Neurobiology of Sleep and Circadian Rhythms最新文献

{"title":"Association of restless legs syndrome and obesity: A sub-population of the MASHAD cohort study","authors":"Azam Vafaei ,&nbsp;Fatemeh Khorashadizadeh ,&nbsp;Maryam Saberi-Karimian ,&nbsp;Sara Saffar Soflaei ,&nbsp;Mahnaz Amini ,&nbsp;Abolfazl Rashid ,&nbsp;Sara Yousefian ,&nbsp;Gordon A. Ferns ,&nbsp;Habibollah Esmaily ,&nbsp;Majid Ghayour-Mobarhan ,&nbsp;Reza Salaran ,&nbsp;Fatemeh Taherian","doi":"10.1016/j.nbscr.2025.100113","DOIUrl":"10.1016/j.nbscr.2025.100113","url":null,"abstract":"<div><h3>Introduction</h3><div>Restless Legs Syndrome (RLS), as a relatively unknown sleep disorder, often associated with obesity. The purpose of this study was to examine the relationship between RLS and different definitions of obesity within the Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study population.</div></div><div><h3>Methods</h3><div>A total of 1006 subjects, with an average age of 57 (51.75–63.00) years old, were randomly selected from the MASHAD cohort study phase II. This sample included 449 males and 557 females, who were contacted by phone to inquire about RLS. Anthropometric measurements such as weight, height, waist circumference (WC), and hip circumference (HC) were taken. Central obesity was defined as a WC &gt; 90 cm for men and &gt;85 cm for women, as well as a waist-to-hip ratio (WHR) greater than 0.90 for men and 0.85 for women. Statistical analyses were conducted using R version 4.3.2 for Windows, with a significance level set at a two-sided P-value&lt;0.05. Chi-squared and Fisher's exact tests were used to compare the categorical variables between two study groups. Logistic models applied to evaluate the association between RLS and BMI while adjusting for age effects.</div></div><div><h3>Results</h3><div>The study found a significant relationship between RLS and employment status (p-value = 0.04), marital status (p-value = 0.05), and BMI (p-value&lt;0.001). The results showed that in the total population, the OR of RLS in subjects having BMI&gt;30 kg/m² increased to 1.50(1.10–2.03) after adjusting for confounding factors (p-value&lt;0.01). A BMI&gt;30 kg/m² increased odds of RLS by 1.72 times in males (95%CI: 1.03–2.84, p-value&lt;0.05), however this association was diminished after adjustment (OR = 1.20, 95%CI: 0.64–2.17). There was no significant association between BMI and RLS in females. Moreover, there was no significant association between RLS and obesity based on WC and WHR in fully adjusted model respectively.</div></div><div><h3>Conclusion</h3><div>There was a significant association between BMI and RLS. A BMI&gt;30 kg/m² increased the odds of RLS by 1.50 times in the study population.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies","authors":"Charlotte Helfrich-Förster,&nbsp;Nils Reinhard","doi":"10.1016/j.nbscr.2025.100112","DOIUrl":"10.1016/j.nbscr.2025.100112","url":null,"abstract":"<div><div>Circadian master clocks in the brain consist of multiple neurons that are organized into populations with different morphology, physiology, and neuromessenger content and presumably different functions. In most animals, these master clocks are distributed bilaterally, located in close proximity to the visual system, and synchronized by the eyes with the light-dark cycles of the environment. In mammals and cockroaches, each of the two master clocks consists of a core region that receives information from the eyes and a shell region from which most of the output projections originate, whereas in flies and several other insects, the master clocks are distributed in lateral and dorsal brain regions. In all cases, morning and evening clock neurons seem to exist, and the communication between them and other populations of clock neurons, as well as the connection across the two brain hemispheres, is a prerequisite for normal rhythmic function. Phenomena such as rhythm splitting, and internal desynchronization are caused by the \"decoupling\" of the master clocks in the two brain hemispheres or by the decoupling of certain clock neurons within the master clock of one brain hemisphere. Since the master clocks in flies contain relatively few neurons that are well characterized at the individual level, the fly is particularly well suited to study the communication between individual clock neurons. Here, we review the organization of the bilateral master clocks in the fly brain, with a focus on synaptic and paracrine connections between the multiple clock neurons, in comparison with other insects and mammals.