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Reconsidering Patellofemoral Outcomes in Medially Stabilized Total Knee Arthroplasty: The Role of Implant Design and Rotational Strategy in Kinematic Alignment 重新考虑内侧稳定全膝关节置换术髌骨结果:假体设计和旋转策略在运动学对齐中的作用
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-11-03 DOI: 10.1016/j.artd.2025.101895
Chia-Hao Hsu MD
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引用次数: 0
Letter to the Editor Regarding “Utility of Frailty Index in Predicting Discharge Disposition and Prolonged Length of Stay Following Enhanced Recovery After Surgery Protocol Total Hip and Knee Arthroplasty” 致编辑的关于“虚弱指数在预测全髋关节置换术后增强恢复后出院处置和延长住院时间中的效用”的信
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-11-03 DOI: 10.1016/j.artd.2025.101893
Parth Aphale PhD, Himanshu Shekhar BHMS, Shashank Dokania BHMS
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引用次数: 0
Effect of Anatomic Joint-Line Obliquity Prostheses on Coronal Plane Alignment of the Knee Alignment in a Chinese Population 解剖关节线倾斜假体对中国人群膝关节对齐冠状面对齐的影响
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-11-02 DOI: 10.1016/j.artd.2025.101888
Poon Jerome Chi Wang MBBS, HKU, Qunn-jid Lee MB-ChB, CUHK, Kenneth Wing-kin Law MB-ChB, CUHK, Daniel Wai-yip Wong MBBS, HKU, Cho Pong Lo MB-ChB, CUHK

Background

The Coronal Plane Alignment of the Knee (CPAK) classification describes knee phenotypes based on limb alignment and joint-line obliquity (JLO). This study evaluates CPAK distribution in the Hong Kong population and assesses how prosthesis design affects CPAK reproducibility and clinical outcomes.

Methods

This retrospective study included patients who underwent navigated total knee arthroplasty (TKA) with adjusted mechanical alignment in a single institution in 2021. First, we analyzed the epidemiology of CPAK phenotypes in our population. Second, patients were divided into 2 propensity score-matched groups based on implant design: Journey II BCS TKA (JLO prothesis) vs Persona PS TKA (joint line neutral prothesis). Radiological outcomes (mechanical hip–knee–ankle angle, lateral distal femoral angle, medial proximal tibial angle) and clinical outcomes (range of motion, Knee Society Knee Score, Western Ontario and McMaster Universities Osteoarthritis Index score, Forgotten Joint Score) assessed preoperatively and at 6 and 12 months postoperatively.

Results

Our CPAK distribution was comparable to that of other East Asian populations. The Journey II BCS TKA more effectively restored JLO and CPAK phenotypes compared to the Persona PS TKA. However, there was no statistically significant clinical correlation between the restoration of JLO, arithmetic HKA, and CPAK.

Conclusions

Although radiological restoration improves with JLO prostheses, short-term clinical outcomes remain unaffected.
膝关节冠状面对齐(CPAK)分类描述了基于肢体对齐和关节线倾角(JLO)的膝关节表型。本研究评估了CPAK在香港人群中的分布,并评估了假体设计如何影响CPAK的可重复性和临床结果。方法:本回顾性研究纳入了2021年在单一机构接受导航式全膝关节置换术(TKA)的患者。首先,我们分析了我国人群中CPAK表型的流行病学。其次,根据种植体设计将患者分为2个倾向评分匹配组:Journey II BCS TKA (JLO假体)和Persona PS TKA(关节线中性假体)。术前和术后6个月和12个月评估放射学结果(机械髋关节-膝关节-踝关节角、股骨外侧远端角、胫骨内侧近端角)和临床结果(活动范围、膝关节学会评分、西安大略和麦克马斯特大学骨关节炎指数评分、遗忘关节评分)。结果我们的CPAK分布与其他东亚人群相似。与Persona PS TKA相比,Journey II BCS TKA更有效地恢复了JLO和CPAK表型。然而,JLO的恢复、算数HKA和CPAK之间没有统计学意义的临床相关性。结论JLO假体虽能改善放射学修复,但短期临床效果不受影响。
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引用次数: 0
Femoral Nerve Palsy After Anterior Total Hip Arthroplasty: A Systematic Review 前路全髋关节置换术后股神经麻痹:系统回顾
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-31 DOI: 10.1016/j.artd.2025.101889
Mallery Zeiman BS, Athena Makrides, Jason Lee DO, Richard S. Yoon MD

