Neurobiology of Sleep and Circadian Rhythms最新文献

{"title":"Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection","authors":"Mark R. Zielinski ,&nbsp;Sean D. Carey ,&nbsp;John A. Craig","doi":"10.1016/j.nbscr.2025.100121","DOIUrl":"10.1016/j.nbscr.2025.100121","url":null,"abstract":"<div><div>Evidence indicates relationships between sleep and the innate immune system during homeostatic sleep and sleep responses after infection. The innate immune system and sleep-like states are highly conserved between simple species and more complex species such as humans. A wide variety of bacteria, viruses, and parasites change sleep patterns in the host during infection. The effects of infection on sleep can occur, in part, due to the bolus and route of infection, prior exposure, immune status of the individual/organism, and the type of pathogen. In addition, elements of circadian patterns and sleep prior to and after infection can modulate the infection pathology and resolution. Innate immune molecules, such as the cytokines interleukin-1 beta and tumor necrosis factor-alpha, fluctuate with the time of day of increased activity and sleep propensity, increase in response to increased waking activity from sleep loss, and are altered from infection by bacteria and viruses to alter sleep and the electroencephalogram. This review focuses innate immune mechanisms of how pathogen recognition receptors, pathogen-associated molecular patterns and danger-associated molecular patterns, energy-related molecules, oxidative stress, and inflammasomes are activated with infection to potentially affect sleep.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep in disease: inflammation and chronic rhinosinusitis","authors":"Vivek C. Pandrangi ,&nbsp;Jeremiah A. Alt","doi":"10.1016/j.nbscr.2025.100120","DOIUrl":"10.1016/j.nbscr.2025.100120","url":null,"abstract":"<div><div>Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is associated with significant quality of life (QOL) impairment, including sleep dysfunction. There are multiple factors that have been independently associated with poor sleep among this population including alterations in inflammatory mediators, rhinologic symptom interference such as nasal discharge, obstruction, and facial pain, and co-morbid conditions including asthma. While there is a high prevalence of sleep dysfunction among this population, treatment with both medical and surgical options may lead to sustained improvements in sleep. This review aims to highlight the burden of sleep dysfunction, discuss common theories regarding the etiology, and evaluate strategies that may facilitate improvement in sleep dysfunction among patients with CRS.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic signals in sleep regulation: the role of brown adipose tissue","authors":"Éva Szentirmai ,&nbsp;Levente Kapás","doi":"10.1016/j.nbscr.2025.100122","DOIUrl":"10.1016/j.nbscr.2025.100122","url":null,"abstract":"<div><div>The regulation of sleep, while primarily attributed to the interplay between circadian and homeostatic processes, is significantly influenced by a multitude of additional factors that profoundly impact sleep quantity and quality. These factors encompass both external environmental stimuli, such as ambient temperature and somatosensory inputs, and internal physiological changes. The intricate relationship between metabolism and sleep has been a subject of extensive research, with particular attention given to the role of metabolic signals in sleep regulation. Among these, the brown adipose tissue (BAT) has emerged as a key player, studied from various perspectives including its physiological responses to sleep deprivation, its effects on sleep when activated, the consequences of impaired BAT thermogenesis on sleep patterns, and its metabolic activity across different sleep states. The cumulative evidence from these investigations suggests that BAT plays a crucial role in maintaining an optimal metabolic environment conducive to sleep, a function that becomes particularly significant in contexts of prior sleep loss, inflammatory conditions, and fluctuations in ambient temperature.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of restless legs syndrome and obesity: A sub-population of the MASHAD cohort study","authors":"Azam Vafaei ,&nbsp;Fatemeh Khorashadizadeh ,&nbsp;Maryam Saberi-Karimian ,&nbsp;Sara Saffar Soflaei ,&nbsp;Mahnaz Amini ,&nbsp;Abolfazl Rashid ,&nbsp;Sara Yousefian ,&nbsp;Gordon A. Ferns ,&nbsp;Habibollah Esmaily ,&nbsp;Majid Ghayour-Mobarhan ,&nbsp;Reza Salaran ,&nbsp;Fatemeh Taherian","doi":"10.1016/j.nbscr.2025.100113","DOIUrl":"10.1016/j.nbscr.2025.100113","url":null,"abstract":"<div><h3>Introduction</h3><div>Restless Legs Syndrome (RLS), as a relatively unknown sleep disorder, often associated with obesity. The purpose of this study was to examine the relationship between RLS and different definitions of obesity within the Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study population.