Pub Date : 2025-09-27DOI: 10.1016/j.endinu.2025.501639
María Asunción Martínez-Brocca , Virginia Bellido , Roque Cardona-Hernandez , Luis Castaño , Ignacio Conget , Alberto Fernández , Ana Lucía Gómez Gila , Isabel Leiva-Gea , Dídac Mauricio
Type 1 diabetes (T1D) is an autoimmune disease whose late diagnosis can lead to serious complications such as diabetic ketoacidosis, especially in children. The presence of specific autoantibodies allows for the identification of a presymptomatic phase, opening the door to screening strategies targeting populations at high genetic risk, such as first-degree relatives. This document presents the consensus recommendations of the Spanish Diabetes Society (SED), the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Paediatric Endocrinology (SEEP) on the screening, staging and monitoring of T1D in preclinical stages. Early identification of the disease will enable a personalised approach to be established, promote health education and, eventually, consider therapeutic interventions that may delay progression to the symptomatic phase. This consensus seeks to establish a common framework for clinical action based on the available evidence, with clear recommendations for its proper implementation.
{"title":"Resumen ejecutivo. Cribado, estadificación y seguimiento de la diabetes tipo 1 en estadios preclínicos: consenso de las sociedades científicas SED, SEEN y SEEP","authors":"María Asunción Martínez-Brocca , Virginia Bellido , Roque Cardona-Hernandez , Luis Castaño , Ignacio Conget , Alberto Fernández , Ana Lucía Gómez Gila , Isabel Leiva-Gea , Dídac Mauricio","doi":"10.1016/j.endinu.2025.501639","DOIUrl":"10.1016/j.endinu.2025.501639","url":null,"abstract":"<div><div>Type 1 diabetes (T1D) is an autoimmune disease whose late diagnosis can lead to serious complications such as diabetic ketoacidosis, especially in children. The presence of specific autoantibodies allows for the identification of a presymptomatic phase, opening the door to screening strategies targeting populations at high genetic risk, such as first-degree relatives. This document presents the consensus recommendations of the Spanish Diabetes Society (SED), the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Paediatric Endocrinology (SEEP) on the screening, staging and monitoring of T1D in preclinical stages. Early identification of the disease will enable a personalised approach to be established, promote health education and, eventually, consider therapeutic interventions that may delay progression to the symptomatic phase. This consensus seeks to establish a common framework for clinical action based on the available evidence, with clear recommendations for its proper implementation.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501639"},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-11DOI: 10.1016/j.endinu.2025.501637
Anna Aulinas , Elizabeth A. Lawson
{"title":"Oxytocin in hypopituitarism: What do we know?","authors":"Anna Aulinas , Elizabeth A. Lawson","doi":"10.1016/j.endinu.2025.501637","DOIUrl":"10.1016/j.endinu.2025.501637","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501637"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-03DOI: 10.1016/j.endinu.2025.501634
David Sanchis-Pascual , Agustín Ramos Prol , María Argente Pla , Cristina Montalbán Méndez , Darío Lara Gálvez , Carlos Folgado Bisbal , Montserrat León Fábregas , María Amparo Rubio Broseta , Eva Gascó Santana , Pilar Morillas-Amat , Mónica García Peris , Patricia Correcher Medina , Juan Francisco Merino-Torres
This is the case of a man with hepatorenal tyrosinemia type 1 (HT-1). Following the omission of his usual treatment with nitisinone and the withdrawal of dietary recommendations, the patient developed a severe neurological crisis requiring admission to the intensive care unit (ICU) due to profound diaphragmatic weakness. Despite the initial severity, appropriate management led to a favorable outcome and, eventually, weaning from mechanical ventilation. This case underscores the critical importance of a multidisciplinary approach in the management of inborn errors of metabolism, where nutritional therapy remains the cornerstone of treatment to prevent life-threatening complications.