Background

Femoral nerve palsy (FNP) is a rare but debilitating complication of total hip arthroplasty (THA). The direct anterior approach (DAA) has been gaining popularity in recent years. Concerns regarding the risk of FNP after DAA THA have been rising due to the anatomical proximity of the femoral nerve. This systematic review evaluates the risk and incidence of FNP after DAA THA.

Methods

A search was conducted using PubMed, Cochrane, Ovid Medline, and Scopus databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Data were extracted pertaining to incidence, comparison to other approaches and recovery. A qualitative analysis was done.

Results

Our study included 9 studies—1 randomized control trial, 3 retrospective reviews, 4 case series, and 1 case report. The total sample size of DAA THA patients was 16,258 with an incidence of 0.36% (95% confidence interval (CI), 0.28-0.47%). The 3 studies that compared DAA to other approaches reported a higher incidence of FNP with the DAA. Of the studies that included recovery, most cases of FNP demonstrated full motor recovery in 3-15 months.

Conclusions

FNP is a rare complication of THA that occurs more frequently in the DAA. Retractor placement, patient positioning, and patient related risk factors play a key role in increasing risk. Further high quality studies are needed to assess the risk and preventative measures.

Level of Evidence

V.
背景:股神经麻痹(FNP)是全髋关节置换术(THA)中一种罕见但使人衰弱的并发症。直接前路入路(DAA)近年来越来越受欢迎。由于解剖上接近股神经,对DAA THA术后FNP风险的担忧一直在上升。本系统综述评估DAA THA术后FNP的风险和发生率。方法使用PubMed、Cochrane、Ovid Medline和Scopus数据库进行检索。遵循系统评价和荟萃分析指南的首选报告项目。提取有关发病率、与其他方法的比较和恢复的数据。进行了定性分析。结果共纳入9项研究,1项随机对照试验,3项回顾性分析,4项病例系列,1例病例报告。DAA THA患者的总样本量为16,258例,发生率为0.36%(95%可信区间(CI), 0.28-0.47%)。将DAA与其他方法进行比较的3项研究报告了DAA的FNP发生率更高。在包括恢复的研究中,大多数FNP病例在3-15个月内表现出完全的运动恢复。结论sfnp是THA的罕见并发症,多见于DAA。牵开器放置、患者体位和患者相关的危险因素在增加风险中起关键作用。需要进一步的高质量研究来评估风险和预防措施。证据水平
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引用次数: 0
The Routine Use of Femoral Heads Sized 40 mm or Greater in Primary Total Hip Arthroplasty: A Review of Current Practice 在初次全髋关节置换术中常规使用40毫米或更大的股骨头:当前实践的回顾
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-29 DOI: 10.1016/j.artd.2025.101887
Martin S. Davey MCh, MRCS, MD , Peter K. Sculco MD
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引用次数: 0
Evaluating the Impact of a Preoperative Risk Management Program on Outcomes Following Total Joint Arthroplasty: A Retrospective Cohort Study 评估术前风险管理程序对全关节置换术后预后的影响:一项回顾性队列研究
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-27 DOI: 10.1016/j.artd.2025.101880
Chloe Dlott MD , Sebastian Romero BS , Claire A. Donnelley MD , Stephanie Kaszuba MD , Daniel Wiznia MD

Background

Total joint arthroplasty is an effective intervention for end-stage joint disease, but carries elevated risks for patients with comorbidities and those from historically marginalized populations. Preoperative risk management programs are designed to mitigate these risks by optimizing patient health prior to surgery. This study evaluated the impact of such a program on postoperative outcomes at a single academic institution, with attention to racial and ethnic minorities and patients with public insurance.

