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Effect of Anatomic Joint-Line Obliquity Prostheses on Coronal Plane Alignment of the Knee Alignment in a Chinese Population 解剖关节线倾斜假体对中国人群膝关节对齐冠状面对齐的影响
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-02 DOI: 10.1016/j.artd.2025.101888
Poon Jerome Chi Wang MBBS, HKU, Qunn-jid Lee MB-ChB, CUHK, Kenneth Wing-kin Law MB-ChB, CUHK, Daniel Wai-yip Wong MBBS, HKU, Cho Pong Lo MB-ChB, CUHK

Background

The Coronal Plane Alignment of the Knee (CPAK) classification describes knee phenotypes based on limb alignment and joint-line obliquity (JLO). This study evaluates CPAK distribution in the Hong Kong population and assesses how prosthesis design affects CPAK reproducibility and clinical outcomes.

Methods

This retrospective study included patients who underwent navigated total knee arthroplasty (TKA) with adjusted mechanical alignment in a single institution in 2021. First, we analyzed the epidemiology of CPAK phenotypes in our population. Second, patients were divided into 2 propensity score-matched groups based on implant design: Journey II BCS TKA (JLO prothesis) vs Persona PS TKA (joint line neutral prothesis). Radiological outcomes (mechanical hip–knee–ankle angle, lateral distal femoral angle, medial proximal tibial angle) and clinical outcomes (range of motion, Knee Society Knee Score, Western Ontario and McMaster Universities Osteoarthritis Index score, Forgotten Joint Score) assessed preoperatively and at 6 and 12 months postoperatively.

Results

Our CPAK distribution was comparable to that of other East Asian populations. The Journey II BCS TKA more effectively restored JLO and CPAK phenotypes compared to the Persona PS TKA. However, there was no statistically significant clinical correlation between the restoration of JLO, arithmetic HKA, and CPAK.

Conclusions

Although radiological restoration improves with JLO prostheses, short-term clinical outcomes remain unaffected.
膝关节冠状面对齐(CPAK)分类描述了基于肢体对齐和关节线倾角(JLO)的膝关节表型。本研究评估了CPAK在香港人群中的分布,并评估了假体设计如何影响CPAK的可重复性和临床结果。方法:本回顾性研究纳入了2021年在单一机构接受导航式全膝关节置换术(TKA)的患者。首先,我们分析了我国人群中CPAK表型的流行病学。其次,根据种植体设计将患者分为2个倾向评分匹配组:Journey II BCS TKA (JLO假体)和Persona PS TKA(关节线中性假体)。术前和术后6个月和12个月评估放射学结果(机械髋关节-膝关节-踝关节角、股骨外侧远端角、胫骨内侧近端角)和临床结果(活动范围、膝关节学会评分、西安大略和麦克马斯特大学骨关节炎指数评分、遗忘关节评分)。结果我们的CPAK分布与其他东亚人群相似。与Persona PS TKA相比,Journey II BCS TKA更有效地恢复了JLO和CPAK表型。然而,JLO的恢复、算数HKA和CPAK之间没有统计学意义的临床相关性。结论JLO假体虽能改善放射学修复,但短期临床效果不受影响。
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引用次数: 0
Evaluating the Impact of a Preoperative Risk Management Program on Outcomes Following Total Joint Arthroplasty: A Retrospective Cohort Study 评估术前风险管理程序对全关节置换术后预后的影响:一项回顾性队列研究
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1016/j.artd.2025.101880
Chloe Dlott MD , Sebastian Romero BS , Claire A. Donnelley MD , Stephanie Kaszuba MD , Daniel Wiznia MD

Background

Total joint arthroplasty is an effective intervention for end-stage joint disease, but carries elevated risks for patients with comorbidities and those from historically marginalized populations. Preoperative risk management programs are designed to mitigate these risks by optimizing patient health prior to surgery. This study evaluated the impact of such a program on postoperative outcomes at a single academic institution, with attention to racial and ethnic minorities and patients with public insurance.

Methods

We conducted a retrospective cohort study of 2748 patients who underwent total hip or knee arthroplasty between 2019 and 2021 at a single academic institution. Of these, 1548 patients received preoperative optimization targeting modifiable risk factors such as diabetes, obesity, and anemia, while 1200 followed standard preoperative protocols. Outcomes assessed included length of stay, prosthetic joint infection, 30- and 90-day readmissions, and emergency department (ED) visits. Patients were stratified by race/ethnicity, insurance type, and American Society of Anesthesiology physical classification.

Results

The optimized cohort had a higher average Charlson Comorbidity Index (1.1 vs 0.9; P = .01). There were no significant differences between groups in length of stay, readmissions, or overall ED visit rates. Black patients experienced higher ED utilization within 90 days postoperatively, regardless of optimization status. Medicaid patients with severe systemic disease had the highest rates of prosthetic joint infection (3.8%), and optimization was not associated with improved outcomes in this group. Patients with American Society of Anesthesiology physical classification ≥3 had increased ED visits postoperatively despite optimization.

