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Social Networks, Community Engagement, and Cognitive Impairment among Community-Dwelling Chinese Older Adults 中国社区居住老年人的社会网络、社区参与与认知障碍
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-09-10 DOI: 10.1159/000502090
Jinlei Li, Zijuan Wang, Z. Lian, Zhikai Zhu, Yuanli Liu
Aims: To examine the association of social networks and community engagement with cognitive impairment among community-dwelling Chinese older adults. Methods: From November 2017 to May 2018, we selected 1,115 elderly individuals from 3 Chinese communities (Beijing, Hefei, and Lanzhou) using a random-cluster sampling method, and recorded data on demographics, social network characteristics, community activities, and cognitive function. The odds ratios (ORs) of these associations were adjusted for potential confounders in logistic regression models. Results: The prevalence of cognitive impairment was 25.7% (n = 287). An adequate social network (OR 0.55; 95% confidence interval [CI] 0.33–0.91) and enough social support from friends (OR 0.43; 95% CI 0.29–0.62) were negatively associated with cognitive impairment. Family support was not significantly associated with cognitive impairment (OR 0.64; 95% CI 0.34–1.21). Taking part in elderly group travel, communication with others using WeChat, and community activities such as Tai Chi and walking together were negatively associated with cognitive impairment. Conclusion: Social network characteristics and community engagement were found to be related to cognitive function among community-dwelling Chinese elderly adults.
目的:探讨社区居住的中国老年人的社会网络和社区参与与认知障碍的关系。方法:2017年11月至2018年5月,采用随机整群抽样方法,从北京、合肥和兰州3个华人社区抽取1115名老年人,记录人口统计学、社会网络特征、社区活动和认知功能等数据。在逻辑回归模型中对这些关联的比值比(ORs)进行了校正,以排除潜在的混杂因素。结果:认知功能障碍患病率为25.7% (n = 287)。充足的社交网络(OR 0.55;95%可信区间[CI] 0.33-0.91)和来自朋友的足够的社会支持(OR 0.43;95% CI 0.29-0.62)与认知障碍呈负相关。家庭支持与认知障碍无显著相关性(OR 0.64;95% ci 0.34-1.21)。参加老年人团体旅游、使用b微信与他人交流、以及太极和一起散步等社区活动与认知障碍呈负相关。结论:社会网络特征和社区参与与社区居住老年人的认知功能有关。
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引用次数: 10
Psychometric Properties of the Czech Version of the Falls Efficacy Scale-International in Patients with Early-Stage Dementia 国际瀑布疗效量表捷克版对早期痴呆患者的心理测量特性
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-08-29 DOI: 10.1159/000501676
Helena Kisvetrová, D. Školoudík, R. Herzig, K. Langová, Petra Kurková, J. Tomanová, Yukari Yamada
Introduction: A fear of falling marks an important psychological factor connected with a reduction in the life space of people with dementia. The Czech version of the Falls Efficacy Scale-International (FES-I) has not been validated in patients with early-stage dementia. Methods: The tests were administered to 282 patients with early-stage dementia. The test battery included the following: the FES-I, the Short Physical Performance Battery, the Geriatric Depression Scale, the Bristol Activity Daily Living Scale, and the Quality of Life-Alzheimer’s Disease Scale. Internal reliability (Cronbach’s α and intraclass correlation [ICC]), Pearson’s and Spearman’s correlations, exploratory factor analysis, and a t test for independent samples were used for statistical analyses. Results: The Czech version of the FES-I had excellent internal and test-retest reliability (Cronbach’s α = 0.98, ICC = 0.90; 95% CI 0.82–0.94). Factor analysis suggested 2 relevant factors. A significantly higher FES-I score was associated with patients with early-stage dementia who were older (p = 0.003) or female (p = 0.001), lived alone (p = 0.0001), spent >8 h a day alone (p = 0.032), used mobility aids (p < 0.0001), or had severe hearing (p = 0.004) or vision impairment (p < 0.0001) or a lower education (r = –0.16, p = 0.007). Conclusion: The Czech version of the FES-I had very good reliability and validity and may be useful in future cross-cultural comparisons in research among patients with early-stage dementia.
