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Polyurethane: An Old Material for a New Generation of Antibiotic Spacer Implants 聚氨酯:新一代抗生素间隔植入物的旧材料
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-09 DOI: 10.1016/j.artd.2024.101409

Background

Polyurethane tibial and acetabular inserts that release high concentrations of antibiotics were used with debridement and implant retention to treat prosthetic joint infections. The hypothesis was that a low-friction, antibiotic-releasing bearing could provide a simpler, safer, and more patient-accepted treatment for infection using antibiotic cement and intravenous antibiotics.

Methods

Patients (n = 106) with culture-positive infections received antibiotic inserts. Vancomycin and tobramycin were mixed into the polyurethane polymer at 7% by weight. Contraindications to debridement antibiotics and implant retention were a sinus tract, loose prostheses, and/or the wound could not be closed. Measurable outcomes were success in controlling infection, complications, patient acceptable symptomatic state, and need for revision surgery. Antibiotic levels were measured in joint fluid and blood; laboratory mechanical wear tests were performed; and results were compared to bone cement and polyethylene containing antibiotics.

Results

Antibiotic-infused spacers sustained joint fluid antibiotic levels 8-12 times the therapeutic level and produced low serum levels with no toxicities. Mechanical testing showed low wear and retained mechanical integrity. All patients achieved complication-free remission of infection at a follow-up of 5-26 years. All patients had Harris hip and Knee Society scores above 85, and 68% achieved patient acceptable symptomatic state.

Conclusions

All patients achieved remission of infection, fewer complications compared to revision using antibiotic bone cement, no antibiotic toxicity or adverse drug reactions, and 68% achieved patient acceptance. The antibiotic polyurethane inserts provided antibacterial efficacy comparable with currently used bone cement spacers, and their wear rate was approximately 20 times lower than bone cement as an articulation.

背景将可释放高浓度抗生素的聚氨酯胫骨和髋臼衬垫与清创和植入物固定一起用于治疗假体关节感染。我们的假设是,使用抗生素骨水泥和静脉注射抗生素治疗感染时,低摩擦、释放抗生素的轴承可以提供一种更简单、更安全、更容易被患者接受的治疗方法。万古霉素和妥布霉素以 7% 的重量混入聚氨酯聚合物中。清创抗生素和植入物保留的禁忌症是窦道、假体松动和/或伤口无法闭合。可测量的结果包括感染控制的成功率、并发症、患者可接受的症状状态以及翻修手术的需求。对关节液和血液中的抗生素水平进行了测量;进行了实验室机械磨损测试;并将结果与骨水泥和含有抗生素的聚乙烯进行了比较。机械测试显示,磨损程度低,机械完整性保持良好。所有患者在 5-26 年的随访中均无并发症,感染症状得到缓解。结论与使用抗生素骨水泥进行翻修相比,所有患者均感染缓解,并发症较少,无抗生素毒性或药物不良反应,68%的患者可接受。抗生素聚氨酯插入物的抗菌效果与目前使用的骨水泥垫片相当,其磨损率比骨水泥作为衔接物低约20倍。
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引用次数: 0
Establishing a Per-Hour Rate for Early-Career Adult Reconstruction Surgeons Performing Medicare Primary Total Joint Arthroplasty 为执行医疗保险初级全关节成形术的早期职业成人重建外科医生确定每小时费率
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-07 DOI: 10.1016/j.artd.2024.101416

Background

There is a paucity of data regarding compensation for early-career adult reconstruction surgeons. This study aims to quantify the time throughout the full episode of care for a Medicare primary total hip/knee arthroplasty and convert to per-hour pay for early-career arthroplasty surgeons at various geographic locations and practice settings. Using Center for Medicare and Medicaid Services data, this study also compares the compensation of early-career vs established total joint arthroplasty (TJA) surgeons.

Methods

Between January 2022 and January 2023, 3 early-career surgeons in 3 different locations collected prospective data on time spent in patient care during the global period following primary TJAs (pTJAs). A weighted average time spent per pTJA during global period was calculated with the 2024 work relative value unit and conversion factor to establish a per-hour rate. This rate was compared to the compensation rates of other healthcare-related fields and established TJA surgeons using Relative Value Scale Update Committee (RUC) values.

