Parasite Epidemiology and Control最新文献

{"title":"Economic burden of malaria on developing countries: A mini review","authors":"Kelechi Chinemerem Mezieobi ,&nbsp;Esther Ugo Alum ,&nbsp;Okechukwu Paul-Chima Ugwu ,&nbsp;Daniel Ejim Uti ,&nbsp;Benedict Nnachi Alum ,&nbsp;Simeon Ikechukwu Egba ,&nbsp;Clinton Michael Ewah","doi":"10.1016/j.parepi.2025.e00435","DOIUrl":"10.1016/j.parepi.2025.e00435","url":null,"abstract":"<div><div>Malaria remains a major public health challenge in developing nations, particularly in sub-Saharan Africa, with profound economic implications. This study examines the economic burden of malaria by analyzing its effects on economic growth, labor productivity, healthcare expenditure, and overall economic stability. A systematic literature review was conducted using databases such as PubMed, Google Scholar, JSTOR, Web of Science, MEDLINE, and EMBASE, with search terms including “Malaria,” “Economic Costs,” “GDP Effect,” “Labor Productivity,” “Health Care Expenditure Impact,” and “Economic Growth.” The search was restricted to studies published between 2000 and 2023, excluding those lacking quantitative data or precise economic evaluations. Findings indicate that malaria significantly hampers GDP growth, reduces investment, and negatively impacts the tourism sector and human capital development. The disease contributes to high absenteeism and presentism, particularly in the agricultural sector, exacerbating poverty and food insecurity. Both direct and indirect economic costs impose a substantial burden on healthcare systems, households, and public services, creating poverty cycles and increasing debt among affected populations. To mitigate these effects, the study underscores the need for strengthened healthcare systems, enhanced prophylactic interventions, sustained research and development, economic support programs, and global collaboration. Given the significant impact of malaria on the health and economic status of nations, tackling both its health and economic effects will fast tract the attainment of sustainable development especially in malaria-endemic countries.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00435"},"PeriodicalIF":2.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global geographical distribution of Toxoplasma gondii genotypes from dogs: A systematic review","authors":"Maryam Hataminejad ,&nbsp;Mahbobeh Montazeri ,&nbsp;Asal Tanzifi ,&nbsp;Tahereh Mikaeili Galeh","doi":"10.1016/j.parepi.2025.e00433","DOIUrl":"10.1016/j.parepi.2025.e00433","url":null,"abstract":"<div><div><em>Toxoplasma gondii</em> (<em>T. gondii</em>) is a ubiquitous protozoan parasite with a complex life cycle involving various intermediate hosts, including dogs. Dogs can act as intermediate hosts for <em>T. gondii</em>, allowing the parasite to undergo asexual reproduction within their tissues. This can lead to the formation of tissue cysts containing bradyzoites, which can be transmitted to other hosts. Therefore, the infectious strains of <em>T. gondii</em> in dogs could reflect the primary genotypes infecting the environment, humans, and animals. This comprehensive research aims to assess the genetic diversity of <em>T. gondii</em> isolates collected from dogs worldwide. A thorough search of four academic databases (PubMed, Scopus, ScienceDirect, and Web of Science) and Google Scholar was conducted for literature published from January 1990 to March 2024. In the present study, a total of 26 papers met the criteria for inclusion. The results revealed that atypical genotypes were the most prevalent, accounting for 78.2 % of the total isolates (151 out of 193). Clonal Types III, II, and I were less frequent, with prevalence rates of 9.8 % (19 out of 193), 7.8 % (15 out of 193), and 3.1 % (6 out of 193), respectively. Type I clonal isolates have been documented in regions including Asia, Europe, and North America. Type II isolates have been identified in Africa, Europe, Oceania, and North America. Furthermore, Type III isolates, along with atypical genotypes, have been reported across Africa, Asia, North America, and South America. According to an analysis of 159 ToxoDB genotypes found in dogs worldwide, ToxoDB #2 (Type III) was the most prevalent genotype (18/159), followed by ToxoDB #1 or #3 (Type II) (15/159), ToxoDB #9 (15/159), and ToxoDB #20 (15/159). Overall, our study revealed low genetic diversity of <em>T. gondii</em> in dogs from Europe, Oceania, and Africa, with circulating clonal strains. Conversely, despite the higher number of isolates in Asia, North America, and South America, non-clonal parasites with extensive genetic diversity were prevalent.