Endocrinologia, Diabetes y Nutricion最新文献

英文中文

Polimorfismos TLR4 e IL6: potenciales factores de riesgo de obesidad y resistencia a la insulina en individuos venezolanos TLR4和IL6多态性：委内瑞拉人肥胖和胰岛素抵抗的潜在危险因素

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501657

Stefani Hernández Osorio , María Fátima Garcés , Eva Salazar Alcalá , José Manuel Pestana , Mercedes Fernández Mestre

Objective

This study investigated the association between genetic polymorphisms in the TLR4 (rs4986790 and rs4986791) and IL6 (rs1800795) genes with obesity in a Venezuelan population.

Methods

We conducted a retrospective case-control study with 207 unrelated Venezuelans (137 obese, 70 normal weight). Blood samples were obtained to measure glucose, cholesterol, triglycerides, HDL, insulin, and insulin resistance (HOMA-IR ≥ 2.6) and genotype the TLR4 (rs4986790 and rs4986791) and IL6 (rs1800795) polymorphisms using PCR-SSP. Statistical tests: Student's t-test, Pearson correlation coefficient, chi-square test, odds ratio (OR) with 95%CI were used.

Results

The relationship between obesity and insulin resistance (IR) was confirmed. Heterozygous genotypes A/G (TLR4 rs4986790, P=.012) and C/T (TLR4 rs4986791, P=.005) were more frequent in normal-weight individuals, while homozygous genotypes A/A (TLR4 rs4986790, P=.012) and C/C (TLR4 rs4986791, P=.005) were more frequent in obese individuals. The C allele and CC genotype of IL6 rs1800795 (P=.007) were associated with obesity. The IL6 C/C genotype was associated with higher insulin and HOMA in obese individuals. In obese individuals with IR, the CC genotype (TLR4 rs4986791, P=.03) was more common, as opposted to CT, which was less common (P=.03). The C/C genotype of IL6 rs1800795 was more frequent in obese individuals with IR (P<.0001). Obese individuals with IR and the AA genotype of TLR4 rs4986790 had higher BMI, HOMA-IR, and glucose.

Conclusion

These findings suggest that genetic variations in the TLR4 and IL6 genes may predispose to obesity and its metabolic complications in the Venezuelan population.

目的研究委内瑞拉人群TLR4 （rs4986790和rs4986791）和IL6 （rs1800795）基因多态性与肥胖的关系。方法对207名委内瑞拉人（137名肥胖，70名正常体重）进行回顾性病例对照研究。采集血样，测定血糖、胆固醇、甘油三酯、HDL、胰岛素和胰岛素抵抗（HOMA-IR≥2.6），并利用PCR-SSP对TLR4 （rs4986790和rs4986791）和IL6 （rs1800795）多态性进行基因分型。统计学检验：采用学生t检验、Pearson相关系数、卡方检验、比值比（OR）， 95%CI。结果肥胖与胰岛素抵抗（IR）之间的关系得到证实。杂合子基因型A/G （TLR4 rs4986790， P= 0.012）和C/T （TLR4 rs4986791， P= 0.005）在正常体重人群中多见，纯合子基因型A/A （TLR4 rs4986790， P= 0.012）和C/C （TLR4 rs4986791， P= 0.005）在肥胖人群中多见。IL6 rs1800795的C等位基因和CC基因型与肥胖相关（P= 0.007）。在肥胖个体中，IL6 C/C基因型与较高的胰岛素和HOMA相关。在肥胖IR患者中，CC基因型（TLR4 rs4986791， P=.03）更为常见，而CT基因型较少（P=.03）。il - 6 rs1800795的C/C基因型在肥胖IR患者中更为常见（P< 0.0001）。具有IR和TLR4 rs4986790 AA基因型的肥胖个体具有较高的BMI、HOMA-IR和葡萄糖。结论这些发现表明，TLR4和IL6基因的遗传变异可能导致委内瑞拉人群肥胖及其代谢并发症。

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引用次数: 0

¡3, 2, 1! Del análogo de GLP-2 a GLP-1 a lo largo de 10 años 三，二，一！10年从GLP-2到GLP-1

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501662

María Sara Tapia-Sanchiz, Miguel Antonio Sampedro-Núñez, Sara Jiménez-Blanco, Begoña Molina-Baena

Short bowel syndrome (SBS) represents one of the central conditions in clinical nutrition, with a complex and challenging management. Teduglutide, an analog of human glucagon-like peptide-2 (GLP-2), is the first approved long-term, non-symptomatic treatment for SBS. We present the case of a 62-year-old woman with SBS who required prolonged home parenteral nutrition (HPN). Following clinical stabilization, teduglutide was initiated, leading to significant clinical and nutritional improvement, including spontaneous closure of enterocutaneous fistulas and a 70% reduction in parenteral nutrition requirements. This allowed for a surgical reconstruction, after which she achieved full enteral autonomy, later developing grade 1 obesity. This case highlights the therapeutic potential of teduglutide as a bridging therapy and the remaining uncertainties regarding its long-term management.

