Endocrinologia, Diabetes y Nutricion最新文献

{"title":"In young adult males, bitterness perception is associated with excess body mass and metabolic dysregulation","authors":"Julieta Cigarroa-Durán ,&nbsp;Gabriel López-Ramírez ,&nbsp;Mirian Carolina Martínez-López ,&nbsp;Itandehui Castro-Quezada ,&nbsp;Arturo Ortega Soto ,&nbsp;Orquidia G. Méndez-Flores","doi":"10.1016/j.endinu.2025.501629","DOIUrl":"10.1016/j.endinu.2025.501629","url":null,"abstract":"<div><h3>Introduction</h3><div>Bitterness perception requires activation of the taste-receptor cells (TRCs) in the lingual papillae. The TAS2R38 specialist receptor (T2R family) is activated by thiol-urea chemicals, where 3 haplotype combinations are highly related to bitterness perception. Tasters (PAV/PAV) and non-tasters (AVI/AVI) represent the homozygous phenotypes, while the heterozygous combinations form the moderate tasters, who comprise approximately half of the population.</div></div><div><h3>Material and methods</h3><div>We determined the bitterness perception phenotype of 153 young adults, as they reacted to a phenylthiocarbamide (PTC) impregnated paper strip placed on their tongues. We measured their weight, height, waist and hip circumferences, total body fat and lean body mass. Mean and standard deviation is shown to express quantitative variables, Kruskal–Wallis test and Dunn's multiple comparison test was used, with 95% confidence intervals.</div></div><div><h3>Results</h3><div>PTC tasters comprised 27% of the study group, with non-tasters making up 18%. When analyzed by sex, 32% of women were PTC tasters vs 18% of men. Notably, for men, PTC tasters exhibited higher mean values across several body composition measures than non-tasters, including a BMI of 28<!--> <!-->kg/m² vs 24<!--> <!-->kg/m², a waist circumference of 94<!--> <!-->cm vs 79<!--> <!-->cm, a waist-to-height ratio of 0.54 vs 0.49, and a body fat percentage of 28% vs 15%. In contrast, women showed no significant differences in these measures based on their bitterness perception.</div></div><div><h3>Conclusions</h3><div>The distribution of perception groups and preponderance of female PTC tasters corresponds to previously reported data. Taster men had a body composition distant from healthy parameters and above the non-tasters values, yet not significant differences were found for female participants.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501629"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromedin U and BMI correlation in T1DM and T2DM vs healthy controls: A comparative study","authors":"Yasemin Çalışkan ,&nbsp;Emre Sarandöl ,&nbsp;Nizameddin Koca","doi":"10.1016/j.endinu.2025.501631","DOIUrl":"10.1016/j.endinu.2025.501631","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess serum Neuromedin U (NmU) levels in patients with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM) vs healthy controls and evaluate the correlation between NmU and body mass index (BMI).</div></div><div><h3>Research design and methods</h3><div>We conducted a cross-sectional study with 134 participants: 45 with T1DM, 49 with T2DM, and 40 healthy controls. Serum NmU levels were measured using enzyme-linked immunosorbent assay (ELISA), and the correlation with BMI was assessed.</div></div><div><h3>Results</h3><div>NmU levels were not significantly different between diabetic patients and healthy controls. No significant correlation was observed between NmU and BMI in T1DM or T2DM groups. However, the healthy control group found a significant inverse correlation between NmU and BMI (rho<!--> <!-->=<!--> <!-->−0.373, <em>p</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>NmU may not be a direct biomarker for diabetes, but its significant correlation with BMI in healthy individuals suggests a potential role in metabolic regulation. This is the first study ever conducted to compare NmU levels across diabetic subtypes, offering novel insights into the role of in metabolic homeostasis.