Results

A total of 334 pTJAs (148 hips and 186 knees) were performed among 3 surgeons, and per-hour rates of $87.62 and $87.70 were found, respectively. These are less than hospital/healthcare system/health insurance/med tech CEOs, lawyers, dentists, and travel nurses. Early-career TJA surgeons were found to take 7.98%-8.68% longer than RUC standard times for a TJA episode of care.

Conclusions

This study quantifies the per-hour compensation of early-career arthroplasty surgeons, who earn lower compensation rates to travel nurses and take longer than Center for Medicare and Medicaid Services RUC times for pTJAs. Given the increasing demand for pTJAs, decreasing reimbursement rates, and concern over burnout, access to quality pTJA care for patients is concerning.

背景有关早期职业成人重建外科医生报酬的数据很少。本研究旨在量化医疗保险初级全髋/膝关节置换术整个护理过程的时间,并将不同地理位置和执业环境下的早期职业关节置换外科医生的每小时报酬进行换算。方法在 2022 年 1 月至 2023 年 1 月期间,3 个不同地点的 3 位早期职业外科医生收集了初级全髋关节/膝关节置换术(pTJA)后全球患者护理时间的前瞻性数据。使用 2024 年工作相对价值单位和转换系数计算了全球期间每个 pTJA 所花费的加权平均时间,从而确定了每小时的费率。结果3名外科医生共完成了334例pTJA(148例髋关节和186例膝关节),每小时费率分别为87.62美元和87.70美元。这低于医院/医疗保健系统/医疗保险/医疗科技公司的首席执行官、律师、牙医和旅行护士。结论这项研究量化了职业生涯早期的关节成形外科医生的每小时报酬,他们的报酬率低于旅行护士,而且比医疗保险和医疗补助服务中心 RUC 的 pTJA 时间更长。鉴于对 pTJA 的需求不断增加、报销率不断下降以及对职业倦怠的担忧,患者能否获得高质量的 pTJA 护理令人担忧。
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引用次数: 0
Influence of Contralateral Hip Status on Pelvic Tilt After Total Hip Arthroplasty 全髋关节置换术后对侧髋关节状态对骨盆倾斜的影响
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-05 DOI: 10.1016/j.artd.2024.101460

Background

Every degree of change in pelvic tilt (PT) leads to a 0.7° change in anteversion and a 0.3° change in inclination. This study aimed to determine the significance of contralateral hip arthritis on changes in PT using preoperative and postoperative anteroposterior radiographs.

Methods

There were 193 primary total hip arthroplasties done by 2 surgeons at a single academic tertiary referral center reviewed between September 2021 and January 2023. PT was calculated as Tilt = −(ln[(B/A) × (1/0.483)]) / 0.051. Value A is the distance from the base of the SI joint to the superior margin of the obturator foramen; value B is the height of the obturator foramen. After exclusions, contralateral hips were identified as being normal (n = 75), arthritic (n = 39) (Tönnis grade 3/4), replaced (n = 34), or having undergone simultaneous bilateral total hip arthroplasty (n = 5) on postoperative films. Difference in PT was measured between preoperative and postoperative films taken 1-3 months after surgery. Analyses for statistical significance were calculated using t-tests and one-way analysis of variance.

Results

Average change in PT in patients with normal contralateral hips was −5.2° with an absolute mean difference of 7.6°, −1.5° for arthritic contralateral hips with an absolute mean difference of 5.0°, −1.6° for replaced contralateral hips with a mean absolute difference of 4.3°, and 2.2° for bilateral hips with a mean absolute difference of 2.6° (P < .01).

Conclusions

Differences in postoperative PT changes between healthy, arthritic, and replaced contralateral hip study groups were significant. Changes in preoperative to postoperative tilt may have implications for optimal cup placement.

