Pub Date : 2023-09-03DOI: 10.33091/amj.2023.140234.1142
Khalid Awad, Omar Bargas
34-year-old male presented to the Dermatology Clinic complaining of unsightly bilateral auricular growths (Panels A and B) obstructing the external auditory meatus and sparing the face. The lesions are characterized by multiple asymptomatic, firm, pink, and scaly papules. An otolaryngologist was then consulted to assess the extent of the lesion. This was found to involve the outer ear canal part, resulting in aural fullness with no discharge or tinnitus. No other otological findings were seen. A punch biopsy was done, and it revealed a superficial dermal tumor with prominent keratinized horn cysts (Black arrowhead) and fibrous stroma (Black arrow) (Panel C: H&E X 40), which correlates with a trichoepithelioma diagnosis. Trichoepithelioma is a rare and benign skin tumor, mostly found on the face. It is thought to arise from the hair follicle wall and is characterized by benign epithelial and mesenchymal proliferation. Aside from facial involvement, a few auricular cases were reported, some of which involved both auricles while others involved one auricle. Females are affected more than males and may be predisposed to psychological upset. It may be solitary, multiple, or desmoplastic.
34岁男性到皮肤科就诊，主诉双侧耳廓生长(A组和B组)妨碍外耳道并保留面部。病变的特点是多个无症状，坚定，粉红色和鳞状丘疹。然后咨询耳鼻喉科医生评估病变的程度。我们发现这涉及到外耳道部分，导致耳朵充盈，没有分泌物或耳鸣。未见其他耳科发现。穿刺活检显示浅表真皮肿瘤伴明显角化角囊肿(黑色箭头)和纤维间质(黑色箭头)(C图:H&E X 40)，与毛上皮瘤诊断相关。毛上皮瘤是一种罕见的良性皮肤肿瘤，多见于面部。它被认为起源于毛囊壁，以良性上皮和间充质增生为特征。除了面部受累外，还报道了一些耳部病例，其中一些涉及双耳，而另一些涉及单耳。女性比男性更容易受到影响，可能更容易产生心理困扰。可能是单发、多发或结缔组织增生。
{"title":"Bilateral auricular Trichoepitheliomas","authors":"Khalid Awad, Omar Bargas","doi":"10.33091/amj.2023.140234.1142","DOIUrl":"https://doi.org/10.33091/amj.2023.140234.1142","url":null,"abstract":"34-year-old male presented to the Dermatology Clinic complaining of unsightly bilateral auricular growths (Panels A and B) obstructing the external auditory meatus and sparing the face. The lesions are characterized by multiple asymptomatic, firm, pink, and scaly papules. An otolaryngologist was then consulted to assess the extent of the lesion. This was found to involve the outer ear canal part, resulting in aural fullness with no discharge or tinnitus. No other otological findings were seen. A punch biopsy was done, and it revealed a superficial dermal tumor with prominent keratinized horn cysts (Black arrowhead) and fibrous stroma (Black arrow) (Panel C: H&E X 40), which correlates with a trichoepithelioma diagnosis. Trichoepithelioma is a rare and benign skin tumor, mostly found on the face. It is thought to arise from the hair follicle wall and is characterized by benign epithelial and mesenchymal proliferation. Aside from facial involvement, a few auricular cases were reported, some of which involved both auricles while others involved one auricle. Females are affected more than males and may be predisposed to psychological upset. It may be solitary, multiple, or desmoplastic.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130407966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.33091/amj.2023.139181.1078
Mohammed Rasheed Mohammed, R. Abduljabbar, A. Raziq, Dildar Musa
.