{"title":"Neurological crisis in tyrosinemia type 1: Essential roles of replacement therapy and nutrition in multidisciplinary management","authors":"David Sanchis-Pascual , Agustín Ramos Prol , María Argente Pla , Cristina Montalbán Méndez , Darío Lara Gálvez , Carlos Folgado Bisbal , Montserrat León Fábregas , María Amparo Rubio Broseta , Eva Gascó Santana , Pilar Morillas-Amat , Mónica García Peris , Patricia Correcher Medina , Juan Francisco Merino-Torres","doi":"10.1016/j.endinu.2025.501634","DOIUrl":"10.1016/j.endinu.2025.501634","url":null,"abstract":"<div><div>This is the case of a man with hepatorenal tyrosinemia type 1 (HT-1). Following the omission of his usual treatment with nitisinone and the withdrawal of dietary recommendations, the patient developed a severe neurological crisis requiring admission to the intensive care unit (ICU) due to profound diaphragmatic weakness. Despite the initial severity, appropriate management led to a favorable outcome and, eventually, weaning from mechanical ventilation. This case underscores the critical importance of a multidisciplinary approach in the management of inborn errors of metabolism, where nutritional therapy remains the cornerstone of treatment to prevent life-threatening complications.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501634"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.endinu.2025.501635
Fidel Jesús Enciso Izquierdo , María José Amaya García , Paula Gómez Turégano , María Luengo Andrada , Ana Alejandra Cordero Vaquero , José Antonio Lucas Gamero , Sergio Garrido Domínguez , Irene Álvarez Reyes
Introduction
The active insulin time (AIT) is an adjustable parameter of the MiniMed™ 780G (MM780G) system. We analyze glucose outcomes and patient perception at different AIT settings.
Method
We conducted a quasi-experimental study on type 1 diabetes mellitus patients treated with MM780G, seen consecutively in our center. AIT was set at 2, 3 and 4 h consecutively, during a 2-week period each. Glucose metrics, insulin delivery and a questionnaire about patient perception were evaluated. At the end, results were discussed with the patient and the most appropriate AIT was agreed upon.
Results
A total of 58 users were included, aged 18–65 years, 58.6% of whom were women. At baseline, 2-h AIT was set in 6.70% of the patients, >2-h AIT and ≤3-h AIT in 24.67%, >3-h AIT and ≤4-h AIT in 58.62%, and >4-h AIT in 10.34%. Under the 2-h AIT, TIR increased by 2.28% and 6.35% vs 3- and 4-h AIT, respectively. The auto-correction boluses percentage was 21.19% at 2-h AIT, 16.90% at 3-h AIT and 14.40% at 4-h AIT.
A total of 41.4% of the users considered that 3 h was the AIT that most met their needs and 43.1% felt safer and less vulnerable to hypoglycemia at this setting. After trying on different AIT durations, 2 h increased from 6.7% of participants to 62%.
Conclusion
At 2-h AIT, the system delivers more auto-correction insulin and improves TIR vs 3- and 4-h AIT. Patients feel safer and less susceptible to hypoglycemia at 3-h AIT, but 2 out of 3 would rather choose the 2-h AIT after knowing glycemic outcomes.
胰岛素活性时间（AIT）是MiniMed™780G （MM780G）系统的可调参数。我们分析了不同AIT设置下的血糖结果和患者感知。方法对1型糖尿病患者进行MM780G治疗的准实验研究，在本中心连续观察。AIT分别于2、3、4小时连续设置，每次2周。评估血糖指标、胰岛素输送和患者感知问卷。最后，与患者讨论结果并商定最合适的AIT。结果共纳入58例患者，年龄18 ~ 65岁，其中58.6%为女性。基线时，6.70%的患者有2小时AIT， 24.67%的患者有2小时AIT和≤3小时AIT， 58.62%的患者有3小时AIT和≤4小时AIT， 10.34%的患者有4小时AIT。经2 h处理后，TIR比3 h和4 h分别提高了2.28%和6.35%。2 h自动校正丸率为21.19%，3 h为16.90%，4 h为14.40%。共有41.4%的用户认为3小时是最能满足他们需求的AIT， 43.1%的用户认为在这个设置下更安全，更不容易发生低血糖。在尝试不同的AIT持续时间后，2小时的参与者从6.7%增加到62%。结论与3 h和4 h AIT相比，2 h AIT系统可提供更多的自动校正胰岛素，提高TIR。患者感觉3小时AIT更安全，更不易发生低血糖，但3人中有2人在了解血糖结果后更愿意选择2小时AIT。
{"title":"Active insulin time setting in MiniMed™ 780G: Impact on glucose control and patient perception","authors":"Fidel Jesús Enciso Izquierdo , María José Amaya García , Paula Gómez Turégano , María Luengo Andrada , Ana Alejandra Cordero Vaquero , José Antonio Lucas Gamero , Sergio Garrido Domínguez , Irene Álvarez Reyes","doi":"10.1016/j.endinu.2025.501635","DOIUrl":"10.1016/j.endinu.2025.501635","url":null,"abstract":"<div><h3>Introduction</h3><div>The active insulin time (AIT) is an adjustable parameter of the MiniMed™ 780G (MM780G) system. We analyze glucose outcomes and patient perception at different AIT settings.</div></div><div><h3>Method</h3><div>We conducted a quasi-experimental study on type 1 diabetes mellitus patients treated with MM780G, seen consecutively in our center. AIT was set at 2, 3 and 4<!--> <!