背景骨盆倾斜度(PT)每变化一度,前倾角就会变化0.7°,后倾角就会变化0.3°。本研究旨在通过术前和术后的前后位X光片确定对侧髋关节炎对PT变化的影响。方法在2021年9月至2023年1月期间,对一家学术三级转诊中心的两名外科医生完成的193例初次全髋关节置换术进行了复查。PT的计算公式为倾斜度=-(ln[(B/A) × (1/0.483)]) / 0.051。/ 0.051.A值为SI关节底部到闭孔上缘的距离;B值为闭孔的高度。经排除后,对侧髋关节被确定为正常(n = 75)、关节炎(n = 39)(Tönnis 3/4级)、置换(n = 34)或术后拍片时同时接受了双侧全髋关节置换术(n = 5)。术前和术后1-3个月拍摄的PT片之间的差异进行测量。结果对侧髋关节正常的患者 PT 平均变化为-5.2°,绝对平均差值为 7.6°;对侧髋关节炎患者 PT 平均变化为-1.5°,绝对平均差值为 5.0°;对侧髋关节炎患者 PT 平均变化为-1.6°,绝对平均差值为 5.0°。结论健康、关节炎和置换对侧髋关节研究组之间的术后 PT 变化差异显著。从术前到术后倾斜度的变化可能会对髋臼杯的最佳置放位置产生影响。
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引用次数: 0
Accuracy and Outcomes of a Novel Cut-Block Positioning Robotic-Arm Assisted System for Total Knee Arthroplasty: A Systematic Review and Meta-Analysis 用于全膝关节置换术的新型切块定位机械臂辅助系统的准确性和疗效:系统回顾与元分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-04 DOI: 10.1016/j.artd.2024.101451

Background

The primary objective of this study was to determine the accuracy and precision of component positioning of the ROSA Robotic System for total knee arthroplasty (TKA).

Methods

A Preferred Reporting Items for Systematic Reviews and Meta-Analysis systematic review was conducted using 4 electronic databases (MEDLINE, EMBASE, Pubmed, and Cochrane Library) to identify all clinical and radiological studies reporting information about the use and results of the ROSA system. The criteria for inclusion were published research articles evaluating the accuracy of component positioning, learning curve, component alignment, complications, and functional outcomes in adults who underwent robotic-assisted TKA. The National Institutes of Health Quality Assessment Tool was used to evaluate the quality of all the included studies.

Results

A total of 26 studies were assessed for eligibility, and 17 met the inclusion criteria. Nine studies reported on the accuracy and precision of component positioning. The ROSA platform for TKA had a cutting error of less than 0.6° for all coronal and sagittal parameters. Pooled analysis demonstrated accuracy within 0.61-1.87° and precision within 0.97-1.34° when the final intraoperative plan was compared to postoperative radiographs with fewer outliers. Four studies reported improved functional scores with ROSA-assisted TKA than conventional TKA within 1 year of surgery. There was no difference in overall complication rates when compared to conventional TKA.

Conclusions

The ROSA system is both highly accurate and precise, with fewer outliers when analyzed at various time points, including postoperative standing radiographs. Future studies with robust methodology and longer follow-up are required to demonstrate whether these findings have any clinical benefits in the long term.

背景本研究的主要目的是确定 ROSA 机器人系统用于全膝关节置换术 (TKA) 的部件定位的准确性和精确性。方法使用 4 个电子数据库(MEDLINE、EMBASE、Pubmed 和 Cochrane Library)进行了系统综述,以确定所有报道 ROSA 系统使用和结果的临床和放射学研究。纳入标准是已发表的研究文章,这些文章评估了接受机器人辅助 TKA 的成人的组件定位准确性、学习曲线、组件对齐、并发症和功能结果。美国国立卫生研究院质量评估工具用于评估所有纳入研究的质量。结果 共有26项研究通过了资格评估,其中17项符合纳入标准。九项研究报告了组件定位的准确性和精确性。用于 TKA 的 ROSA 平台在所有冠状和矢状参数上的切割误差均小于 0.6°。汇总分析表明,当术中最终计划与异常值较少的术后 X 光片进行比较时,准确度在 0.61-1.87° 以内,精确度在 0.97-1.34° 以内。四项研究报告称,术后一年内,ROSA辅助TKA的功能评分高于传统TKA。结论ROSA系统具有高度准确性和精确性,在不同时间点进行分析,包括术后立位X光片,其异常值较少。未来的研究需要采用可靠的方法并进行更长时间的随访,以证明这些发现是否会带来长期的临床益处。
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引用次数: 0
Calipered Kinematically Aligned Medial Unicompartmental Knee Arthroplasty: A Surgical Technique Calipered Kinematically Aligned Medial Unicompartmental Knee Arthroplasty:一种手术技术
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-03 DOI: 10.1016/j.artd.2024.101470

