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Economic Perspectives on Personalized Health Care and Prevention 个性化医疗保健和预防的经济学观点
Q3 Economics, Econometrics and Finance Pub Date : 2013-09-01 DOI: 10.1515/fhep-2013-0010
K. Phillips, J. Sakowski, S. Liang, N. Ponce
Abstract The objective of this paper is to provide an overview of economic evaluation of personalized medicine, focusing particularly on the use of cost-effectiveness analysis and other methods of valuation. We draw on insights from the literature and our work at the University of California, San Francisco Center for Translational and Policy Research on Personalized Medicine (TRANSPERS). We begin with a discussion of why personalized medicine is of interest and challenges to adoption, whether personalized medicine is different enough to require different evaluation approaches, and what is known about the economics of personalized medicine. We then discuss insights from TRANSPERS research and six areas for future research: Develop and Apply Multiple Methods of Assessing Value Identify Key Factors in Determining the Value of Personalized Medicine Use Real World Perspectives in Economic Analyses Consider Patient Heterogeneity and Diverse Populations in Economic Analyses Prepare for Upcoming Challenges of Assessing Value of Emerging Technologies Incorporate Behavioral Economics into Value Assessments
摘要本文的目的是提供个性化医疗的经济评估概述,特别侧重于使用成本效益分析和其他评估方法。我们从文献和我们在加州大学旧金山分校个性化医疗转化和政策研究中心(TRANSPERS)的工作中吸取了见解。我们首先讨论了为什么个性化医疗引起人们的兴趣,以及采用个性化医疗面临的挑战,个性化医疗是否足够不同,需要不同的评估方法,以及个性化医疗的经济学知识。然后,我们讨论了来自TRANSPERS研究的见解和未来研究的六个领域:开发和应用多种评估价值的方法确定确定个性化医疗价值的关键因素在经济分析中使用现实世界的视角在经济分析中考虑患者异质性和多样化的人群为即将到来的新兴技术价值评估的挑战做好准备将行为经济学纳入价值评估
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引用次数: 15
Better Quality of Care or Healthier Patients? Hospital Utilization by Medicare Advantage and Fee-for-Service Enrollees. 更好的护理质量还是更健康的患者?医疗保险优势和按服务收费的参保人对医院的利用。
Q3 Economics, Econometrics and Finance Pub Date : 2013-05-15 DOI: 10.1515/fhep-2012-0037
Lauren Hersch Nicholas

Do differences in rates of use among managed care and Fee-for-Service Medicare beneficiaries reflect selection bias or successful care management by insurers? I demonstrate a new method to estimate the treatment effect of insurance status on health care utilization. Using clinical information and risk-adjustment techniques on data on acute admission that are unrelated to recent medical care, I create a proxy measure of unobserved health status. I find that positive selection accounts for between one-quarter and one-third of the risk-adjusted differences in rates of hospitalization for ambulatory care sensitive conditions and elective procedures among Medicare managed care and Fee-for-Service enrollees in 7 years of Healthcare Cost and Utilization Project State Inpatient Databases from Arizona, Florida, New Jersey and New York matched to Medicare enrollment data. Beyond selection effects, I find that managed care plans reduce rates of potentially preventable hospitalizations by 12.5 per 1,000 enrollees (compared to mean of 46 per 1,000) and reduce annual rates of elective admissions by 4 per 1,000 enrollees (mean 18.6 per 1,000).

