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Association of Knee Osteoarthritis Treatment Types, Patient Characteristics, and Medical History With Subsequent Risk for Total Knee Arthroplasty: Data From a New Real-World Registry
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-26 DOI: 10.1016/j.artd.2025.101643
Andrew L. Concoff MD , Jennifer H. Lin PhD , Andrew I. Spitzer MD , Vinod Dasa MD , Adam Rivadeneyra MD , David Rogenmoser DO , Mitchell K. Ng MD , Mary DiGiorgi PhD, MPH , Stan Dysart MD , Joshua Urban MD , William M. Mihalko MD, PhD , Michael A. Mont MD

Background

This article examines predictors of subsequent total knee arthroplasty (TKA) within 6 months of nonoperative intervention based on (1) patient demographics; (2) knee osteoarthritis (OA) severity; and (3) various nonoperative treatments (cryoneurolysis with superficial or deep genicular nerve block, intra-articular [IA] hyaluronic acid injections, nonsteroidal inflammatory drug injections, IA-corticosteroids injections, or IA-triamcinolone extended-release [IA-TA-ER] injections).

Methods

Patients who had unilateral knee OA and received nonoperative intervention were identified in the Innovations in Genicular Outcomes Research registry between September 2021 and February 2024, identifying 505 patients. Baseline patient demographics were tabulated by knee OA severity as graded by Kellgren-Lawrence (KL) and nonoperative treatment, identifying patients who underwent TKA within 6 months. Predictors of TKA were identified using 20 potential demographic/clinical variables and calculating individual hazard ratios.

Results

Obesity and KL grade IV knees were significant predictors of TKA within 6 months of nonoperative treatment (P < .05). Age, sex, marital status, number of comorbidities, physical activity level, smoking status, insurance type, and baseline pain and functional scores were not associated with subsequent TKA. Overall, treatment type was also not linked to subsequent TKA, although pairwise comparison suggested use of IA-TA-ER was associated with a decreased conversion to subsequent TKA (P = .002).

Conclusions

Apart from obesity and KL grade IV knees, it remains challenging to identify which patients are at risk for conversion to subsequent TKA after nonoperative treatment. It appears IA hyaluronic acid and IA-TA-ER are most associated with decreased conversion to TKA within 6 months.
{"title":"Association of Knee Osteoarthritis Treatment Types, Patient Characteristics, and Medical History With Subsequent Risk for Total Knee Arthroplasty: Data From a New Real-World Registry","authors":"Andrew L. Concoff MD ,&nbsp;Jennifer H. Lin PhD ,&nbsp;Andrew I. Spitzer MD ,&nbsp;Vinod Dasa MD ,&nbsp;Adam Rivadeneyra MD ,&nbsp;David Rogenmoser DO ,&nbsp;Mitchell K. Ng MD ,&nbsp;Mary DiGiorgi PhD, MPH ,&nbsp;Stan Dysart MD ,&nbsp;Joshua Urban MD ,&nbsp;William M. Mihalko MD, PhD ,&nbsp;Michael A. Mont MD","doi":"10.1016/j.artd.2025.101643","DOIUrl":"10.1016/j.artd.2025.101643","url":null,"abstract":"<div><h3>Background</h3><div>This article examines predictors of subsequent total knee arthroplasty (TKA) within 6 months of nonoperative intervention based on (1) patient demographics; (2) knee osteoarthritis (OA) severity; and (3) various nonoperative treatments (cryoneurolysis with superficial or deep genicular nerve block, intra-articular [IA] hyaluronic acid injections, nonsteroidal inflammatory drug injections, IA-corticosteroids injections, or IA-triamcinolone extended-release [IA-TA-ER] injections).</div></div><div><h3>Methods</h3><div>Patients who had unilateral knee OA and received nonoperative intervention were identified in the Innovations in Genicular Outcomes Research registry between September 2021 and February 2024, identifying 505 patients. Baseline patient demographics were tabulated by knee OA severity as graded by Kellgren-Lawrence (KL) and nonoperative treatment, identifying patients who underwent TKA within 6 months. Predictors of TKA were identified using 20 potential demographic/clinical variables and calculating individual hazard ratios.</div></div><div><h3>Results</h3><div>Obesity and KL grade IV knees were significant predictors of TKA within 6 months of nonoperative treatment (<em>P</em> &lt; .05). Age, sex, marital status, number of comorbidities, physical activity level, smoking status, insurance type, and baseline pain and functional scores were not associated with subsequent TKA. Overall, treatment type was also not linked to subsequent TKA, although pairwise comparison suggested use of IA-TA-ER was associated with a decreased conversion to subsequent TKA (<em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>Apart from obesity and KL grade IV knees, it remains challenging to identify which patients are at risk for conversion to subsequent TKA after nonoperative treatment. It appears IA hyaluronic acid and IA-TA-ER are most associated with decreased conversion to TKA within 6 months.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101643"},"PeriodicalIF":1.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiotensin-Converting Enzyme Inhibition as a Potential Risk Factor for Periprosthetic Joint Infection Following Total Knee Arthroplasty
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-25 DOI: 10.1016/j.artd.2025.101641
Rishi Trikha MD , Nicolas Cevallos BS , Alan L. Zhang MD , Sanjiv M. Narayan MD, PhD , Christos Photopoulos MD , Alexandra Stavrakis MD , Nicholas M. Bernthal MD