</div></div><div><h3>Methods</h3><div>A total of 1006 subjects, with an average age of 57 (51.75–63.00) years old, were randomly selected from the MASHAD cohort study phase II. This sample included 449 males and 557 females, who were contacted by phone to inquire about RLS. Anthropometric measurements such as weight, height, waist circumference (WC), and hip circumference (HC) were taken. Central obesity was defined as a WC &gt; 90 cm for men and &gt;85 cm for women, as well as a waist-to-hip ratio (WHR) greater than 0.90 for men and 0.85 for women. Statistical analyses were conducted using R version 4.3.2 for Windows, with a significance level set at a two-sided P-value&lt;0.05. Chi-squared and Fisher's exact tests were used to compare the categorical variables between two study groups. Logistic models applied to evaluate the association between RLS and BMI while adjusting for age effects.</div></div><div><h3>Results</h3><div>The study found a significant relationship between RLS and employment status (p-value = 0.04), marital status (p-value = 0.05), and BMI (p-value&lt;0.001). The results showed that in the total population, the OR of RLS in subjects having BMI&gt;30 kg/m² increased to 1.50(1.10–2.03) after adjusting for confounding factors (p-value&lt;0.01). A BMI&gt;30 kg/m² increased odds of RLS by 1.72 times in males (95%CI: 1.03–2.84, p-value&lt;0.05), however this association was diminished after adjustment (OR = 1.20, 95%CI: 0.64–2.17). There was no significant association between BMI and RLS in females. Moreover, there was no significant association between RLS and obesity based on WC and WHR in fully adjusted model respectively.</div></div><div><h3>Conclusion</h3><div>There was a significant association between BMI and RLS. A BMI&gt;30 kg/m² increased the odds of RLS by 1.50 times in the study population.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association between chronotype and cardiovascular response to a cognitive challenge in the morning using a Bayesian approach","authors":"Larissa N. Wüst ,&nbsp;Christian Cajochen ,&nbsp;Ruta Lasauskaite","doi":"10.1016/j.nbscr.2025.100125","DOIUrl":"10.1016/j.nbscr.2025.100125","url":null,"abstract":"<div><div>A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we sought to find associations between chronotypes determined from self-reported habitual sleep timing and from salivary melatonin onset with mental effort during a 2-back working memory task. Mental effort was operationalized as sympathetic beta-adrenergic impact on the heart, which is best reflected by the cardiac pre-ejection period (PEP) and also influences systolic blood pressure (SBP). Each participant underwent two experimental sessions in the morning: once after sleeping for 8 h and once after sleeping for 5 h the night before. To determine the timing of evening melatonin onset, participants took saliva samples at hourly intervals at home in the evening, prior to their experimental sessions. Chronotypes were determined using reported sleep times from the Munich Chronotype Questionnaire and average melatonin onset during both sleep conditions. Based on this, participants were grouped into early, intermediate, or late types. Neither alertness (<em>BF</em>_<em>10</em> = 0.019), perceived task demand (<em>BF</em>_<em>10</em> = 0.008), nor SBP response (<em>BF</em>_<em>10</em> = 0.268) were credibly impacted by sleep-time derived chronotype, while the association with PEP response (<em>BF</em>_<em>10</em> = 0.631) during a cognitive challenge in the morning was inconclusive. Similarly, the timing of evening melatonin onset did not affect alertness (<em>BF</em>_<em>10</em> = 0.003), perceived task demand (<em>BF</em>_<em>10</em> = 0.006), or PEP or SBP response (PEP: <em>BF</em>_<em>10</em> = 0.232, SBP: <em>BF</em>_<em>10</em> = 0.263) during the cognitive challenge. Our data shows no impact of chronotypes on effort-related cardiovascular response during a cognitive challenge in the morning, which was scheduled according to habitual sleep times.