Endocrinologia, Diabetes y Nutricion最新文献

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LÍPIDOS Y RIESGO CARDIOVASCULAR (COMUNICACIONES ORALES) 血脂与心血管风险（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00178-2

引用次数: 0

LÍPIDOS Y RIESGO CARDIOVASCULAR (PÓSTERES) 血脂与心血管风险（海报）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00189-7

引用次数: 0

OBESIDAD (PÓSTERES) 肥胖（体重）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00188-5

引用次数: 0

ENFERMEDAD HEPÁTICA METABÓLICA (PÓSTERES) 代谢性肝病（海报）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00190-3

引用次数: 0

METABOLISMO ÓSEO Y FOSFOCÁLCICO (PÓSTERES) 骨与磷钙代谢（海报）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00191-5

引用次数: 0

Integration of big data analytics in the investigation of the relationship between acromegaly and cancer 将大数据分析融入肢端肥大症与癌症关系的研究中

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/j.endinu.2024.05.005

Pedro Iglesias , Javier Arias , Guillermo López , Iago Romero , Juan J. Díez

Objective

To evaluate the association between acromegaly and cancer and different types of cancer by using natural language processing systems and big data analytics.

Material and methods

We conducted an observational, retrospective study utilizing data from the electronic health records (EHRs) of Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. Information from the EHRs was extracted using artificial intelligence techniques and analyzed using Savana Manager 4.0 software.

Results

Out of a total of 708,047 registered patients (54.7% females), 544 patients (0.08%; 330 women, 60.7%; mean age at diagnosis 53.0 ± 15.8 yr) were diagnosed with acromegaly. The incidence of cancer was higher in patients with acromegaly vs those without this condition (7.7% vs 3.9%, p < 0.001; OR, 2.047, 95%CI, 1.493–2.804). Male acromegalic patients had a higher prevalence of cancer vs females (57.1% vs 42.9%, p = 0.012). A significantly higher prevalence of colorectal cancer (2.9% vs 1.4%, p = 0.006), bladder cancer (1.1% vs 0.3%, p = 0.005), and lymphoma (1.1% vs 0.3%, p = 0.009) was observed in patients with acromegaly vs those without the condition. Acromegalic men had significantly higher prevalence rates of colorectal cancer (4.7% vs 1.3%, p = 0.001), bladder cancer (2.8% vs 0.4%, p < 0.001), breast cancer (0.9% vs 0.2%, p = 0.042), gastric cancer (0.9% vs 0.1%, p = 0.011), lymphoma (1.4% vs 0.3%, p = 0.037), and liver cancer (0.9% vs 0.1%, p = 0.012) vs non-acromegalic men. On the other hand, acromegalic women showed a higher prevalence of thyroid cancer (1.2% vs 0.4%, p = 0.043) vs non-acromegalic women.

Conclusion

Our study, based on artificial intelligence techniques and analysis of real-world data and information, revealed a significant association between acromegaly and cancer in our hospital population, mainly acromegalic men, with a higher frequency of colorectal cancer, bladder cancer and lymphoma in particular.

材料与方法我们利用西班牙马德里 Puerta de Hierro Majadahonda 大学医院电子健康记录（EHR）中的数据开展了一项观察性、回顾性研究。结果在708047名登记患者（54.7%为女性）中，有544名患者（0.08%；330名女性，60.7%；诊断时的平均年龄为53.0 ± 15.8岁）被确诊为肢端肥大症。肢端肥大症患者与非肢端肥大症患者相比，癌症发病率更高（7.7% vs 3.9%，p < 0.001；OR，2.047，95%CI，1.493-2.804）。男性肢端肥大症患者的癌症发病率高于女性（57.1% vs 42.9%，P = 0.012）。肢端肥大症患者与非肢端肥大症患者相比，结肠直肠癌（2.9% 对 1.4%，p = 0.006）、膀胱癌（1.1% 对 0.3%，p = 0.005）和淋巴瘤（1.1% 对 0.3%，p = 0.009）的发病率明显更高。肢端肥大症男性患者的结直肠癌（4.7% vs 1.3%，p = 0.001）、膀胱癌（2.8% vs 0.4%，p <0.001）、乳腺癌（0.9% vs 0.2%，p = 0.042）、胃癌（0.9% vs 0.1%，p = 0.011）、淋巴瘤（1.4% vs 0.3%，p = 0.037）和肝癌（0.9% vs 0.1%，p = 0.012）。结论：我们的研究基于人工智能技术和对真实世界数据与信息的分析，揭示了肢端肥大症与癌症之间的显著关联，在我们医院的人群中，主要是肢端肥大症男性，尤其是结直肠癌、膀胱癌和淋巴瘤的发病率较高。