Background

Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) portends significant morbidity. In-vivo studies demonstrating angiotensin-converting enzyme inhibitors (ACEis) may have an immunosuppressive effect. This study leveraged a large national registry to test if propensity-matched patients taking ACEis would have higher rates of PJI following TKA than patients taking angiotensin receptor blockers (ARBs).

Methods

A retrospective review of the Mariner PearlDiver database was performed. Patients were divided into those taking either an ACEi or an ARB for 1 year prior to primary TKA. Irrigation and debridement and/or removal of knee prostheses procedural codes were used to identify PJI. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed with significance defined as a P value < .05.

Results

After propensity score matching, 39,103 patients were included in each group. The ACEi group had a higher rate of PJI compared to the ARB group at 6 months (OR: 2.69; 95% CI: 1.43-5.09; P < .01) and 1 year (OR: 2.94; 95% CI: 1.67-5.19; P < .001). The ACEi group also had higher rates of deep vein thromboses (OR: 1.33; 95% CI: 1.23-1.44), pulmonary embolisms (OR: 1.99; 95% CI: 1.73-2.30), pneumonias (OR: 1.29; 95% CI: 1.15-1.45), hematomas (OR: 1.47; 95% CI: 1.20-1.81), and transfusion (OR: 1.87; 95% CI: 1.69-2.08) within 90 days postoperatively, all P values < .001.

Conclusions

Perioperative use of ACEi was associated with a substantially higher rate of PJI than use of ARBs. Further studies are warranted to elucidate if this represents immunosuppression or other mechanisms related to ACEi. Regardless, given the relative clinical interchangeability of ACEis and ARBs, ACEi treatment may represent an underappreciated, modifiable perioperative infectious risk factor.
{"title":"Angiotensin-Converting Enzyme Inhibition as a Potential Risk Factor for Periprosthetic Joint Infection Following Total Knee Arthroplasty","authors":"Rishi Trikha MD ,&nbsp;Nicolas Cevallos BS ,&nbsp;Alan L. Zhang MD ,&nbsp;Sanjiv M. Narayan MD, PhD ,&nbsp;Christos Photopoulos MD ,&nbsp;Alexandra Stavrakis MD ,&nbsp;Nicholas M. Bernthal MD","doi":"10.1016/j.artd.2025.101641","DOIUrl":"10.1016/j.artd.2025.101641","url":null,"abstract":"<div><h3>Background</h3><div>Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) portends significant morbidity. <em>In-vivo</em> studies demonstrating angiotensin-converting enzyme inhibitors (ACEis) may have an immunosuppressive effect. This study leveraged a large national registry to test if propensity-matched patients taking ACEis would have higher rates of PJI following TKA than patients taking angiotensin receptor blockers (ARBs).</div></div><div><h3>Methods</h3><div>A retrospective review of the Mariner PearlDiver database was performed. Patients were divided into those taking either an ACEi or an ARB for 1 year prior to primary TKA. Irrigation and debridement and/or removal of knee prostheses procedural codes were used to identify PJI. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed with significance defined as a <em>P</em> value &lt; .05.</div></div><div><h3>Results</h3><div>After propensity score matching, 39,103 patients were included in each group. The ACEi group had a higher rate of PJI compared to the ARB group at 6 months (OR: 2.69; 95% CI: 1.43-5.09; <em>P</em> &lt; .01) and 1 year (OR: 2.94; 95% CI: 1.67-5.19; <em>P</em> &lt; .001). The ACEi group also had higher rates of deep vein thromboses (OR: 1.33; 95% CI: 1.23-1.44), pulmonary embolisms (OR: 1.99; 95% CI: 1.73-2.30), pneumonias (OR: 1.29; 95% CI: 1.15-1.45), hematomas (OR: 1.47; 95% CI: 1.20-1.81), and transfusion (OR: 1.87; 95% CI: 1.69-2.08) within 90 days postoperatively, all <em>P</em> values &lt; .001.</div></div><div><h3>Conclusions</h3><div>Perioperative use of ACEi was associated with a substantially higher rate of PJI than use of ARBs. Further studies are warranted to elucidate if this represents immunosuppression or other mechanisms related to ACEi. Regardless, given the relative clinical interchangeability of ACEis and ARBs, ACEi treatment may represent an underappreciated, modifiable perioperative infectious risk factor.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101641"},"PeriodicalIF":1.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Limited Femorotomy as an Alternative to Extensive Trochanteric Osteotomy for Cementless Femoral Prosthesis Revision
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-25 DOI: 10.1016/j.artd.2025.101640
Thomas Aubert MD, Aurelien Hallé MD, Florian Kruse MD, Simon Marmor MD, Luc Lhotellier MD, Wilfrid Graff MD