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{"title":"Categorization of the Nottingham Prognostic Index in Breast Carcinoma: A Retrospective Study of 473 Female Patients","authors":"Mohammed Rasheed Mohammed, R. Abduljabbar, A. Raziq, Dildar Musa","doi":"10.33091/amj.2023.139181.1078","DOIUrl":"https://doi.org/10.33091/amj.2023.139181.1078","url":null,"abstract":".","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116119811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.33091/amj.2023.138711.1041
Wassan Nori, Zeena Raad Helmi, Alea Farhan Salman, Ban H. Hameed
Background: Red cell distribution width (RDW) is an inflammatory biomarker and a component of complete blood count that gains increased attention. Pre-eclampsia (PE) is a unique pregnancy syndrome for which inflammation was proposed for pathogenesis. Objectives: We aimed to examine RDW’s role in PE and explore confounders that limit its implication in practice. Materials and methods: A case-control study recruited 120 participants matched in body mass index (BMI) and gestational age into 3 subgroups; late-onset severe PE cases (30/120), late-onset non-severe PE cases (30/120), and healthy controls (60/120). Participants’ demographics (age, BMI, systolic and diastolic blood pressure (SBP, and DBP), hematological and biochemical parameters were evaluated. Results: RDW was significantly higher in PE cases (P-value < 0.01 ); In addition, RDW was positively correlated to SBP, DBP, and protein urea, r =0.5, r = 0.46, and r = 0.47 ; P-value < 0.0001, respectively. Liver enzymes, hemoglobin, and white blood cell count were all significantly linked to RDW (r = 0.27, P-value = 0.015), (r = 0.32, P-value = 0.005), (r = -0.27, P-value = 0.02) and (r = 0.39; P-value = 0.0004) respectively. Applying ROC Curve analysis showed that RDW cut-off value of > 14.4% discriminated PE cases from healthy controls (P-value < 0.001). At a cut-off value > 15.6% RDW distinguished severe from non-severe PE cases (P-value < 0.001). Conclusion: RDW was significantly correlated to PE predictors and severity markers independent of gestational age and BMI. The ROC curve showed that RDW distinguished PE from healthy controls in addition to non-severe from severe PE cases with high sensitivity and specificity. Being an inexpensive, reliable test with good predictive and prognostic value warrants further studies for RDW’s role in PE screening and follow-up.
{"title":"Role of Red Cell Distribution Width in Late-onset Preeclampsia: A Single-Center Experience","authors":"Wassan Nori, Zeena Raad Helmi, Alea Farhan Salman, Ban H. Hameed","doi":"10.33091/amj.2023.138711.1041","DOIUrl":"https://doi.org/10.33091/amj.2023.138711.1041","url":null,"abstract":"Background: Red cell distribution width (RDW) is an inflammatory biomarker and a component of complete blood count that gains increased attention. Pre-eclampsia (PE) is a unique pregnancy syndrome for which inflammation was proposed for pathogenesis. Objectives: We aimed to examine RDW’s role in PE and explore confounders that limit its implication in practice. Materials and methods: A case-control study recruited 120 participants matched in body mass index (BMI) and gestational age into 3 subgroups; late-onset severe PE cases (30/120), late-onset non-severe PE cases (30/120), and healthy controls (60/120). Participants’ demographics (age, BMI, systolic and diastolic blood pressure (SBP, and DBP), hematological and biochemical parameters were evaluated. Results: RDW was significantly higher in PE cases (P-value < 0.01 ); In addition, RDW was positively correlated to SBP, DBP, and protein urea, r =0.5, r = 0.46, and r = 0.47 ; P-value < 0.0001, respectively. Liver enzymes, hemoglobin, and white blood cell count were all significantly linked to RDW (r = 0.27, P-value = 0.015), (r = 0.32, P-value = 0.005), (r = -0.27, P-value = 0.02) and (r = 0.39; P-value = 0.0004) respectively. Applying ROC Curve analysis showed that RDW cut-off value of > 14.4% discriminated PE cases from healthy controls (P-value < 0.001). At a cut-off value > 15.6% RDW distinguished severe from non-severe PE cases (P-value < 0.001). Conclusion: RDW was significantly correlated to PE predictors and severity markers independent of gestational age and BMI. The ROC curve showed that RDW distinguished PE from healthy controls in addition to non-severe from severe PE cases with high sensitivity and specificity. Being an inexpensive, reliable test with good predictive and prognostic value warrants further studies for RDW’s role in PE screening and follow-up.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129813837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.33091/amj.2023.138651.1038
Omar Qahtan
Background: Wilson’s disease (WD) is a genetic disorder (autosomal recessive) that affects copper metabolism. A favorable prognosis for WD can be achieved with early diagnosis and treatment. It is also strongly advised to conduct a family screening. Objectives: To find the relationship between genotype and phenotype to facilitate the diagnosis of the disease as well as using modern methods in diagnosing WD. Materials and methods: This study included nine WD patients and fifteen healthy participants. Members of patients with WD and healthy members provided whole blood. Blood DNA was extracted, and Exon 14 was amplified using specific primers using polymerase chain reaction (PCR). The results of the PCR products were aligned to the published human genome database using the BLAST tool. Results: Three different variations have been recorded as a result of the experiment. All of the changes point to a deficiency in the ATP7B protein, which has been identified as a cause of WD. Conclusion: The ATP7B gene mutation spectrum in Iraqi patients has been enhanced as a result of our research, and this information could be used to develop gene therapy and clinical/prenatal diagnosis to prevent WD in Iraq.