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 8","pages":"Article 501631"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between fragmented QRS and left ventricular diastolic dysfunction in type 2 diabetes patients with or without microalbuminuria","authors":"Lili Wang ,&nbsp;Linjun Zheng ,&nbsp;Jiayu Hu ,&nbsp;Nongnong Zhao","doi":"10.1016/j.endinu.2025.501623","DOIUrl":"10.1016/j.endinu.2025.501623","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Cardiovascular disease (CVD) is the leading cause of death in patients with type 2 diabetes mellitus (T2DM), and left ventricular diastolic dysfunction (LVDD) is considered one of the earliest markers of myocardial dysfunction. Fragmented QRS (fQRS) and microalbuminuria (MAU) are important biomarkers of cardiac electrophysiological changes and CVD, but their relationship with LVDD in T2DM remains unclear. This study aims to explore the impact of fQRS and MAU on LVDD in T2DM patients and to analyze whether the association between fQRS and LVDD differs across varying MAU statuses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A total of 374 patients with T2DM were ultimately enrolled in this study. Twelve-lead electrocardiography (ECG) and echocardiography were performed, and the patients’ baseline characteristics, laboratory results, and echocardiographic parameters were collected. Univariate and multivariate logistic regression analyses were conducted to assess the association between fQRS, MAU, and LVDD in T2DM patients. A stratified analysis was performed to examine the relationship between fQRS and LVDD across different MAU statuses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean age of the T2DM patients was 57.19&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;12.47 years, and 62.57% were male. fQRS, MAU, and age were independent risk factors for LVDD in patients with T2DM. The risk of developing LVDD was 3.72 times higher in patients with fQRS compared to those without fQRS [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;2.125–6.513, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. The risk of LVDD was 4.05 times higher in patients with MAU compared to those without MAU [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;2.252–7.282, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. For each additional year of age, the risk of LVDD increased by 5.2% [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;1.022–1.084, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.001]. Stratified analysis based on MAU status revealed that in patients without MAU, the association between fQRS and LVDD was stronger [OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;7.084, 95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;3.255–15.419, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. However, in patients with MAU, the relationship between fQRS and LVDD was no longer significant [OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;1.499, 95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.603–3.722, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.383].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Our study found that both fQRS and MAU are independent risk factors for LVDD in patients with T2DM. The presence of fQRS increased the risk of LVDD by 3.72 times, while MAU increased the risk by 4.05 times. Stratified analysis further revealed that in patients without MAU, the association between fQRS and LVDD was significantly stronger (OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;7.084, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001), while in patients with MAU, this association was no longer significant (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.383). These findings suggest that combining the detection of fQRS and MAU may provide valuab","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 9","pages":"Article 501623"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolución del sodio en la hiponatremia: análisis retrospectivo en un centro de tercer nivel","authors":"Karina Mercedes Becerra Añez ,&nbsp;Carlos Sánchez Juan ,&nbsp;Ana Artero Fullana ,&nbsp;Ana Jiménez Portilla ,&nbsp;Juan Carlos Ferrer García","doi":"10.1016/j.endinu.2025.501563","DOIUrl":"10.1016/j.endinu.2025.501563","url":null,"abstract":"<div><h3>Introduction</h3><div>Hyponatremia is the most common electrolyte disorder in hospitals. This study analyzes the evolution of serum sodium levels during hospitalization.