Methods

We conducted a retrospective cohort study of 2748 patients who underwent total hip or knee arthroplasty between 2019 and 2021 at a single academic institution. Of these, 1548 patients received preoperative optimization targeting modifiable risk factors such as diabetes, obesity, and anemia, while 1200 followed standard preoperative protocols. Outcomes assessed included length of stay, prosthetic joint infection, 30- and 90-day readmissions, and emergency department (ED) visits. Patients were stratified by race/ethnicity, insurance type, and American Society of Anesthesiology physical classification.

Results

The optimized cohort had a higher average Charlson Comorbidity Index (1.1 vs 0.9; P = .01). There were no significant differences between groups in length of stay, readmissions, or overall ED visit rates. Black patients experienced higher ED utilization within 90 days postoperatively, regardless of optimization status. Medicaid patients with severe systemic disease had the highest rates of prosthetic joint infection (3.8%), and optimization was not associated with improved outcomes in this group. Patients with American Society of Anesthesiology physical classification ≥3 had increased ED visits postoperatively despite optimization.

Conclusions

Preoperative risk management did not consistently improve outcomes, particularly among patients with greater comorbidity burdens or those facing socioeconomic disadvantage. These findings support the need for tailored optimization strategies that address both clinical risk and social determinants of health.
背景:全关节置换术是治疗终末期关节疾病的有效干预手段,但对于有合并症的患者和历史上处于边缘地位的人群,风险较高。术前风险管理程序旨在通过在手术前优化患者健康来减轻这些风险。本研究在单一学术机构评估了此类项目对术后结果的影响,并关注了种族和少数民族以及有公共保险的患者。方法:我们对2019年至2021年在单一学术机构接受全髋关节或膝关节置换术的2748例患者进行了回顾性队列研究。其中,1548例患者接受了针对糖尿病、肥胖和贫血等可改变危险因素的术前优化,1200例患者遵循标准术前方案。评估的结果包括住院时间、假体关节感染、30天和90天再入院以及急诊(ED)就诊。患者按种族/民族、保险类型和美国麻醉学会物理分类进行分层。结果优化后的队列平均Charlson合并症指数较高(1.1 vs 0.9; P = 0.01)。两组患者在住院时间、再入院率或总体急诊科就诊率方面没有显著差异。无论优化状态如何,黑人患者在术后90天内ED使用率较高。患有严重全身性疾病的医疗补助患者的假体关节感染率最高(3.8%),优化与该组预后改善无关。尽管进行了优化,但美国麻醉学会物理分类≥3的患者术后急诊次数增加。结论:术前风险管理并不能持续改善预后,特别是在合并症负担更重或面临社会经济劣势的患者中。这些发现支持需要量身定制的优化策略,以解决临床风险和健康的社会决定因素。
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引用次数: 0
Utilization of Jumbo-Sized Cups in Conjunction With Dual-Mobility Constructs Does Not Increase Risk of Re-Revision in Revision Hip Arthroplasty 在翻修髋关节置换术中,使用超大杯和双活动装置不会增加再次翻修的风险
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-23 DOI: 10.1016/j.artd.2025.101879
Ramesh B. Ghanta MD, Jeffrey Barry MD, Jeffrey Kwong MD, Hunter Warwick MD, Erik Hansen MD, Claudio Diaz-Ledezma MD

Background

Dual-mobility (DM) articulations are increasingly used in revision total hip arthroplasty (THA) to reduce instability, but their effectiveness in conjunction with jumbo cups is unclear. This study evaluated the risk of all-cause and instability-related re-revision when DM articulations were used with jumbo vs standard cups in revision THA.

Methods

A retrospective review included 199 revision THA patients with DM articulations: 156 with regular cups and 43 with jumbo cups (≥62 mm for females, ≥66 mm for males). Exclusion criteria were cup-cage constructs, cemented DM liners in pre-existing cups, and tumor cases. The primary outcome was re-revision, with focus on instability. Student's t-test compared revision rates, and multivariable logistic regression with backward selection was used to assess the relationship between cup size and re-revision risk.

Results

At a mean 4.6-year follow-up, re-revision rates were similar between groups (10.3% regular vs 11.6% jumbo, P = .79). Instability-related re-revisions were also comparable (5.1% regular vs 7% jumbo; P = .64). Logistic regression demonstrated that jumbo cup utilization was not associated with risk of all-cause revision (P = .99) or instability-related re-revision (P = .77). However, the number of prior surgeries increased risk for both all-cause (OR: 1.32 [1.07, 1.63], P = .009) and instability-related (OR: 1.46 [1.13, 1.87], P = .003) re-revisions.