Conclusions

Preoperative risk management did not consistently improve outcomes, particularly among patients with greater comorbidity burdens or those facing socioeconomic disadvantage. These findings support the need for tailored optimization strategies that address both clinical risk and social determinants of health.
背景:全关节置换术是治疗终末期关节疾病的有效干预手段,但对于有合并症的患者和历史上处于边缘地位的人群,风险较高。术前风险管理程序旨在通过在手术前优化患者健康来减轻这些风险。本研究在单一学术机构评估了此类项目对术后结果的影响,并关注了种族和少数民族以及有公共保险的患者。方法:我们对2019年至2021年在单一学术机构接受全髋关节或膝关节置换术的2748例患者进行了回顾性队列研究。其中,1548例患者接受了针对糖尿病、肥胖和贫血等可改变危险因素的术前优化,1200例患者遵循标准术前方案。评估的结果包括住院时间、假体关节感染、30天和90天再入院以及急诊(ED)就诊。患者按种族/民族、保险类型和美国麻醉学会物理分类进行分层。结果优化后的队列平均Charlson合并症指数较高(1.1 vs 0.9; P = 0.01)。两组患者在住院时间、再入院率或总体急诊科就诊率方面没有显著差异。无论优化状态如何,黑人患者在术后90天内ED使用率较高。患有严重全身性疾病的医疗补助患者的假体关节感染率最高(3.8%),优化与该组预后改善无关。尽管进行了优化,但美国麻醉学会物理分类≥3的患者术后急诊次数增加。结论:术前风险管理并不能持续改善预后,特别是在合并症负担更重或面临社会经济劣势的患者中。这些发现支持需要量身定制的优化策略,以解决临床风险和健康的社会决定因素。
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引用次数: 0
Robotic-Assisted Primary Total Knee Arthroplasty is Associated With Decreased 90-Day Opioid Prescribing Patterns Compared to Manual Instrumentation 与人工器械相比,机器人辅助的初次全膝关节置换术与减少90天阿片类药物处方模式相关
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.artd.2025.101886
Nathaniel T. Ondeck MD, MHS, Colin C. Neitzke MD, Yu-Fen Chiu MS, Sonia K. Chandi MD, Pravjit Bhatti MD, Alejandro Gonzalez Della Valle MD, Geoffrey H. Westrich MD, Brian P. Chalmers MD

Background

Robotic assistance minimizes bony resection and surrounding soft tissue damage during total knee arthroplasty (TKA), potentially decreasing postoperative pain. The objective of this study was to evaluate in-hospital opioid consumption, 90-day opioid prescribing patterns, length of stay (LOS), and patient-reported outcome measures (PROMs) following robotic-assisted vs manual primary TKA.

Methods

Utilizing an institutional database, all patients undergoing primary unilateral TKA between 2019 and 2022 with 90-day minimum follow-up were retrospectively queried. Patients were excluded if they had another surgery within 90 days of the index TKA, were discharged to a rehabilitation center, or were prescribed opioid or benzodiazepine medications preoperatively. One-to-one propensity score matching identified 1476 patients undergoing robotic-assisted (n = 738) or manual (n = 738) TKA. Multivariable regression analysis assessed in-hospital morphine milligram equivalents (MMEs) consumption, LOS, 90-day opioid prescribing patterns (not necessarily consumption), and PROMs (preoperative, 6 weeks, and 3 months).

Results

The robotic-assisted cohort consumed on average 12 fewer in-hospital MMEs (P = .026) and had an average LOS that was 8 hours shorter than the manual cohort (P < .001). There was no difference in MMEs prescribed at discharge (P = .12), but the robotic-assisted cohort had on average 113 fewer 90-day postdischarge MMEs prescribed (P = .001) and 145 fewer total 90-day MMEs (consumed in-hospital plus prescribed) (P < .001). There was no difference in PROMs at 6 weeks or 3 months.

Conclusions

Robotic-assisted TKA may confer shorter LOS with decreased 90-day opioid use patterns. This information is important given the increased scrutiny on opioid usage and recent focus on rapid recovery and ambulatory TKA pathways.
背景:在全膝关节置换术(TKA)中,机器人辅助最大限度地减少了骨切除和周围软组织损伤,潜在地减少了术后疼痛。本研究的目的是评估院内阿片类药物消耗、90天阿片类药物处方模式、住院时间(LOS)和患者报告的结果测量(PROMs),机器人辅助与手动原发性TKA。方法利用机构数据库,回顾性查询2019年至2022年期间所有接受原发性单侧TKA的患者,随访时间至少为90天。如果患者在TKA指数90天内进行了另一次手术,出院到康复中心,或术前开了阿片类药物或苯二氮卓类药物,则排除患者。一对一倾向评分匹配确定了1476例接受机器人辅助(n = 738)或人工(n = 738) TKA的患者。多变量回归分析评估了院内吗啡毫克当量(MMEs)消耗、LOS、90天阿片类药物处方模式(不一定是消耗)和PROMs(术前、6周和3个月)。结果与人工组相比,机器人辅助组平均少使用12个住院MMEs (P = 0.026),平均LOS缩短8小时(P < .001)。出院时处方的MMEs没有差异(P = .12),但机器人辅助队列在出院后90天的MMEs处方平均减少113个(P = .001),总90天MMEs减少145个(院内消耗加上处方)(P < .001)。6周和3个月时的PROMs无差异。结论机器人辅助TKA可缩短LOS,减少90天阿片类药物使用模式。鉴于对阿片类药物使用的审查越来越严格,以及最近对快速恢复和动态TKA途径的关注,这一信息很重要。
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引用次数: 0
Use of a Novel Surgical Irrigant Significantly Reduces Rate of Infection in Primary Hip and Knee Arthroplasty at 1 year 一种新型手术冲洗剂的使用显著降低了髋关节置换术1年内的感染率
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-26 DOI: 10.1016/j.artd.2025.101907
Ravi K. Bashyal MD , Avinash Inabathula MD , Samantha Lariosa BS , S. David Stulberg MD