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related disturbances in rest-activity rhythms and integrity of the hippocampal network: An exploratory study","authors":"Aurore Jouvencel ,&nbsp;Bixente Dilharreguy ,&nbsp;Marion Baillet ,&nbsp;Karine Pérès ,&nbsp;Jean-François Dartigues ,&nbsp;Hélène Amieva ,&nbsp;Willy Mayo ,&nbsp;Gwenaëlle Catheline","doi":"10.1016/j.nbscr.2024.100111","DOIUrl":"10.1016/j.nbscr.2024.100111","url":null,"abstract":"<div><div>To better understand the relationship between the rest-activity rhythms and cognitive impairments during aging, we assessed the longitudinal changes in the rest-activity rhythms in an elderly population and their possible detrimental effect on the hippocampal network.</div><div>This was done longitudinally in a rural cohort with two actigraphic assessments and brain imaging examinations, seven years apart. A segmentation of the hippocampus and its related structures was used to assess volumes and functional connectivity in this network based on anatomical and resting state functional data. Regression models were carried out to investigate the potential association of the evolution of sleep and rest-activity rhythms parameters with the structural and functional integrity of the hippocampal network.</div><div>Our sample was composed of 33 subjects aged 75.2 ± 2.4 years old at the first time point with 40% of women. After seven years, the sleep of our participants did not change but their rest-activity rhythms did (p &lt; 0.05), with a decrease in relative amplitude (∂RA = −0.021) and stability (∂IS = −0.044) as well as an increase in fragmentation (∂IV = +0.072). The deterioration of rest-activity rhythms was correlated with a lower anterior hippocampal volume (p corrected &lt;0.05) while no correlation with functional connectivity was observed.</div><div>These findings suggest that a degradation of rest-activity rhythms in people over 70 years old could constitute a factor of hippocampal vulnerability. Preventive interventions should consider rest-activity rhythms in the oldest-old population.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond sleep: Rest and activity rhythm as a marker of preclinical and mild dementia in older adults with less education","authors":"Erika Satomi ,&nbsp;Daniel Apolinário ,&nbsp;Regina Miksian Magaldi ,&nbsp;Alexandre Leopold Busse ,&nbsp;Gisele Cristina Vieira Gomes ,&nbsp;Elyse Ribeiro ,&nbsp;Pedro Rodrigues Genta ,&nbsp;Ronaldo Delmonte Piovezan ,&nbsp;Dalva Poyares ,&nbsp;Wilson Jacob-Filho ,&nbsp;Claudia Kimie Suemoto","doi":"10.1016/j.nbscr.2024.100110","DOIUrl":"10.1016/j.nbscr.2024.100110","url":null,"abstract":"<div><h3>Background</h3><div>Although sleep duration and sleep-related breathing disorders were associated with dementia previously, few studies examined the association between circadian rhythm association and cognitive status.</div></div><div><h3>Objective</h3><div>We aimed to investigate the association of rest and activity rhythm with cognitive performance in older people with cognitive complaints and less education.</div></div><div><h3>Methods</h3><div>Activity rhythm was evaluated with wrist actigraphy in 109 community-dwelling older people with cognitive complaints without diagnosed dementia. Each participant completed a neuropsychological battery and was classified as having cognitive impairment (MCI), dementia, or normal cognition. We used adjusted multinomial logistic regression and linear regression models to compare sleep and circadian non-parametric measures with cognitive groups and cognitive z-scores, respectively.