{"title":"Sorting Intolerant from Tolerant and PolyPhen-2 Algorithms: A Variation in Exon 14 of ATP7B Gene among 4 West Iraqi Families with Wilson’s Disease","authors":"Omar Qahtan","doi":"10.33091/amj.2023.138651.1038","DOIUrl":"https://doi.org/10.33091/amj.2023.138651.1038","url":null,"abstract":"Background: Wilson’s disease (WD) is a genetic disorder (autosomal recessive) that affects copper metabolism. A favorable prognosis for WD can be achieved with early diagnosis and treatment. It is also strongly advised to conduct a family screening. Objectives: To find the relationship between genotype and phenotype to facilitate the diagnosis of the disease as well as using modern methods in diagnosing WD. Materials and methods: This study included nine WD patients and fifteen healthy participants. Members of patients with WD and healthy members provided whole blood. Blood DNA was extracted, and Exon 14 was amplified using specific primers using polymerase chain reaction (PCR). The results of the PCR products were aligned to the published human genome database using the BLAST tool. Results: Three different variations have been recorded as a result of the experiment. All of the changes point to a deficiency in the ATP7B protein, which has been identified as a cause of WD. Conclusion: The ATP7B gene mutation spectrum in Iraqi patients has been enhanced as a result of our research, and this information could be used to develop gene therapy and clinical/prenatal diagnosis to prevent WD in Iraq.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131142244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.33091/amj.2023.139728.1106
Idman Gushaendri, Faiza Shafia, N. Hairunisa, E. Yousif, Husnun Amalia
The unprecedented impact of the coronavirus disease-19 (COVID-19) pandemic on society and the global economy has highlighted the urgent need for an effective and safe vaccine. One of the very rare side effects of this vaccine is myocarditis, which was realized to be a terrible complication of the COVID-19 mRNA vaccine. A recent study showed an increase in 1824 events of myocarditis re-ported to VAERS, 383 (21.00%) reported after receiving a single dose of vaccine, then 956 (52.41%) after injection of the second dose. The most common complaint is chest pain that appears within 1 week after the injection. Young and male patients have a high incidence. The pathophysiology of post-mRNA vaccination myocarditis remains unclear, with one study hypothesizing it to be due to hypersensitivity myocarditis and another study suggesting another possible mechanism is molecular mimicry. The main aim of this literature review is to improve knowledge, prevention
{"title":"Myocarditis Related-COVID-19 mRNA Vaccination: A Narrative Review","authors":"Idman Gushaendri, Faiza Shafia, N. Hairunisa, E. Yousif, Husnun Amalia","doi":"10.33091/amj.2023.139728.1106","DOIUrl":"https://doi.org/10.33091/amj.2023.139728.1106","url":null,"abstract":"The unprecedented impact of the coronavirus disease-19 (COVID-19) pandemic on society and the global economy has highlighted the urgent need for an effective and safe vaccine. One of the very rare side effects of this vaccine is myocarditis, which was realized to be a terrible complication of the COVID-19 mRNA vaccine. A recent study showed an increase in 1824 events of myocarditis re-ported to VAERS, 383 (21.00%) reported after receiving a single dose of vaccine, then 956 (52.41%) after injection of the second dose. The most common complaint is chest pain that appears within 1 week after the injection. Young and male patients have a high incidence. The pathophysiology of post-mRNA vaccination myocarditis remains unclear, with one study hypothesizing it to be due to hypersensitivity myocarditis and another study suggesting another possible mechanism is molecular mimicry. The main aim of this literature review is to improve knowledge, prevention","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122077906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.33091/amj.2023.138829.1051
N. Ali, S. Rasool
Background: Obesity and insulin resistance elevate plasma leptin, while it lowers plasma levels of soluble leptin receptors (sOB-R). Objectives: To measure the levels of sOB-R in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) and compare it to healthy controls. The study also aimed to investigate the influence of metformin on the levels of sOB-R in patients with T2DM and MetS. Materials and methods: A cross-sectional study was conducted on 66 participants (33 patients and 33 controls). Patients were divided into two groups; Group I included 17 newly diagnosed T2DM patients, and Group II included 16 patients with MetS. Patients were studied before and 3 months after treatment with 850 mg metformin treatment. Group III included 33 non-obese healthy individuals as a control group. Measurements such as height, weight, waist circumference, hip circumference, blood pressure examination, and biochemical tests including fasting blood sugar, HbA1c, total cholesterol (Ch), triglyceride, high-density