This study presents a surgical technique for kinematically aligned medial unicompartmental knee arthroplasty with the MOTO (Medacta Corporate, Switzerland) partial knee implant. This technique aims to replicate the native medial femoral and tibial morphology by providing caliper-verified bone resections and kinematic alignment principles. The paper provides a comprehensive overview of the surgical steps and discusses the implications for implant longevity.

本研究介绍了一种使用 MOTO(瑞士 Medacta 公司)部分膝关节假体进行运动学配准的内侧单室膝关节成形术的手术技术。该技术旨在通过提供卡尺验证的骨切除和运动学配准原则,复制原生内侧股骨和胫骨形态。本文全面概述了手术步骤,并讨论了植入物寿命的影响。
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引用次数: 0
Metallosis-Induced Warm Antibody Auto-Immune Hemolytic Anemia After Bilateral, Large-Diameter Metal-on-Metal Total Hip Arthroplasty With Complete Remission After Revision 双侧大直径金属对金属全髋关节置换术后金属病诱发的温抗体自身免疫性溶血性贫血,翻修后完全缓解
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-03 DOI: 10.1016/j.artd.2024.101471

The use of metal-on-metal bearing couples in total hip arthroplasty can lead to an increased release of metal ions, particularly cobalt and chromium over time. This can lead to local and systemic metallosis, which has cytotoxic, genotoxic, and immunotoxic effects and can cause a host of secondary disorders. We describe the case of a 37-year-old female patient that was diagnosed with warm-antibody autoimmune hemolytic anemia (WAIHA) one and a half years after bilateral large-diameter head metal-on-metal total hip arthroplasty. For 11 years, it was refractory to all therapy, including splenectomy and rituximab, requiring long-term oral prednisone for disease control. Ultimately, systemic metallosis and periprosthetic joint infection were diagnosed, requiring explantation of the prostheses. By the sixth week postoperatively, she experienced complete spontaneous remission of her WAIHA. In conclusion, WAIHA can be associated with systemic metallosis in patients with metal-on-metal prosthetic joint replacements. Both hematologists and orthopedic surgeons should be aware of this.

在全髋关节置换术中使用金属对金属轴承偶件会导致金属离子的释放增加,尤其是钴和铬的长期释放。这可能导致局部和全身性金属中毒,具有细胞毒性、基因毒性和免疫毒性作用,并可能引起一系列继发性疾病。我们描述了一例 37 岁女性患者的病例,她在双侧大直径头金属对金属全髋关节置换术后一年半被诊断出患有温抗体自身免疫性溶血性贫血(WAIHA)。在长达 11 年的时间里,包括脾切除术和利妥昔单抗在内的所有治疗方法均无效,需要长期口服泼尼松才能控制病情。最终确诊为全身金属化和假体周围关节感染,需要对假体进行拆卸。术后第六周,她的 WAIHA 完全自发缓解。总之,金属假体关节置换术患者的WAIHA可能与全身金属病变有关。血液科医生和骨科医生都应该意识到这一点。
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引用次数: 0
Total Knee Arthroplasty in a Patient With Neurofibromatosis 1 一名神经纤维瘤病 1 患者的全膝关节置换术
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-03 DOI: 10.1016/j.artd.2024.101453