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of traumatic brain injury severity and sex on sleep architecture, duration, and fragmentation","authors":"Grant S. Mannino ,&nbsp;Tabitha R.F. Green ,&nbsp;Sean M. Murphy ,&nbsp;Michael R. Sierks ,&nbsp;Mark R. Opp ,&nbsp;Rachel K. Rowe","doi":"10.1016/j.nbscr.2025.100127","DOIUrl":"10.1016/j.nbscr.2025.100127","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) is frequently associated with acute and chronic disturbances in sleep architecture. However, the extent to which injury severity and biological sex influence post-traumatic sleep patterns remains underexplored in preclinical models. Here, we used a validated, noninvasive piezoelectric monitoring system to assess sleep in male and female mice following sham (n = 30), mild (n = 32), or moderate (n = 32) midline fluid percussion injury (mFPI). Physiological parameters were recorded non-invasively to determine sleep for 48 h post-injury. Hierarchical mixed-effects models were used to evaluate effects of injury severity and sex on sleep duration, architecture, and fragmentation. We found that sleep increased during the acute post-injury period regardless of TBI severity, but that sleep fragmentation was selectively elevated after moderate injury. Notably, female mice exhibited greater overall sleep disturbances compared to males, highlighting a sex-dependent vulnerability. These effects varied across the light-dark cycle. This study provides the first detailed characterization of sex- and severity-specific changes in sleep architecture and fragmentation following diffuse TBI using a high-throughput, noninvasive method. Importantly, it reveals that injury severity predicts the extent of sleep fragmentation highlighting a direct link between injury severity and disrupted sleep architecture. These findings contribute to the growing recognition of sleep fragmentation as a relevant biomarker in TBI and establish a framework for future mechanistic and interventional studies.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies","authors":"Charlotte Helfrich-Förster,&nbsp;Nils Reinhard","doi":"10.1016/j.nbscr.2025.100112","DOIUrl":"10.1016/j.nbscr.2025.100112","url":null,"abstract":"<div><div>Circadian master clocks in the brain consist of multiple neurons that are organized into populations with different morphology, physiology, and neuromessenger content and presumably different functions. In most animals, these master clocks are distributed bilaterally, located in close proximity to the visual system, and synchronized by the eyes with the light-dark cycles of the environment. In mammals and cockroaches, each of the two master clocks consists of a core region that receives information from the eyes and a shell region from which most of the output projections originate, whereas in flies and several other insects, the master clocks are distributed in lateral and dorsal brain regions. In all cases, morning and evening clock neurons seem to exist, and the communication between them and other populations of clock neurons, as well as the connection across the two brain hemispheres, is a prerequisite for normal rhythmic function. Phenomena such as rhythm splitting, and internal desynchronization are caused by the \"decoupling\" of the master clocks in the two brain hemispheres or by the decoupling of certain clock neurons within the master clock of one brain hemisphere. Since the master clocks in flies contain relatively few neurons that are well characterized at the individual level, the fly is particularly well suited to study the communication between individual clock neurons. Here, we review the organization of the bilateral master clocks in the fly brain, with a focus on synaptic and paracrine connections between the multiple clock neurons, in comparison with other insects and mammals.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury","authors":"Katherine R. Giordano ,&nbsp;Tabitha R.F. Green ,&nbsp;Mark R. Opp ,&nbsp;Rachel K. Rowe","doi":"10.1016/j.nbscr.2025.100115","DOIUrl":"10.1016/j.nbscr.2025.100115","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) causes persistent sleep disturbances, leading to long-term neurological consequences and reduced quality of life. We hypothesized that microglial depletion via PLX5622 (PLX), a colony-stimulating factor 1 receptor (CSFR1R) inhibitor, would exacerbate sleep disturbances and alter inflammatory profiles after TBI, and that microglial repopulation would ameliorate these effects. Male mice received PLX or control diets (21 days) followed by a midline fluid percussion injury (mFPI) or sham surgery. Physiological parameters were recorded non-invasively to determine sleep for 7 days post-injury. Subsequently, PLX was withdrawn to allow microglial repopulation, and sleep was assessed during the 7-day repopulation period. In a subset of mice, repeated blood draws were taken to quantify sleep regulatory cytokine concentrations (interleukin [IL]-6, IL-1β, tumor necrosis factor [TNF]-α). TBI significantly reduced sleep in mice on a control diet during the light period (3, 5, and 7 days post-injury), but not the dark period. In PLX-treated mice, TBI did not alter sleep in the light period, however, sleep in the dark period was increased at 3 days post-injury. During the microglial repopulation period, PLX-treated TBI mice slept significantly more in the dark period compared to PLX sham mice and sleep was similar in control TBI vs PLX TBI mice. Analyses revealed that elimination of microglia did not alter baseline cytokine levels. IL-6 was elevated in PLX TBI mice at 1 and 7 days post-injury compared to TBI mice on control diet, while IL-1β and TNF-α remained unchanged. This study highlights the critical role of microglia in modulating post-TBI sleep and inflammation. Findings suggest differential effects of TBI on sleep depending on microglial depletion or repopulation status, with IL-6 serving as a marker of the inflammatory response in microglia-depleted conditions.