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00433"},"PeriodicalIF":2.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implemented strategic trypanosomosis and vector control activities along the Birbir River Basin through the application of deltamethrin-based insecticides using stationary attractive devices (targets), ground spraying, and live bait techniques","authors":"Behablom Meharenet,&nbsp;Tekalegn Desta,&nbsp;Dessalew Shitu,&nbsp;Mintesnot Tsegaye","doi":"10.1016/j.parepi.2025.e00432","DOIUrl":"10.1016/j.parepi.2025.e00432","url":null,"abstract":"<div><div>Baseline and control intervention entomological and parasitological studies were conducted from September 2016 to February 2018 with the intended purpose of evaluating the effectiveness of implemented strategic trypanosomosis and vector control activities. The baseline and control intervention entomological studies compared and revealed a decline in the overall apparent fly density from 2.61 flies/trap/day during the baseline study to 1.68 flies/trap/day after the control intervention, representing a reduction of 64.37%. Additionally, the mean daily catch per trap showed a significant reduction from 5.23 ± 1.58 to 3.35 ± 1.58 (mean catch ± SD). The comparison of baseline and control study results showed a significant decline in the overall prevalence of bovine trypanosomosis, from 7.91% to 4.81% (likelihood ratio = 13.49, <em>P</em> ≤ 0.00), corresponding to a reduction of 60.81%. Furthermore, a better herd mean packed cell volume (PCV) was observed during the control intervention study (22.53 ± 4.48 and 25.68 ± 4.04, mean PCV ± SD) compared to the baseline (21.87 ± 4.57 and 25.41 ± 4.27, mean PCV ± SD) in parasite-infected cattle. Therefore, the results of the study clearly showed that the implemented vector control activity, specifically the application of deltamethrin insecticides on stationary attractive devices (targets), ground sprays, and live bait techniques, effectively suppressed both the vector population (Glossina flies) and parasite prevalence (trypanosomiasis) during the study period.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00432"},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocontrol potential of Arabidopsis thaliana against Biomphalaria glabrata, the intermediate host of Schistosoma mansoni, focusing on biological, physiological, histopathological, and genotoxic impacts","authors":"Najla Y. Beit Elmal ,&nbsp;Fathy A. Abdel Ghaffar ,&nbsp;Salwa A.H. Hamdi ,&nbsp;Amina M. Ibrahim ,&nbsp;Mona F. Fol ,&nbsp;Nesma A. Mostafa","doi":"10.1016/j.parepi.2025.e00428","DOIUrl":"10.1016/j.parepi.2025.e00428","url":null,"abstract":"<div><div>Controlling <em>Biomphalaria</em> species with plant products is crucial in the treatment of schistosomiasis since it is eco-friendly and generally less harmful to non-target organisms. The goal of this study was to determine the molluscicidal activity of an aqueous extract of <em>Arabidopsis thaliana</em> leaves against <em>Biomphalaria glabrata.</em> A preliminary phytochemical screening test revealed the presence of flavonoids, terpenoids, steroids, anthraquinones, alkaloids, saponins, tannins, and carbohydrates. Following exposure to sub-lethal concentrations (LC₁₀ 75.62 mg/L and LC₂₅ 90.52 mg/L) of aqueous extract of <em>A. thaliana</em>, a reduction in survival, reproductive, and fecundity rates of <em>B. glabrata</em> were detected, as well as a substantial decrease in GSH, CAT, and SOD, while increasing MDA and NO levels. In addition, there was an increase in liver and renal functions as well as lipid profiles, compared to the control group. Histopathological examination of the digestive gland of treated <em>B. glabrata</em> showed a shrinkage of the tubules and an increase in the inter-tubular spaces as well as degeneration in the oocytes and spermatocytes of the hermaphrodite glands with a loss of connective tissues between the acini. Also, the comet assay revealed a genotoxic effect of aqueous extract of <em>A. thaliana</em> on <em>B. glabrata,</em> with a significant increase in the tail moment, tail length, and DNA percentage reflecting DNA damage compared to the control group. Conclusively, <em>Arabidopsis thaliana</em> aqueous extract acts as a natural molluscicidal agent against <em>Biomphalaria glabrata</em>.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00428"},"PeriodicalIF":2.