短肠综合征（SBS）是临床营养的中心疾病之一，具有复杂和具有挑战性的管理。Teduglutide是一种类似于人胰高血糖素样肽-2 （GLP-2）的药物，是首个被批准用于SBS的长期无症状治疗药物。我们提出的情况下，62岁的妇女SBS谁需要延长家庭肠外营养（HPN）。在临床稳定后，开始使用teduglutide，导致显著的临床和营养改善，包括肠皮瘘的自发闭合和肠外营养需求减少70%。这允许手术重建，之后她实现了完全的肠内自主，后来发展为1级肥胖。该病例突出了特杜卢肽作为桥接疗法的治疗潜力，以及其长期管理的不确定性。

引用次数: 0

Enhancing levothyroxine dosing accuracy post-total thyroidectomy using body fat percentage 利用体脂率提高甲状腺全切除术后左旋甲状腺素给药准确性

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501645

Ana M. Díaz Abram , Federico Volpi , Estefanía Chumbiauca , Marta García Goñi , Juan C. Galofré

引用次数: 0

Implantación de la ecografía cervical y técnicas asociadas en los servicios de endocrinología y nutrición en España. Estudio ECOSEEN 2025 在西班牙的内分泌和营养服务中植入宫颈超声和相关技术。ECOSEEN 2025研究

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501659

Jordi L. Reverter , Gonzalo Díaz Soto , Tomás Martin , Manuel Gargallo , Marcel Sambo , Iñaki Argüelles , Grupo de Imagen Cervical y Técnicas Asociadas de la Sociedad Española de Endocrinología y Nutrición

Introduction

Before 2014, few endocrinology and nutrition departments nationwide routinely used cervical ultrasound. Following the training activities promoted by the Thyroid Pathology Imaging Group, it is important to evaluate the current level of implementation of ultrasound and ultrasound-guided techniques in clinical practice.

Material and methods

A structured, self-administered survey was designed and sent electronically to hospitals throughout the country.

Results

Responses were received from a total of 101 hospitals. Ninety-three percent of the departments surveyed reported routine use of ultrasound in clinical practice, with specialized consultations in 71% of cases. Sixty percent performed fine-needle aspiration cytology, and 55% performed staging and follow-up of differentiated thyroid cancer. Among minimally invasive techniques (MIT), 42% of centers perform enolization of thyroid cysts and 12% offer thermal ablation techniques, with radiofrequency being the most commonly used modality. Eighty-six% of professionals have received training through the Applied Imaging Techniques for Thyroid Pathology Group of the SEEN (National Institute of Endocrinology and Nutrition). Currently, 56 centers offer specific ultrasound training for medical residents in the specialty.

Conclusion

Over the last decade, ultrasound has been widely implemented in the endocrinology and nutrition departments affiliated with the SEEN, including the incorporation of ultrasound-guided techniques into routine practice. However, the use of MIT such as thermal ablation is still limited, so it is considered necessary to strengthen both specific training and institutional support to promote its maximum implementation.

2014年以前，全国很少有内分泌科和营养科常规使用宫颈超声检查。随着甲状腺病理影像学组的培训活动，评估超声和超声引导技术在临床实践中的实施水平是很重要的。材料和方法设计了一份结构化的、自我管理的调查，并以电子方式发送给全国各地的医院。结果共收到101家医院的回复。93%的受访科室报告在临床实践中常规使用超声，71%的病例进行了专门咨询。60%的患者接受细针穿刺细胞学检查，55%的患者接受分化型甲状腺癌的分期和随访。在微创技术（MIT）中，42%的中心提供甲状腺囊肿烯醇化治疗，12%的中心提供热消融技术，其中射频是最常用的方式。86%的专业人员接受了美国国家内分泌与营养研究所甲状腺病理应用成像技术组的培训。目前，有56个中心为该专业的住院医师提供专门的超声培训。结论近十年来，超声技术在我院内分泌科和营养科得到了广泛的应用，包括超声引导技术在常规诊疗中的应用。然而，热消融等麻省理工技术的应用仍然有限，因此有必要加强具体培训和制度支持，以促进其最大限度地实施。