引言:对跌倒的恐惧是一个重要的心理因素,与痴呆症患者生活空间的减少有关。捷克版的国际瀑布疗效量表(FES-I)尚未在早期痴呆患者中得到验证。方法:对282例早期痴呆患者进行测试。测试组包括以下内容:FES-I、短期体能测试组、老年抑郁症量表、布里斯托尔日常生活活动量表和阿尔茨海默病生活质量量表。内部可靠性(Cronbachα和组内相关性[ICC])、Pearson和Spearman相关性、探索性因素分析和独立样本的t检验用于统计分析。结果:捷克版FES-I具有良好的内部和重测可靠性(Cronbachα=0.98,ICC=0.90;95%CI 0.82–0.94)。因子分析表明有2个相关因素。早期痴呆患者年龄较大(p=0.003)或女性(p=0.001)、独自生活(p=0.0001)、每天独自生活时间>8小时(p=0.032)、使用助行器(p<0.0001)、,或有严重听力(p=0.004)或视力障碍(p<0.0001)或受教育程度较低(r=-0.16,p=0.007)。结论:捷克版本的FES-I具有很好的可靠性和有效性,可能有助于未来对早期痴呆患者进行跨文化比较研究。
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引用次数: 7
Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan 轻度至中度阿尔茨海默病患者从口服胆碱酯酶抑制剂转为利匹的明透皮贴剂1步滴定的疗效、安全性和耐受性:一项在日本进行的24周开放标签多中心研究
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-08-15 DOI: 10.1159/000501364
Kengo Ueda, S. Katayama, T. Arai, Nobuo Furuta, S. Ikebe, Y. Ishida, K. Kanaya, S. Ouma, H. Sakurai, M. Sugitani, Makio Takahashi, Toshihisa Tanaka, N. Tsuno, Y. Wakutani, Ankita Shekhawat, Ayan Das Gupta, Kazuki Kiyose, Kazuhiro Toriyama, Yu Nakamura
Background: Few studies have investigated treatment options for patients with Alzheimer’s disease (AD) showing a poor response to oral cholinesterase inhibitors (ChEIs) in Japan. Objective: To investigate the efficacy and safety of switching from oral ChEIs to rivastigmine transdermal patch in patients with AD. Methods: In this multicenter, open-label, phase IV study in outpatient clinics in Japan, patients with mild-moderate AD who had a poor response to or experienced difficulty in continuing donepezil or galantamine were switched to rivastigmine transdermal patch (5 cm2; loaded dose 9 mg, delivery rate 4.6 mg/24 h) with a 1-step titration in week 4 (10 cm2; loaded dose 18 mg, delivery rate 9.5 mg/24 h), which was continued for 4 weeks in the titration period and 16 weeks in a maintenance period. The primary endpoint was the change in Mini-Mental State Examination (MMSE) total score from baseline to week 24. Results: A total of 118 patients were enrolled and switched to rivastigmine, of which 102 completed the 24-week study. The MMSE total score was essentially unchanged during the study, with a least-square mean change (SD) of −0.35 (2.64) at week 24 (p = 0.1750). Exploratory analysis with a mixed-effect model comparing changes in MMSE between the pre- and post-switch periods suggested that switching to rivastigmine prevented a worsening of MMSE. Application site skin reactions/irritations occurred in 30.5% of patients overall, in 22.0% in the 8-week titration period, and in 10.2% in the 16-week maintenance period. Conclusion: Within-class switching from an oral ChEI to rivastigmine transdermal patch might be an efficacious and tolerable option for AD patients showing a poor or limited response to a prior oral ChEI.
背景:在日本,很少有研究调查阿尔茨海默病(AD)患者对口服胆碱酯酶抑制剂(ChEIs)反应不佳的治疗方案。目的:研究AD患者从口服ChEIs转为利瓦斯汀透皮贴剂的疗效和安全性。方法:在日本门诊进行的这项多中心、开放标签的IV期研究中,对多奈哌齐或加兰他敏反应不佳或难以继续使用的轻度-中度AD患者在第4周通过一步滴定(10 cm2;负荷剂量18 mg,给药率9.5 mg/24 h)改用利瓦斯汀透皮贴剂(5 cm2;负荷量9 mg,给药剂量4.6 mg/24小时),其在滴定期中持续4周,在维持期中持续16周。主要终点是从基线到第24周的简易精神状态检查(MMSE)总分的变化。结果:共有118名患者入组并改用利瓦斯汀,其中102人完成了为期24周的研究。在研究期间,MMSE总分基本上没有变化,在第24周时,最小均方变化(SD)为-0.35(2.64)(p=0.1750)。通过比较切换前后MMSE变化的混合效应模型进行的探索性分析表明,改用利伐他明可防止MMSE恶化。用药部位皮肤反应/刺激发生在30.5%的患者中,22.0%发生在8周滴定期,10.2%发生在16周维持期。结论:对于对先前口服ChEI反应不佳或有限的AD患者,从口服ChEI到利瓦斯汀透皮贴剂的类内转换可能是一种有效且可耐受的选择。