lipoprotein (HDL), insulin level, plasma sOB-R levels were performed. Ch/HDL ratio, non-HDL cholesterol, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Waist Hip Ratio (WHR), and Body Mass Index (BMI) were calculated. Results: No statistically significant difference was found among the groups regarding sOB-R levels initially, but after metformin treatment, T2DM patients showed a significantly higher level (10.19 ng/ml). There was a significant increase in the levels of sOB-R after metformin treatment, as it increased from 7.82 ng/ml to 10.19 ng/ml in T2DM, and from 6.92 ng/ml to 7.82 ng/ml in MetS patients. Conclusion: Metformin significantly increases the plasma levels of sOB-R in T2DM patients but only slightly increases these levels in MetS patients.
{"title":"Metformin Affects Plasma Levels of Soluble Leptin Receptors in Type 2 Diabetes Mellitus and Metabolic Syndrome Patients","authors":"N. Ali, S. Rasool","doi":"10.33091/amj.2023.138829.1051","DOIUrl":"https://doi.org/10.33091/amj.2023.138829.1051","url":null,"abstract":"Background: Obesity and insulin resistance elevate plasma leptin, while it lowers plasma levels of soluble leptin receptors (sOB-R). Objectives: To measure the levels of sOB-R in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) and compare it to healthy controls. The study also aimed to investigate the influence of metformin on the levels of sOB-R in patients with T2DM and MetS. Materials and methods: A cross-sectional study was conducted on 66 participants (33 patients and 33 controls). Patients were divided into two groups; Group I included 17 newly diagnosed T2DM patients, and Group II included 16 patients with MetS. Patients were studied before and 3 months after treatment with 850 mg metformin treatment. Group III included 33 non-obese healthy individuals as a control group. Measurements such as height, weight, waist circumference, hip circumference, blood pressure examination, and biochemical tests including fasting blood sugar, HbA1c, total cholesterol (Ch), triglyceride, high-density lipoprotein (HDL), insulin level, plasma sOB-R levels were performed. Ch/HDL ratio, non-HDL cholesterol, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Waist Hip Ratio (WHR), and Body Mass Index (BMI) were calculated. Results: No statistically significant difference was found among the groups regarding sOB-R levels initially, but after metformin treatment, T2DM patients showed a significantly higher level (10.19 ng/ml). There was a significant increase in the levels of sOB-R after metformin treatment, as it increased from 7.82 ng/ml to 10.19 ng/ml in T2DM, and from 6.92 ng/ml to 7.82 ng/ml in MetS patients. Conclusion: Metformin significantly increases the plasma levels of sOB-R in T2DM patients but only slightly increases these levels in MetS patients.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114202932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.33091/amj.2023.138915.1058
Alhussein Ali, A. Mohammed
Background: Adults who have periodontitis are more likely to lose teeth, which affects their quality of life and causes masticatory dysfunction. Most people agree that smoking tobacco makes them more likely to get oral mucosal and periodontal diseases and makes the oral microbiome less balanced. Melatonin is a naturally occurring hormone that is released in a variety of organs. Objectives: To examine the relationship between smoking and salivary melatonin levels in periodontitis patients vs healthy people, and to establish a relationship between melatonin levels and periodontal parameters. Materials and methods: The study was conducted at the College of Dentistry, University of Baghdad, Baghdad, Iraq. The study period was from February to May 2022. There were a total of 74 male subjects aged 35-55 years, and they were divided into four different groups; Group 1: a control group of non-smokers (n = 12), Group 2: a control group of smokers (n = 12), Group 3: a group of individuals with periodontitis (n = 25), Group 4: a group of individuals with both periodontitis and a record of smoking (n = 25). A whole, unstimulated sample of the participant’s saliva (5 ml) was taken, and this was followed by an evaluation of clinical periodontal variables (probing pocket depth and clinical attachment level). To measure melatonin concentrations, saliva samples were biochemically analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA). Results: Melatonin concentrations were shown to be lower in groups with periodontitis than in control groups, as well as lower in groups with smoking than in groups without smoking. It was found that there was a strong negative link between periodontal variables and the amount of melatonin in the saliva. Conclusion: According to this study, a reduced melatonin level was noticed in the salivary fluid of the smoker (healthy and periodontitis) groups in comparison with the non-smoker (healthy and periodontitis) groups. This suggests that active cigarette smoking had a retarding effect on the salivary levels of melatonin.