Background

Periprosthetic joint infection (PJI) prevention in primary hip and knee arthroplasty remains an important challenge in arthroplasty. Dilute topical povidone–iodine followed by a sterile saline rinse is widely used for intraoperative irrigation and infection prophylaxis in surgery. The Food and Drug Administration recently issued a reminder about the nonsterility of topical iodine preparations used in deep surgical wounds. Thus, our institution sought a terminally sterilized alternative. We investigated a terminally sterile irrigant with minimal cytotoxicity, efficacy against biofilm, and no required secondary rinse.

Methods

This was a single-surgeon retrospective cohort study of 2087 consecutive primary total hip and knee arthroplasties with minimum 1-year follow-up in a major metropolitan community hospital. The control group of 1045 patients received a dilute povidone-iodine soak followed by saline rinse. The experimental group of 1042 patients received the new irrigant (XPerience (XP)) without secondary rinse. The International Consensus Meeting 2018 recommended algorithm and criteria were used to diagnose PJI.

Results

Overall, the PJI rate was 0% (0 of 1042) in the XP group and 0.6% (6/1045) in the povidone-iodine group (P = .017). The overall return to operating room rate was 0.5% (5 of 1042) in the XP group and 1.1% (12 of 1045) in the control group (P = .11).

Conclusions

The novel solution had a lower infection rate in our cohort. We conclude that it is a comparable alternative to povidone–iodine. An ongoing prospective randomized control trial and a cost-benefit analysis may provide stronger guidance for surgeons.
背景原发性髋关节和膝关节置换术中假体周围关节感染(PJI)的预防仍然是关节置换术中的一个重要挑战。外用稀聚维酮碘,然后用无菌生理盐水冲洗,广泛用于术中冲洗和手术感染预防。美国食品和药物管理局(Food and Drug Administration)最近发布了一项提醒,提醒人们在深度手术伤口中使用局部碘制剂的非无菌性。因此,我们的机构寻求一种绝育的替代方案。我们研究了一种具有最小细胞毒性、对生物膜有效且无需二次冲洗的终末无菌冲洗剂。方法:本研究是一项单一外科医生回顾性队列研究,在一家大城市社区医院进行了至少1年随访的2087例连续原发性全髋关节和膝关节置换术。对照组1045例,先用稀聚维酮碘浸泡,再用生理盐水冲洗。试验组1042例患者采用新型冲洗剂XPerience (XP),不进行二次冲洗。2018年国际共识会议推荐了用于诊断PJI的算法和标准。结果总的来说,XP组的PJI率为0%(0 / 1042),聚维酮碘组为0.6% (6/1045)(P = 0.017)。XP组总手术室回复率为0.5%(1042例中的5例),对照组为1.1%(1045例中的12例)(P = 0.11)。结论新型溶液在我们的队列中具有较低的感染率。我们的结论是,它是一种与聚维酮碘相当的替代品。一项正在进行的前瞻性随机对照试验和成本效益分析可能为外科医生提供更强的指导。
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引用次数: 0
Erythrocyte Exchange Transfusion Enabling Simultaneous Bilateral Total Hip Arthroplasty by a direct anterior approach in a Young Patient with Sickle Cell Disease 年轻镰状细胞病患者经直接前路同时行双侧全髋关节置换术的红细胞交换输血
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1016/j.artd.2025.101909
Enrique Alberto Vargas Meouchi MD , Ricard Llovera González-Adrio MD , David Beneitez Pastor MD , Veronica Pons MD , Marta Garcia Bernal MD , Victor Manuel Barro Ojeda MD
Sickle cell disease (SCD) is a known risk factor for femoral head osteonecrosis, often leading to early joint degeneration. We report a 17-year-old male with homozygous SCD and bilateral femoral head collapse who underwent simultaneous bilateral total hip arthroplasty through a direct anterior approach. Preoperative optimization included erythrocyte exchange transfusion effectively reducing hemoglobin S from 76% to 26%. The procedure was completed without complications, and the patient recovered uneventfully, with no sickling crises or acute chest syndrome. Cemented implants were used due to poor bone quality. The patient regained full, pain-free ambulation by three months. This case supports the safety and feasibility of simultaneous bilateral total hip arthroplasty in selected SCD patients when preceded by targeted erythrocyte exchange transfusion and managed by a multidisciplinary team.
镰状细胞病(SCD)是已知的股骨头骨坏死的危险因素,通常导致早期关节变性。我们报告了一位17岁男性纯合子SCD和双侧股骨头塌陷患者,他同时通过直接前路行双侧全髋关节置换术。术前优化包括红细胞交换输血有效地将血红蛋白S从76%降低到26%。手术完成后无并发症,患者恢复平稳,无镰状危象或急性胸综合征。由于骨质量差,采用骨水泥种植体。3个月后,患者恢复了完全无痛的行走。本病例支持在选择的SCD患者中同时进行双侧全髋关节置换术的安全性和可行性,在此之前进行靶向红细胞交换输血并由多学科团队管理。
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引用次数: 0
Avoiding Orthostatic Intolerance During Early Ambulation After Total Knee Arthroplasty: The Impact of Lying-to-Standing Time 全膝关节置换术后早期活动中避免直立性不耐受:躺到站立时间的影响
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.artd.2025.101905
Nonn Jaruthien MD , Supparurk Suksumran MD , Chotetawan Tanavalee MD , Chavarin Amarase MD , Aree Tanavalee MD , Wirinaree Kampitak MD , Srihatach Ngarmukos MD