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引用次数: 6
Accuracy of the Cognitive Assessment Battery in a Primary Care Population 初级保健人群认知评估的准确性
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-08-14 DOI: 10.1159/000501365
A. S. Kvitting, Maria M. Johansson, J. Marcusson
Background: There are several cognitive assessment tools used in primary care, e.g., the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment. The Cognitive Assessment Battery (CAB) was introduced as a sensitive tool to detect cognitive decline in primary care. However, primary care validation is lacking. Therefore, we investigated the accuracy of the CAB in a primary care population. Objective: To investigate the accuracy of the CAB in a primary care population. Methods: Data from 46 individuals with cognitive impairment and 33 individuals who visited the primary care with somatic noncognitive symptoms were analyzed. They were investigated with the MMSE, the CAB, and a battery of neuropsychological tests; they also underwent consultation with a geriatric specialist. The accuracy of the CAB was assessed using c-statistics and the area under the receiver operating characteristic curve (AUC) was used to quantify the binary outcomes (“no cognitive impairment” or “cognitive impairment”). Results: The “cognitive impairment” group was significantly different from the unimpaired group for all the subtests of the CAB. When accuracy was based on binary significant reduction or not in one or several domains of the CAB, the AUC varied between 0.685 and 0.772. However, when a summation or logistic regression of several subcategories was performed, using the numerical values for each subcategory, the AUC was >0.9. For comparison, the AUC for the MMSE was 0.849. Conclusions: The accuracy of the CAB in a primary care population is poor to good when using binary cutoffs. Accuracy can be improved to high when using a summation or logistic regression of the numerical data of the subcategories. Considering CAB time, lack of adequate age norms, and a good accuracy for the MMSE, implementation of the CAB in primary care is not recommended at present based on the results of this study.
背景:在初级保健中有几种认知评估工具,如简易精神状态检查(MMSE)和蒙特利尔认知评估。认知评估电池(CAB)被引入作为一种敏感的工具来检测初级保健的认知能力下降。然而,缺乏初级保健验证。因此,我们在初级保健人群中调查了CAB的准确性。目的:探讨初级保健人群CAB的准确性。方法:对46例认知障碍患者和33例因躯体非认知症状就诊的初级保健患者的资料进行分析。他们接受了MMSE、CAB和一系列神经心理学测试的调查;他们还接受了老年专家的咨询。使用c-statistics评估CAB的准确性,并使用受试者工作特征曲线下面积(AUC)量化二元结果(“无认知障碍”或“认知障碍”)。结果:认知障碍组与非认知障碍组在CAB各子测试上均有显著性差异。当精度基于CAB的一个或几个域的二进制显著降低或不显著降低时,AUC在0.685和0.772之间变化。然而,当对几个子类别进行求和或逻辑回归时,使用每个子类别的数值,AUC为>0.9。相比之下,MMSE的AUC为0.849。结论:在初级保健人群中,当使用二元截止时,CAB的准确性从差到好。当使用子类别的数值数据的总和或逻辑回归时,精度可以提高到很高。考虑到CAB的时间,缺乏足够的年龄规范,以及MMSE的良好准确性,根据本研究的结果,目前不建议在初级保健中实施CAB。
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引用次数: 2
Responding to Varying Levels of Certainty about Pain in People with Dementia after Initial Pain Assessment 痴呆症患者初始疼痛评估后对不同程度疼痛确定性的反应
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-08-13 DOI: 10.1159/000501030
Mohammad J Rababa, M. Aldalaykeh
