbsp;Dulce María Carrillo-Córdova ,&nbsp;Rafael López-Loya ,&nbsp;Bruno Estañol-Vidal","doi":"10.1016/j.rcreu.2024.01.002","DOIUrl":"10.1016/j.rcreu.2024.01.002","url":null,"abstract":"<div><h3>Introduction/Objective</h3><div>Secondary Raynaud's phenomenon is one of the primary cutaneous manifestations of various rheumatological diseases, which can significantly impact quality of life and whose systemic treatment can lead to several adverse effects. Therefore, this study was conducted to assess the effectiveness of glyceryl trinitrate (in transdermal patch form) in patients with secondary Raynaud's phenomenon (SRP), evaluated through vascular flow photoplethysmography.</div></div><div><h3>Materials and methods</h3><div>A comparative, analytical, open-label, non-randomized study was conducted to evaluate the efficacy of 4.5<!--> <!-->mg of glyceryl trinitrate in a transdermal patch placed on the proximal region of one hand in patients diagnosed with SRP compared to the untreated contralateral hand. To determine the primary outcome, vascular flow photoplethysmography assessment was performed 30 days after daily patch use. Secondary results were obtained using an infrared thermometer to measure local temperature in both hands before patch application, 30<!--> <!-->minutes after patch use, and at the end of the follow-up period. Additionally, various questionnaires, including the Visual Analogue Scale for pain, Raynaud's Condition Score (RCS), and Dermatology Quality of Life Index (DLQI), were administered on the first and last days of the study.</div></div><div><h3>Results</h3><div>Sixteen patients, all female, with a median age of 54 years, were included. Regarding the rheumatological diseases associated with secondary Raynaud's phenomenon, twelve patients (75% of the sample) were associated with systemic sclerosis, three patients (19%) with lupus erythematosus, and one (6%) with mixed connective tissue disease (MCTD). There was a significant increase in peripheral blood flow after 30 days of treatment with 4.5<!--> <!-->mg of glyceryl trinitrate every 24<!--> <!-->hours, along with improvement in clinical symptom and quality of life questionnaires.</div></div><div><h3>Conclusions</h3><div>This study supports the use of low-dose glyceryl trinitrate via transdermal patches to improve vascular flows, translating into short-term clinical symptom improvement associated with SRP.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 130-136"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El ABC de la nefritis lúpica","authors":"José A. Gómez-Puerta","doi":"10.1016/j.rcreu.2025.02.001","DOIUrl":"10.1016/j.rcreu.2025.02.001","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 103-104"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comite Editorial online","authors":"","doi":"10.1016/S0121-8123(24)00107-5","DOIUrl":"10.1016/S0121-8123(24)00107-5","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages E1-E3"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of medications and understanding of Mexican patients regarding the non-medical switch from originator to its biosimilar in inflammatory arthritis","authors":"Carlos Andrés Díaz-Garza ,&nbsp;Alejandro Garza-Alpirez ,&nbsp;David Vega-Morales ,&nbsp;Deshiré Alpizar-Rodríguez ,&nbsp;Berenice Carrillo-Haro","doi":"10.1016/j.rcreu.2023.12.007","DOIUrl":"10.1016/j.rcreu.2023.12.007","url":null,"abstract":"<div><h3>Introduction/Objective</h3><div>Our aim was to know patient's understanding and concerns about biosimilars, switching, and non-medical switch in Mexican population.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional social media survey via the Mexican Foundation for Rheumatic Patients (FUMERAC) was conducted from November 2020 to January 2021. Patients were eligible if they were &gt;18 years of age with any inflammatory rheumatic condition.</div></div><div><h3>Results</h3><div>A total of 165 participants completed the survey. The most frequent diagnoses were Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis. Disease-modifying antirheumatic drugs as monotherapy was the most common treatment. Prior or current users of biologics were reported. Most participants had never heard the term biosimilar<span>. Some would accept the change from an originator to its biosimilar and few would take legal measure or file a complaint if a non-medical switch were to happen. Patients had concerns on treatment effectiveness, adverse effects, reason for change, treatment duration, and other patient's experience.