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Phenomenological Models of Three Scenarios of Local SARS-COV-2 Coronavirus Epidemics in New York, Brazil, and Japan 纽约、巴西和日本地方性 SARS-COV-2 冠状病毒流行三种情况的现象学模型
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700078
A. Yu. Perevaryukha

Abstract

The COVID-19 pandemic did not end in the summer of 2023 but moved into the stage of a dynamic confrontation between a mutating pathogen and herd immunity (natural and vaccine). Pandemic influenza strains were guaranteed to die out after three waves. SARS-COV-2 is able to maintain variability in its E and S proteins. The diversity of SARS-COV-2 strains increases in bursts (XBB.x in India, XBC in the Philippines). Most strains drop out of distribution, but the remaining ones give rise to new branches such as BA.2.86 Pirola and its descendants of the JN.x series, active in the winter wave of 2024. The evolution is reflected by the pulsation in the number of recorded infections, but the frequency and amplitude of the peaks differ in regions. Regional epidemic scenarios are emerging, and some of them are unusual. It is not only the property of the variability of the antigens of the virus that leads to new repeated outbreaks after the attenuation of the oscillations in the number of infections. Regional epidemic scenarios are being formed, some of them are unusual and interesting for modeling. For a phenomenological model description of scenarios for the emergence of new waves, we propose equations with a delay as a flexible tool for analyzing complex forms of oscillatory dynamics. The equations are supplemented with special threshold damping functions. In the models, it is possible to obtain scenarios of both collapsing and damping oscillations with the possibility of a new outbreak, which describes the effect of a single extreme wave after an increase in the length of active infection chains in New York with a sharp J-shaped peak with oscillatory attenuation that stands out sharply among the morbidity oscillations. The wave scenario in Brazil differs significantly from both the primary outbreak in 2020 and the specific epidemic scenario in Japan in 2022–2023 in the form of a series of eight consecutive short peaks with increasing wave amplitude. Since the coronavirus successfully counteracts the immune system, there is an increase in severe cases of reinfection with COVID-19 in a group that is particularly susceptible. An important factor for slowing down the evolution of the virus is heterogeneity of the population immunity, when activated T-lymphocytes and antibodies produced in the population are able to respond to a wide range of epitopes from different conservative regions of proteins. In the spring of 2024 a new strain JN with significantly reduced affinity for the cell receptor spreads.

摘要 COVID-19 大流行并没有在 2023 年夏天结束,而是进入了变异病原体与群体免疫(天然免疫和疫苗免疫)之间的动态对抗阶段。流感大流行菌株在经历三波后必将消亡。SARS-COV-2 能够保持其 E 蛋白和 S 蛋白的变异性。SARS-COV-2 株系的多样性在爆发时会增加(印度的 XBB.x,菲律宾的 XBC)。大多数菌株退出了分布,但剩下的菌株又产生了新的分支,如 BA.2.86 Pirola 及其 JN.x 系列的后代,在 2024 年的冬季浪潮中十分活跃。记录在案的感染数量的脉动反映了这一演变,但不同地区的峰值频率和振幅各不相同。区域性流行病情况正在出现,其中一些是不寻常的。病毒抗原的变异性并不仅仅是在感染数量的振荡减弱后导致新的重复爆发的特性。目前正在形成区域性疫情,其中一些疫情不同寻常,对建模很有意义。为了从现象学角度描述新一波疫情出现的情景,我们提出了带延迟的方程,作为分析复杂形式振荡动力学的灵活工具。这些方程辅以特殊的阈值阻尼函数。在这些模型中,我们可以得到有可能爆发新疫情的坍塌振荡和阻尼振荡情景,这描述了在纽约活动感染链长度增加后出现的单次极端波浪的影响,该波浪在发病率振荡中突出地表现为具有振荡衰减的尖锐 J 形峰值。巴西的波浪情景与 2020 年的原发疫情和 2022-2023 年日本的特定疫情情景明显不同,其形式为一系列连续的 8 个短峰值,波幅不断增大。由于冠状病毒能成功抵消免疫系统的作用,COVID-19 的重症再感染病例在特别易感人群中有所增加。减缓病毒进化的一个重要因素是群体免疫力的异质性,即群体中产生的活化 T 淋巴细胞和抗体能够对蛋白质不同保守区的多种表位做出反应。2024 年春天,一种对细胞受体亲和力明显降低的新毒株 JN 扩散开来。
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引用次数: 0
On the Influence of a Dynamic Diffusion Coefficient with the Feibelman Parameter on the Quantum Nonlocal Effect of Hybrid Plasmon Nanoparticles 费伯曼参数动态扩散系数对混合等离子体纳米粒子量子非局部效应的影响
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700017
Yu. A. Eremin, V. V. Lopushenko

Abstract

In this paper, we consider the problem of polarized light scattering by a hybrid nanoparticle consisting of a dielectric core and plasmonic gold shell. A quantum effect of nonlocality arises in the shell, which is considered in the framework of the semiclassical generalized nonlocal optical response (GNOR) theory. Based on the discrete source method (DSM), a mathematical model of the GNOR theory with a dynamic diffusion coefficient is formulated and implemented. The dynamic diffusion coefficient is determined using the Feibelman quantum surface parameter. In the calculations, the values of the Feibelman parameter are taken from the experimental data available. A comparative analysis of the results of the GNOR theory with constant and dynamic diffusion coefficients is performed. It is established that the results obtained for the dynamic diffusion coefficient and for the traditional semiclassical model with a constant coefficient can differ significantly, especially when studying the behavior of fields near the surface of a hybrid particle in the frequency domain.