</div></div><div><h3>Results</h3><div>The mean age of the 109 participants was 79.3 ± 6.3 years old, 74% were women, 68% were white, and the mean education was 5.6 ± 5.2 years. Daytime activity intensity was associated with better language (β = 0.178; 95% CI = 0.022, 0.334; p = 0.03) and visuospatial performance (β = 0.158; 95%CI = 0.008, 0.308; p = 0.04). Also, less fragmented rhythm was associated with better visuospatial (β = 0.172; 95%CI = 0.025, 0.320; p = 0.02) and global cognitive scores (β = 0.134; 95%CI = 0.005, 0.263; p = 0.04). More interdaily stability was associated with a lower risk of MCI and dementia (RR = 0.54; 95%CI = 0.29–0.99; p = 0.04, and RR = 0.44; 95%CI = 0.21–0.94; p = 0.03, respectively). Moreover, more daytime activity (RR = 0.40; 95%CI = 0.18–0.89; p = 0.02) and less rhythm fragmentation (RR = 0.31; 95%CI = 0.14–0.73; p = 0.007) were associated with lower risk for dementia.</div></div><div><h3>Conclusion</h3><div>Daytime activity intensity and fragmented rhythm during the day and night may play an important role as markers for cognitive impairment in less educated populations. Future studies with larger samples should confirm these findings.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions","authors":"Shirin Rezazadeh ,&nbsp;Saeed Rastgoo Salami ,&nbsp;Mehran Hosseini ,&nbsp;Henrik Oster ,&nbsp;Mohammad Reza Saebipour ,&nbsp;Mohammad Mehdi Hassanzadeh-Taheri ,&nbsp;Hamed Shoorei","doi":"10.1016/j.nbscr.2024.100109","DOIUrl":"10.1016/j.nbscr.2024.100109","url":null,"abstract":"<div><div>Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health. A total of 40 male Wistar rats were divided into five groups: a control group, a group with circadian rhythm disruption (CIR), a group with sleep deprivation during the light phase (SD-AM), a group with sleep deprivation during the dark phase (SD-PM), and a group with combined sleep deprivation and circadian rhythm disruption (SD-CIR). Sleep deprivation was induced using a specialized machine, depriving rats of sleep for 4 h daily, while circadian rhythm disruption was achieved through a 3.5-h light/dark cycle. After four weeks, kidney tissues and blood samples were collected for histological and biochemical analyses. The results showed that all experimental groups exhibited reduced water intake, with the CIR and SD-CIR groups also showing significantly lower food intake and reduced weight gain compared to controls. Oxidative stress markers revealed increased serum malondialdehyde (MDA) levels in the SD-PM and SD-CIR groups. Despite these metabolic and oxidative changes, histological examination of the kidneys revealed no significant alterations in renal structure or function across the groups. This study highlights the negative effects of chronic partial sleep deprivation and circadian rhythm disruption on feeding behavior, weight gain, and oxidative stress in rats. However, these interventions did not significantly alter renal structure or function. Further research is needed to explore the physiological mechanisms underlying these findings and the potential long-term effects of sleep disturbances on kidney health.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One interesting and elusive two-coupled oscillator problem","authors":"Gisele A. Oda","doi":"10.1016/j.nbscr.2024.100108","DOIUrl":"10.1016/j.nbscr.2024.100108","url":null,"abstract":"<div><div>Chronobiology experiments often reveal intriguing non-linear phenomena, which require mathematical models and computer simulations for their interpretation. One example is shown here, where the two circadian oscillators located in the eyes of the mollusk <em>Bulla gouldiana</em> were isolated and measured <em>in vitro</em>. By maintaining one eye under control conditions and manipulating the period of the second eye, Page and Nalovic (1992) obtained a diversity of results, including synchronized and desynchronized eyes, associated to weak coupling and period differences. A subset of eye pairs, however, showed increasing phase angle followed by phase jumps. These occur and have been satisfactorily modeled in more complex systems where two zeitgebers play clear entraining roles. However, simulations of a simple model of free-running, two mutually coupled limit-cycle oscillators with unilateral change in oscillator period failed completely to reproduce these phase jumps. Here we explain how phase jumps arise in two-zeitgeber systems and then show the closest but unsatisfying, intermediate model that was fit to the <em>Bulla</em> system.