Revista Colombiana de Reumatologia最新文献

{"title":"Detection of latent tuberculosis by tuberculin booster in patients with immunosuppressive treatment","authors":"Luis Javier Cajas ,&nbsp;María Carolina Torres ,&nbsp;Mayelin Fernanda Ceballos","doi":"10.1016/j.rcreu.2023.10.006","DOIUrl":"10.1016/j.rcreu.2023.10.006","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>One-third of the world's population has latent tuberculosis. Because it can be reactivated by immunosuppressive treatments, screening is suggested. In Colombia, the tuberculin test with the booster is recommended in this population because of the risk of false negative results and anergy caused by treatments. Currently, the number of patients detected with this second test is unknown, so the primary objective is to determine the percentage of additional positive detections.</div></div><div><h3>Materials and methods</h3><div>From 2017 to 2022, a cross-sectional, analytical study was conducted on a group of patients from a rheumatology service who had a tuberculin test and a booster within a year to check for latent tuberculosis. Over the course of a year and three weeks, we looked at the number of patients whose booster tests showed new findings. A study was conducted to see if there were any differences in treatment based on the first tuberculin result.</div></div><div><h3>Results</h3><div>A tuberculin test was performed on 674 subjects, of whom 496 were immunosuppressed. From the 382 whose test was negative, 191 and 74 booster tests were performed within a year and three weeks; 8 (4.1%) and 3 (3.6%) were positive, respectively. When evaluating the differences in treatments between the groups with a positive and negative first tuberculin test, significant differences were found. Use of prednisolone at 5<!--> <!-->mg or more per day (<em>p</em> <!-->=<!--> <!-->.02) and three immunosuppressants (<em>p</em> <!-->=<!--> <!-->.005) was more frequent in negative tuberculin tests.</div></div><div><h3>Conclusions</h3><div>It can be said that the booster test raises the number of people with latent tuberculosis by 4%. More use of prednisolone at 5<!--> <!-->mg/day or three immunosuppressants in the group with the negative tuberculin test was found to be statistically significant.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 10-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfermedad de Erdheim-Chester, una histiocitosis de células no Langerhans infrecuente y su asociación con el síndrome de Sjögren","authors":"Alejandra Espinosa Trujillo ,&nbsp;Francisco Brañas Fernández ,&nbsp;Aitor Abuín Blanco ,&nbsp;Robustiano Pego Reigosa ,&nbsp;María Rodríguez Rodríguez","doi":"10.1016/j.rcreu.2024.01.003","DOIUrl":"10.1016/j.rcreu.2024.01.003","url":null,"abstract":"<div><div>Erdheim Chester disease (ECD) is a rare non-Langerhans cell histiocytosis. It is characterized by the infiltration of various organs and tissues by foamy histiocytes with a heterogeneous clinical course that varies from mild forms to disseminated forms with progressive and lethal behaviour. The case of a patient who presented with a cerebellar syndrome associated with autoimmune pathology is presented. In the course of the disease, refractoriness to glucocorticoids and clinical manifestation with bone involvement in the form of symmetrical osteosclerosis of long bones were determining factors for suspicion of this entity. We reviewed scientific articles through the PubMed metasearch engine with the keywords «erdheim chester disease», «erdheim chester and nervous system», and «autoimmunity and erdheim chester disease», selecting those with greater emphasis on clinical presentation with neurological involvement and associated autoimmune pathology. Advances in the pathogenesis of ECD have allowed us to understand the nature of the disease, as well as the use of targeted therapies. It is interesting to keep this entity in mind, as well as the pathologies with which it is frequently associated, with the objective of an early diagnosis and a better clinical approach.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 90-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of motor skill in patients with juvenile idiopathic arthritis: A cross sectional study","authors":"Sinem Yenil ,&nbsp;Elif Gur Kabul ,&nbsp;Bilge Basakci Calik ,&nbsp;Gulsah Kilbas ,&nbsp;Selcuk Yuksel","doi":"10.1016/j.rcreu.2023.11.005","DOIUrl":"10.1016/j.rcreu.2023.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The inflammatory process of Juvenile Idiopathic Arthritis (JIA) is associated comorbidities. The JIA patients can fall behind their healthy peers, and motor and functional skills can reduce.</div></div><div><h3>Objectives</h3><div>The primary aim is to compare the motor skills of JIA patients with healthy controls. The secondary aim is to determine whether disease activity affects patients with JIA.