Conclusions

Our results demonstrate satisfactory midterm outcomes in both jumbo and regular cup patients implanted with DM systems. These findings demonstrate that the use of DM liners in jumbo cups does not portend increased risk of re-revision compared to use of DM in regular sized cups.
背景双活动关节(DM)越来越多地用于翻修全髋关节置换术(THA)以减少不稳定性,但其与大杯联合使用的有效性尚不清楚。本研究评估了DM关节在翻修THA中使用大杯与标准杯时的全因和不稳定性相关的重新翻修风险。方法回顾性分析199例DM关节翻修THA患者:常规杯156例,特大杯43例(女性≥62 mm,男性≥66 mm)。排除标准是杯笼结构、预先存在的杯中胶结DM衬垫和肿瘤病例。主要结局是重新修订,重点是不稳定性。学生t检验比较复习率,多变量logistic回归与逆向选择评估罩杯大小与复习风险的关系。结果平均随访4.6年,两组患者的再修订率相似(普通组10.3% vs大组11.6%,P = 0.79)。与不稳定性相关的再修订也具有可比性(5.1%常规vs 7%巨型;P = 0.64)。逻辑回归表明,大杯的使用与全因修正(P = 0.99)或不稳定性相关的再修正(P = 0.77)的风险无关。然而,既往手术次数增加了全因(OR: 1.32 [1.07, 1.63], P = 0.009)和不稳定相关(OR: 1.46 [1.13, 1.87], P = 0.003)再次翻修的风险。结论大杯和普通杯患者植入DM系统的中期结果均令人满意。这些发现表明,在大杯中使用DM衬垫与在常规杯中使用DM衬垫相比,并不预示着再次翻修的风险增加。
{"title":"Utilization of Jumbo-Sized Cups in Conjunction With Dual-Mobility Constructs Does Not Increase Risk of Re-Revision in Revision Hip Arthroplasty","authors":"Ramesh B. Ghanta MD,&nbsp;Jeffrey Barry MD,&nbsp;Jeffrey Kwong MD,&nbsp;Hunter Warwick MD,&nbsp;Erik Hansen MD,&nbsp;Claudio Diaz-Ledezma MD","doi":"10.1016/j.artd.2025.101879","DOIUrl":"10.1016/j.artd.2025.101879","url":null,"abstract":"<div><h3>Background</h3><div>Dual-mobility (DM) articulations are increasingly used in revision total hip arthroplasty (THA) to reduce instability, but their effectiveness in conjunction with jumbo cups is unclear. This study evaluated the risk of all-cause and instability-related re-revision when DM articulations were used with jumbo vs standard cups in revision THA.</div></div><div><h3>Methods</h3><div>A retrospective review included 199 revision THA patients with DM articulations: 156 with regular cups and 43 with jumbo cups (≥62 mm for females, ≥66 mm for males). Exclusion criteria were cup-cage constructs, cemented DM liners in pre-existing cups, and tumor cases. The primary outcome was re-revision, with focus on instability. Student's <em>t</em>-test compared revision rates, and multivariable logistic regression with backward selection was used to assess the relationship between cup size and re-revision risk.</div></div><div><h3>Results</h3><div>At a mean 4.6-year follow-up, re-revision rates were similar between groups (10.3% regular vs 11.6% jumbo, <em>P</em> = .79). Instability-related re-revisions were also comparable (5.1% regular vs 7% jumbo; <em>P</em> = .64). Logistic regression demonstrated that jumbo cup utilization was not associated with risk of all-cause revision (<em>P</em> = .99) or instability-related re-revision (<em>P</em> = .77). However, the number of prior surgeries increased risk for both all-cause (OR: 1.32 [1.07, 1.63], <em>P</em> = .009) and instability-related (OR: 1.46 [1.13, 1.87], <em>P</em> = .003) re-revisions.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate satisfactory midterm outcomes in both jumbo and regular cup patients implanted with DM systems. These findings demonstrate that the use of DM liners in jumbo cups does not portend increased risk of re-revision compared to use of DM in regular sized cups.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101879"},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis and Accuracy of Surgeon- and Prosthesis Manufacturer–Generated Radiographic Templates in Total Hip Arthroplasty 全髋关节置换术中外科医生和假体制造商生成的x线片模板的比较分析和准确性
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-23 DOI: 10.1016/j.artd.2025.101881
Brandon K. Couch MD, Allyson N. Pfeil BS, Corey F. Hryc PhD, Robin Goytia MD, Vasilios Mathews MD