Background

Orthostatic intolerance (OI), characterized by dizziness, blurred vision, syncope, can occur during ambulation after total knee arthroplasty (TKA) causing delayed rehabilitation and hospital discharge. Standardized guidelines to prevent OI during early ambulation are lacking. This study aimed to provide evidence regarding the impact of postural transition timing or lying-to-standing time (LTST) on OI during early postoperative ambulation following TKA.

Methods

We evaluated 120 patients undergoing unilateral primary TKA for OI with varying LTST. Patients with significant comorbidities, body mass index ≥40 kg/m2, or presence of preoperative OI or orthostatic hypotension were excluded. Preoperatively and at 12 hours postoperatively, patients performed three protocols with varying LTST: after changing position from lying to sitting, wait 60 seconds before standing (protocol A), wait 30 seconds before standing (protocol B), and immediate standing (protocol C). Systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation were measured at sitting and standing positions for each protocol. OI was defined if signs of cerebral hypoperfusion were detected, or decrease in systolic blood pressure >20 mmHg, or decrease in diastolic blood pressure >10 mmHg.

Results

From 120 TKAs, 98 patients were included (mean age 74 years, mean body mass index 26.46 kg/m2). The incidences of postoperative OI were 0% for protocol A, 16.3% for protocol B, and 44.9% for protocol C. All protocol B patients with OI also experienced it in protocol C.

Conclusions

This study demonstrates that a 60-second sitting interval between lying and standing effectively prevents OI during early ambulation after TKA.
背景:全膝关节置换术(TKA)后活动时,可发生以头晕、视力模糊、晕厥为特征的坐姿不耐受(OI),导致康复和出院延迟。缺乏预防早期活动时成骨不全的标准化指南。本研究旨在为TKA术后早期活动中姿势转换时间或躺-站时间(LTST)对成骨不全的影响提供证据。方法我们评估了120例单侧原发性全髋关节置换术治疗不同LTST的成骨不全患者。排除有明显合并症、体重指数≥40 kg/m2、术前存在成骨不全或体位性低血压的患者。术前和术后12小时,患者采用三种不同的LTST方案:从躺姿改为坐姿后,等待60秒后站立(方案A),等待30秒后站立(方案B),立即站立(方案C)。分别在坐姿和站立位置测量收缩压、舒张压、心率和血氧饱和度。如果检测到脑灌注不足的迹象,或收缩压下降20mmhg,或舒张压下降10mmhg,则定义为成骨不全。结果共纳入120例tka患者98例,平均年龄74岁,平均体重指数26.46 kg/m2。方案A术后成骨不全发生率为0%,方案B为16.3%,方案c为44.9%。所有方案B的成骨不全患者在方案c中也发生了成骨不全。结论本研究表明,在TKA术后早期活动中,躺着和站立之间60秒的坐姿间隔可有效预防成骨不全。
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引用次数: 0
Presence of Metallosis Can Interfere With Culture Positivity in Prosthetic Joint Infection of the Hip 金属病的存在会干扰髋关节假体感染的培养阳性
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-24 DOI: 10.1016/j.artd.2025.101910
Ayesha Abdeen MD , Nelson Merchan MD , Marcos R. Gonzalez MD , Joshua B. Davis BS , Jacob Drew MD , Rubén Monárrez MD , Antonia F. Chen MD, MBA , Edward K. Rodriguez MD

Background

Metallosis is a well-described complication of total hip arthroplasty (THA); however, its impact on periprosthetic joint infection (PJI) diagnosis and treatment remains unknown. We assessed whether coexisting metallosis at the time of revision THA is associated with delayed diagnosis and poorer PJI treatment outcomes.