Background

Cementless stem extraction during hip arthroplasty revision can be challenging and sometimes requires a femoral opening to be performed with limited posterior femorotomy techniques been described. The study objective was to assess the efficacy of these techniques and the perioperative and postoperative complication rates.

Methods

This study included 224 patients who underwent cementless stem revision. Stem extraction followed the same sequence: an initial endomedullary extraction attempt, followed by suspended posterior unicortical vertical diaphyseal femoral osteotomy. Metaphyseal extension of the osteotomy and lateral-distal cortical extension at the stem tip were performed if the procedure failed, followed by extended trochanteric osteotomy (ETO). The incidence rates of perioperative fracture, reimplanted stem type (standard or revision), postoperative subsidence, and fracture were analyzed.

Results

Femoral opening was required in 15.6% of patients; 75% underwent limited femorotomy (28 patients, 75% suspended, and 25% extended), and 25% (7 patients) underwent ETO. Endomedullary extraction was performed in 84.4% (189) of the patients. The perioperative fracture rates were 16.9%, 0%, and 14.3% in the endomedullary, limited femorotomy, and ETO groups, respectively (P = .032). The standard stem utilization rates were 94.9%, 82.1%, 58.6%, and 28.6% (P < .001) for the endomedullary, limited femorotomy, perioperative fracture, and ETO groups, respectively. Postoperatively, the subsidence rates were 7.5%, 0%, and 28.6% (P = .042), and the fracture rates were 4.3%, 3.6%, and 0% (P > .999) in the endomedullary, limited osteotomy, and ETO groups, respectively.