</div></div><div><h3>Materials and methods</h3><div>This is an observational, retrospective, and analytical study. Patients hospitalized for hyponatremia in a tertiary care hospital were included. Demographic and laboratory variables were collected, and hyponatremia was classified according to severity and etiology. Criteria and risk factors for serum sodium overcorrection were defined, and the effectiveness of treatments used for hyponatremia was described. The Chi-square test was used for qualitative variables, while Student's t-test and Mann-Whitney U test were applied for quantitative variables. Predictive models were also used to determine the risk of an event.</div></div><div><h3>Results</h3><div>A total of 216 patients hospitalized for hyponatremia were included, with a higher prevalence in patients over 75 years of age and females. Longer hospital stays were associated with older age and male gender. Severe hyponatremia and hypokalemia were linked to a higher risk of overcorrection. The therapies for hyponatremia correction across the three groups were effective either alone or in combination. Additionally, severe hyponatremia was associated with increased 5-year mortality.</div></div><div><h3>Conclusions</h3><div>Hyponatremia in hospitalized patients is more prevalent in those over 75 years old and in females. Severe hyponatremia increases 5-year mortality. There are factors that increase the risk of overcorrection, so treatment should be carefully managed to avoid osmotic demyelination syndrome (ODS).</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501563"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach to finding the compositional differences and biomarkers in gut microbiota in type 2 diabetic patients via meta-analysis, data-mining, and multivariate analysis","authors":"Faezeh Ebrahimi ,&nbsp;Hadi Maleki ,&nbsp;Mansour Ebrahimi ,&nbsp;Amir Hossein Beiki","doi":"10.1016/j.endinu.2025.501561","DOIUrl":"10.1016/j.endinu.2025.501561","url":null,"abstract":"<div><h3>Background/Purpose of the study</h3><div>Type 2 diabetes mellitus (T2DM)—one of the fastest globally spreading diseases—is a chronic metabolic disorder characterized by elevated blood glucose levels. It has been suggested that the composition of gut microbiota plays key roles in the prevalence of T2DM. In this study, a novel approach of large-scale data mining and multivariate analysis of the gut microbiome of T2DM patients and healthy controls was conducted to find the key compositional differences in their microbiota and potential biomarkers of the disease.</div></div><div><h3>Methods</h3><div>First, suitable datasets were identified (9 in total with 946 samples), analyzed, and their operational taxonomic units (OTUs) were computed by identical parameters to increase accuracy. The following OTUs were merged and compared based on their health status, and compositional differences detected. For biomarker identification, the OTUs were subjected to 9 different attribute weighting models. Additionally, OTUs were independently analyzed by multivariate algorithms (LEfSe test) to verify the realized biomarkers.</div></div><div><h3>Results</h3><div>Overall, 23 genera and 4 phyla were identified as possible biomarkers. At genus level, the decrease of <em>Bacteroides</em>, <em>Methanobrevibacter</em>, <em>Paraprevotella</em>, and [<em>Eubacterium</em>] <em>hallii group</em> in T2DM and the increase of <em>Prevotella</em>, <em>Megamonas</em>, <em>Megasphaera</em>, <em>Ligilactobacillus</em>, and <em>Lachnoclostridium</em> were selected as biomarkers; and at phylum level, the increase of <em>Synergistota</em> and the decrease of <em>Euryarchaeota</em>, <em>Desulfobacterota</em> (<em>Thermodesulfobacteriota</em>), and <em>Ptescibacteria</em>.</div></div><div><h3>Conclusion</h3><div>This is the first study ever conducted to find the microbial compositional differences and biomarkers in T2DM using data mining models applied on a widespread metagenome dataset and verified by multivariate analysis.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501561"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of length of hospital stay in patients presenting to the emergency department with hyperosmolar hyperglycemic crises","authors":"Tomás González-Vidal ,&nbsp;Diego Rivas-Otero ,&nbsp;Carmen Lambert ,&nbsp;Jessica Ares Blanco ,&nbsp;Elías Delgado-Álvarez ,&nbsp;Edelmiro Menéndez Torre","doi":"10.1016/j.endinu.2025.501577","DOIUrl":"10.1016/j.endinu.2025.501577","url":null,"abstract":"<div><h3>Objective</h3><div>To predict the length of hospital stay in hyperosmolar hyperglycemic crises (HHC) using variables available on admission.