</span></div></div><div><h3>Conclusion</h3><div>In Mexico, the concept of biosimilars is barely known. Most patients would not take any measure if they were changed from an originator to its biosimilar.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 105-109"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of simple hematological parameters with disease activity and damage indices among Egyptian patients with systemic lupus erythematosus","authors":"Hanan H. Ahmed ,&nbsp;Hebatallah S. Farag ,&nbsp;Nesreen Sobhy","doi":"10.1016/j.rcreu.2024.01.006","DOIUrl":"10.1016/j.rcreu.2024.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the correlation of different hematological parameters in lupus patients with SLE disease activity index (SLEDAI), the Systemic Lupus International Collaboration Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI), and some laboratory data related to kidney functions in active patients with nephritis.</div></div><div><h3>Material and methods</h3><div>80 inactive SLE patients (SLEDAI score<!--> <!-->&lt;<!--> <!-->10 points), and 80 active patients (SLEDAI<!--> <!-->≥<!--> <span>10 points) were enrolled in this study. All patients underwent full medical history taking, clinical evaluation including calculation of SLEDAI<span> and SLICC/ACR DI scores, and laboratory investigations including complete blood count. The two groups were compared regarding different disease parameters. Correlations of some hematological parameters with SLEDAI, SLICC/ACR DI scores and some laboratory data related to kidney function in patients with nephritis were made.</span></span></div></div><div><h3>Results</h3><div>The active group showed statistically significantly higher mean NLR (<em>P</em> <!-->=<!--> <!-->0.000), NC3R (<em>P</em> <!-->=<!--> <!-->0.000), MLR (<em>P</em> <!-->=<!--> <!-->0.000), PLR (<em>P</em> <!-->=<!--> <!-->0.000), and RDW (<em>P</em> <!-->=<!--> <!-->0.001), and statistically significantly lower mean MPV (<em>P</em> <!-->=<!--> <!-->0.002). The mean MLR (<em>P</em> <!-->=<!--> <!-->0.018) and PLR (<em>P</em> <!-->=<!--> <span>0.005) were statistically significantly higher in the active patients with nephritis. For both groups, there were no significant correlations between studied parameters and SLEDAI or SLICC/ACR DI, except with NC3R values in the active group which were associated with SLEDAI (</span><em>r</em> <!-->=<!--> <!-->.221, <em>P</em> <!-->=<!--> <!-->0.049).</div></div><div><h3>Conclusion</h3><div>The hematological parameters in SLE have promising potential clinical application as a novel activity marker, especially in patients with nephritis.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 145-151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common variable immune deficiency complicating proliferative lupus nephropathy: A diagnostic and therapeutic challenge","authors":"Lamia Bengherbia,&nbsp;Said Taharboucht,&nbsp;Oussama Souas,&nbsp;Hassina Chicha,&nbsp;Ahcene Chibane","doi":"10.1016/j.rcreu.2024.02.002","DOIUrl":"10.1016/j.rcreu.2024.02.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Common variable immunodeficiency (CVID) is a rare condition characterized by a constitutional humoral immune deficiency. Its association with systemic lupus is extremely rare.</div></div><div><h3>Case presentation</h3><div>In this case report, we present a 21-year-old woman with a history of Hashimoto's thyroiditis, who, following the onset of nephrotic syndrome revealing her lupus disease, subsequently developed clinical and laboratory features consistent with CVID, alongside recurrent lupus flares. Her initial therapeutic management was intricate, ultimately resulting in stable remission achieved through monthly immunoglobulin infusions.</div></div><div><h3>Conclusion</h3><div>This case illustrates the diagnostic and therapeutic difficulty of lupus disease and a common variable immune deficiency.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 168-172"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia hemolítica autoinmune por crioaglutininas asociado a lupus eritematoso sistémico. Presentación de casos y revisión de la literatura","authors":"Jaime Alberto Coral Enríquez ,&nbsp;Victoria Eugenia Cajas Bravo","doi":"10.1016/j.rcreu.2024.02.003","DOIUrl":"10.1016/j.rcreu.2024.02.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Cold agglutinin autoimmune haemolytic anaemia (AIHA) secondary to systemic lupus erythematosus (SLE) is a rare manifestation. There are no cohorts or case series that allow us to evaluate the characteristics of this group of patients.