-->h consecutively, during a 2-week period each. Glucose metrics, insulin delivery and a questionnaire about patient perception were evaluated. At the end, results were discussed with the patient and the most appropriate AIT was agreed upon.</div></div><div><h3>Results</h3><div>A total of 58 users were included, aged 18–65 years, 58.6% of whom were women. At baseline, 2-h AIT was set in 6.70% of the patients, >2-h AIT and ≤3-h AIT in 24.67%, >3-h AIT and ≤4-h AIT in 58.62%, and >4-h AIT in 10.34%. Under the 2-h AIT, TIR increased by 2.28% and 6.35% vs 3- and 4-h AIT, respectively. The auto-correction boluses percentage was 21.19% at 2-h AIT, 16.90% at 3-h AIT and 14.40% at 4-h AIT.</div><div>A total of 41.4% of the users considered that 3<!--> <!-->h was the AIT that most met their needs and 43.1% felt safer and less vulnerable to hypoglycemia at this setting. After trying on different AIT durations, 2<!--> <!-->h increased from 6.7% of participants to 62%.</div></div><div><h3>Conclusion</h3><div>At 2-h AIT, the system delivers more auto-correction insulin and improves TIR vs 3- and 4-h AIT. Patients feel safer and less susceptible to hypoglycemia at 3-h AIT, but 2 out of 3 would rather choose the 2-h AIT after knowing glycemic outcomes.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 8","pages":"Article 501635"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.endinu.2025.501636
Sara Ribeiro , Telma Moreno , Maria Lume , Marisa C. Couto , Diana Baptista , Conceição Souto-Moura , Ana Varela , Sandra Belo , Paula Freitas , Davide Carvalho
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare precursor to lung carcinoids. We report a case of ACTH-dependent Cushing's syndrome in a 73-year-old female patient with metastatic lung carcinoid arising on a background of DIPNECH. She presented with lower limb oedema, hypokalaemia, hypertension, and de novo diabetes. Clinical suspicion for hypercortisolism was confirmed by abnormal cortisol tests. A thoracic CT scan showed multiple lung nodules suggestive of DIPNECH and biopsy of one of the nodules identified an ACTH-expressing carcinoid tumour. A PET-Ga-68-DOTATOC revealed pulmonary and multiple tumour lesions in the ganglia, bone and liver with overexpression of somatostatin receptors. A liver biopsy demonstrated involvement by a well-differentiated neuroendocrine neoplasia, consistent with metastasis. Hypercortisolism was managed with octreotide and metyrapone, but the patient succumbed to complications 14 months post-diagnosis. This case suggests DIPNECH's potential to progress to hyperfunctioning, metastatic carcinoids and highlights the necessity for vigilant long-term surveillance and early intervention.
{"title":"Ectopic Cushing's syndrome in a patient with DIPNECH and metastatic lung carcinoid","authors":"Sara Ribeiro , Telma Moreno , Maria Lume , Marisa C. Couto , Diana Baptista , Conceição Souto-Moura , Ana Varela , Sandra Belo , Paula Freitas , Davide Carvalho","doi":"10.1016/j.endinu.2025.501636","DOIUrl":"10.1016/j.endinu.2025.501636","url":null,"abstract":"<div><div>Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare precursor to lung carcinoids. We report a case of ACTH-dependent Cushing's syndrome in a 73-year-old female patient with metastatic lung carcinoid arising on a background of DIPNECH. She presented with lower limb oedema, hypokalaemia, hypertension, and de novo diabetes. Clinical suspicion for hypercortisolism was confirmed by abnormal cortisol tests. A thoracic CT scan showed multiple lung nodules suggestive of DIPNECH and biopsy of one of the nodules identified an ACTH-expressing carcinoid tumour. A PET-Ga-68-DOTATOC revealed pulmonary and multiple tumour lesions in the ganglia, bone and liver with overexpression of somatostatin receptors. A liver biopsy demonstrated involvement by a well-differentiated neuroendocrine neoplasia, consistent with metastasis. Hypercortisolism was managed with octreotide and metyrapone, but the patient succumbed to complications 14 months post-diagnosis. This case suggests DIPNECH's potential to progress to hyperfunctioning, metastatic carcinoids and highlights the necessity for vigilant long-term surveillance and early intervention.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 8","pages":"Article 501636"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-30DOI: 10.1016/j.endinu.2025.501624
Cristina Mª Díaz Perdigones , Daniel Hinojosa Nogueira , Alba Rodríguez Muñoz , Alba Subiri Verdugo , Alberto Vilches-Pérez , Virginia Mela , Francisco J. Tinahones , Isabel Moreno Indias