</div></div><div><h3>Materials and methods</h3><div><span><span>Fifteen patients with JIA and 15 healthy controls were included in the study. Motor skills were evaluated with Bruininks-Oseretsky Test of Motor Proficiency Second Edition Short Form (BOT-2 SF) in patients with JIA and healthy controls. BOT-2 SF measures four motor area composites with eight subtests. Disease activity was evaluated with Juvenile Arthritis Disease Activity Score-27 (JADAS-27), disability level with Childhood </span>Health Assessment Questionnaire Disability Index (CHAQ-DI), and disease-related quality of life with </span>Pediatric Quality of Life Inventory (PedsQL) 3.0 Arthritis Module for JIA. According to disease activity, patients with JIA were divided into two groups as remission and active.</div></div><div><h3>Results</h3><div>The patients with JIA had significantly lower scores in the total and four motor area of BOT-2 SF compared to healthy controls (<em>p</em> <!-->&lt;<!--> <!-->.05). When the remission and active groups were compared, there was no difference in the total and four motor area of BOT-2 SF, CHAQ-DI, or PedsQL (<em>p</em> <!-->&gt;<!--> <!-->.05).</div></div><div><h3>Conclusion</h3><div>The motor skills of patients with JIA are lower than their healthy peers, and their motor skills, quality of life, and disability did not make a difference between the remission and active period.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 36-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139687625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveles de expresión génica relativa del gen codificante de la proteína quimioatractante de monocitos-1 (MCP-1) como biomarcador urinario en nefropatía lúpica","authors":"Esther Casablanca Alarcón ,&nbsp;Mabel de la Cruz Mendoza ,&nbsp;María de los Ángeles Terán de Baudoin ,&nbsp;Rolando Pastén Vargas ,&nbsp;Manuel Montero Jauregui ,&nbsp;Carlos Guachalla Castro ,&nbsp;Luis Fernando Sosa Tordoya","doi":"10.1016/j.rcreu.2023.12.006","DOIUrl":"10.1016/j.rcreu.2023.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Lupus nephropathy (LN) is a chronic inflammatory process, characterized by the activation of T<!--> <!-->cells and high levels of various cytokines, such as MCP-1 at the level of the renal glomerulus and the interstitial tubule. MCP-1 is a chemoattractant of monocytes and lymphocytes, it is responsible for the infiltration of leukocytes in the kidney, which is why MCP-1 levels in urine of patients with LN correlate with the active form of the disease.</div></div><div><h3>Objective</h3><div>The present study aims to evaluate the expression levels of MCP-1 in patients with LN and to correlate their urinary levels with serum autoimmunity markers.</div></div><div><h3>Material and methods</h3><div>Our study is of the case-control type, where the groups were made up of 112 patients diagnosed with SLE or LN, and 28 apparently healthy people with no clinical or family history of autoimmune diseases, respectively. MCP-1 expression levels were estimated using qRT-PCR. In addition, clinical parameters and serum levels were evaluated (anti-ds-DNA, anti-nucleosome, anti-C1q antibodies, β2-microglobulin levels, and C3 and C4 complement fraction). Finally, clinical, and molecular data were correlated.</div></div><div><h3>Results</h3><div>Our study included 39 patients with active SLE (median 36<!--> <!-->years), 32 with active LN (median 32.5<!--> <!-->years), 28 with inactive SLE (median 41.5<!--> <!-->years), 13 with inactive LN (median 38<!--> <!-->years), and 28 control patients (median 28.5<!--> <!-->years). The comparison of MCP-1 expression levels between patients with active LN and active SLE did not show statistically significant values (<em>P</em> <!-->&gt;<!--> <!-->.05). Likewise, a statistically significant correlation was observed between the expression levels of MCP-1 with the levels of anti-C1q (r<!--> <!-->=<!--> <!-->.255; <em>P</em> <!-->&lt;<!--> <!-->.025); however, no correlation was found with the other markers.</div></div><div><h3>Conclusion</h3><div>The use of MCP-1 expression levels in the Bolivian population would not be a useful biomarker to evaluate lupus nephropathy. However, the anti-C1q biomarker is suggested as a serological marker for monitoring the disease.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 49-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diseño e implementación de centros de cuidado clínico en espondiloartritis. Un modelo de atención y de enfermedad referente en patologías crónicas","authors":"","doi":"10.1016/j.rcreu.2023.04.002","DOIUrl":"10.1016/j.rcreu.2023.04.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Spondyloarthritis (SpA) is a musculoskeletal disease presenting with phenotypic clinical manifestations, integrating a set of interrelated inflammatory conditions, which share immunogenetic, epidemiological, and therapeutic characteristics.</div></div><div><h3>Objective</h3><div>to do a reflection exercise through the experience of designing and implementing a clinical care center for spondyloarthropathies, from the administrative and clinical perspective to the implications in decision making and impact on the different indicators related to efficiencies and safety of the services included in the model.