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular identification of Coranus spp. in a pregnant patient: A case of misidentified Chagas disease vector in Spain","authors":"Jorge Ligero-López ,&nbsp;María Dolores Bargues ,&nbsp;Patricio Artigas ,&nbsp;Giulia Colangeli ,&nbsp;Fabiola Peiró-Codina ,&nbsp;María Ducons-Márquez ,&nbsp;Beatriz López-Alonso ,&nbsp;Pilar Goñi ,&nbsp;Antonio Beltrán-Rosel","doi":"10.1016/j.parepi.2025.e00426","DOIUrl":"10.1016/j.parepi.2025.e00426","url":null,"abstract":"<div><div>Chagas disease is a significant public health concern in the Americas, transmitted primarily by vectors of the Triatominae subfamily. While Europe, particularly Spain, is free from endemic vectors, the potential for misidentification of non-hematophagous insects as Chagas vectors exists, leading to unnecessary alarm. We present the case of a 31-year-old pregnant Venezuelan woman residing in Spain, who sought medical attention after being bitten by an arthropod she identified as <em>Triatoma infestans</em>. The patient's awareness of Chagas disease in her country of origin heightened her concern about vertical transmission of <em>Trypanosoma cruzi</em> to her fetus. However, serological testing for <em>T. cruzi</em> antibodies was negative. The insect was initially misidentified as <em>T. infestans</em> but was later confirmed through molecular analysis to be <em>Coranus</em> spp., a non-hematophagous reduviid predator. The 18S rRNA gene sequence revealed a 99.37 % similarity to <em>Coranus</em> spp., ruling out any vectorial capacity for Chagas disease. This case underscores the importance of accurate arthropod identification, especially in non-endemic regions, to prevent misdiagnosis and unnecessary treatment. From a public health perspective, the introduction of a Chagas disease vector into Spain would represent a serious threat, necessitating prompt identification and containment measures. Our findings highlight the challenges posed by invasive species and the need for vigilance in regions where Chagas disease is not endemic. Proper identification of suspected vectors is crucial to ensure appropriate clinical and public health responses, preventing unwarranted anxiety and ensuring accurate disease surveillance.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00426"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entamoeba sp. in a city in the Amazon interior in Brazil: Microscopic parasitological, immunological, and molecular diagnosis","authors":"Claudijane Ramos dos Santos ,&nbsp;Maria Regina Reis Amendoeira ,&nbsp;Laís Verdan Dib ,&nbsp;Laís Lisboa Corrêa ,&nbsp;Alynne da Silva Barbosa","doi":"10.1016/j.parepi.2025.e00424","DOIUrl":"10.1016/j.parepi.2025.e00424","url":null,"abstract":"<div><div>Humans can become infected with different parasites, including intestinal protozoa that can cause diarrhea, dysentery, or even death. These parasites affect mainly individuals living in situations of low socioeconomic conditions, an economic and social context found in most cities in the Amazon interior. The main objective of this study was to evaluate the frequency of <em>Entamoeba</em> sp., with an emphasis on <em>E. histolytica</em>, in patients treated at the Municipal Laboratory of Oriximiná, a city located in the Amazon interior. In 2019, 294 fecal samples were obtained from people treated at the city's laboratory. All samples that showed <em>Entamoeba</em> cysts via microscopic parasitological techniques or that were positive by immunodiagnosis to <em>E. histolytica</em>/<em>E. dispar</em> complex were subjected to polymerase chain reaction (PCR) to identify positivity for <em>E. histolytica</em>, <em>E. dispar</em>, and <em>E. moshkovskii</em>. When the 81 fecal samples considered positive for <em>Entamoeba</em> were subjected to PCR, DNA amplification was observed in 37/81 (45.7 %) samples. <em>E. histolytica</em> was the most diagnosed species in 31/81 (38.3 %), and <em>E. dispar</em> was detected in 22/81 (27.2 %). All reactions performed for <em>E. moshkovskii</em> were negative. The mixed molecular diagnosis of both <em>E. histolytica</em> and <em>E. dispar</em> was confirmed in 16 (19.8 %) fecal samples. Analysis of risk factors revealed that diarrhea was significantly associated with infection by <em>Entamoeba</em> sp. and that the consumption of vegetables produced at home was associated with infection by the complex (<em>p</em> ≤ 0.05). Most of the PCR-positive samples were obtained from residents of neighborhoods from the outskirts of the city, which has the city's lowest socioeconomic indices. The results obtained in this study highlight the precariousness of basic sanitation in these cities, since the detected pathogens, including the pathogenic species <em>E. histolytica</em>, are transmitted mainly through contaminated water and food. Notably, this is the first study to confirm via molecular diagnosis the circulation of <em>E. histolytica</em> in cities in the Amazon interior of Brazil.