Conclusions

Limited femorotomy techniques are reliable methods for extracting cementless stems, when necessary, with a reduced risk of fracture. Postoperatively, these patients appear to have comparable stem subsidence and a low risk of fracture.
{"title":"Use of Limited Femorotomy as an Alternative to Extensive Trochanteric Osteotomy for Cementless Femoral Prosthesis Revision","authors":"Thomas Aubert MD,&nbsp;Aurelien Hallé MD,&nbsp;Florian Kruse MD,&nbsp;Simon Marmor MD,&nbsp;Luc Lhotellier MD,&nbsp;Wilfrid Graff MD","doi":"10.1016/j.artd.2025.101640","DOIUrl":"10.1016/j.artd.2025.101640","url":null,"abstract":"<div><h3>Background</h3><div>Cementless stem extraction during hip arthroplasty revision can be challenging and sometimes requires a femoral opening to be performed with limited posterior femorotomy techniques been described. The study objective was to assess the efficacy of these techniques and the perioperative and postoperative complication rates.</div></div><div><h3>Methods</h3><div>This study included 224 patients who underwent cementless stem revision. Stem extraction followed the same sequence: an initial endomedullary extraction attempt, followed by suspended posterior unicortical vertical diaphyseal femoral osteotomy. Metaphyseal extension of the osteotomy and lateral-distal cortical extension at the stem tip were performed if the procedure failed, followed by extended trochanteric osteotomy (ETO). The incidence rates of perioperative fracture, reimplanted stem type (standard or revision), postoperative subsidence, and fracture were analyzed.</div></div><div><h3>Results</h3><div>Femoral opening was required in 15.6% of patients; 75% underwent limited femorotomy (28 patients, 75% suspended, and 25% extended), and 25% (7 patients) underwent ETO. Endomedullary extraction was performed in 84.4% (189) of the patients. The perioperative fracture rates were 16.9%, 0%, and 14.3% in the endomedullary, limited femorotomy, and ETO groups, respectively (<em>P</em> = .032). The standard stem utilization rates were 94.9%, 82.1%, 58.6%, and 28.6% (<em>P</em> &lt; .001) for the endomedullary, limited femorotomy, perioperative fracture, and ETO groups, respectively. Postoperatively, the subsidence rates were 7.5%, 0%, and 28.6% (<em>P</em> = .042), and the fracture rates were 4.3%, 3.6%, and 0% (<em>P</em> &gt; .999) in the endomedullary, limited osteotomy, and ETO groups, respectively.</div></div><div><h3>Conclusions</h3><div>Limited femorotomy techniques are reliable methods for extracting cementless stems, when necessary, with a reduced risk of fracture. Postoperatively, these patients appear to have comparable stem subsidence and a low risk of fracture.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101640"},"PeriodicalIF":1.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revision Rates for Aseptic Loosening in the Obese Patient: A Comparison Between Stemmed, Uncemented, and Unstemmed Tibial Total Knee Arthroplasty Components
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-22 DOI: 10.1016/j.artd.2025.101621
Bernard H. van Duren BEng, MBChB, DPhil (Oxon), CEng FIMechE, FRCS Orth, Amy M. Firth BSc (Hons), BMBS, FRCS Orth, Reshid Berber FRCS Orth, PhD, Hosam E. Matar MSc (Res), FRCS Orth, Peter J. James BMedSci, BMBS (Hons), DipBiomech, FRCS Orth, Benjamin V. Bloch BSc (Hons), MBBS, FRCS Orth

Background

Total knee arthroplasty (TKA) is an effective treatment option for high body mass index (BMI) patients achieving similar outcomes to nonobese patients. However, increased rates of aseptic loosening in patients with a high BMI have been reported. Component fixation is a concern when performing TKA in the obese patient. To address this concern in cemented TKA, extended tibial stems have been used. Uncemented implants that take advantage of biologic osseointegration have also been advocated. This retrospective study examined the use of and revision rates of extended cemented tibial stems and uncemented implants compared with conventional cemented implants in our high BMI patient population.

Methods

We retrospectively reviewed a prospectively maintained database of 3239 primary Attune TKAs (Depuy, Warsaw, Indiana). All obese patients (BMI > 30 kg/m2) with > 30 months of follow-up were included in our analysis. Those who underwent cemented TKA using a tibial stem extension (Group 1) (n = 145) and those where cementless implants were used (Group 2) (n = 100) were compared to a control group (n = 1243) using a standard cemented implant. Primary outcome measures were all-cause revision, revision for aseptic loosening, and revision for tibial loosening. Kaplan-Meier survival analysis and Cox regression models were used to compare the primary outcomes between groups.

Results

In total, there were 1512 knees that met the inclusion criteria. The mean follow-up was 6.8, 5.1, and 5.3 years for cemented, stemmed, and cementless groups, respectively. There were 37 all-cause revisions identified. Seven were for aseptic loosening (2 tibial, 1 femoral, and 4 involving both components); all of these were in the standard cemented implant group. There were no revisions in the stemmed or cementless implant groups. Survival analysis did not show any significant differences between groups for either all-cause revision or for aseptic loosening.

Conclusions

This retrospective analysis showed that there were no revisions required for aseptic loosening when a cemented, stemmed, or uncemented implant was used in obese patients. These findings show that cementless and extended stem implants are a reasonable option in obese patients.