</div></div><div><h3>Results</h3><div>In clinical practice, the reality of the care process in patients diagnosed with SpA represents an area of opportunity in multiple aspects. The fragmentation of clinical care and the heterogeneous flow of the patient in the care pathway, are associated with suboptimal and undesired clinical outcomes. Several aspects highlight the reality of patients with SpA in the national scenario, which -to a certain extent- could reflect what is observed in other Latin American countries. SpA represents a very significant burden for society and for individuals affected by this condition. Comprehensive assessment of the burden of disease from the perspective of the clinician and the patient is important, in order to support decisions related to treatment and comprehensive management of this condition. The improvement in health outcomes and the reduction in the cost of chronic inflammatory diseases, such as SpA, are the main advantages of implementing a care model in specialized centres integrating a multidisciplinary team.</div></div><div><h3>Conclusion</h3><div>This is an opportunity to include the perspective of individuals affected by this condition, seeking integration between an informed patient and a highly qualified multidisciplinary care team in the comprehensive management of patients with SpA.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 511-516"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41323859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validación de la escala FACIT-fatiga en una muestra de población hispanohablante con artritis reumatoide","authors":"","doi":"10.1016/j.rcreu.2023.05.004","DOIUrl":"10.1016/j.rcreu.2023.05.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Fatigue is a frequent symptom in patients with rheumatoid arthritis (RA). The Functional Assessment of Chronic illnesses Therapy-Fatigue (FACIT-F) is an instrument that assesses self-reported fatigue and was validated for measuring fatigue in RA.</div></div><div><h3>Objective</h3><div>The aim of this study was to validate the FACIT-F for use in Spanish-speaking RA patients.</div></div><div><h3>Materials and methods</h3><div>Cross-sectional, multicentre study. We included patients (n = 192) with RA diagnosis from two hospitals. Exploratory and confirmatory analyses were conducted. Construct validity and internal consistency were evaluated.</div></div><div><h3>Results</h3><div>FACIT-F showed high internal consistency (alpha = .87, omega = .93). Analysis of the main components showed a single factor, which explained 62% of the variance. The confirmatory factor analysis showed a satisfactory fit of the model. We found a correlation between FACIT–F, VAS fatigue (-.72 <em>P</em> &lt; .001), and BRAF-MDQ (-.81 <em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>FACIT-F is a valid instrument with a high internal consistency for measuring fatigue in clinical practice and research in Spanish-speaking patients with RA.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 435-441"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49523844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caracterización de los pacientes menores de 18 años con nefritis lúpica en el Hospital Pablo Tobón Uribe y en el Hospital San Vicente Fundación de la ciudad de Medellín, entre 2008 y 2017","authors":"","doi":"10.1016/j.rcreu.2023.09.005","DOIUrl":"10.1016/j.rcreu.2023.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The kidney is one of the organs frequently affected in systemic lupus erythematosus (40-60%); the manifestations are variable, from a silent pattern to the irreversible impairment of renal function.</div></div><div><h3>Objetives</h3><div><ul><li><span>•</span><span><div>To characterize patients under 18 years of age with a diagnosis of lupus nephritis treated at the Pablo Tobón Uribe Hospital and San Vicente Fundación Hospital during the years 2006 to 2017.</div></span></li><li><span>•</span><span><div>Establish the frequency of lupus nephritis in patients diagnosed with childhood systemic lupus erythematosus.</div></span></li><li><span>•</span><span><div>Describe the general, sociodemographic, clinical and paraclinical characteristics, as well as histopathological characteristics, immunosuppressive treatment and complications such as chronic kidney disease, high blood pressure, need for renal replacement therapy and death in patients diagnosed with lupus nephritis.</div></span></li><li><span>•</span><span><div>Explore the association between lupus nephritis with a histological pattern defined as moderate or severe and chronic kidney disease, arterial hypertension, need for renal replacement therapy and death.</div></span></li></ul></div></div><div><h3>Materials and methods</h3><div>Descriptive study with retrospective information in a group of patients under 18<!--> <!-->years of age with a diagnosis of lupus nephritis, attended in two referral centres of the city of Medellin between 2008 and 2017. Clinical records of patients who met the inclusion criteria were reviewed.