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00424"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of seropositive cases of Chagas disease in pregnant women in a non-endemic risk area of the state of Mexico: The importance of screening prenatal","authors":"Saúl González-Guzmán ,&nbsp;José A. Crescencio-Trujillo ,&nbsp;Carla I. Arroyo-Anduiza ,&nbsp;María Guadalupe Córdova-Espinoza ,&nbsp;Roberto Alvarado-Velázquez ,&nbsp;Vladimir Paredes-Cervantes","doi":"10.1016/j.parepi.2025.e00427","DOIUrl":"10.1016/j.parepi.2025.e00427","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aimed to identify seropositive cases of <em>Trypanosoma cruzi</em> in pregnant women from the northeastern region of the State of Mexico and underscore the importance of screening for this disease in prenatal care.</div></div><div><h3>Methods</h3><div>We analyzed 879 serum samples from pregnant women in this non-endemic area for antibodies to <em>Trypanosoma cruzi</em>.</div></div><div><h3>Results</h3><div>We found a seroprevalence of 0.34 % to <em>Trypanosoma cruzi</em> in pregnant women aged 20 to 29.</div></div><div><h3>Conclusions</h3><div>The confirmation of anti-<em>Trypanosoma cruzi</em> antibodies in 3 pregnant women in this non-endemic area further highlights the need to incorporate the diagnosis of this disease as part of prenatal care.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00427"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of strongyloidiasis in immunocompromised patients in Mazandaran province of northern Iran: A comprehensive study utilizing simultaneous parasitological, serological, and molecular techniques","authors":"Reza Saberi ,&nbsp;Aliasghar Ghorbanzadeh ,&nbsp;Rabeeh Tabaripour ,&nbsp;Shahabeddin Sarvi ,&nbsp;Shirzad Gholami ,&nbsp;Seyed Abdollah Hosseini","doi":"10.1016/j.parepi.2025.e00425","DOIUrl":"10.1016/j.parepi.2025.e00425","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Strongyloides stercoralis</em> is a soil-transmitted helminth (STH) responsible for strongyloidiasis, a neglected tropical disease (NTD) that affects nearly 614 million people globally. This intestinal nematode poses significant health risks, particularly in immunocompromised individuals. The present study aimed to investigate the prevalence of <em>S. stercoralis</em> in high-risk populations in northern Iran, employing a combination of parasitological, serological, and molecular techniques.</div></div><div><h3>Methods</h3><div>Blood and fecal samples were collected from 92 patients in Mazandaran province, northern Iran, consisting of 52 patients with HIV+/AIDS and 40 cancer patients undergoing chemotherapy or corticosteroid treatment. Initially, all fecal samples were examined using the nutrient agar culture method for parasitological assessment. Following this, DNA extraction was performed on all samples for identify <em>S. stercoralis</em> (by COX1- Nested PCR). Additionally, the sera of the patients were analyzed using the enzyme-linked immunosorbent assay (ELISA) kit (NovaTec Immunodiagnostica GmbH, Dietzenbach, Germany).</div></div><div><h3>Results</h3><div>The stool samples from these patients were negative in agar plate cultures. Among the 92 patients in the study, stool microscopy for <em>Strongyloides</em> rhabditiform larvae was positive in three cases. Using nested PCR, four samples (4.34 %) tested positive for <em>S. stercoralis</em>. Serological investigations revealed that 4 out of 52 HIV-positive patients (7.69 %) and 15 out of 40 cancer patients (37.5 %) had a history of infection with <em>S. stercoralis</em>.</div></div><div><h3>Conclusions</h3><div>These results emphasis the importance of employing a multifaceted diagnostic approach, combining parasitological, serological, and molecular techniques, to accurately identify infections in at risk populations. Given the potential for severe complications associated with strongyloidiasis in immunocompromised individuals, regular screening and prompt treatment are essential to reduce health risks.