Introduction: Pain is still inadequately treated in people with dementia (PWD) due to the complexity of assessing it. Pain assessment in PWD is still challenging because of patient-related or nurse-related factors. The patient-related factors have been studied extensively. However, the nurse-related factors, e.g., nurses’ certainty regarding suspected pain in PWD, have been given little attention by researchers. Purpose: This study aims to investigate how the degree of nurses’ certainty is compromised after pain assessment and how this affects levels of pain and agitation in PWD. Method: A descriptive, correlational design was used, and a convenience sample of 104 nursing home residents with dementia were recruited. Results: This study found that nurses’ certainty after the pain assessment mediates the relationship between the type of pain assessment and patient outcomes when the nurses had a high initial certainty. When nurses had a low initial certainty, their certainty after the assessment and the type of assessment predicted the levels of pain and agitation in PWD. Conclusion: Understanding how nurses’ certainty can be compromising after pain assessment and how this relates to pain management in PWD is crucial.
引言:由于评估的复杂性,痴呆症患者的疼痛仍然没有得到充分的治疗。由于患者或护士相关的因素,痴呆症的疼痛评估仍然具有挑战性。与患者相关的因素已被广泛研究。然而,与护士相关的因素,例如护士对PWD疑似疼痛的确定性,很少受到研究人员的关注。目的:本研究旨在调查疼痛评估后护士的确定度是如何受到影响的,以及这如何影响PWD的疼痛和激动程度。方法:采用描述性相关设计,以104名痴呆症疗养院居民为方便样本。结果:本研究发现,当护士具有较高的初始确定性时,护士在疼痛评估后的确定性介导了疼痛评估类型与患者结果之间的关系。当护士最初的确定性较低时,他们在评估后的确定性和评估类型预测了PWD的疼痛和激动程度。结论:了解护士在疼痛评估后的确定性是如何受损的,以及这与PWD疼痛管理的关系至关重要。
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引用次数: 6
Association between Chronic Obstructive Pulmonary Disease and Dementia: Systematic Review and Meta-Analysis of Cohort Studies 慢性阻塞性肺疾病与痴呆的关系:队列研究的系统回顾和荟萃分析
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-07-11 DOI: 10.1159/000496475
Ying Wang, Xiaotong Li, Biying Wei, T. Tung, P. Tao, Ching-Wen Chien
Background: Chronic obstructive pulmonary disease (COPD) is a common disease among the elderly, which has been linked to cognitive decline. However, the relationship between COPD and dementia remains unclear. Summary: We conducted a systematic literature review by searching databases such as Pubmed, Embase, EBSCO, and Cochrane Library (from inception to April 18, 2018) for studies on COPD that also investigated the prevalence of dementia. We found 3 cohort studies including a total of 39,392 COPD patients. Then we applied the Newcastle-Ottawa Scale to evaluate the risk of bias. Key Messages: COPD patients faced a higher risk of dementia (HR 1.46; 95% CI 1.22–1.75; p < 0.001). Subgroup analysis on gender determined that the association between COPD and dementia was stronger in male patients (HR 1.49, 95% CI 1.20–1.86, p < 0.001) than in female patients (HR 1.41, 95% CI 1.27–1.57, p < 0.001). A subset study of patients aged >65 years revealed that the HR was greater for patients aged ≥75 years (HR 1.46, 95% CI 1.07–2.00, p = 0.02) than for those aged 65–74 years (HR 1.40, 95% CI 1.28–1.53, p < 0.001). The cohort studies included were from similar population-based databases, suggesting possible regional limitations and publication bias.
背景:慢性阻塞性肺疾病(COPD)是老年人的常见病,与认知能力下降有关。然而,COPD与痴呆之间的关系尚不清楚。摘要:我们通过检索Pubmed、Embase、EBSCO和Cochrane图书馆等数据库(从成立到2018年4月18日)进行了系统的文献综述,以寻找COPD的研究,并调查痴呆的患病率。我们发现了3项队列研究,共包括39,392名COPD患者。然后我们应用纽卡斯尔-渥太华量表来评估偏倚风险。关键信息:COPD患者面临更高的痴呆风险(HR 1.46;95% ci 1.22-1.75;P < 0.001)。性别亚组分析表明,男性患者COPD与痴呆之间的相关性(HR 1.49, 95% CI 1.20-1.86, p < 0.001)强于女性患者(HR 1.41, 95% CI 1.27-1.57, p < 0.001)。一项针对bb0 ~ 65岁患者的亚组研究显示,≥75岁患者的HR (HR 1.46, 95% CI 1.07 ~ 2.00, p = 0.02)高于65 ~ 74岁患者(HR 1.40, 95% CI 1.28 ~ 1.53, p < 0.001)。纳入的队列研究来自相似的基于人群的数据库,提示可能存在区域局限性和发表偏倚。
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引用次数: 19
Associations between Frailty and Delirium among Older Patients Admitted to an Emergency Department. 急诊科老年患者虚弱和谵妄的关系。
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-06-21 eCollection Date: 2019-05-01 DOI: 10.1159/000499707
Sandra Choutko-Joaquim, Nadine Tacchini-Jacquier, Géraldine Pralong D'Alessio, Henk Verloo