Methods

We retrospectively reviewed patients undergoing revision THA due to chronic and acute hematogenous PJI with coexisting metallosis (metallosis and PJI group). A matched cohort of patients with chronic and acute hematogenous PJI without metallosis was established (control group). The 2018 International Consensus Meeting criteria were used to define PJI. Metallosis was diagnosed based on the intraoperative findings or serum chromium/cobalt levels. The primary outcomes were culture positivity and survival free of reoperation or revision. Thirteen and 42 patients were included in the metallosis and PJI and the control groups, respectively.

Results

The initial set of cultures was negative in 38% of patients in the metallosis and PJI group, compared to only 12% in the control group (P = .03). Time elapsed between presentation of symptoms and first positive culture was significantly longer in the metallosis and PJI group compared to the control (14.5 vs 0 days, P < .001). The revision rate was 46% in the metallosis and PJI group and 24% in the control group (P = .12). Revision-free survival in patients treated with debridement, antibiotics, and implant retention was 28% in the metallosis and PJI group and 79.7% in the control group, (P = .21).

Conclusions

Metallosis may increase the likelihood of initial false negative culture results and delay PJI diagnosis in patients undergoing revision THA.
金属病是全髋关节置换术(THA)的一种常见并发症;然而,其对假体周围关节感染(PJI)诊断和治疗的影响尚不清楚。我们评估了翻修THA时共存的金属病是否与延迟诊断和较差的PJI治疗结果相关。方法回顾性分析因慢性和急性血液性PJI合并金属病而行改良THA的患者(金属病和PJI组)。建立无金属病的慢性和急性血液性PJI患者的匹配队列(对照组)。2018年国际共识会议标准用于定义PJI。金属中毒是根据术中发现或血清铬/钴水平诊断的。主要结果是培养阳性和无再手术或翻修的生存。金属病组、PJI组和对照组分别为13例和42例。结果金属病合并PJI组患者初始培养阴性率为38%,对照组为12% (P = 0.03)。与对照组相比,金属病和PJI组出现症状和首次阳性培养之间的时间间隔明显更长(14.5天vs 0天,P < 0.001)。金属病合并PJI组修复率为46%,对照组为24% (P = 0.12)。采用清创、抗生素和种植体保留治疗的患者,金属矫正组和PJI组的无修复生存率为28%,对照组为79.7%,(P = 0.21)。结论金属中毒可增加改良THA患者初始培养假阴性的可能性,延误PJI诊断。
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引用次数: 0
Utilization of an Anteromedial Cortical Window for Tibial Component Removal During Revision Total Knee Arthroplasty 全膝关节置换术中应用前内侧皮质窗去除胫骨假体
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-12-09 DOI: 10.1016/j.artd.2025.101890
Bailey J. Ross MD , Jacob Glassman BS , Grayson Nour BS , Jacob M. Wilson MD , Jose A. Rodriguez MD , Ajay Premkumar MD, MPH
Revision total knee arthroplasty often entails removal of well-fixed components. Tibial component removal is particularly challenging due to (I) mechanical barriers that limit circumferential disruption when pegs, keels, or stems are present; (II) restricted access to implant-cement and cement-bone interfaces within the proximal canal; and (III) the proximity of critical structures, including the collateral ligaments, patellar tendon, popliteal artery, and distal femur. We present a novel anteromedial cortical window technique that facilitates removal of well-fixed tibial components by improving access to the implant-cement, burr-cement, and cement-bone interfaces within the proximal tibial metaphysis. This technique is suited for cases not requiring posterolateral exposure, offering a less morbid alternative to tibial tubercle osteotomy with the option for conversion if greater exposure is needed.
翻修全膝关节置换术通常需要移除固定良好的部件。胫骨假体移除尤其具有挑战性,因为(1)当存在骨钉、龙骨或骨干时,机械屏障限制了周向破坏;(II)近端管内种植体-水泥和水泥-骨界面的接触受限;(III)靠近关键结构,包括副韧带、髌骨肌腱、腘动脉和股骨远端。我们提出了一种新的前内侧皮质窗技术,通过改善胫骨近端干骺端内的植入物-水泥、毛刺-水泥和水泥-骨界面,促进了固定良好的胫骨部件的移除。该技术适用于不需要后外侧暴露的病例,提供了一种不太病态的替代胫骨结节截骨术,如果需要更大的暴露,可以选择转换。
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引用次数: 0
Preoperative Malnutrition Is Associated With Increased Rates of Periprosthetic Fractures in Total Knee Arthroplasty 术前营养不良与全膝关节置换术中假体周围骨折发生率增加有关
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-12-02 DOI: 10.1016/j.artd.2025.101914
Andrew Ni MD, Shawn Dripchak MD, Coltin Gerhart MD, Victor Martinez DO, Zachary Jodoin MD, Chance Moore MD, Frank Buttacavoli MD

Background

Periprosthetic fractures (PPFx) after total knee arthroplasty (TKA) are associated with high morbidity and mortality. While previous studies have shown the potential role of malnutrition as a predictor of PPFx in total hip arthroplasty, no studies have evaluated malnutrition as a risk factor for PPFx in TKA patients. This study aims to evaluate the relationship between preoperative nutrition status and PPFx after TKA.