{"title":"Correlation of Salivary Melatonin Levels and Many Periodontal Parameters in Cigarette Smokers with Periodontitis","authors":"Alhussein Ali, A. Mohammed","doi":"10.33091/amj.2023.138915.1058","DOIUrl":"https://doi.org/10.33091/amj.2023.138915.1058","url":null,"abstract":"Background: Adults who have periodontitis are more likely to lose teeth, which affects their quality of life and causes masticatory dysfunction. Most people agree that smoking tobacco makes them more likely to get oral mucosal and periodontal diseases and makes the oral microbiome less balanced. Melatonin is a naturally occurring hormone that is released in a variety of organs. Objectives: To examine the relationship between smoking and salivary melatonin levels in periodontitis patients vs healthy people, and to establish a relationship between melatonin levels and periodontal parameters. Materials and methods: The study was conducted at the College of Dentistry, University of Baghdad, Baghdad, Iraq. The study period was from February to May 2022. There were a total of 74 male subjects aged 35-55 years, and they were divided into four different groups; Group 1: a control group of non-smokers (n = 12), Group 2: a control group of smokers (n = 12), Group 3: a group of individuals with periodontitis (n = 25), Group 4: a group of individuals with both periodontitis and a record of smoking (n = 25). A whole, unstimulated sample of the participant’s saliva (5 ml) was taken, and this was followed by an evaluation of clinical periodontal variables (probing pocket depth and clinical attachment level). To measure melatonin concentrations, saliva samples were biochemically analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA). Results: Melatonin concentrations were shown to be lower in groups with periodontitis than in control groups, as well as lower in groups with smoking than in groups without smoking. It was found that there was a strong negative link between periodontal variables and the amount of melatonin in the saliva. Conclusion: According to this study, a reduced melatonin level was noticed in the salivary fluid of the smoker (healthy and periodontitis) groups in comparison with the non-smoker (healthy and periodontitis) groups. This suggests that active cigarette smoking had a retarding effect on the salivary levels of melatonin.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126208758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.33091/amj.2023.138442.1021
Wassan Nori, N. Akram, Methaq Mueen Al-kaabi
Probiotic use to improve health is not new; but recently, it has attracted much attention concerning human health and diseases. The human gut is a delicate ecosystem where bacteria and host cells interact with each other. This is an important part of gut homeostasis and human development. Disruption of this sensitive ecosystem may have detrimental health repercussions linked to impaired gut microbiota (GM). GM were extensively examined as an underlying mechanism for disease development and progression. Additionally, it was used as a tailored method for preventing and treating disease. Because of the strong association between GM, health, and disease, there has been much interest in employing probiotics or living microorganisms, to regulate GM to prevent or cure specific diseases. Herein, probiotics’ role in enhancing women’s and pediatric well-being was addressed as a marker of disease and as therapeutic avenues; where we discussed probiotics indications, efficacy, safety profiles, and future prospects in clinical practice.