Background

Preoperative templating in total hip arthroplasty (THA) improves surgical accuracy and predictability. Recently, prosthesis manufacturers (PMs) have introduced industry-generated templating systems, but their accuracy compared to surgeon-generated templates has yet to be evaluated.

Methods

A retrospective review was conducted on THAs performed by 2 surgeons between October 2023 and September 2024. Surgeon-generated and PM-generated templates were compared to actual implanted components. Accuracy of acetabular and femoral component sizing, as well as femoral offset prediction, was assessed using χ2 analysis (P < .05). Subgroup analyses examined the influence of patient sex and body mass index on accuracy.

Results

A total of 306 surgeon templates and 240 PM templates were analyzed. Surgeons correctly predicted acetabular and femoral component sizes in 45.1% and 28.4% of cases, respectively, while PM templates achieved 33.8% and 35.0%. No significant difference was found between groups in component size accuracy (acetabular: P = .09; femoral: P = .08). However, surgeons demonstrated significantly greater accuracy in offset prediction (83.7% vs 73.3%, P = .003). Additionally, surgeon-generated femoral component accuracy was significantly associated with patient body mass index (P < .001).

Conclusions

PM templating demonstrated a reasonable ability to predict implant sizes in THA, with comparable performance to high-volume, fellowship-trained arthroplasty surgeons. While surgeon-generated templates outperformed PM templates in offset prediction, these findings suggest that industry-generated templates could be a valuable tool for surgical planning and inventory management in hospitals.
背景全髋关节置换术(THA)的术前模板可提高手术的准确性和可预测性。最近,假体制造商(pm)已经引入了工业生成的模板系统,但与外科医生生成的模板相比,它们的准确性尚未得到评估。方法回顾性分析2023年10月至2024年9月间2例外科医生行tha手术的资料。将外科医生生成的和pm生成的模板与实际植入的组件进行比较。采用χ2分析评估髋臼和股骨假体尺寸以及股骨偏移预测的准确性(P < 0.05)。亚组分析检验了患者性别和体重指数对准确性的影响。结果共分析外科医生模板306份,PM模板240份。外科医生正确预测髋臼和股骨假体大小的比例分别为45.1%和28.4%,而PM模板分别为33.8%和35.0%。各组间假体尺寸准确性无显著差异(髋臼:P = 0.09;股骨:P = 0.08)。然而,外科医生在偏移预测方面的准确性明显更高(83.7% vs 73.3%, P = 0.003)。此外,手术生成的股骨成分准确性与患者体重指数显著相关(P < .001)。结论spm模板在THA中具有合理的预测假体大小的能力,其性能可与大容量、培训过的关节置换外科医生相媲美。虽然外科医生生成的模板在偏移量预测方面优于PM模板,但这些发现表明,行业生成的模板可能是医院手术计划和库存管理的有价值的工具。
{"title":"Comparative Analysis and Accuracy of Surgeon- and Prosthesis Manufacturer–Generated Radiographic Templates in Total Hip Arthroplasty","authors":"Brandon K. Couch MD,&nbsp;Allyson N. Pfeil BS,&nbsp;Corey F. Hryc PhD,&nbsp;Robin Goytia MD,&nbsp;Vasilios Mathews MD","doi":"10.1016/j.artd.2025.101881","DOIUrl":"10.1016/j.artd.2025.101881","url":null,"abstract":"<div><h3>Background</h3><div>Preoperative templating in total hip arthroplasty (THA) improves surgical accuracy and predictability. Recently, prosthesis manufacturers (PMs) have introduced industry-generated templating systems, but their accuracy compared to surgeon-generated templates has yet to be evaluated.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted on THAs performed by 2 surgeons between October 2023 and September 2024. Surgeon-generated and PM-generated templates were compared to actual implanted components. Accuracy of acetabular and femoral component sizing, as well as femoral offset prediction, was assessed using χ<sup>2</sup> analysis (<em>P</em> &lt; .05). Subgroup analyses examined the influence of patient sex and body mass index on accuracy.</div></div><div><h3>Results</h3><div>A total of 306 surgeon templates and 240 PM templates were analyzed. Surgeons correctly predicted acetabular and femoral component sizes in 45.1% and 28.4% of cases, respectively, while PM templates achieved 33.8% and 35.0%. No significant difference was found between groups in component size accuracy (acetabular: <em>P</em> = .09; femoral: <em>P</em> = .08). However, surgeons demonstrated significantly greater accuracy in offset prediction (83.7% vs 73.3%, <em>P</em> = .003). Additionally, surgeon-generated femoral component accuracy was significantly associated with patient body mass index (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>PM templating demonstrated a reasonable ability to predict implant sizes in THA, with comparable performance to high-volume, fellowship-trained arthroplasty surgeons. While surgeon-generated templates outperformed PM templates in offset prediction, these findings suggest that industry-generated templates could be a valuable tool for surgical planning and inventory management in hospitals.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101881"},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes After Definitive Knee Resection Arthroplasty for Recurrent Periprosthetic Joint Infection 膝关节置换术治疗复发性假体周围关节感染的疗效
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-23 DOI: 10.1016/j.artd.2025.101883
Kiran Kittur BS , Josue G. Layuno-Matos Ba , Matthew Nester BS , Connor C. Diaz MD , Michael Miranda DO , Thomas Bernasek MD