管理式医疗和按服务收费的医疗保险受益人之间使用率的差异是否反映了保险公司的选择偏差或成功的医疗管理?本文提出了一种新的方法来估计保险状况对医疗保健利用的治疗效果。利用临床信息和风险调整技术对与近期医疗护理无关的急性入院数据,我创建了一个未观察到的健康状况的代理度量。我发现积极的选择占了四分之一到三分之一的风险调整后的住院率的差异,在流动护理敏感条件和选择性程序中,医疗保险管理护理和按服务收费的注册者在7年的医疗成本和利用项目中,来自亚利桑那州,佛罗里达州,新泽西州和纽约州的住院患者数据库与医疗保险注册数据相匹配。除了选择效应,我发现管理式医疗计划将潜在可预防的住院率降低了12.5 / 1000(平均为46 / 1000),将选择性住院率降低了4 / 1000(平均为18.6 / 1000)。
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引用次数: 20
AIDS and Conflict: Micro Evidence from Burundi1) 艾滋病与冲突:来自布隆迪的微观证据
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2012-0035
Matthias Rieger
Abstract This paper studies the relationship between civil war and HIV/AIDS in Burundi at the micro level. The case of Burundi provides interesting grounds of analysis, as seroprevalence rates are heterogeneous across the country, the serological and conflict data for Burundi are of good quality and conclusions can inform HIV/AIDS policies in Burundi and other fragile states. Ordinary least squares and instrumental variable results indicate that there is no empirical relationship between seroprevalence at the general population level and three measures of local conflict intensity within provinces. This evidence could imply that areas that are relatively more conflict affected do not need to be prioritized over others in terms of HIV/AIDS policies. Further research should focus on individual rather than geographical exposure to conflict. There are likely certain groups and individuals at risk in the general population that need special attention after conflict. Furthermore, violence changes societies, in particular gender relations, thereby indirectly feeding and possibly fueling the dynamics of the epidemic.
本文从微观层面研究布隆迪内战与艾滋病的关系。布隆迪的情况提供了有趣的分析基础,因为全国各地的血清患病率各不相同,布隆迪的血清学和冲突数据质量良好,结论可以为布隆迪和其他脆弱国家的艾滋病毒/艾滋病政策提供信息。普通最小二乘和工具变量结果表明,一般人群水平的血清患病率与省内地方冲突强度的三个指标之间没有经验关系。这一证据可能意味着,在艾滋病毒/艾滋病政策方面,受冲突影响相对较大的地区不需要优先于其他地区。进一步的研究应侧重于个人而不是地理上受冲突影响的程度。在一般人群中,可能有某些处于危险中的群体和个人在冲突后需要特别关注。此外,暴力改变社会,特别是改变两性关系,从而间接助长并可能助长这一流行病的动态。
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引用次数: 0
Price-Shopping in Consumer-Directed Health Plans. 消费者导向健康计划中的价格购物
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/thep-2012-0028
Neeraj Sood, Zachary Wagner, Peter Huckfeldt, Amelia Haviland

We use health insurance claims data from 63 large employers to estimate the extent of price shopping for nine common outpatient services in consumer-directed health plans (CDHPs) compared to traditional health plans. The main measures of price-shopping include: (1) the total price paid on the claim, (2) the share of claims from low and high cost providers and (3) the savings from price shopping relative to choosing prices randomly. All analyses control for individual and zip code level demographics and plan characteristics. We also estimate differences in price shopping within CDHPs depending on expected health care costs and whether the service was bought before or after reaching the deductible. For 8 out of 9 services analyzed, prices paid by CDHP and traditional plan enrollees did not differ significantly; CDHP enrollees paid 2.3% less for office visits. Similarly, office visits was the only service where CDHP enrollment resulted in a significantly larger share of claims from low cost providers and greater savings from price shopping relative to traditional plans. There was also no evidence that, within CDHP plans, consumers with lower expected medical expenses exhibited more price-shopping or that consumers exhibited more price-shopping before reaching the deductible.