Level of evidence

Level III.
{"title":"Revision Rates for Aseptic Loosening in the Obese Patient: A Comparison Between Stemmed, Uncemented, and Unstemmed Tibial Total Knee Arthroplasty Components","authors":"Bernard H. van Duren BEng, MBChB, DPhil (Oxon), CEng FIMechE, FRCS Orth,&nbsp;Amy M. Firth BSc (Hons), BMBS, FRCS Orth,&nbsp;Reshid Berber FRCS Orth, PhD,&nbsp;Hosam E. Matar MSc (Res), FRCS Orth,&nbsp;Peter J. James BMedSci, BMBS (Hons), DipBiomech, FRCS Orth,&nbsp;Benjamin V. Bloch BSc (Hons), MBBS, FRCS Orth","doi":"10.1016/j.artd.2025.101621","DOIUrl":"10.1016/j.artd.2025.101621","url":null,"abstract":"<div><h3>Background</h3><div>Total knee arthroplasty (TKA) is an effective treatment option for high body mass index (BMI) patients achieving similar outcomes to nonobese patients. However, increased rates of aseptic loosening in patients with a high BMI have been reported. Component fixation is a concern when performing TKA in the obese patient. To address this concern in cemented TKA, extended tibial stems have been used. Uncemented implants that take advantage of biologic osseointegration have also been advocated. This retrospective study examined the use of and revision rates of extended cemented tibial stems and uncemented implants compared with conventional cemented implants in our high BMI patient population.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed a prospectively maintained database of 3239 primary Attune TKAs (Depuy, Warsaw, Indiana). All obese patients (BMI &gt; 30 kg/m<sup>2</sup>) with &gt; 30 months of follow-up were included in our analysis. Those who underwent cemented TKA using a tibial stem extension (Group 1) (n = 145) and those where cementless implants were used (Group 2) (n = 100) were compared to a control group (n = 1243) using a standard cemented implant. Primary outcome measures were all-cause revision, revision for aseptic loosening, and revision for tibial loosening. Kaplan-Meier survival analysis and Cox regression models were used to compare the primary outcomes between groups.</div></div><div><h3>Results</h3><div>In total, there were 1512 knees that met the inclusion criteria. The mean follow-up was 6.8, 5.1, and 5.3 years for cemented, stemmed, and cementless groups, respectively. There were 37 all-cause revisions identified. Seven were for aseptic loosening (2 tibial, 1 femoral, and 4 involving both components); all of these were in the standard cemented implant group. There were no revisions in the stemmed or cementless implant groups. Survival analysis did not show any significant differences between groups for either all-cause revision or for aseptic loosening.</div></div><div><h3>Conclusions</h3><div>This retrospective analysis showed that there were no revisions required for aseptic loosening when a cemented, stemmed, or uncemented implant was used in obese patients. These findings show that cementless and extended stem implants are a reasonable option in obese patients.</div></div><div><h3>Level of evidence</h3><div>Level III.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101621"},"PeriodicalIF":1.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real Component Spacers for Two-Stage Exchange Demonstrate Low Bacterial Colonization
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-20 DOI: 10.1016/j.artd.2025.101633
Logan E. Finger MD, Alan E. Wilson MD, Brandon K. Couch MD, Alexander P. Hoffman MD, Confidence Njoku-Austin BS, Brian A. Klatt MD, Michael J. O’Malley MD, Johannes F. Plate MD, PhD

Background

Patients undergoing two-stage exchange arthroplasty for chronic periprosthetic joint infection (PJI) with real component spacers (RC) benefit from improved function. While RCs have similar reinfection rates compared to other spacer types, concerns exist regarding the potential for bacterial colonization and biofilm formation on the RC metal components.

Methods

Patients who completed two-stage exchange arthroplasty for treatment of Musculoskeletal Infection Society-defined hip or knee PJI were included and explanted spacer components were sent for sonication fluid culture (SFC). Medical records were reviewed for demographics, laboratory values, culture results, and clinical outcome data including 90-day reoperations and all-cause revisions.

Results

A total of 112 patients (57 hips and 64 knees) were included. Sixty (49.6%) patients received an articulating cement spacer (AC), 35 (28.9%) received an RC, and 26 (21.5%) received a static spacer (SS). No positive SFCs were identified with RC compared to 18.3% with AC and 11.5% with SS (P = .01). The number of positive tissue cultures was similar (RC 8.6%, AC 1.7%, SS 3.8%; P = .18). No patients who received an RC required repeat debridement within 90 days, while 11.8% with AC and 4.5% with SS required repeat debridement (P = .14). The difference in the rate of all-cause revision and revision due to recurrent infection among the 3 groups was found to be similar (P = .43 and P = .50, respectively).