Background

Knee resection arthroplasty (KRA) is performed as definitive treatment for recurrent periprosthetic joint infection (PJI). This study aims to evaluate infection eradication and functional outcomes following KRA as a definitive treatment of PJI.

Methods

We reviewed all KRAs performed between 2002 and 2022. We identified 28 knees (27 patients) treated with definitive KRA for recurrent PJI. Primary outcomes included infection eradication, ambulatory status, and ambulatory aid use. Failure to eradicate infection was defined as any reoperation for infection. Ambulation was defined as any level of weight-bearing mobility using assistive devices, such as a walker.

Results

The mean age at KRA was 72 years and average follow-up was 22 months. Patients had on average 3 knee operations prior to KRA. Of the 28 infections, 79% were eradicated by KRA. Of the remaining 6 persistently infected knees, 4 required an average of 4 irrigation and debridement to eventually control infection, resulting in 93% of infections eradicated overall. At latest visit, 33% of patients were on chronic antibiotic suppression. A total of 67% of patients could ambulate. Most patients (85%) required knee–ankle–foot orthoses for instability. Subsequent knee fusion was chosen by 3 patients. A patient with bilateral KRAs died within 90 days of surgery. The overall reoperation rate for KRA patients was 29%, and the overall mortality rate was 15%.

Conclusions

Definitive treatment with KRA demonstrated effectiveness in eradicating infection, although with moderate rate of reoperation. Postoperatively, most patients could ambulate with assistive devices. The KRA is an effective alternative for knee salvage when managing chronic, recalcitrant PJI.