Obesity is a growing public health problem. In recent decades, scientific evidence has linked gut microbiota to obesity. This systematic review summarizes current knowledge on the composition and functional differences in gut microbiota between individuals with obesity and those with normal weight. Following PRISMA 2020 recommendations, studies published in adult populations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, and Scopus databases were searched for observational studies that had used advanced sequencing methods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The quality of these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studies shows a reduction in microbial diversity in individuals with obesity. In addition, a higher relative abundance of the phylum Firmicutes, the families Enterobacteriaceae, Gemellaceae, Prevotellaceae, Streptococcaceae and Veillonellaceae, as well as the genera Blautia, Butyricimonas, Collinsella, Megamonas, and Streptococcus, while beneficial bacteria such as the families Porphyromonadaceae and Rikenellaceae, and the genera Bifidobacterium spp. and Faecalibacterium prausnitzii, were depleted. Functional analysis showed a tendency to an increase in metabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathways related to short-chain fatty acid production. Obesity is associated with altered gut microbiota composition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Future research should prioritize standardized methodologies and confounding factors to elucidate the role of the gut microbiome in obesity.
肥胖是一个日益严重的公共健康问题。近几十年来，科学证据表明肠道微生物群与肥胖有关。这篇系统综述总结了目前关于肥胖个体和正常体重个体之间肠道微生物群组成和功能差异的知识。根据PRISMA 2020的建议，对2014年1月至2024年5月期间发表的成人研究进行了回顾。PubMed， Web of Science和Scopus数据库检索了使用先进测序方法（如16S rRNA和shotgun宏基因组学）评估肠道微生物群的观察性研究。这些研究的质量也用纽卡斯尔-渥太华量表进行了分析。我们对16项研究的回顾表明，肥胖个体的微生物多样性减少。此外，厚壁菌门、Enterobacteriaceae、Gemellaceae、Prevotellaceae、Streptococcaceae和Veillonellaceae以及Blautia属、Butyricimonas、Collinsella、Megamonas和Streptococcus等有益菌的相对丰度较高，而Porphyromonadaceae和Rikenellaceae、Bifidobacterium spp.和Faecalibacterium prausnitzii等有益菌的相对丰度则相对较少。功能分析显示，与碳水化合物和脂质代谢相关的代谢途径有增加的趋势，与短链脂肪酸产生相关的代谢途径减少。肥胖与肠道菌群组成和功能的改变有关。然而，关于人群特征、饮食模式和测序技术的研究差异限制了研究结果的可比性。未来的研究应优先考虑标准化的方法和混杂因素，以阐明肠道微生物群在肥胖中的作用。
{"title":"Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review","authors":"Cristina Mª Díaz Perdigones , Daniel Hinojosa Nogueira , Alba Rodríguez Muñoz , Alba Subiri Verdugo , Alberto Vilches-Pérez , Virginia Mela , Francisco J. Tinahones , Isabel Moreno Indias","doi":"10.1016/j.endinu.2025.501624","DOIUrl":"10.1016/j.endinu.2025.501624","url":null,"abstract":"<div><div>Obesity is a growing public health problem. In recent decades, scientific evidence has linked gut microbiota to obesity. This systematic review summarizes current knowledge on the composition and functional differences in gut microbiota between individuals with obesity and those with normal weight. Following PRISMA 2020 recommendations, studies published in adult populations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, and Scopus databases were searched for observational studies that had used advanced sequencing methods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The quality of these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studies shows a reduction in microbial diversity in individuals with obesity. In addition, a higher relative abundance of the phylum <em>Firmicutes</em>, <em>the families Enterobacteriaceae</em>, <em>Gemellaceae</em>, <em>Prevotellaceae</em>, <em>Streptococcaceae</em> and <em>Veillonellaceae</em>, as well as the genera <em>Blautia</em>, <em>Butyricimonas</em>, <em>Collinsella</em>, <em>Megamonas</em>, and <em>Streptococcus</em>, while beneficial bacteria such as the families <em>Porphyromonadaceae</em> and <em>Rikenellaceae</em>, and the genera <em>Bifidobacterium</em> spp<em>.</em> and <em>Faecalibacterium prausnitzii</em>, were depleted. Functional analysis showed a tendency to an increase in metabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathways related to short-chain fatty acid production. Obesity is associated with altered gut microbiota composition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Future research should prioritize standardized methodologies and confounding factors to elucidate the role of the gut microbiome in obesity.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501624"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1016/j.endinu.2025.501613
Alba Escolà-Rodríguez , Berta de Andrés , Tamara Hervis , Marina Rovira-Illamola