</div></div><div><h3>Results</h3><div>The median age was 13 years, with predominance in females. The majority had renal involvement at the time of diagnosis of lupus. Histological class<!--> <!-->IV was the most frequent (48%). Age under 10<!--> <!-->years, absence of response to induction therapy, and histological class<!--> <!-->IV, were related to the development of chronic kidney disease (&gt;<!--> <!-->60<!--> <!-->ml/min/1.73<!--> <!-->m²).</div></div><div><h3>Conclusions</h3><div>Renal involvement was higher in this study. Age, class<!--> <!-->IV, and non-response to induction were associated with impaired renal function.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 463-472"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comite Editorial online","authors":"","doi":"10.1016/S0121-8123(24)00088-4","DOIUrl":"10.1016/S0121-8123(24)00088-4","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages E1-E3"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing up with juvenile idiopathic arthritis: Social issues","authors":"","doi":"10.1016/j.rcreu.2023.08.006","DOIUrl":"10.1016/j.rcreu.2023.08.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Juvenile idiopathic arthritis is a chronic inflammatory condition interfering with daily activities, social integration, and school attendance in children because of pain and joint inflammation during disease flares. Online resources might help children with JIA improve their social interactions and enhance their knowledge about their disease and the available therapeutic strategies.</div></div><div><h3>Objective</h3><div>This study aims to reveal the social issues encountered by teenagers prone to JIA and determine their perception of the impact of social media on their daily life.</div></div><div><h3>Material and methods</h3><div>We conducted this study using inductive qualitative methods to describe the sociocultural perception and experience of adolescents with JIA aged between 8 and 16 years.</div></div><div><h3>Results</h3><div>Individual interviews were held with 22 adolescents diagnosed with JIA. Fifty-two percent felt like outcasts and rejected by their peers because of their illness. Most of the participants expressed a need for their friends to be informed about their JIA diagnosis. Twenty-two-point-seven percent stated that they played sports for more than 5<!--> <!-->h a week. A total of 31.8% found their physical performance was not affected by their disease. Ninety-seven of the participants confirmed that they use social media on average 3<!--> <!-->h a day. YouTube and Facebook were ranked respectively as the first and the second preferred platforms. Seventeen percent of the children viewed these platforms as positive and helpful in dealing with JIA, especially by taking their minds off the pain, dealing with the stress resulting from the lack of mobility, and facilitating interactions with others.</div></div><div><h3>Conclusion</h3><div>Social integration in children with JIA is still challenging. Social media is helpful in managing JIA and improving social interactions, and in gaining useful information.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 452-456"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hallazgos clínicos, de laboratorio y evolución en pacientes con síndrome autoinmune/autoinflamatorio inducido por adyuvantes (ASIA)","authors":"","doi":"10.1016/j.rcreu.2023.09.008","DOIUrl":"10.1016/j.rcreu.2023.09.008","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) suggests that contact with different adjuvants such as silicones or aluminium used as excipient in some vaccines can cause the appearance of different symptomatology.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis of the clinical manifestations, laboratory parameters, treatment, and evolution of a case series of 13 patients with ASIA syndrome related to silicone implants and vaccines was performed.</div></div><div><h3>Results</h3><div>In 10 (77%) of the patients there was a history of silicone implants, in the rest of the patients there was a history of vaccination. The most frequent symptom in patients with silicone prostheses was Raynaud's phenomenon (72%), while in patients with a history of vaccination, arthralgias and myalgias were the most frequent symptoms. One patient met the criteria for primary Sjögren's syndrome while another patient had limited systemic sclerosis and associated Sjögren's syndrome. Most of the patients had elevated acute phase reactants (61%), while in the group of patients with a history of silicone prosthesis 60% presented positivity for antinuclear antibodies.</div></div><div><h3>Conclusion</h3><div>Raynaud's phenomenon and skeletal muscle symptoms were the most common manifestations in patients with breast prosthesis and vaccination history, respectively.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 457-462"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139303182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}