Neurofibromatosis 1 (NF1) is a rare genetic syndrome that leads to the development of neurofibromas and increases the risk of malignancy, including malignant peripheral nerve sheath tumors. Patients with NF1 often have other orthopaedic manifestations, including short stature, osteopenia, and dysplasia. A 47-year-old patient with a history of NF1 and multiple neurofibromas of the right lower extremity presented with a severe valgus deformity, instability, and osteoarthritis of the right knee that was debilitating to daily life. Over time, the patient lost proprioception and potentially some sensation to the right knee with neurofibroma formation, leading to the development of Charcot arthropathy of the right knee with secondary osteoarthritis. The preoperative workup consisted of a magnetic resonance imaging of the knee to confirm no malignancy was present and templating to ensure the standard implant size was amenable for the patient. A primary total knee arthroplasty was performed with a cemented-stemmed hinged knee implant. At 6 months post-surgery, the patient had a dramatic improvement in her pain and quality of life.

神经纤维瘤病 1(NF1)是一种罕见的遗传综合征,会导致神经纤维瘤的发生,并增加恶性肿瘤(包括恶性周围神经鞘瘤)的风险。NF1患者通常还有其他骨科表现,包括身材矮小、骨质增生和发育不良。一名 47 岁的患者有 NF1 和右下肢多发性神经纤维瘤病史,右膝盖出现严重外翻畸形、不稳定和骨关节炎,使日常生活受到影响。随着时间的推移,神经纤维瘤的形成使患者丧失了本体感觉,右膝盖可能也失去了一些感觉,从而导致右膝盖夏科关节病并继发骨关节炎。术前检查包括膝关节磁共振成像,以确认没有恶性肿瘤,以及模板设计,以确保患者可以接受标准的植入物尺寸。手术使用了骨水泥柄铰链膝关节假体,进行了初级全膝关节置换术。术后 6 个月,患者的疼痛和生活质量得到了显著改善。
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引用次数: 0
Fracture of the Proximal Body of a Modern Cementless Modular Fluted Tapered Stem 现代无水泥模块化凹槽锥形支架近端主体骨折
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-02 DOI: 10.1016/j.artd.2024.101472

Previous reports have described failures of modular fluted tapered femoral stems secondary to fatigue failure at the modular junction. However, the present study is the first reported case of modular fluted tapered femoral component failure involving atraumatic fracture of the proximal body following revision total hip arthroplasty. The failure occurred in a 52-year-old female with a history of postmenopausal osteoporosis on bisphosphonates who sustained an atraumatic fracture of the proximal body of a modular revision femoral stem. In the present case, revision THA utilizing a wider proximal body segment with proximal augmentation using strut allografts for biological and mechanical support provided the patient with a stable construct at 30-month follow-up.

以前的报告曾描述过模块化凹槽锥形股骨柄因模块交界处的疲劳失效而导致的失败。然而,本研究是首次报道翻修全髋关节置换术后模块化凹槽锥形股骨组件失效并导致近端体创伤性骨折的病例。失败发生在一名52岁的女性患者身上,她有绝经后骨质疏松症史,并服用过双磷酸盐类药物,她的模块化翻修股骨柄近端体发生了创伤性骨折。在本病例中,翻修股骨头置换术采用了更宽的近端主体部分,并使用支柱异体移植物进行近端增高,以提供生物和机械支撑,使患者在30个月的随访中获得了稳定的结构。
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引用次数: 0
Hypoallergenic Knee Implant Usage and Clinical Outcomes: Are They Safe and Effective? 低过敏性膝关节假体的使用和临床效果:它们安全有效吗?
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-01 DOI: 10.1016/j.artd.2024.101399

Background

One of the most debated topics in modern total knee arthroplasty (TKA) is the impact of metal hypersensitivity (MH) as a potential cause of prosthesis failure. Implanting hypoallergenic prostheses to avoid potential problems in suspected cases of MH is one treatment option that can be used in such cases. However, their long-term clinical safety and efficacy are not well proven.

Methods

All literature relevant to modern hypoallergenic implants were reviewed and summarized to provide a comprehensive synopsis. In addition, a detailed literature search was performed on PUBMED, MEDLINE, and Google Scholar to identify all the clinical studies reporting outcomes for hypoallergenic knee implants. Our search was confined to those studies published as full manuscripts in the English language from July 2018 to July 2023.