Background: Switzerland's demographic trends show, as elsewhere on the planet, increasing numbers of older and very old adults. This suggests that its healthcare system will suffer serious repercussions, including in the use of care and especially the use of emergency services. Significant numbers of older adults will be at risk of developing multiple chronic conditions including one or more geriatric syndromes, such as frailty and delirium. Few studies to date have documented associations between frailty and delirium.

Aim: To explore the relationships between frailty and delirium in older adult patients consulting (n = 114) at an emergency department (ED) in Switzerland.

Method: A cross-sectional study was conducted in a peripheral hospital ED in the French-speaking part of Switzerland. Frailty was assessed using the Tilburg Frailty Indicator (TFI). Delirium was assessed using the Confusion Assessment Method (CAM). Participants' cognitive states were assessed using the 6-item Cognitive Impairment Test (6CIT) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQ-CODE), completed by the participant's most significant informal caregiver.

Results: The mean participant age was 77.6 years (SD = 7.7); the majority of the subjects were women (54%). The participants took an average of 4.7 different medications a day (SD = 3.2, median = 4). More than half (62%) of the participants were frail; 2 and 14% presented signs and symptoms of delirium and subsyndromal delirium, respectively. A weak but significant association between scores for frailty and delirium (p < 0.05) was demonstrated, and clinical observation confirmed this. A 4-h follow-up measurement of delirium in the ED revealed no significant or clinical difference.

Conclusion: Although the literature describes strong associations between frailty and delirium in surgical units and community care settings, the present study only demonstrated a weak-to-moderate association between frailty and delirium in our ED.

背景:瑞士的人口趋势显示,与地球上其他地方一样,老年人和高龄老人的数量在增加。这表明,其医疗保健系统将受到严重影响,包括在护理使用方面,尤其是在紧急服务使用方面。大量老年人将有患多种慢性疾病的风险,包括一种或多种老年综合征,如虚弱和谵妄。迄今为止,很少有研究记录虚弱和谵妄之间的联系。目的:探讨在瑞士急诊科咨询的老年患者(n=114)的虚弱和谵妄之间的关系。方法:在瑞士法语区的一家外围医院急诊科进行横断面研究。使用Tilburg脆弱性指标(TFI)评估脆弱性。使用混淆评估方法(CAM)对谵妄进行评估。参与者的认知状态使用6项认知障碍测试(6CIT)和老年人认知能力下降告知问卷(IQ-CODE)进行评估,该问卷由参与者最重要的非正式照顾者完成。结果:参与者的平均年龄为77.6岁(SD=7.7);大多数受试者是女性(54%)。参与者平均每天服用4.7种不同的药物(SD=3.2,中位数=4)。超过一半(62%)的参与者身体虚弱;2和14%分别出现谵妄和亚综合征性谵妄的体征和症状。虚弱和谵妄评分之间存在微弱但显著的相关性(p<0.05),临床观察证实了这一点。ED中谵妄的4小时随访测量显示没有显著或临床差异。结论:尽管文献描述了在外科手术室和社区护理环境中虚弱和谵妄之间的强烈关联,但本研究仅证明了在我们的ED中虚弱与谵妄之间存在弱至中度关联。
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引用次数: 9
Evaluation of Activities of Daily Living/Instrumental Activities of Daily Living to Accurately Determine Severity of Moderate and Severe Alzheimer's Disease: Comparison of Assessments by Receiver Operating Characteristic Curve and Discriminant Analyses. 日常生活活动/工具性日常生活活动评估可准确判断中度和重度阿尔茨海默病的严重程度:受试者工作特征曲线和判别分析评估的比较
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-06-21 eCollection Date: 2019-05-01 DOI: 10.1159/000500019
Yukiko Suzuki, Koji Teruya, Hideki Mochizuki, Akira Nagasawa, Tomoko Kondo, Nobuaki Shimoda

Aim: The aim of this study was to determine Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL) evaluations that will enable better understanding of the severity of Alzheimer's disease (AD).