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00425"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of Culicoides paraensis (Goeldi, 1905) (Diptera: Ceratoponidae) in Cuba: A new challenge for public health","authors":"Yanet Martínez Pérez ,&nbsp;Ariamys Companioni Ibáñez ,&nbsp;Zulema Menéndez Díaz ,&nbsp;Eric Camacho Acosta ,&nbsp;Mónica Sánchez González ,&nbsp;Nell Cox García ,&nbsp;Quenia del Rosario Casanova Drake ,&nbsp;Gladys Gutierrez-Bugallo","doi":"10.1016/j.parepi.2025.e00423","DOIUrl":"10.1016/j.parepi.2025.e00423","url":null,"abstract":"<div><div><em>Culicoides paraensis</em> (Goeldi) (Diptera: Ceratoponidae) is considered the primary vector of Oropouche virus (Orthobunyavirus, Peribunyaviridae) in the American Tropics. Here, we report the first record of <em>C. paraensis</em> in Cuba, during the first known outbreak of Oropouche fever outside its endemic range in the Amazon region. Using human landing catches, we collected 98 specimens of <em>C. paraensis</em> in three Cuban provinces (Santiago de Cuba, Cienfuegos, and Havana), where Oropouche fever had been documented in humans. This species was not captured using various traps deployed at the sampling sites (BG-Sentinel, New Jersey traps, and CDC light traps), which may explain why <em>C. paraensis</em> had not been previously reported in Cuba. In North America, <em>C. paraensis</em> develops in wet treeholes, while in tropical regions, it uses cacao husks and banana stumps as larval habitats. However, the specific larval development sites for this species in Cuba are unknown. The capture of adult female <em>C. paraensis</em> in areas of active Oropouche virus circulation suggests their involvement in virus transmission in Cuba.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00423"},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of malaria and Schistosoma mansoni coinfection in sub Saharan Africa: A systematic review and meta-analysis","authors":"Wagaw Abebe ,&nbsp;Birhanu Kassanew ,&nbsp;Tadesse Misganaw ,&nbsp;Agenagnew Ashagre ,&nbsp;Getinet Kumie ,&nbsp;Marye Nigatie ,&nbsp;Yalewayker Gashaw ,&nbsp;Ephrem Tamrat ,&nbsp;Dagmawi Woldesenbet ,&nbsp;Alembante Bazezew","doi":"10.1016/j.parepi.2025.e00422","DOIUrl":"10.1016/j.parepi.2025.e00422","url":null,"abstract":"<div><h3>Background</h3><div>Malaria and schistosomiasis are two parasite illnesses that share transmission sites in distinct tropical climates. Malaria-schistosomiasis coinfection is widespread in Africa. Also, malaria and <em>Schistosoma mansoni</em> coinfection cause exacerbation of health consequences and co-morbidities. However, there is limited pooled data on the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in sub-Saharan Africa.</div></div><div><h3>Objective</h3><div>This systemic review and meta-analysis aimed to assess the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in sub-Saharan Africa.</div></div><div><h3>Method</h3><div>Systematic search on PubMed, Scopus, Google Scholar, and Science Direct was used to identify relevant studies following reviews and meta-analysis guidelines. A total of eighteen relevant articles on the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection were identified for final systematic review and meta-analysis. Extracted data was analyzed using STATA software version 17.0. The absence or presence of publication bias was assessed using Egger's test. Heterogeneity across studies was checked by I² statistics; if the I² value was ≥50 %, significant heterogeneity was considered and subgroup analysis was done.</div></div><div><h3>Results</h3><div>A total of 18 studies were included for this systematic review and meta-analysis. From this meta-analysis, the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection was 17.39 % (95 % CI: 5.94–28.84). There was significant heterogeneity in prevalence of coinfection, with I² values greater than or equal to 99.97 % at <em>P</em> = 0.00. The subgroup analysis based on year of publication showed that the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in studies conducted 2014–2018 was 20.73 % (95 % CI: 0.66–40.80), while it was 14.68 % (95 % CI: 1.02–28.34) in studies conducted 2019–2024. On the other hand, subgroup analysis on diagnostic techniques showed significant differences in the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis showed that malaria and <em>Schistosoma mansoni</em> coinfection are prevalent in sub-Saharan Africa.This highlights the region's major challenges in controlling malaria and <em>Schistosoma mansoni</em> coinfections.To ensure the efficiency of coinfections control and treatment, regular monitoring, identification, and reduction of the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection must be maintained. Furthermore, cooperative efforts at local, countrywide, and global levels are necessary to address the multifaceted factors causal to malaria-<em>S.mansoni</em> coinfection.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00422"},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}