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引用次数: 0

Continuidad asistencial en la atención clínica de la obesidad 肥胖临床护理的连续性

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501658

Irene Bretón , José Manuel Fernández García , Nuria Vilarrasa , Violeta Ramírez Arroyo , Ani de Hollanda , Guadalupe Blay Cortés , María D. Ballesteros-Pomar , en representación de SEEN, SEMERGEN, semFYC y SEMG

Obesity is a chronic, multifactorial and relapsing disease with a great impact on public health. Due to its high prevalence and complications, it is essential to coordinate clinical care in different health care settings in order to improve the clinical evaluation and treatment of people with obesity and to optimize the use of health care resources. This document, prepared by experts from the Spanish Society of Endocrinology and Nutrition (SEEN), the Spanish Society of Primary Care Physicians (SEMERGEN), the Spanish Society of Family and Community Medicine (semFYC) and the Spanish Society of General Practitioners (SEMG), proposes a comprehensive clinical approach to obesity, based on effective coordination between Primary Care and Endocrinology and Nutrition Departments.

肥胖是一种慢性、多因素、反复发作的疾病，对公众健康有很大影响。由于其高患病率和并发症，协调不同卫生保健机构的临床护理，以提高对肥胖患者的临床评价和治疗，优化卫生保健资源的利用是必不可少的。该文件由西班牙内分泌与营养学会（SEEN）、西班牙初级保健医师学会（SEMERGEN）、西班牙家庭与社区医学学会（semFYC）和西班牙全科医生学会（SEMG）的专家编写，提出了一种基于初级保健和内分泌与营养部门有效协调的综合临床方法。

引用次数: 0

Beyond vectorial bioelectrical impedance: Assessing body composition changes with novel electrical parameters in obese osteoarthritis patients on a meal-replacement diet 超越矢量生物电阻抗：用新的电参数评估肥胖骨关节炎患者在代餐饮食中的身体成分变化

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501644

José-Joaquín Alfaro-Martínez , David Primo-Martín , César Gonzalvo-Díaz , Olatz Izaola-Jauregui , Marina Jara-Vidal , Lourdes García-Blasco , Beatriz Ramos-Bachiller , Diego Bellido-Guerrero , Daniel A. De Luis-Román , Juan José López-Gómez

Background

Rapid weight loss with restricted diets can cause muscle mass decline. The aim of this work is to evaluate a new method for representing the raw electrical values obtained in the bioelectrical impedance analysis (BIA) in patients with obesity and osteoarthritis undergoing a meal-replacement diet.

Methods

We conducted a 1-group intervention study with meal-replacement diet for 3 months in patients with osteoarthritis prior to orthopedic surgery. Anthropometry and BIA was registered at baseline (B) and 3 months (3M) after the intervention. We have calculated traditional estimations of body composition over the raw electrical parameters of BIA parameters and a new bioelectrical impedance vector analysis (BIVA) based method to detect nutrition (NP), hydration (HP) and fat (FP) parameters without estimation.

Results

A total of 272 patients (23.16% men; 76.84% women) were analyzed. There was a correlation between NP and body composition estimates (body cell mass [BCM] standardized by height (BCM/h): men: 0.96; p < 0.01; women: 0.88; p < 0.01). The correlation coefficient between HP and estimated total body water was 0.769 for men and 0.63 for women (p < 0.01 in both cases). The correlation coefficient between FP and estimated fat mass (FM) standardized by height was 0.83 for men and 0.89 for women (p < 0.01). There was a significant decrease in body weight (B: 99.33(15.0) kg; 3M: 92.03(16.0) kg; p < 0.01); and FM (B: 49.93(6.67) kg; 3M: 44.22(9.08) kg). There was no difference in BCM and fat free mass. In new parameters a decrease in NP (B: +0.50(0.31); 3M: +0.42(0.42); p = 0.03) and FP (B: +0.49(0.17) was reported; 3M: +0.38(0.16); p < 0.01), although there was no difference in HP.

Conclusions

The new interpretation of BIVA as NP and HP have a high correlation with the body composition parameters estimated by regression models, and they report changes in body composition after a partial meal-replacement diet such as regression equations.