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of domestic white LED light on cognitive functions and amelioration of blue light blocking lens (BBL) on healthy adults","authors":"Mousumi Ghosh ,&nbsp;Hari Prakash Palaniswamy ,&nbsp;Nishitha. G ,&nbsp;Stelyna Joylin ,&nbsp;Shwetha. T.S ,&nbsp;M. Sanjana ,&nbsp;R.P. Radhika ,&nbsp;Nagarajan Theruveethi","doi":"10.1016/j.nbscr.2025.100119","DOIUrl":"10.1016/j.nbscr.2025.100119","url":null,"abstract":"<div><div>White light-emitting diodes <strong>(</strong>WLEDs) can affect cognition and working memory. Blue light-blocking lenses (BBL) may help alleviate this. We aim to study the relationship between WLED and the ameliorative effect of BBL. We included 15 healthy participants based on the PSQI and Mini-Cog™ screening. The eligible participants underwent a baseline recording of event-related potential (ERP) of P300 using electroencephalography (EEG) while performing a 2-back task, followed by exposure to WLED (600 lux) that was given (45° with 80 cm apart from the participant's eye plane) for 30 min. A similar protocol was maintained when BBL was worn with WLED exposure. The participants' mean PSQI and Mini-Cog™ scores (n = 15) were 3 and 5, respectively. The behavioral functioning of participants using a 2-back task revealed enhancement in working memory cognition by fastening the response time (ms) from base to post-WLED to post-WLED + BBL (p &lt; 0.001). Still, no significant difference (p &gt; 0.05) in accuracy (%) was observed. The learning effect in the control group using a 2-back task revealed no statistically significant difference (p &gt; 0.05) in both accuracy (%) and response time (ms). Additionally, no significant change (p &gt; 0.05) was found within the three light groups in latency (ms) and amplitude (μV) at the P300 region of ERP in the prefrontal cortex. The existing results found that domestic WLED exposure significantly leads to a faster response time in working memory performance in the prefrontal cortex, thus remaining alert. BBL is not protective in the nonvisual senses when exposed to WLED for 30 min.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions","authors":"Shirin Rezazadeh ,&nbsp;Saeed Rastgoo Salami ,&nbsp;Mehran Hosseini ,&nbsp;Henrik Oster ,&nbsp;Mohammad Reza Saebipour ,&nbsp;Mohammad Mehdi Hassanzadeh-Taheri ,&nbsp;Hamed Shoorei","doi":"10.1016/j.nbscr.2024.100109","DOIUrl":"10.1016/j.nbscr.2024.100109","url":null,"abstract":"<div><div>Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health. A total of 40 male Wistar rats were divided into five groups: a control group, a group with circadian rhythm disruption (CIR), a group with sleep deprivation during the light phase (SD-AM), a group with sleep deprivation during the dark phase (SD-PM), and a group with combined sleep deprivation and circadian rhythm disruption (SD-CIR). Sleep deprivation was induced using a specialized machine, depriving rats of sleep for 4 h daily, while circadian rhythm disruption was achieved through a 3.5-h light/dark cycle. After four weeks, kidney tissues and blood samples were collected for histological and biochemical analyses. The results showed that all experimental groups exhibited reduced water intake, with the CIR and SD-CIR groups also showing significantly lower food intake and reduced weight gain compared to controls. Oxidative stress markers revealed increased serum malondialdehyde (MDA) levels in the SD-PM and SD-CIR groups. Despite these metabolic and oxidative changes, histological examination of the kidneys revealed no significant alterations in renal structure or function across the groups. This study highlights the negative effects of chronic partial sleep deprivation and circadian rhythm disruption on feeding behavior, weight gain, and oxidative stress in rats. However, these interventions did not significantly alter renal structure or function. Further research is needed to explore the physiological mechanisms underlying these findings and the potential long-term effects of sleep disturbances on kidney health.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}