我们使用来自63家大型雇主的健康保险索赔数据来估计与传统健康计划相比,消费者导向健康计划(CDHPs)中9种常见门诊服务的价格购物程度。价格购物的主要衡量标准包括:(1)索赔支付的总价;(2)低成本和高成本供应商的索赔份额;(3)相对于随机选择价格,价格购物节省的费用。所有的分析都控制了个人和邮政编码水平的人口统计和计划特征。我们还估计了cdhp内价格购物的差异,这取决于预期的医疗保健成本,以及服务是在达到免赔额之前还是之后购买的。在分析的9项服务中,CDHP和传统计划参保人支付的价格没有显著差异;CDHP参保者的办公室就诊费用减少2.3%。同样,诊所就诊是唯一一项CDHP注册导致低成本供应商索赔比例显著增加的服务,并且与传统计划相比,价格购物节省了更多费用。也没有证据表明,在CDHP计划中,预期医疗费用较低的消费者表现出更多的价格购物,或者消费者在达到免赔额之前表现出更多的价格购物。
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引用次数: 25
Measuring the Financial Exposure from Medical Care Spending Among Families with Employer Sponsored Insurance 衡量雇主赞助保险家庭医疗保健支出的财务风险
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2012-0012
J. Abraham, A. Royalty, T. DeLeire
Abstract We develop an empirical method to assess the degree of financial exposure associated with medical care spending among non-elderly US families with employer-sponsored insurance. A key feature of this method is its simplicity – it only requires data on out-of-pocket (OOP) health care spending and total health care spending and does not require detailed knowledge of health insurance benefit design. We apply our method to assess whether families with a chronically ill member face more financial exposure given their level of total spending relative to families with no chronically ill members. We find that the insured chronically ill face more financial exposure than the insured non-chronically ill. Additional analyses suggest that the reason for this additional financial exposure is not that families with a chronically ill member are in different, less generous plans, on average. Rather, families with a chronically ill member have higher spending on certain types of medical services (e.g., pharmaceuticals) that face higher levels of coinsurance. Given recent work on value-based insurance design and coinsurance as an obstacle to medication adherence, our findings suggest that the current design of health plans could jeopardize both the health and the financial well-being of the chronically ill.
摘要:我们开发了一种实证方法来评估与医疗保健支出相关的非老年美国家庭与雇主赞助的保险的财务风险程度。这种方法的一个关键特点是它的简单性——它只需要自付(OOP)医疗保健支出和总医疗保健支出的数据,而不需要详细了解医疗保险福利设计。我们应用我们的方法来评估是否有慢性病成员的家庭面临更多的财务风险,因为他们的总支出水平相对于没有慢性病成员的家庭。我们发现,被保险的慢性病患者比被保险的非慢性病患者面临更多的财务风险。其他分析表明,造成这种额外财务风险的原因,并不是平均而言,有慢性病成员的家庭在不同的、不那么慷慨的计划中。相反,有慢性病成员的家庭在某些类型的医疗服务(如药品)上的支出更高,面临更高的共同保险水平。鉴于最近关于基于价值的保险设计和共同保险作为药物依从性障碍的工作,我们的研究结果表明,目前的健康计划设计可能会危及慢性病患者的健康和财务状况。
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引用次数: 1
Price Shopping in Consumer-Directed Health Plans 消费者导向健康计划中的价格购物
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2012-0028
N. Sood, Z. Wagner, P. Huckfeldt, A. Haviland
Abstract We use health insurance claims data from 63 large employers to estimate the extent of price shopping for nine common outpatient services in consumer-directed health plans (CDHPs) compared to traditional health plans. The main measures of price shopping include (1) the total price paid on the claim, (2) the share of claims from low- and high-cost providers, and (3) the savings from price shopping relative to choosing prices randomly. All analyses control for individual and zip code level demographics and plan characteristics. We also estimate differences in price shopping within CDHPs depending on expected health care costs and whether the service was bought before or after reaching the deductible. For eight out of nine services analyzed, prices paid by CDHP and traditional plan enrollees did not differ significantly; CDHP enrollees paid 2.3% less for office visits. Similarly, office visits was the only service where CDHP enrollment resulted in a significantly larger share of claims from low-cost providers and greater savings from price shopping relative to traditional plans. There was also no evidence that, within CDHP plans, consumers with lower expected medical expenses exhibited more price shopping or that consumers exhibited more price shopping before reaching the deductible.