Methods: AD patients were evaluated by Functional Independence Measure (FIM), Hyogo Activities of Daily Living Scale (HADLS), and Assessment of Motor and Process Skills (AMPS) to identify the assessments that will enable highly precise discrimination of AD Clinical Dementia Rating (CDR) 2 (moderate) and CDR3 (severe) using receiver operating characteristic (ROC) curve and discriminant analyses.

Results: The participants were 75 AD patients (CDR2 = 50, mean age = 80.3 ± 5.9 years; CDR3 = 25, mean age = 78.3 ± 9.0 years). The evaluation methods consisted of FIM, HADLS, and AMPS. The results were divided into FIM-M, FIM-C, HADLS-ADL, HADLS-IADL, AMPS-motor skills, and AMPS-process skills. The values for the area under the curve (AUC) were compared by ROC curve and discriminant analyses. AUC values for FIM-C and AMPS-process skills were 0.956 and 0.947, respectively. With these two evaluations only, values ≥0.9 were shown. Moreover, the AUC of the discrimination score (combination of the FIM-C and AMPS-process skills) was significantly higher than those for FIM-M, FIM-C, HADLS-ADL, HADLS-IADL, and AMPS-motor skills.

Conclusions: The results demonstrated that evaluation by FIM-C and AMPS-process skills methods was useful for discriminating between CDR2 (moderate) and CDR3 (severe) AD. Moreover, the results indicated that these two evaluation methods enabled more accurate determination of severity and the spared capabilities of AD patients.

目的:本研究的目的是确定日常生活活动/日常生活工具活动(ADL/IADL)评估,以便更好地了解阿尔茨海默病(AD)的严重程度。方法:采用功能独立量表(FIM)、兵库日常生活活动量表(HADLS)和运动与过程技能评估量表(AMPS)对AD患者进行评估,通过受试者工作特征曲线(ROC)和判别分析,确定能够高度精确区分AD临床痴呆等级(CDR) 2(中度)和CDR3(重度)的评估。结果:75例AD患者(CDR2 = 50,平均年龄= 80.3±5.9岁;CDR3 = 25,平均年龄= 78.3±9.0岁)。评价方法包括FIM、HADLS和AMPS。结果分为FIM-M、FIM-C、HADLS-ADL、HADLS-IADL、amps -运动技能和amps -过程技能。曲线下面积(AUC)采用ROC曲线和判别分析进行比较。FIM-C和AMPS-process skills的AUC值分别为0.956和0.947。仅这两项评价,其值≥0.9。辨别得分(FIM-C和amps -过程技能组合)的AUC显著高于FIM-M、FIM-C、HADLS-ADL、HADLS-IADL和amps -运动技能。结论:FIM-C和AMPS-process skills评价方法可用于区分CDR2(中度)和CDR3(重度)AD。此外,结果表明,这两种评估方法能够更准确地确定AD患者的严重程度和生存能力。
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引用次数: 3
Testing Episodic Memory in Elderly Subjects: Not as Simple as It Looks. 老年人情景记忆测试:不像看起来那么简单。
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-06-18 eCollection Date: 2019-05-01 DOI: 10.1159/000499836
Leo Boelaarts, Sascha R A Meyer, Philip Scheltens, Jos F M de Jonghe

Background/aims: The available episodic memory tests are not specifically constructed to examine older subjects. Their use in outpatient memory clinics may result in aborted test administration. We used a strict adherence to the test protocol in cognitively healthy, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia subjects to assess the possibility of preventing this.

Methods: This is a cross-sectional study in memory outpatient subjects with a mean age of 74.5 years. Primary study outcomes were: number of missing values and test results in the Visual Association Test (VAT) and the 15 Word Test (15WT).

Results: A strict adherence to the test protocol resulted in a 10-fold decrease in the number of missing values in the VAT. For the 15WT this could not be realized mostly because the test was deemed too demanding for 1 in 6 patients.