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study with 132 patients (65 [49.2%] men; median age 72 years; range 19–98 years) hospitalized for HHC (including hyperosmolar hyperglycemic state and diabetic ketoacidosis with elevated osmolality) in a Spanish teaching hospital. Baseline variables and those upon arrival to the emergency department were collected (both variables related to physical examination and biochemical tests), as well as the in-hospital mortality rate and overall length of hospital stay in survivors.</div></div><div><h3>Results</h3><div>Patients who died (<em>n</em> <!-->=<!--> <!-->13) had higher total serum osmolality and higher C-reactive protein concentrations on admission vs survivors. Among survivors, the length of stay correlated positively with total serum osmolality (Rho<!--> <!-->=<!--> <!-->0.398; <em>p</em> <!-->&lt;<!--> <!-->0.001) and C-reactive protein (Rho<!--> <!-->=<!--> <!-->0.342; <em>p</em> <!-->&lt;<!--> <!-->0.001) on admission. Older age, female sex, lack of pre-admission diagnosis of insulin-requiring diabetes, impaired mental status on arrival, non-ketotic metabolic acidosis, and low serum potassium concentrations were also associated with long lengths of stay. In multivariate analysis, only serum glucose (one of the three components of total osmolality) and C-reactive protein concentrations on admission kept a positive association with the length of stay.</div></div><div><h3>Conclusions</h3><div>Hyperglycemia and elevated C-reactive protein on admission are independent predictors of long lengths of stay in survivors with HHC.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501577"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipopatía y disglucemia en la enfermedad metabólica sistémica: hacia un abordaje integral multidisciplinar liderado por el endocrinólogo","authors":"Núria Alonso ,&nbsp;María Teresa Julián","doi":"10.1016/j.endinu.2025.501600","DOIUrl":"10.1016/j.endinu.2025.501600","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501600"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valoración en vida real de la eficacia y de la seguridad del cambio de dulaglutida semanal a semaglutida semanal: estudio SEMA-SWITCH","authors":"Felipe Pardo Lozano ,&nbsp;Arantxa Rubio Marcos ,&nbsp;Rosa Casañ Fernández ,&nbsp;Amparo Bartual Rodrigo ,&nbsp;Sergio Martínez-Hervás ,&nbsp;Francisco Javier Ampudia-Blasco","doi":"10.1016/j.endinu.2025.501574","DOIUrl":"10.1016/j.endinu.2025.501574","url":null,"abstract":"<div><h3>Introduction</h3><div>Dulaglutide and semaglutide are once-weekly administered GLP-1 receptor agonists (GLP-1 RAs) indicated for the treatment of hyperglycemia in individuals with type<!--> <!-->2 diabetes mellitus (T2DM) and obesity (BMI ≥<!--> <!-->30<!--> <!-->kg/m²).</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of switching from subcutaneous (SC) dulaglutide to SC semaglutide, in real-world conditions.</div></div><div><h3>Materials and methods</h3><div>A total of 123 individuals with T2DM on SC dulaglutide, either as monotherapy or with other antihyperglycemic drugs, who switched to SC semaglutide were included. This switch was motivated by insufficient reduction in glycated hemoglobin (HbA1c), the need for greater weight loss, or gastrointestinal intolerance associated with dulaglutide. Changes with semaglutide in HbA1c and weight at 6, 12, 18, and 24<!--> <!-->months, as well as any changes in associated adverse effects. Data are expressed as mean ±<!--> <!-->standard deviation.</div></div><div><h3>Results</h3><div>Previous treatment with dulaglutide (duration 16.9<!--> <!-->±<!--> <!-->13.8 months) reduced HbA1c by 0.38% (<em>P</em> <!-->=<!--> <!-->.003 vs. baseline) and weight by −1.3<!--> <!-->kg (<em>P</em> <!-->=<!--> <!-->.003 vs. baseline). After switching to semaglutide, an additional reduction in HbA1c levels was observed at 6, 12, 18, and 24<!--> <!-->months (−0.43%, <em>P</em> <!-->=<!--> <!-->.000; −0.54%, <em>P</em> <!-->=<!--> <!-->.000; −0.38%, <em>P</em> <!-->=<!--> <!-->.021; −0.12%, <em>P</em> <!-->=<!--> <!-->.622, respectively) and in weight at 6, 12, 18, and 24<!--> <!-->months (−2.7<!--> <!-->kg, <em>P</em> <!-->=<!--> <!-->.000; −3.7<!--> <!-->kg, <em>P</em> <!-->=<!--> <!-->.000; −5.4<!--> <!-->kg, <em>P</em> <!