背景：限制饮食的快速减肥会导致肌肉质量下降。这项工作的目的是评估一种新的方法来表示在进行代餐饮食的肥胖和骨关节炎患者的生物电阻抗分析（BIA）中获得的原始电值。方法对骨科手术前骨关节炎患者进行为期3个月的代餐饮食干预研究。在基线(B)和干预后3个月（3M）记录人体测量和BIA。我们计算了基于BIA参数的原始电参数的传统身体成分估计值，以及一种新的基于生物电阻抗矢量分析（BIVA）的检测营养（NP）、水合（HP）和脂肪（FP）参数的方法。结果共分析272例患者，其中男性23.16%，女性76.84%。NP与身体成分估计值（身高标准化的体细胞质量[BCM] (BCM/h)）之间存在相关性：男性：0.96；p < 0.01；女性:0.88;p < 0.01)。HP与估计的总体内水分之间的相关系数男性为0.769，女性为0.63（两种情况的p <； 0.01）。男性的FP与身高标准化的估计脂肪量（FM）的相关系数为0.83，女性为0.89 （p < 0.01）。体重显著下降(B: 99.33(15.0) kg；3M: 92.03(16.0) kg；p < 0.01)；FM (B): 49.93(6.67) kg；3米：44.22（9.08）公斤。BCM和无脂质量无显著差异。在新参数下，NP (B)降低：+0.50(0.31)；3 m: + 0.42 (0.42);p = 0.03)和FP (B: +0.49(0.17))；3 m: + 0.38 (0.16);p < 0.01)，但HP无差异。结论BIVA的新解释为NP和HP与回归模型估计的体成分参数具有高度相关性，它们报告了部分代餐饮食后体成分的变化，如回归方程。

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引用次数: 0

Pancreatitis aguda en un lactante, un diagnóstico infrecuente 婴儿急性胰腺炎，罕见的诊断

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501660

Fátima Pareja Marín, María Pilar Valverde Viu, Sara Vicent Martí, Violeta Martí Enrique

引用次数: 0

Radioactive iodine-induced esophagitis: A rare complication 放射性碘引起的食管炎：一种罕见的并发症

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501656

Ignacio Jiménez Hernando , Irene Bretón Lesmes , Arantxa Díaz Gómez , Miguel Sebastián Casallas Cepeda , Santiago Salcedo Cortés

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Avances recientes en tumores hipofisarios tras la clasificación OMS 2022 世卫组织2022年分类后垂体肿瘤的最新进展

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2026-01-01 DOI: 10.1016/j.endinu.2025.501747

Ignacio Ruz-Caracuel

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Executive summary of the consensus document for the management of severe Cushing's syndrome: Consensus document of the Neuroendocrinology Focus Group of the Spanish Society of Endocrinology and Nutrition (SEEN) 严重库欣综合征治疗共识文件执行摘要：西班牙内分泌与营养学会（SEEN）神经内分泌焦点小组共识文件

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2025-12-01 DOI: 10.1016/j.endinu.2025.501654

Marta Araujo-Castro , Rogelio García-Centeno , Javier Aller , Mónica Marazuela , Alfonso Soto , María Ángeles Gálvez , Rosa Cámara , Elena Valassi , Ignacio Bernabeu , Rocío Villar-Taibo , Felicia A. Hanzu

Severe Cushing's syndrome (SCS) is usually defined as a CS with urinary free cortisol (UFC) levels above five times the upper limit of normal or associated with severe complications of hypercortisolism. Combination therapy with ketoconazole and metyrapone is a useful option for these patients. Osilodrostat is the most potent and effective oral drug in monotherapy for the treatment of SCS. For cases with very severe hypercortisolism and/or oral intolerance, etomidate is the most effective and rapid drug for reducing cortisol levels. Bilateral adrenalectomy may be indicated in cases of life-threatening severe hypercortisolism, but UFC should be reduced before surgery to reduce the perioperative morbimortality. Prompt treatment of comorbidities and thrombo- and infection prophylaxis are recommended. In conclusion, a rapid control of hypercortisolism is vital in SCS, and for this purpose combination therapy or potent drugs with a rapid onset of action such as etomidate or osilodrostat are indicated.

严重库欣综合征（SCS）通常定义为尿游离皮质醇（UFC）水平高于正常上限5倍或伴有严重高皮质醇症并发症的CS。酮康唑和美替拉酮联合治疗对这些患者是一个有用的选择。奥西洛他是单药治疗SCS最有效的口服药物。对于非常严重的高皮质醇血症和/或口服不耐受的病例，依托咪酯是降低皮质醇水平最有效和最快速的药物。在危及生命的严重高皮质醇血症病例中，可能需要双侧肾上腺切除术，但术前应减少UFC，以降低围手术期的死亡率。建议及时治疗合并症，预防血栓和感染。总之，快速控制高皮质醇血症对SCS至关重要，为此需要联合治疗或快速起效的强效药物，如依托咪酯或奥西洛他。

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