Results

To minimize the risk of MH, new implant variants have been developed which are either under clinical evaluation or in routine clinical use. These include conventional metal implants with protective coatings (mono- or multilayer) and metal-free implants. However, there is insufficient clinical data to confirm the rationale and effectiveness of using these “hypoallergenic” TKA implants.

Conclusions

Published studies and arthroplasty registry data analyses indicate no significant differences between hypoallergenic and standard TKAs with overall good survival rates. In the future, further high-quality studies are needed to better understand the complexity of this subject.

背景现代全膝关节置换术(TKA)中争论最多的话题之一是金属过敏症(MH)作为假体失败潜在原因的影响。在疑似 MH 的病例中,植入低过敏性假体以避免潜在问题是一种可用于此类病例的治疗方案。方法对所有与现代低过敏性种植体相关的文献进行了回顾和总结,以提供一份全面的概要。此外,我们还在 PUBMED、MEDLINE 和 Google Scholar 上进行了详细的文献检索,以确定所有报告低过敏性膝关节植入物疗效的临床研究。我们的搜索仅限于 2018 年 7 月至 2023 年 7 月期间以英文发表的完整手稿研究。结果为了最大限度地降低 MH 风险,已经开发出了新的植入体变体,这些变体要么正在接受临床评估,要么已投入常规临床使用。其中包括带有保护涂层(单层或多层)的传统金属植入物和无金属植入物。结论已发表的研究和关节置换登记数据分析显示,低过敏性和标准 TKA 之间没有显著差异,总体存活率良好。今后需要进一步开展高质量的研究,以更好地了解这一问题的复杂性。
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引用次数: 0
Evaluation of Adult Reconstruction and Arthroplasty Fellowships in the United States Based on Academic Productivity 基于学术生产力的美国成人重建和关节成形术研究金评估
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2024-08-01 DOI: 10.1016/j.artd.2024.101475

Background

Institutional academic productivity varies on an individual level. This study aims to analyze the research output of adult reconstruction and arthroplasty fellowship programs in the United States.

Methods

The American Association of Hip and Knee Surgeons Fellowship Directory was used to evaluate 112 adult reconstruction and arthroplasty fellowships in the United States. Publication data and Hirsch index (h-index) were collected from the Scopus Database. All of each author’s total publications were analyzed with their current institution, regardless of their affiliation at the time of publication. Multivariate logistic regressions were performed to determine the effect of program size on research productivity.

Results

The total number of publications per institution ranged from 2 to 3743, with a mean of 289 and a median of 135. The h-index of individual faculty members ranged from 0 to 103, with a mean of 16 and a median of 11. The number of faculty (P < .001) and number of fellows (P = .003) per program had a significant effect on the total number of publications. The number of faculty did not have a significant effect on the median number of publications (P = .12) or the median h-index (P = .31). The number of fellows had a significant effect on the median number of publications (P < .001) and the median h-index (P < .001).

Conclusions

Academic productivity in adult reconstruction and arthroplasty fellowships within the United States varies widely, with the top few institutions responsible for a majority of the overall output.

背景机构的学术生产力因人而异。本研究旨在分析美国成人重建和关节成形术研究金项目的研究成果。方法使用美国髋关节和膝关节外科医生协会研究金目录对美国的112个成人重建和关节成形术研究金项目进行评估。从 Scopus 数据库中收集了论文发表数据和赫希指数(h-index)。对每位作者的所有论文进行了分析,不论其在发表论文时的所属机构如何,均以其目前所在的机构为准。结果每个机构的论文总数从 2 篇到 3743 篇不等,平均为 289 篇,中位数为 135 篇。每个专业的教师人数(P < .001)和研究员人数(P = .003)对论文总数有显著影响。教师人数对论文数量中位数(P = .12)或 h 指数中位数(P = .31)没有明显影响。结论美国成人重建和关节成形术研究班的学术生产力差异很大,前几名的研究机构占总产出的大部分。
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引用次数: 0
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Arthroplasty Today
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