{"title":"Probiotics in Women and Pediatrics Health; A Narrative Review","authors":"Wassan Nori, N. Akram, Methaq Mueen Al-kaabi","doi":"10.33091/amj.2023.138442.1021","DOIUrl":"https://doi.org/10.33091/amj.2023.138442.1021","url":null,"abstract":"Probiotic use to improve health is not new; but recently, it has attracted much attention concerning human health and diseases. The human gut is a delicate ecosystem where bacteria and host cells interact with each other. This is an important part of gut homeostasis and human development. Disruption of this sensitive ecosystem may have detrimental health repercussions linked to impaired gut microbiota (GM). GM were extensively examined as an underlying mechanism for disease development and progression. Additionally, it was used as a tailored method for preventing and treating disease. Because of the strong association between GM, health, and disease, there has been much interest in employing probiotics or living microorganisms, to regulate GM to prevent or cure specific diseases. Herein, probiotics’ role in enhancing women’s and pediatric well-being was addressed as a marker of disease and as therapeutic avenues; where we discussed probiotics indications, efficacy, safety profiles, and future prospects in clinical practice.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127061723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.33091/amj.2023.138559.1029
S. Jabuk, E. Jaralla
.
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{"title":"In silico Predictions of Thr136Arg Missense Variant Shows a Remarkable Negative Impact on the Biological Activity of Enterotoxin Type A","authors":"S. Jabuk, E. Jaralla","doi":"10.33091/amj.2023.138559.1029","DOIUrl":"https://doi.org/10.33091/amj.2023.138559.1029","url":null,"abstract":".","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116778283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.33091/amj.2023.138783.1048
Thamir Kubaisi
A 14-year-old healthy boy presented to the Dermatology clinic with asymptomatic multiple lichenified firm papules with calluses formation, and skin dyspigmentation, involving the dorsum of both hands and the distal part of the forearms (Panel A and B). The condition was associated with fine scales and sluffing of the cuticles and the proximal nail fold of several fingers (Panel C). The condition started 2 years ago, as a result of history of a frequent compulsive habit of eating and chewing the involved parts of the body without ingestion. The patient became relaxed and enjoyed himself, especially after a stressful event. He demonstrated a skin thickening in this instance without a wound or an ulcer. The compulsion affected the cuticles of several fingers and did not associate with other known body-focused repetitive performances. A diagnosis of dermatodaxia was made. Dermatodaxia describes as an individual who eats his skin. It is a body-focused repetitive behavior and is classified in the group of obsessive-compulsive disorders. Previously named wolf-biter, because angry or trapped wolves will bite themselves. Other synonyms are chewing pads and dermatophagia. The patient was referred to a psychiatrist for further behavioral management. Meanwhile, he advised keeping the involved skin clean and enclosed with dressings like bandages until it heals.
{"title":"Dermatodaxia (wolf-Biter) of Both Hands","authors":"Thamir Kubaisi","doi":"10.33091/amj.2023.138783.1048","DOIUrl":"https://doi.org/10.33091/amj.2023.138783.1048","url":null,"abstract":"A 14-year-old healthy boy presented to the Dermatology clinic with asymptomatic multiple lichenified firm papules with calluses formation, and skin dyspigmentation, involving the dorsum of both hands and the distal part of the forearms (Panel A and B). The condition was associated with fine scales and sluffing of the cuticles and the proximal nail fold of several fingers (Panel C). The condition started 2 years ago, as a result of history of a frequent compulsive habit of eating and chewing the involved parts of the body without ingestion. The patient became relaxed and enjoyed himself, especially after a stressful event. He demonstrated a skin thickening in this instance without a wound or an ulcer. The compulsion affected the cuticles of several fingers and did not associate with other known body-focused repetitive performances. A diagnosis of dermatodaxia was made. Dermatodaxia describes as an individual who eats his skin. It is a body-focused repetitive behavior and is classified in the group of obsessive-compulsive disorders. Previously named wolf-biter, because angry or trapped wolves will bite themselves. Other synonyms are chewing pads and dermatophagia. The patient was referred to a psychiatrist for further behavioral management. Meanwhile, he advised keeping the involved skin clean and enclosed with dressings like bandages until it heals.","PeriodicalId":378741,"journal":{"name":"Al- Anbar Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127056731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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