摘要:我们使用来自63家大型雇主的健康保险索赔数据来估计消费者导向健康计划(CDHPs)中9种常见门诊服务的价格购物程度与传统健康计划相比。价格购物的主要度量包括(1)索赔支付的总价,(2)低成本和高成本供应商的索赔份额,以及(3)相对于随机选择价格的价格购物节省的费用。所有的分析都控制了个人和邮政编码水平的人口统计和计划特征。我们还估计了cdhp内价格购物的差异,这取决于预期的医疗保健成本,以及服务是在达到免赔额之前还是之后购买的。在分析的9项服务中,CDHP和传统计划参保人支付的价格没有显著差异;CDHP参保者的办公室就诊费用减少2.3%。同样,诊所就诊是唯一一项CDHP注册导致低成本供应商索赔比例显著增加的服务,与传统计划相比,价格购物节省了更多费用。也没有证据表明,在CDHP计划中,预期医疗费用较低的消费者表现出更多的价格购物,或者消费者在达到免赔额之前表现出更多的价格购物。
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引用次数: 11
Should Global Health be Tailored Toward the Rich? Altruism and Efficient R&D for Neglected Diseases 全球健康应该为富人量身定制吗?被忽视疾病的利他主义与高效研发
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2012-0036
A. Jena, Stéphane Mechoulan, T. Philipson
Abstract We analyze the problem of incentivizing research and development (R&D) into developing world disease from an economic efficiency perspective. We view the problem as how to best promote R&D into goods with positive external effects in the sense that medicines that directly affect the health of the poor also indirectly affect the utility of the altruistic “rich.” We demonstrate why existing policy proposals – such as price concessions by manufacturers – adversely impact the poor by placing the burden of R&D only on innovators rather than all altruists in the rich world. We offer policy solutions that are based on economic efficiency and therefore rely on a broad sense of how the world values the treatment of developing world disease. We estimate that global altruism toward those with malaria is, at a minimum, valued between $835 million and $2.4 billion annually and for HIV/AIDS, between $9.1 billion and $26.6 billion annually. We argue that future policies toward neglected diseases need to better incorporate how efficient R&D meets the need of this global altruism.
摘要本文从经济效率的角度分析了发展中国家疾病研究与开发的激励问题。我们认为,问题在于如何最好地促进研发成为具有积极外部效应的产品,因为直接影响穷人健康的药物也会间接影响利他的“富人”的效用。我们论证了为什么现有的政策建议——比如制造商的价格让步——把研发的负担只放在创新者身上,而不是富国的所有利他主义者身上,从而对穷人产生了不利影响。我们提供的政策解决方案以经济效率为基础,因此依赖于对世界如何重视发展中国家疾病治疗的广泛认识。我们估计,全球对疟疾患者的利他主义每年至少价值8.35亿至24亿美元,对艾滋病毒/艾滋病的利他主义每年价值91亿至266亿美元。我们认为,未来针对被忽视疾病的政策需要更好地纳入研发效率如何满足这种全球利他主义的需求。
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引用次数: 0
Quantifying the Value of Personalized Medicines: Evidence from COX-2 Inhibitors 量化个体化药物的价值:来自COX-2抑制剂的证据
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2013-0005
N. Sood, T. Philipson, P. Huckfeldt
Abstract We develop a conceptual framework for estimating the value of personalized medicines. We show that personalizing medicines generates value from two sources. The first is a market-expansion effect by persons who initiate treatment due to reduced pre-treatment uncertainty about the effectiveness or side effects of treatment. The second is a market-contraction effect due to discontinuation of treatment by persons unresponsive to treatment. We apply the conceptual framework to evaluate the value of a predictive test to assess whether patients are at elevated risk for cardiac complications from COX-2 inhibitors. We find that this predictive test would yield an overall value to patients of about $16 billion per year or $1284 per likely patient.