{"title":"Semaglutide-associated psychiatric disorders: A case report and literature review","authors":"Alba Escolà-Rodríguez , Berta de Andrés , Tamara Hervis , Marina Rovira-Illamola","doi":"10.1016/j.endinu.2025.501613","DOIUrl":"10.1016/j.endinu.2025.501613","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501613"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1016/j.endinu.2025.501614
Marina Jara Vidal, Andrés Ruiz de Assín Valverde, Marta Gallach Martínez, Noel Roig Marín, César Gonzalvo Díaz, Rosa Pilar Quílez Toboso, Lourdes García Blasco, Silvia Aznar Rodríguez, José Juan Lozano García, José Joaquín Alfaro Martínez
Introduction
This study investigates the concordance of bioelectrical impedance vector analysis (BIVA) measurements in both hemisomes in patients receiving fluid therapy, since clinical practice suggests performing them in the hemisoma contralateral to that of its administration to avoid interferences.
The primary objective of this study was to evaluate the concordance of phase angle (PhA), resistance and reactance, both standardized by height (Rz/h, Xc/h) between the hemisoma where the patient is receiving iv fluids and the other one.
Methods
Clinical, prospective and descriptive study, which included 100 hospitalized patients with total parenteral nutrition (TPN) or other intravenous fluid therapy. BIVA measurements were taken in both hemisomes and analyzed by means of Bland–Altman plots, Passing–Block test and conditional method agreement trees (COAT).
Results
100 patients were included (57 men and 43 women), with an average age of 67.2 ± 15.1 years. Univariate analysis using the Bland–Altman plot showed no concordance of PhA, Rz/h and Xc/h between both hemisomes in patients who received fluid therapy, but Passing–Block test showed no systematic or proportional differences between hemisomas and multivariate COAT analysis did not show that the specified covariates affected concordance.
Conclusions
No systematic or proportional differences between hemisomas in resistance and reactance has been demonstrated, suggesting the possibility of being able to perform the measurement independently of the side of fluid administration.
{"title":"The hemisoma in which the bioelectrical impedance vector analysis is performed has no influence on outcomes in patients receiving intravenous fluid therapy","authors":"Marina Jara Vidal, Andrés Ruiz de Assín Valverde, Marta Gallach Martínez, Noel Roig Marín, César Gonzalvo Díaz, Rosa Pilar Quílez Toboso, Lourdes García Blasco, Silvia Aznar Rodríguez, José Juan Lozano García, José Joaquín Alfaro Martínez","doi":"10.1016/j.endinu.2025.501614","DOIUrl":"10.1016/j.endinu.2025.501614","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the concordance of bioelectrical impedance vector analysis (BIVA) measurements in both hemisomes in patients receiving fluid therapy, since clinical practice suggests performing them in the hemisoma contralateral to that of its administration to avoid interferences.</div><div>The primary objective of this study was to evaluate the concordance of phase angle (PhA), resistance and reactance, both standardized by height (Rz/h, Xc/h) between the hemisoma where the patient is receiving iv fluids and the other one.</div></div><div><h3>Methods</h3><div>Clinical, prospective and descriptive study, which included 100 hospitalized patients with total parenteral nutrition (TPN) or other intravenous fluid therapy. BIVA measurements were taken in both hemisomes and analyzed by means of Bland–Altman plots, Passing–Block test and conditional method agreement trees (COAT).</div></div><div><h3>Results</h3><div>100 patients were included (57 men and 43 women), with an average age of 67.2<!--> <!-->±<!--> <!-->15.1 years. Univariate analysis using the Bland–Altman plot showed no concordance of PhA, Rz/h and Xc/h between both hemisomes in patients who received fluid therapy, but Passing–Block test showed no systematic or proportional differences between hemisomas and multivariate COAT analysis did not show that the specified covariates affected concordance.</div></div><div><h3>Conclusions</h3><div>No systematic or proportional differences between hemisomas in resistance and reactance has been demonstrated, suggesting the possibility of being able to perform the measurement independently of the side of fluid administration.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501614"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1016/j.endinu.2025.501616
Fernando Guerrero-Pérez
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