Conclusions

RC showed fewer SFCs when compared to AC and SS, though there was no significant difference in positive tissue cultures, reoperation within 90 days, all-cause revision, or revision due to recurrent infection among the groups.
{"title":"Real Component Spacers for Two-Stage Exchange Demonstrate Low Bacterial Colonization","authors":"Logan E. Finger MD,&nbsp;Alan E. Wilson MD,&nbsp;Brandon K. Couch MD,&nbsp;Alexander P. Hoffman MD,&nbsp;Confidence Njoku-Austin BS,&nbsp;Brian A. Klatt MD,&nbsp;Michael J. O’Malley MD,&nbsp;Johannes F. Plate MD, PhD","doi":"10.1016/j.artd.2025.101633","DOIUrl":"10.1016/j.artd.2025.101633","url":null,"abstract":"<div><h3>Background</h3><div>Patients undergoing two-stage exchange arthroplasty for chronic periprosthetic joint infection (PJI) with real component spacers (RC) benefit from improved function. While RCs have similar reinfection rates compared to other spacer types, concerns exist regarding the potential for bacterial colonization and biofilm formation on the RC metal components.</div></div><div><h3>Methods</h3><div>Patients who completed two-stage exchange arthroplasty for treatment of Musculoskeletal Infection Society-defined hip or knee PJI were included and explanted spacer components were sent for sonication fluid culture (SFC). Medical records were reviewed for demographics, laboratory values, culture results, and clinical outcome data including 90-day reoperations and all-cause revisions.</div></div><div><h3>Results</h3><div>A total of 112 patients (57 hips and 64 knees) were included. Sixty (49.6%) patients received an articulating cement spacer (AC), 35 (28.9%) received an RC, and 26 (21.5%) received a static spacer (SS). No positive SFCs were identified with RC compared to 18.3% with AC and 11.5% with SS (<em>P</em> = .01). The number of positive tissue cultures was similar (RC 8.6%, AC 1.7%, SS 3.8%; <em>P</em> = .18). No patients who received an RC required repeat debridement within 90 days, while 11.8% with AC and 4.5% with SS required repeat debridement (<em>P</em> = .14). The difference in the rate of all-cause revision and revision due to recurrent infection among the 3 groups was found to be similar (<em>P</em> = .43 and <em>P</em> = .50, respectively).</div></div><div><h3>Conclusions</h3><div>RC showed fewer SFCs when compared to AC and SS, though there was no significant difference in positive tissue cultures, reoperation within 90 days, all-cause revision, or revision due to recurrent infection among the groups.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101633"},"PeriodicalIF":1.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential Knee and Hip Arthroplasty in a Patient With Pfeifer-Weber-Christian Disease
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-17 DOI: 10.1016/j.artd.2025.101637
Edgar Barros Prieto MD , Eduardo Noboa Freile MD , Carlos Peñaherrera Carillo MD , Francisco Endara Urresta MD , Alejandro Barros Castro MD , Paul Vaca Perez MD
Pfeifer-Weber-Christian Disease (PWCD) is a rare chronic inflammatory condition characterized by recurrent painful subcutaneous nodules and systemic manifestations. Long-term corticosteroid therapy, essential for managing PWCD, predisposes patients to complications such as osteoarthritis and avascular necrosis, often necessitating joint replacement surgeries. This report discusses a 38-year-old woman with a 15-year history of PWCD who underwent sequential knee and hip arthroplasty due to severe joint degeneration. The patient presented with debilitating pain, significant functional impairment, and advanced degenerative changes in the left knee and right hip. A multidisciplinary team provided comprehensive perioperative care to address the complexities of chronic inflammation, immunosuppression, and poor bone quality. This case highlights the feasibility of joint replacement in PWCD patients when a multidisciplinary approach and meticulous planning are applied. It underscores the importance of individualized surgical strategies and extended follow-up to optimize outcomes in complex cases.
{"title":"Sequential Knee and Hip Arthroplasty in a Patient With Pfeifer-Weber-Christian Disease","authors":"Edgar Barros Prieto MD ,&nbsp;Eduardo Noboa Freile MD ,&nbsp;Carlos Peñaherrera Carillo MD ,&nbsp;Francisco Endara Urresta MD ,&nbsp;Alejandro Barros Castro MD ,&nbsp;Paul Vaca Perez MD","doi":"10.1016/j.artd.2025.101637","DOIUrl":"10.1016/j.artd.2025.101637","url":null,"abstract":"<div><div>Pfeifer-Weber-Christian Disease (PWCD) is a rare chronic inflammatory condition characterized by recurrent painful subcutaneous nodules and systemic manifestations. Long-term corticosteroid therapy, essential for managing PWCD, predisposes patients to complications such as osteoarthritis and avascular necrosis, often necessitating joint replacement surgeries. This report discusses a 38-year-old woman with a 15-year history of PWCD who underwent sequential knee and hip arthroplasty due to severe joint degeneration. The patient presented with debilitating pain, significant functional impairment, and advanced degenerative changes in the left knee and right hip. A multidisciplinary team provided comprehensive perioperative care to address the complexities of chronic inflammation, immunosuppression, and poor bone quality. This case highlights the feasibility of joint replacement in PWCD patients when a multidisciplinary approach and meticulous planning are applied. It underscores the importance of individualized surgical strategies and extended follow-up to optimize outcomes in complex cases.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101637"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic-assisted Conversion of Arthrodesis to Primary Total Knee Arthroplasty 机器人辅助将关节置换术转化为初级全膝关节置换术
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-17 DOI: 10.1016/j.artd.2025.101628
Ricarda Stauss MD, Peter Savov MD, Hendrik Pott MD, Max Ettinger MD
Conversion of arthrodesis to total knee arthroplasty (TKA) is technically demanding surgical procedure. In the literature, most cases are treated with stemmed semi-constrained or hinged prostheses. We present a case of a robotic-assisted conversion of arthrodesis to primary TKA (rTKA) in a 35-year-old patient using a non-constrained posterior stabilized implant. At follow-up, the patient reported outcomes improved remarkably with the highest increase for function and activities of daily living and a substantial improvement of health-related quality of life. This article is the first report of robotic-assisted conversion of arthrodesis to TKA using a non-constrained implant, thus it may serve as a proof of concept for the use of robotics for desarthrodesis. Future studies are warranted to investigate the long-term outcomes in a larger patient cohort.
{"title":"Robotic-assisted Conversion of Arthrodesis to Primary Total Knee Arthroplasty","authors":"Ricarda Stauss MD,&nbsp;Peter Savov MD,&nbsp;Hendrik Pott MD,&nbsp;Max Ettinger MD","doi":"10.1016/j.artd.2025.101628","DOIUrl":"10.1016/j.artd.2025.101628","url":null,"abstract":"<div><div>Conversion of arthrodesis to total knee arthroplasty (TKA) is technically demanding surgical procedure. In the literature, most cases are treated with stemmed semi-constrained or hinged prostheses. We present a case of a robotic-assisted conversion of arthrodesis to primary TKA (rTKA) in a 35-year-old patient using a non-constrained posterior stabilized implant. At follow-up, the patient reported outcomes improved remarkably with the highest increase for function and activities of daily living and a substantial improvement of health-related quality of life. This article is the first report of robotic-assisted conversion of arthrodesis to TKA using a non-constrained implant, thus it may serve as a proof of concept for the use of robotics for desarthrodesis. Future studies are warranted to investigate the long-term outcomes in a larger patient cohort.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101628"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Hip Pain Through Social Media: An Initial Overview of an International Web-Based Survey
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-15 DOI: 10.1016/j.artd.2025.101625
John M. Gaddis BS , Erika Shults MS , Bretton Laboret BS , Ryan Bialaszewski BS , Katerina Wells MD, MPH , Charles South PhD , Joel E. Wells MD, MPH