Methods

We conducted a retrospective cohort study using data from the TriNetX Registry to identify patients who underwent primary TKA or revision TKA (rTKA) from 2005 to 2025. Preoperative nutrition status was assessed using albumin levels within 3 months prior to TKA based on prior arthroplasty and nutrition literature. Hypoalbuminemia was defined as < 3.5 g/dl. The primary outcome was PPFx occurring at least 1 day after TKA surgery, thereby excluding intraoperative PPFx. Cox proportional hazard models were used to determine hazard ratios (HRs) for each cohort.

Results

There were 176,662 TKA patients and 1301 (0.74%) patients with subsequent PPFx during this study period. Preoperative malnutrition was identified in 19,500 patients (11.5%) in the primary TKA group and 1138 patients (17.9%) in the rTKA group. Both primary TKA (hazard ratio [HR] = 1.37, 95% confidence interval [CI], 1.23-1.52, P ≤ 0.001) and rTKA patients (HR = 1.20, 95% CI, 1.03-1.41, P = .022) with preoperative hypoalbuminemia were at an increased risk of PPFx while albumin levels of greater than 3.5 g/dl were protective against PPFx ((HR = 0.73, 95% CI, 0.58-0.93, P = .009) and (HR = 0.72, 95% CI, 0.53-0.97, P = .029) for primary TKA and rTKA respectively). Other nutritional labs including increased prealbumin and higher lymphocyte percentage were statistically significantly associated with a decreased risk for PPFx. Independent risk factors for PPFx following TKA included diabetes, obesity, female sex, and increased age.

Conclusions

Our study shows that poor preoperative nutrition status is associated with statistically significant increased risks of PPFx following TKA in both primary TKA and rTKA. Optimization of nutrition may help prevent PPFx following TKA.
背景:全膝关节置换术(TKA)后假体周围骨折(PPFx)具有高发病率和死亡率。虽然先前的研究表明营养不良作为全髋关节置换术中PPFx的潜在预测因素,但没有研究评估营养不良作为TKA患者PPFx的危险因素。本研究旨在评估TKA术后术前营养状况与PPFx的关系。方法:我们使用TriNetX Registry的数据进行回顾性队列研究,以确定2005年至2025年间接受原发性TKA或改进性TKA (rTKA)的患者。术前营养状况评估使用白蛋白水平前3个月的TKA基于先前的关节置换术和营养文献。低白蛋白血症定义为<; 3.5 g/dl。主要终点是TKA手术后至少1天发生的PPFx,因此排除术中PPFx。采用Cox比例风险模型确定每个队列的风险比(hr)。结果在本研究期间,共有176662例TKA患者和1301例(0.74%)患者接受了PPFx治疗。术前营养不良19,500例(11.5%)为原发性TKA组,1138例(17.9%)为二次TKA组。原发性TKA(风险比[HR] = 1.37, 95%可信区间[CI], 1.23-1.52, P≤0.001)和rTKA患者(HR = 1.20, 95% CI, 1.03-1.41, P = 0.022)术前低白蛋白血症患者PPFx的风险增加,而白蛋白水平大于3.5 g/dl对PPFx有保护作用(HR = 0.73, 95% CI, 0.58-0.93, P = 0.009)和(HR = 0.72, 95% CI, 0.53-0.97, P = 0.029)分别为原发性TKA和rTKA。其他营养实验包括增加的前白蛋白和更高的淋巴细胞百分比与PPFx的风险降低有统计学意义上的显著相关。TKA后PPFx的独立危险因素包括糖尿病、肥胖、女性和年龄增加。结论我们的研究表明,术前营养状况不佳与TKA术后PPFx风险增加有关,无论是原发性TKA还是二次TKA。营养优化可能有助于预防TKA后的PPFx。
{"title":"Preoperative Malnutrition Is Associated With Increased Rates of Periprosthetic Fractures in Total Knee Arthroplasty","authors":"Andrew Ni MD,&nbsp;Shawn Dripchak MD,&nbsp;Coltin Gerhart MD,&nbsp;Victor Martinez DO,&nbsp;Zachary Jodoin MD,&nbsp;Chance Moore MD,&nbsp;Frank Buttacavoli MD","doi":"10.1016/j.artd.2025.101914","DOIUrl":"10.1016/j.artd.2025.101914","url":null,"abstract":"<div><h3>Background</h3><div>Periprosthetic fractures (PPFx) after total knee arthroplasty (TKA) are associated with high morbidity and mortality. While previous studies have shown the potential role of malnutrition as a predictor of PPFx in total hip arthroplasty, no studies have evaluated malnutrition as a risk factor for PPFx in TKA patients. This study aims to evaluate the relationship between preoperative nutrition status and PPFx after TKA.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using data from the TriNetX Registry to identify patients who underwent primary TKA or revision TKA (rTKA) from 2005 to 2025. Preoperative nutrition status was assessed using albumin levels within 3 months prior to TKA based on prior arthroplasty and nutrition literature. Hypoalbuminemia was defined as &lt; 3.5 g/dl. The primary outcome was PPFx occurring at least 1 day after TKA surgery, thereby excluding intraoperative PPFx. Cox proportional hazard models were used to determine hazard ratios (HRs) for each cohort.</div></div><div><h3>Results</h3><div>There were 176,662 TKA patients and 1301 (0.74%) patients with subsequent PPFx during this study period. Preoperative malnutrition was identified in 19,500 patients (11.5%) in the primary TKA group and 1138 patients (17.9%) in the rTKA group. Both primary TKA (hazard ratio [HR] = 1.37, 95% confidence interval [CI], 1.23-1.52, <em>P</em> ≤ 0.001) and rTKA patients (HR = 1.20, 95% CI, 1.03-1.41, <em>P</em> = .022) with preoperative hypoalbuminemia were at an increased risk of PPFx while albumin levels of greater than 3.5 g/dl were protective against PPFx ((HR = 0.73, 95% CI, 0.58-0.93, <em>P</em> = .009) and (HR = 0.72, 95% CI, 0.53-0.97, <em>P</em> = .029) for primary TKA and rTKA respectively). Other nutritional labs including increased prealbumin and higher lymphocyte percentage were statistically significantly associated with a decreased risk for PPFx. Independent risk factors for PPFx following TKA included diabetes, obesity, female sex, and increased age.</div></div><div><h3>Conclusions</h3><div>Our study shows that poor preoperative nutrition status is associated with statistically significant increased risks of PPFx following TKA in both primary TKA and rTKA. Optimization of nutrition may help prevent PPFx following TKA.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101914"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to Achieve a Minimal Clinically Important Difference After Total Hip Arthroplasty: A Retrospective Cohort Comparison of Robotic-Assisted, Navigation-Assisted, and Conventional Techniques 实现全髋关节置换术后最小临床重要差异的时间:机器人辅助、导航辅助和传统技术的回顾性队列比较
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-12-01 Epub Date: 2025-11-08 DOI: 10.1016/j.artd.2025.101902
Kareem Omran MD, MPhil (Cantab) , Colleen Wixted MD, MBA , Daniel Waren MSPH, CCRP , Joshua C. Rozell MD , Ran Schwarzkopf MD, MSc