</div></div><div><h3>Objective</h3><div>To describe the clinical and serological characteristics of patients with systemic lupus erythematosus (SLE) and cold agglutinin hemolytic anemia.</div></div><div><h3>Materials and methods</h3><div>We present two cases with SLE that debuted with cold agglutinin AHAI, their clinical and immunological profile and response to immunosuppressive treatment.</div></div><div><h3>Results</h3><div>Eleven cases reported in the literature from 1950 to 2023 are described.</div></div><div><h3>Conclusion</h3><div>Cold agglutinin AHAI secondary to SLE is rare, with similar clinical features compared to idiopathic forms and usually not associated with manifestations or serious organic involvement.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 2","pages":"Pages 173-179"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factores asociados con el desarrollo de falla renal crónica terminal durante la hospitalización en los pacientes con poliangitis microscópica y granulomatosis con poliangitis en una población del noroccidente colombiano","authors":"Santiago Cobaleda Cano ,&nbsp;Andrés Felipe Echeverri García ,&nbsp;Adriana Margarita Trejos Tenorio ,&nbsp;Javier Darío Márquez Hernández ,&nbsp;Jhon Edwar García Rueda ,&nbsp;Luis Fernando Pinto Peñaranda","doi":"10.1016/j.rcreu.2023.11.004","DOIUrl":"10.1016/j.rcreu.2023.11.004","url":null,"abstract":"<div><h3>Introduction</h3><div>ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal.</div></div><div><h3>Objectives</h3><div>To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay.</div></div><div><h3>Materials and methods</h3><div>Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson's Chi2 (χ²) or Fisher's test, and Student's t or Mann-Whitney U test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease.</div></div><div><h3>Results</h3><div>Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score &gt;<!--> <!-->1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies.</div></div><div><h3>Conclusion</h3><div>88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 16-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comite Editorial online","authors":"","doi":"10.1016/S0121-8123(24)00103-8","DOIUrl":"10.1016/S0121-8123(24)00103-8","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages E1-E3"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-41 concentrations are decreased in women with rheumatoid arthritis and are not affected by menopausal status, disease activity, or medication","authors":"Dhuha F.N. Bani-Wais ,&nbsp;Ali H. Ad’hiah","doi":"10.1016/j.rcreu.2023.11.001","DOIUrl":"10.1016/j.rcreu.2023.11.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder characterized by immunobiological homeostasis. The recently discovered cytokine interleukin-41 (IL-41) is among the immunobiological components suggested to have modulatory effects in RA and has shown up-regulated levels in patients. However, IL-41 has not been explored during the pre- (PRM) and post-menopausal (POM) periods in women with RA, and its relationship to disease activity and medications has not been well studied.</div></div><div><h3>Materials and methods</h3><div>In this case–control study, serum IL-41 concentrations were quantified in 120 women with RA (70 PRM and 50 POM) and 110 control women using an enzyme-linked immunosorbent assay kit. Thirty patients were newly diagnosed (ND) and 90 patients were on treatment with etanercept (a tumor necrosis factor inhibitor; TNF) plus methotrexate (MD).</div></div><div><h3>Results</h3><div>Median IL-41 concentrations (interquartile range) were significantly lower in RA patients than in control women (49.8 [32.5–79.5] <em>vs</em>. 104.7 [76.9–134.6]<!--> <!-->pg/mL; probability &lt;.001). As indicated by the area under the curve, .827, IL-41 showed reliable discrimination between RA patients and HC. IL-41 concentrations stratified by menopausal status (PRM <em>vs</em>. POM), disease activity score 28 (&lt;3.2 <em>vs</em>. ≥3.2), and medication (ND <em>vs</em>. MD) showed no significant difference in each stratum.</div></div><div><h3>Conclusions</h3><div>In contrast to previous studies, serum IL-41 concentrations were significantly decreased in the present cohort of women with RA. These concentrations were not affected by menopausal status, disease activity, or medication. Data from the current study suggest that IL-41 is involved in the pathophysiology of RA.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 27-35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}