Level of evidence

IV, case series.
背景:膝关节切除术(KRA)是复发性假体周围关节感染(PJI)的最终治疗方法。本研究旨在评估KRA作为PJI的最终治疗后的感染根除和功能结果。方法回顾2002年至2022年间所有KRAs。我们确定了28个膝关节(27例患者)接受了复发性PJI的明确KRA治疗。主要结局包括感染根除、门诊状态和门诊辅助使用情况。未能根除感染被定义为任何感染的再手术。步行被定义为使用辅助设备(如助行器)进行任何程度的负重活动。结果患者平均年龄72岁,平均随访22个月。患者在KRA之前平均有3次膝关节手术。在28例感染中,KRA根除了79%。在其余6例持续感染的膝关节中,4例平均需要4次冲洗和清创才能最终控制感染,导致93%的感染总体根除。最近一次就诊时,33%的患者正在接受慢性抗生素抑制治疗。67%的患者可以走动。大多数患者(85%)因不稳定需要使用膝-踝-足矫形器。3例患者选择后续膝关节融合术。一例双侧KRAs患者在手术后90天内死亡。KRA患者总再手术率为29%,总死亡率为15%。结论虽然再手术率适中,但KRA的最终治疗可有效根除感染。术后,大多数患者可以借助辅助装置行走。当治疗慢性顽固性PJI时,KRA是一种有效的膝关节修复方法。证据等级iv,案例系列。
{"title":"Outcomes After Definitive Knee Resection Arthroplasty for Recurrent Periprosthetic Joint Infection","authors":"Kiran Kittur BS ,&nbsp;Josue G. Layuno-Matos Ba ,&nbsp;Matthew Nester BS ,&nbsp;Connor C. Diaz MD ,&nbsp;Michael Miranda DO ,&nbsp;Thomas Bernasek MD","doi":"10.1016/j.artd.2025.101883","DOIUrl":"10.1016/j.artd.2025.101883","url":null,"abstract":"<div><h3>Background</h3><div>Knee resection arthroplasty (KRA) is performed as definitive treatment for recurrent periprosthetic joint infection (PJI). This study aims to evaluate infection eradication and functional outcomes following KRA as a definitive treatment of PJI.</div></div><div><h3>Methods</h3><div>We reviewed all KRAs performed between 2002 and 2022. We identified 28 knees (27 patients) treated with definitive KRA for recurrent PJI. Primary outcomes included infection eradication, ambulatory status, and ambulatory aid use. Failure to eradicate infection was defined as any reoperation for infection. Ambulation was defined as any level of weight-bearing mobility using assistive devices, such as a walker.</div></div><div><h3>Results</h3><div>The mean age at KRA was 72 years and average follow-up was 22 months. Patients had on average 3 knee operations prior to KRA. Of the 28 infections, 79% were eradicated by KRA. Of the remaining 6 persistently infected knees, 4 required an average of 4 irrigation and debridement to eventually control infection, resulting in 93% of infections eradicated overall. At latest visit, 33% of patients were on chronic antibiotic suppression. A total of 67% of patients could ambulate. Most patients (85%) required knee–ankle–foot orthoses for instability. Subsequent knee fusion was chosen by 3 patients. A patient with bilateral KRAs died within 90 days of surgery. The overall reoperation rate for KRA patients was 29%, and the overall mortality rate was 15%.</div></div><div><h3>Conclusions</h3><div>Definitive treatment with KRA demonstrated effectiveness in eradicating infection, although with moderate rate of reoperation. Postoperatively, most patients could ambulate with assistive devices. The KRA is an effective alternative for knee salvage when managing chronic, recalcitrant PJI.</div></div><div><h3>Level of evidence</h3><div>IV, case series.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101883"},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraosseous Vancomycin in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis 万古霉素在全膝关节置换术中的应用:一项系统综述和荟萃分析
IF 2.1 Q3 ORTHOPEDICS Pub Date : 2025-10-22 DOI: 10.1016/j.artd.2025.101878
Troy B. Puga DO , Vincent Dieu MS , Kyle P. O’Connor MD , Logan Tackett BS , McKenna W. Box MD , John T. Riehl MD

Background

Prosthetic joint infections (PJIs) are a major concern in total knee arthroplasty (TKA). One recent measure of interest has been the use of intraosseous vancomycin (IOV). This systematic review aims to evaluate the efficacy of IOV to prevent infection in TKA.

Methods

A search was conducted across MEDLINE/Pubmed, Wiley Central, Google Scholar, Web of Science, and Embase databases. Demographics and results of the studies were extracted from the articles that met inclusion criteria. Meta-analysis was conducted on primary TKA studies.

Results

Eight studies were included in this systematic review. IOV correlated with decreased odds of infection in primary TKA (odds ratio: 0.31, P = .02) when compared with controls of intravenous antibiotic and no regional IOV. IOV showed no increase in AKI or creatinine concentration in primary TKA when compared with controls. IOV and increased concentration of vancomycin in fat and subcutaneous tissues had a strong correlation (Cohen’s d = 0.9, P = .01). IOV and increased concentration of vancomycin in bone had a moderate correlation (Cohen’s d = 0.59, P = .01). No patients where IOV was used across all studies developed Red Man Syndrome.