Background

We aimed to understand the adult experience of hip pain through a web-based REDCap platform via social media. The purpose of this study was to assess the possibility of collecting patient-reported data through social media in people with hip pain while outlining the contents of the survey and analyzing the demographics of the sample population.

Methods

The survey link was active from October 1, 2023, to May 1, 2024, and available on social media platforms. Respondents provided consent prior to survey participation. Responses were anonymous, and only unique, fully complete surveys were analyzed. The comprehensive hip survey included demographic and overall health reporting, as well as hip-specific diagnoses, hip-specific functional measures, and mental health outcomes.

Results

Six hundred twenty-seven surveys were initiated, with 509 surveys completed. Twenty-six countries were represented with most responses originating from the United States (72.1%, n = 367), United Kingdom (10%, n = 51), Canada (5.5%, n = 28), and Australia (4.1%, n = 21). Ninety-three percent of respondents were women, with a mean age of 39 (range: 18-77). Top diagnoses reported were hip dysplasia (60.9%, n = 310), femoroacetabular impingement syndrome (45.2%, n = 230), Perthes disease (6.4%, n = 33), and osteoarthritis (6.3%, n = 32). Seventy-one percent (n = 366) reported previous hip surgery, with hip arthroscopy (60.7%, n = 222), periacetabular osteotomy (50.3%, n = 184), and total hip arthroplasty (24.3%, n = 89) being the most reported procedures.