我们开发了一个概念框架来估计个体化药物的价值。我们表明,个性化药物可以从两个方面产生价值。首先,由于治疗前对治疗效果或副作用的不确定性降低,开始治疗的人会产生市场扩张效应。第二种是由于对治疗无反应的人停止治疗而产生的市场收缩效应。我们应用概念框架来评估预测试验的价值,以评估患者是否因COX-2抑制剂而出现心脏并发症的风险升高。我们发现,这种预测测试每年将为患者带来约160亿美元的总体价值,或每位潜在患者1284美元。
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引用次数: 5
Integrating Patient Incentives with Episode-Based Payment. 将患者激励措施与分段付费相结合。
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 Epub Date: 2013-04-15 DOI: 10.1515/fhep-2012-0002
Lorens A Helmchen, William E Encinosa, Michael E Chernew, Richard A Hirth

To rein in cost, payers are exploring bundled payment, which aggregates fees for a range of services into a single prospective payment. While under bundled payment providers would have incentives to reduce cost, they might also withhold more expensive care that patients prefer. We explore how bundled payment could be aligned with a benefit design that would encourage patients' consideration of cost without jeopardizing access to the most expensive treatments. Least-costly-alternative approaches allow patient choice but might deter patients from choosing more expensive care by exposing them to potentially large out-of-pocket payments. A novel "shared-savings supplement" would reward patients for choosing the least costly alternative with a supplemental cash disbursement and thus allow them to share in any cost savings. This cash incentive for the least-costly-alternative allows a reduction of the out-of-pocket payment for the expensive alternative. Thus, patients would still have the option of the more expensive therapy while facing only a modest out-of-pocket cost. Such benefit modifications could be aligned with bundled payment by splitting the responsibility for the incremental cost of more expensive care between patients and their providers.

为了控制成本,支付方正在探索捆绑式支付,即将一系列服务的费用汇总到一个单一的预期支付中。虽然在捆绑支付下,医疗服务提供者有动力降低成本,但他们也可能会拒绝提供患者更喜欢的更昂贵的医疗服务。我们探讨了如何将捆绑支付与福利设计相结合,既鼓励患者考虑成本,又不影响患者获得最昂贵的治疗。成本最低的替代方法允许患者选择,但可能会使患者面临潜在的巨额自付费用,从而阻碍他们选择更昂贵的治疗。一种新颖的 "共享节余补充 "方法将对选择成本最低替代方案的患者给予奖励,向他们支付补充现金,从而使他们能够共享所节省的费用。对费用最低替代方案的现金奖励可以减少昂贵替代方案的自付费用。因此,患者仍然可以选择更昂贵的疗法,而只需支付少量的自付费用。通过在患者和医疗服务提供者之间分担更昂贵治疗的增量成本,这种福利调整可以与捆绑式付费相一致。
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引用次数: 0
The Effect of Comprehensive Smoking Bans in European Workplaces 欧洲工作场所全面禁烟的效果
Q3 Economics, Econometrics and Finance Pub Date : 2013-01-01 DOI: 10.1515/fhep-2012-0030
Federica Origo, Claudio Lucifora
Abstract Many European countries have recently implemented comprehensive smoking bans to reduce exposure to tobacco smoke in public places and all indoor workplaces. We use a difference-in-differences approach and comparable microdata for a number of European countries to evaluate the impact of national comprehensive smoking bans on workers’ perceived health. Results show that the introduction of comprehensive smoking bans has a significant effect on the probability of both exposure to smoke and work-related respiratory problems. We also highlight unintended effects in terms of mental distress. The impact across countries is shown to vary with the degree of strictness of the bans.
许多欧洲国家最近实施了全面禁烟,以减少在公共场所和所有室内工作场所接触烟草烟雾。我们使用差异中的差异方法和一些欧洲国家的可比微观数据来评估国家全面禁烟对工人感知健康的影响。结果表明,全面禁烟对暴露于烟雾和与工作有关的呼吸系统疾病的概率都有显著影响。我们还强调了精神痛苦方面的意外影响。各国的影响因禁令的严格程度而异。
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引用次数: 1
期刊
Forum for Health Economics and Policy
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