Background

Technological advancements in total hip arthroplasty (THA), including robotic-assisted (RA-THA) and navigation-assisted (NA-THA) techniques, aim to improve outcomes. However, impact on recovery timing remains unclear. This study examined whether these technologies reduce the time to reach the minimal clinically important difference (MCID) on the Hip Disability and Osteoarthritis Outcome Score for Joint Replacement compared with conventional THA.

Methods

This retrospective study analyzed osteoarthritic THA patients (01/2020-04/2023) who completed preoperative and postoperative Hip Disability and Osteoarthritis Outcome Score for Joint Replacement questionnaires. The exclusion criteria included bilateral procedures or revision within 1 year. MCID was defined using anchor-based (23 points) and distribution-based thresholds (7.6 points). Multivariable interval-censored accelerated failure time models assessed time to MCID.

Results

Among the 1395 patients, 181 (12.9%) underwent RA-THA, 754 (54.1%) underwent NA-THA, and 460 (33.0%) underwent conventional THA. Anchor-based MCID rates were 65.2%, 63.4%, and 66.5%, respectively (P > .05), with median times of 38.9, 48.4, and 45.1 days. Neither RA-THA (time ratio [TR] = 0.86, 95% confidence interval [CI]: 0.63-1.18, P = .347) nor NA-THA (TR = 1.07, 95% CI: 0.87-1.32, P = .502) significantly affected time to MCID vs conventional distribution-based thresholds yielded higher MCID rates (93.9%, 88.9%, 89.8%; P > .05) with median times of 8.6, 11.4, and 12.9 days, respectively. RA-THA reached MCID 33.5% faster than conventional THA (TR = 0.66, 95% 26 CI: 0.52-0.86, P = .002) and 24.3% faster than NA-THA (TR = 0.76, 95% CI: 0.60-0.95, P = .019), while NA-THA showed no significant difference vs conventional THA (TR = 0.88, 95% CI: 0.74-1.04, P = .140).