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"18 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of sleep and circadian rhythms: Function and dysfunction","authors":"Miranda M. Lim,&nbsp;Lucia Peixoto,&nbsp;Matthew S. Kayser,&nbsp;Christopher S. Colwell","doi":"10.1016/j.nbscr.2024.100105","DOIUrl":"10.1016/j.nbscr.2024.100105","url":null,"abstract":"","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"17 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats","authors":"Ayano Shiba ,&nbsp;Paul de Goede ,&nbsp;Roberta Tandari ,&nbsp;Ewout Foppen ,&nbsp;Nikita L. Korpel ,&nbsp;Tom V. Coopmans ,&nbsp;Tom P. Hellings ,&nbsp;Merel W. Jansen ,&nbsp;Annelou Ruitenberg ,&nbsp;Wayne I.G.R. Ritsema ,&nbsp;Chun-Xia Yi ,&nbsp;Joram D. Mul ,&nbsp;Dirk Jan Stenvers ,&nbsp;Andries Kalsbeek","doi":"10.1016/j.nbscr.2024.100106","DOIUrl":"10.1016/j.nbscr.2024.100106","url":null,"abstract":"<div><div>Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect timing of physical activity remains relatively understudied. Here, we modeled the incorrect timing of physical activity in nightshift workers in male Wistar rats, by restricting running wheel access to the innate inactive (light) phase (LR). Controls included no wheel access (NR); access only during the innate active (dark) period (DR); or unrestricted (<em>ad libitum</em>) access (ALR). LR did not shift the phase of the muscle or liver clock, but dampened the muscle clock amplitude. As our previous study demonstrated that light-phase restricted feeding did shift the liver clock, but made the muscle clock arrhythmic, we next combined the time restriction of wheel and food access to either the light phase (LRLF) or dark phase (DRDF). LRLF produced a ∼12 h shift in the majority of clock gene rhythms in both skeletal muscle and liver. On the other hand, DRDF was most effective in reducing body weight and the accumulation of fat mass. Therefore, in order to shift the muscle clock in male Wistar rats, synergy between the timing of feeding and physical activity is necessary. These findings may contribute to further improve the design of lifestyle strategies that try to limit metabolic misalignment caused by circadian disruption.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"17 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245199442400004X/pdfft?md5=55f77d77b927aa3fd8aec6e4581f4bd4&pid=1-s2.0-S245199442400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in sleep quality among Iranian traditional and industrial drug users","authors":"Mohammad Khorrami Ph.D ,&nbsp;Fatemeh Khorrami Undergraduate student ,&nbsp;Kosar Haghani ,&nbsp;Farshid Fathy Karkaragh Ph.D. candidate ,&nbsp;Ayda Khodashenas M.A ,&nbsp;Sara Souri M.A","doi":"10.1016/j.nbscr.2024.100104","DOIUrl":"https://doi.org/10.1016/j.nbscr.2024.100104","url":null,"abstract":"","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"17 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451994424000026/pdfft?md5=4bce6433ca72310602dadf27fcc6a1ed&pid=1-s2.0-S2451994424000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood","authors":"Alexis N. Jameson ,&nbsp;Justin K. Siemann ,&nbsp;Carrie A. Grueter ,&nbsp;BradA. Grueter ,&nbsp;Douglas G. McMahon","doi":"10.1016/j.nbscr.2024.100103","DOIUrl":"https://doi.org/10.1016/j.nbscr.2024.100103","url":null,"abstract":"<div><p>Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"16 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451994424000014/pdfft?md5=7e9b52ffbf8421282f84bc3195a513c5&pid=1-s2.0-S2451994424000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}