Conclusions

This study demonstrates the feasibility of utilizing social media for a comprehensive web-based survey to gather patient-reported outcomes from individuals with various sources of hip pain internationally.
{"title":"Understanding Hip Pain Through Social Media: An Initial Overview of an International Web-Based Survey","authors":"John M. Gaddis BS ,&nbsp;Erika Shults MS ,&nbsp;Bretton Laboret BS ,&nbsp;Ryan Bialaszewski BS ,&nbsp;Katerina Wells MD, MPH ,&nbsp;Charles South PhD ,&nbsp;Joel E. Wells MD, MPH","doi":"10.1016/j.artd.2025.101625","DOIUrl":"10.1016/j.artd.2025.101625","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to understand the adult experience of hip pain through a web-based REDCap platform via social media. The purpose of this study was to assess the possibility of collecting patient-reported data through social media in people with hip pain while outlining the contents of the survey and analyzing the demographics of the sample population.</div></div><div><h3>Methods</h3><div>The survey link was active from October 1, 2023, to May 1, 2024, and available on social media platforms. Respondents provided consent prior to survey participation. Responses were anonymous, and only unique, fully complete surveys were analyzed. The comprehensive hip survey included demographic and overall health reporting, as well as hip-specific diagnoses, hip-specific functional measures, and mental health outcomes.</div></div><div><h3>Results</h3><div>Six hundred twenty-seven surveys were initiated, with 509 surveys completed. Twenty-six countries were represented with most responses originating from the United States (72.1%, n = 367), United Kingdom (10%, n = 51), Canada (5.5%, n = 28), and Australia (4.1%, n = 21). Ninety-three percent of respondents were women, with a mean age of 39 (range: 18-77). Top diagnoses reported were hip dysplasia (60.9%, n = 310), femoroacetabular impingement syndrome (45.2%, n = 230), Perthes disease (6.4%, n = 33), and osteoarthritis (6.3%, n = 32). Seventy-one percent (n = 366) reported previous hip surgery, with hip arthroscopy (60.7%, n = 222), periacetabular osteotomy (50.3%, n = 184), and total hip arthroplasty (24.3%, n = 89) being the most reported procedures.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of utilizing social media for a comprehensive web-based survey to gather patient-reported outcomes from individuals with various sources of hip pain internationally.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101625"},"PeriodicalIF":1.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to ‘A Handheld, Portable Image-Based System May Outperform Computer Navigation or Robotic Platforms in Providing Accurate Acetabular Component Positioning’ [Arthroplasty Today, Volume 30, December 2024, 101511]
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-15 DOI: 10.1016/j.artd.2025.101636
Eric M. Slotkin DO , Francesca Coxe MD , Tristan Jones BaSC, MPT, MBA , Thomas Morton PA-C , Stefan Kreuzer MD , Alejandro Della-Valle MD
{"title":"Corrigendum to ‘A Handheld, Portable Image-Based System May Outperform Computer Navigation or Robotic Platforms in Providing Accurate Acetabular Component Positioning’ [Arthroplasty Today, Volume 30, December 2024, 101511]","authors":"Eric M. Slotkin DO ,&nbsp;Francesca Coxe MD ,&nbsp;Tristan Jones BaSC, MPT, MBA ,&nbsp;Thomas Morton PA-C ,&nbsp;Stefan Kreuzer MD ,&nbsp;Alejandro Della-Valle MD","doi":"10.1016/j.artd.2025.101636","DOIUrl":"10.1016/j.artd.2025.101636","url":null,"abstract":"","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101636"},"PeriodicalIF":1.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "Comment on: A Contemporary Analysis of Discharge Disposition Following Total Joint Arthroplasty"
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-02-15 DOI: 10.1016/j.artd.2025.101634
Swaroopa Vaidya MS, Gregory Panza PhD, Jake Laverdiere BS, Dianne Vye MSN, RN, ONC, Jenna Bernstein MD
{"title":"Reply to \"Comment on: A Contemporary Analysis of Discharge Disposition Following Total Joint Arthroplasty\"","authors":"Swaroopa Vaidya MS,&nbsp;Gregory Panza PhD,&nbsp;Jake Laverdiere BS,&nbsp;Dianne Vye MSN, RN, ONC,&nbsp;Jenna Bernstein MD","doi":"10.1016/j.artd.2025.101634","DOIUrl":"10.1016/j.artd.2025.101634","url":null,"abstract":"","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"32 ","pages":"Article 101634"},"PeriodicalIF":1.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Arthroplasty Today
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