Conclusions

Anchor-based MCID demonstrated comparable recovery times across RA, NA, and conventional THA, suggesting no patient-perceived advantage with technology. Distribution-based thresholds indicated RA-THA achieved faster statistically significant improvement, though the relevance remains uncertain.
全髋关节置换术(THA)的技术进步,包括机器人辅助(RA-THA)和导航辅助(NA-THA)技术,旨在改善结果。然而,对恢复时间的影响尚不清楚。本研究考察了与传统THA相比,这些技术是否减少了达到髋关节残疾和骨关节炎结局评分最小临床重要差异(MCID)的时间。方法回顾性分析2020年1月- 2023年4月完成髋关节失能和骨性关节炎髋关节置换术术前和术后评分问卷的骨关节炎THA患者。排除标准包括双边程序或1年内的修订。MCID的定义采用基于锚点(23分)和基于分布的阈值(7.6分)。多变量间隔截尾加速失效时间模型评估时间到MCID。结果1395例患者中,RA-THA 181例(12.9%),NA-THA 754例(54.1%),常规THA 460例(33.0%)。基于锚定的MCID发生率分别为65.2%、63.4%和66.5% (P > 0.05),中位时间分别为38.9、48.4和45.1天。RA-THA(时间比[TR] = 0.86, 95%可信区间[CI]: 0.63-1.18, P = .347)和NA-THA (TR = 1.07, 95% CI: 0.87-1.32, P = .502)与传统的基于分布的阈值相比,均没有显著影响到MCID的时间,产生更高的MCID率(93.9%,88.9%,89.8%;P > 0.05),中位时间分别为8.6,11.4和12.9天。RA-THA比常规THA快33.5% (TR = 0.66, 95% 26 CI: 0.52 ~ 0.86, P = 0.002),比NA-THA快24.3% (TR = 0.76, 95% CI: 0.60 ~ 0.95, P = 0.019),而NA-THA与常规THA无显著差异(TR = 0.88, 95% CI: 0.74 ~ 1.04, P = 0.140)。结论基于sanchorr的MCID在RA、NA和传统THA中显示出相当的恢复时间,表明患者没有感知到该技术的优势。基于分布的阈值表明RA-THA取得了更快的统计学显著改善,尽管相关性仍不确定。
{"title":"Time to Achieve a Minimal Clinically Important Difference After Total Hip Arthroplasty: A Retrospective Cohort Comparison of Robotic-Assisted, Navigation-Assisted, and Conventional Techniques","authors":"Kareem Omran MD, MPhil (Cantab) ,&nbsp;Colleen Wixted MD, MBA ,&nbsp;Daniel Waren MSPH, CCRP ,&nbsp;Joshua C. Rozell MD ,&nbsp;Ran Schwarzkopf MD, MSc","doi":"10.1016/j.artd.2025.101902","DOIUrl":"10.1016/j.artd.2025.101902","url":null,"abstract":"<div><h3>Background</h3><div>Technological advancements in total hip arthroplasty (THA), including robotic-assisted (RA-THA) and navigation-assisted (NA-THA) techniques, aim to improve outcomes. However, impact on recovery timing remains unclear. This study examined whether these technologies reduce the time to reach the minimal clinically important difference (MCID) on the Hip Disability and Osteoarthritis Outcome Score for Joint Replacement compared with conventional THA.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed osteoarthritic THA patients (01/2020-04/2023) who completed preoperative and postoperative Hip Disability and Osteoarthritis Outcome Score for Joint Replacement questionnaires. The exclusion criteria included bilateral procedures or revision within 1 year. MCID was defined using anchor-based (23 points) and distribution-based thresholds (7.6 points). Multivariable interval-censored accelerated failure time models assessed time to MCID.</div></div><div><h3>Results</h3><div>Among the 1395 patients, 181 (12.9%) underwent RA-THA, 754 (54.1%) underwent NA-THA, and 460 (33.0%) underwent conventional THA. Anchor-based MCID rates were 65.2%, 63.4%, and 66.5%, respectively (<em>P</em> &gt; .05), with median times of 38.9, 48.4, and 45.1 days. Neither RA-THA (time ratio [TR] = 0.86, 95% confidence interval [CI]: 0.63-1.18, <em>P</em> = .347) nor NA-THA (TR = 1.07, 95% CI: 0.87-1.32, <em>P</em> = .502) significantly affected time to MCID vs conventional distribution-based thresholds yielded higher MCID rates (93.9%, 88.9%, 89.8%; <em>P</em> &gt; .05) with median times of 8.6, 11.4, and 12.9 days, respectively. RA-THA reached MCID 33.5% faster than conventional THA (TR = 0.66, 95% 26 CI: 0.52-0.86, <em>P</em> = .002) and 24.3% faster than NA-THA (TR = 0.76, 95% CI: 0.60-0.95, <em>P</em> = .019), while NA-THA showed no significant difference vs conventional THA (TR = 0.88, 95% CI: 0.74-1.04, <em>P</em> = .140).</div></div><div><h3>Conclusions</h3><div>Anchor-based MCID demonstrated comparable recovery times across RA, NA, and conventional THA, suggesting no patient-perceived advantage with technology. Distribution-based thresholds indicated RA-THA achieved faster statistically significant improvement, though the relevance remains uncertain.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101902"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Arthroplasty Today
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