Conclusions: This study is one of the few examining the applicability of well-known episodic memory tests in older subjects. A strict adherence to the test protocol reduced the number of missing values. Floor effects were stronger for the 15WT than for the VAT. Results favor the use of the VAT in senior subjects and show the unsuitability of the 15WT in this group.

背景/目的:现有的情景记忆测试并不是专门用来检查老年受试者的。他们在门诊记忆诊所的使用可能导致流产的测试管理。我们在认知健康、遗忘性轻度认知障碍(aMCI)和阿尔茨海默病痴呆受试者中严格遵守测试方案,以评估预防这种情况的可能性。方法:这是一项平均年龄74.5岁的记忆门诊患者的横断面研究。主要研究结果为:视觉联想测试(VAT)和15字测试(15WT)的缺失值数量和测试结果。结果:严格遵守测试协议导致增值税中缺失值的数量减少10倍。对于15WT来说,这一点无法实现,主要是因为该测试被认为对六分之一的患者要求太高。结论:这项研究是为数不多的对众所周知的情景记忆测试在老年受试者中的适用性进行检验的研究之一。严格遵守测试协议减少了缺失值的数量。15WT的地板效应比VAT的更强。结果支持在老年受试者中使用VAT,并显示15WT在该组不适合。
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引用次数: 1
Clinical Considerations in Physician-Assisted Death for Probable Alzheimer's Disease: Decision-Making Capacity, Anosognosia, and Suffering. 临床考虑在医生协助死亡可能阿尔茨海默病:决策能力,病感失认症,和痛苦。
IF 2.3 Q4 CLINICAL NEUROLOGY Pub Date : 2019-06-18 eCollection Date: 2019-05-01 DOI: 10.1159/000500183
Jaime D Mondragón, Latife Salame, Arnoldo Kraus, Peter Paul De Deyn

Background: Requests for physician-assisted death (PAD) in patients with cognitive impairment are complex and require careful consideration. Of particular difficulty is determination of whether the request is voluntary and well considered.

Results: Euthanasia and physician-assisted suicide (PAS) are both legal in The Netherlands, Luxemburg, Colombia, and Canada. Euthanasia is legal in Belgium, while PAS is legal in Switzerland and Oregon, Washington, Montana, Vermont, and California (USA). Upon a PAD request, evaluation of the capacity to consent medical treatment is relevant for the decision-making process, while evaluation of testamentary capacity is appropriate before an advance euthanasia directive is written. Anosognosia assessment throughout the Alzheimer's disease continuum provides essential and relevant information regarding the voluntary and well-considered nature of the PAD request; meanwhile, early assessment of hypernosognosia or subjective cognitive decline assists in formulation of a clinical prognosis. Furthermore, the assessment of physical and psychological suffering should incorporate verbal and nonverbal cues as well as consideration of the psychosocial factors that might affect due care criteria.

Conclusion: The clinical approach to a PAD request should consider the legal framework and the decision-making capacity, assess memory deficit awareness and the perception of suffering, and evaluate mental competency when considered pertinent.

背景:认知障碍患者的医师协助死亡(PAD)请求是复杂的,需要仔细考虑。特别困难的是确定请求是否是自愿的和经过充分考虑的。结果:安乐死和医生协助自杀(PAS)在荷兰、卢森堡、哥伦比亚和加拿大都是合法的。安乐死在比利时是合法的,而PAS在瑞士和俄勒冈州、华盛顿州、蒙大拿州、佛蒙特州和加利福尼亚州(美国)是合法的。根据临终关怀委员会的要求,对同意医疗的能力进行评估与决策过程有关,而在写安乐死预先指令之前,对遗嘱能力进行评估是适当的。整个阿尔茨海默病连续体的病感失认评估提供了有关PAD请求的自愿和深思熟虑性质的基本和相关信息;同时,早期评估过度诊断或主观认知能力下降有助于制定临床预后。此外,对身体和心理痛苦的评估应结合语言和非语言线索,并考虑可能影响适当护理标准的社会心理因素。结论:临床处理PAD请求应考虑法律框架和决策能力,评估记忆缺陷意识和痛苦感知,并在认为适当时评估心理能力。
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引用次数: 4
期刊
Dementia and Geriatric Cognitive Disorders Extra
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