-->=<!--> <!-->.001; −4.2<!--> <!-->kg, <em>P</em> <!-->=<!--> <!-->.000, respectively) With no significant differences in the frequency of adverse effects after switching to semaglutide.</div></div><div><h3>Conclusions</h3><div>In real-world conditions, switching dulaglutide to semaglutide in obese patients with T2DM is associated with an additional reduction in HbA1c and weight, without notable changes in the frequency of adverse effects.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501574"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proyecto CANTCAM (Carcinoma ANaplásico de Tiroides en CAstilla-La Mancha). Estudio retrospectivo multicéntrico","authors":"Sandra Herranz-Antolín ,&nbsp;Rosa Quílez-Toboso ,&nbsp;Jesús Moreno-Fernández ,&nbsp;Javier González-López ,&nbsp;María López-Iglesias ,&nbsp;Julia Sastre","doi":"10.1016/j.endinu.2025.501580","DOIUrl":"10.1016/j.endinu.2025.501580","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the clinical presentation, diagnosis, management and survival of Anaplastic Thyroid Carcinomas (ATC) in the Hospitals of Castilla-La Mancha (Spain).</div></div><div><h3>Material and methods</h3><div>Retrospective multicenter descriptive study. Adult patients with ATC diagnosed from 2002 to 2022 were included.</div></div><div><h3>Results</h3><div>Of the 43 patients included, 53.5% were women, with a mean age of 72 years (SD 10) at the time of diagnosis. Symptoms were present in 100% of the patients and the most frequent symptom was a rapidly growing mass (79.1% of the cases). Infiltration of neighboring structures (76.7%), lymph node involvement (78.1%) and distant metastasis (51.2%). The AJCC-TNM category was IVa in 9.3%, IVb in 39.5% and IVc in 51.2%. <em>BRAF</em>^{<em>V600E</em>} determination was not performed in 74.4% and 5 of the 11 cases in which it was evaluated (45.4%) had the mutation. Active treatment was received in 76.7% of patients in the first 3 months. Surgical approach was performed in 63.6% of the cases, with complete resection in 23.8%, and 51.5% received multimodality treatment in this period. 42.3% received active treatment during follow-up (≥<!--> <!-->3 months), primarily systemic chemotherapy (72.7%), and 54.4% received multimodality treatment during this period. The median specific survival was 3.5 months (95% CI 1.7-5.2). Factors associated with longer specific survival were initial multimodality treatment (p<!--> <!-->&lt;<!--> <!-->0.01) or during follow-up (p<!--> <!-->=<!--> <!-->0.01) and initial BRAF/MEK inhibitor treatment (p<!--> <!-->=<!--> <!-->0.04).</div></div><div><h3>Conclusion</h3><div>CAT is an infrequent and aggressive tumor that requires early, multidisciplinary, personalized and multimodal treatment.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501580"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic adrenocorticotropic hormone syndrome due to olfactory neuroblastoma: A case report and literature review","authors":"Mónica Baptista Lopes ,&nbsp;Ricardo Fonseca ,&nbsp;João Fernandes Serôdio ,&nbsp;Ricardo Paquete Oliveira ,&nbsp;José Delgado Alves","doi":"10.1016/j.endinu.2025.501576","DOIUrl":"10.1016/j.endinu.2025.501576","url":null,"abstract":"<div><div>Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a cause of Cushing's syndrome usually associated with neuroendocrine tumors. Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the olfactory epithelium. This is the case of a 56-year-old woman with an ONB presenting with EAS. After initiating metyrapone, she developed a <em>Pneumocystis jirovecii</em> pneumonia. Following successful treatment of the infection, she underwent surgical tumor excision and radiotherapy, which has been in remission for the past 3 years. The authors provide a literature review of the 30 previously published cases of ONB presenting with EAS. Most were reported in middle-aged men, with a recurrence rate of 15.6% (3 patients eventually died). A total of 9.5% of all reported had an infection after starting corticosteroid-blocking therapy. ONB is a very rare cause of EAS with poor prognosis and a relapsing course. In the presence of severe hypercortisolism, chemoprophylaxis for common opportunistic agents must be considered.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 6","pages":"Article 501576"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}