Conclusions

IOV is an effective adjunctive treatment for preventing infection in primary TKA, with this study showing a 69% decreased odds of infection when compared with controls of intravenous antibiotic and no regional IOV. IOV also appears to be a safe treatment, and with limited data there seems to not be an increase in AKI or creatinine concentration.

Level of Evidence

Level IV; Therapeutic.
假体关节感染(PJIs)是全膝关节置换术(TKA)中的主要问题。最近的一项措施是使用骨内万古霉素(IOV)。本系统综述旨在评价IOV预防TKA感染的疗效。方法检索MEDLINE/Pubmed、Wiley Central、谷歌Scholar、Web of Science和Embase数据库。从符合纳入标准的文章中提取研究的人口统计学和结果。对主要TKA研究进行meta分析。结果本系统综述纳入8项研究。与静脉注射抗生素和无局部静脉注射的对照组相比,静脉注射与原发性TKA感染几率降低相关(优势比:0.31,P = 0.02)。与对照组相比,IOV未显示原发性TKA患者AKI或肌酐浓度增加。IOV与万古霉素在脂肪和皮下组织中的浓度升高有很强的相关性(Cohen’s d = 0.9, P = 0.01)。骨内万古霉素浓度升高与IOV有中等相关性(Cohen’s d = 0.59, P = 0.01)。在所有研究中使用IOV的患者均未出现红人综合征。结论siv是预防原发性TKA感染的有效辅助治疗方法,本研究显示,与静脉注射抗生素和不注射局部IOV的对照组相比,siv可使TKA感染的几率降低69%。IOV似乎也是一种安全的治疗方法,根据有限的数据,似乎没有AKI或肌酐浓度的增加。证据等级:IV级;治疗。
{"title":"Intraosseous Vancomycin in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis","authors":"Troy B. Puga DO ,&nbsp;Vincent Dieu MS ,&nbsp;Kyle P. O’Connor MD ,&nbsp;Logan Tackett BS ,&nbsp;McKenna W. Box MD ,&nbsp;John T. Riehl MD","doi":"10.1016/j.artd.2025.101878","DOIUrl":"10.1016/j.artd.2025.101878","url":null,"abstract":"<div><h3>Background</h3><div>Prosthetic joint infections (PJIs) are a major concern in total knee arthroplasty (TKA). One recent measure of interest has been the use of intraosseous vancomycin (IOV). This systematic review aims to evaluate the efficacy of IOV to prevent infection in TKA.</div></div><div><h3>Methods</h3><div>A search was conducted across MEDLINE/Pubmed, Wiley Central, Google Scholar, Web of Science, and Embase databases. Demographics and results of the studies were extracted from the articles that met inclusion criteria. Meta-analysis was conducted on primary TKA studies.</div></div><div><h3>Results</h3><div>Eight studies were included in this systematic review. IOV correlated with decreased odds of infection in primary TKA (odds ratio: 0.31, <em>P</em> = .02) when compared with controls of intravenous antibiotic and no regional IOV. IOV showed no increase in AKI or creatinine concentration in primary TKA when compared with controls. IOV and increased concentration of vancomycin in fat and subcutaneous tissues had a strong correlation (Cohen’s d = 0.9, <em>P</em> = .01). IOV and increased concentration of vancomycin in bone had a moderate correlation (Cohen’s d = 0.59, <em>P</em> = .01). No patients where IOV was used across all studies developed Red Man Syndrome.</div></div><div><h3>Conclusions</h3><div>IOV is an effective adjunctive treatment for preventing infection in primary TKA, with this study showing a 69% decreased odds of infection when compared with controls of intravenous antibiotic and no regional IOV. IOV also appears to be a safe treatment, and with limited data there seems to not be an increase in AKI or creatinine concentration.</div></div><div><h3>Level of Evidence</h3><div>Level IV; Therapeutic.</div></div>","PeriodicalId":37940,"journal":{"name":"Arthroplasty Today","volume":"36 ","pages":"Article 101878"},"PeriodicalIF":2.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Arthroplasty Today
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