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引用次数: 0

TIROIDES (PÓSTERES) 犁铧

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00185-X

引用次数: 0

ENFERMEDAD HEPÁTICA METABÓLICA (COMUNICACIONES ORALES) 代谢性肝病（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00179-4

引用次数: 0

Exploring plantar pressure distribution in patients with newly diagnosed diabetes: Implications for foot ulcer prevention in an overweight Mexican population 探索新诊断糖尿病患者的足底压力分布：对墨西哥超重人群足部溃疡预防的启示

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/j.endinu.2024.05.008

Francis Rojas-Torres , Héctor Infanzón-Talango , Ana Cristina García-Ulloa , Sergio Hernández-Jiménez , Gerardo Rodríguez-Reyes

Introduction

Elevated plantar pressure (PP) constitutes a risk factor for developing foot ulcers. Once present, elevated PP increases morbidity and mortality in patients with diabetes. Given the high prevalence of overweight and obesity in the Mexican population, this study aimed to describe the magnitudes and the distribution of the PP observed in a sample of newly diagnosed patients with diabetes, adjusting for body mass index (BMI) groups (normal weight, overweight, grade I obesity, and grade II and III obesity).

Materials and methods

A total of 250 volunteers attending a comprehensive care program for the management of type 2 diabetes received foot assessments that included vascular and neurological evaluation, the identification of musculoskeletal changes, and measurements of PP.

Results

Diabetic neuropathy and peripheral arterial disease were present in 21.6% and 11.2% of all participants. Musculoskeletal alterations were present in 70.8% of participants. A positive and significant correlation (p < 0.001) was observed between BMI and the peak PP of all anatomical regions assessed. After adjusting for BMI, significant differences (p < 0.001) were seen between groups. The metatarsal region, particularly under the third metatarsal head, denoted the highest magnitudes across all BMI.

Conclusions

Periodic PP assessment is recommended to identify the distribution of high-pressure points along the plantar surface. However, as a preventive measure, it is suggested to encourage patients with diabetes and overweight or obesity to wear appropriate footwear and pressure-relief insoles to relieve high-pressure areas – often seen in these populations – to help prevent foot complications.

导言足底压力（PP）升高是导致足部溃疡的一个危险因素。足底压力一旦升高，就会增加糖尿病患者的发病率和死亡率。鉴于墨西哥人口中超重和肥胖的发病率较高，本研究旨在描述在新诊断的糖尿病患者样本中观察到的足底压力的大小和分布情况，并根据体重指数（BMI）分组（正常体重、超重、I 级肥胖、II 级和 III 级肥胖）进行调整。材料与方法共有 250 名志愿者参加了 2 型糖尿病综合治疗项目，并接受了足部评估，包括血管和神经评估、肌肉骨骼变化鉴定以及 PP 测量。70.8%的参与者存在肌肉骨骼变化。体重指数与所有受测解剖区域的 PP 峰值之间存在明显的正相关（p < 0.001）。在对体重指数进行调整后，发现各组之间存在明显差异（p < 0.001）。结论建议定期进行 PP 评估，以确定跖面高压点的分布情况。然而，作为一项预防措施，建议鼓励糖尿病、超重或肥胖患者穿着合适的鞋袜和减压鞋垫，以缓解这些人群中经常出现的高压区，从而帮助预防足部并发症。

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引用次数: 0

ENDOCRINOLOGÍA BÁSICA Y TRASLACIONAL (COMUNICACIONES ORALES) 基础和转化内分泌学（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00171-X

引用次数: 0

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