摘要 在本文中,我们考虑了由电介质内核和等离子金外壳组成的混合纳米粒子的偏振光散射问题。在半经典广义非局域光学响应(GNOR)理论框架下考虑了外壳中出现的非局域量子效应。在离散源方法(DSM)的基础上,制定并实现了一个具有动态扩散系数的 GNOR 理论数学模型。动态扩散系数是利用费伯曼量子表面参数确定的。在计算中,费伯曼参数值取自现有的实验数据。对恒定扩散系数和动态扩散系数的 GNOR 理论结果进行了比较分析。结果表明,动态扩散系数的计算结果与传统的恒定系数半经典模型的计算结果会有很大差异,尤其是在研究频域混合粒子表面附近场的行为时。
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引用次数: 0
Analysis of a Novel Conformable Fractional Order ASIR Dengue Transmission Model in the Perspective of Bangladesh 以孟加拉国为视角的新型可变分数阶 ASIR 登革热传播模型分析
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700157
Md. Asaduzzaman, Adem Kilicman, Abdulla -Al-Mamun, Md. Delowar Hossain

Abstract

Dengue fever is an intense feverish virus related disease dispatched with the nibble of Aedes mosquitoes carrying one of the four serotypes, which are symbolized as DEN-1, DEN-2, DEN-3, DEN-4. Almost fifty two percent people of our planet is at risk due to the dengue fever. Particularly, people of the tropical and subtropical countries as like Bangladesh, India, Pakistan, Nepal, Bhutan, Malaysia, etc. are in very risky position due to this fever. In Bangladesh, dengue fever happens nationally and has been endemic for more than two decades. Therefore, for realizing the dynamical conduct of this fever a perfect scientific model of disease transmission plays a noteworthy role and help us to prevent this disease effectively. From this context, in this article a novel six compartmental ASIR dengue transmission model have been established by using conformable fractional order derivatives. In the proposed model, the dynamics of human and mosquito populations have been constructed with six compartments. Here, the analytical stability of equilibria has been shown by disease free and endemic equilibrium points. Furthermore, a sensitivity analysis of the proposed model has been executed to evaluate the comparative rank of the model parameters for dengue transmission. The data of infected human population has been accumulated from different health institutions of Bangladesh which have been used to compute the infection rate of dengue cases in Bangladesh. Finally, a numerical simulation has been constructed for studying the dynamical behavior of dengue transmission with the help of Conformable fractional differential transformation technique.

摘要 登革热是由携带四种血清型(DEN-1、DEN-2、DEN-3、DEN-4)之一的伊蚊叮咬传播的一种与发热病毒有关的烈性疾病。地球上几乎有百分之五十二的人受到登革热的威胁。尤其是孟加拉、印度、巴基斯坦、尼泊尔、不丹、马来西亚等热带和亚热带国家的人民,因登革热而处于非常危险的境地。在孟加拉国,登革热在全国范围内都有发生,并且已经流行了二十多年。因此,为了解登革热的动态发展,一个完善的疾病传播科学模型将发挥重要作用,并帮助我们有效预防这种疾病。在此背景下,本文利用保形分数阶导数建立了一个新颖的六室 ASIR 登革热传播模型。在该模型中,人类和蚊子种群的动态变化由六个分区构成。在这里,无病平衡点和地方病平衡点显示了平衡点的分析稳定性。此外,还对提出的模型进行了敏感性分析,以评估登革热传播模型参数的比较等级。从孟加拉国不同的卫生机构收集了受感染人口的数据,用于计算孟加拉国登革热病例的感染率。最后,在可变分数微分变换技术的帮助下,构建了一个数值模拟,用于研究登革热传播的动态行为。
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引用次数: 0
Assessment of University Parking Management System: A Simulation-Based Study 大学停车场管理系统评估:基于模拟的研究
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700170
Shahriar Tanvir Alam, Abu Saleh Md. Nakib Uddin, Fahima Akter Azrin

Abstract

The university is having difficulty meeting the demand for parking lots to meet the requirements of students. According to data, the number of registered cars at a specific university has been variable over the last 4 years and is mostly growing, whereas the number of parking lots at the university parking area has been stable over these 04 years. Queueing theory has grown in prominence as it provides the numerical foundation for decision-making assessment. Queueing models with multiple servers provide extensive decision-making data, which is critical for evaluating a server’s performance. The purpose of this study is to assess the current situation of a university parking management system by simulating the university parking area in ARENA simulation software. For reducing traffic congestion and confirming the maximum utilization of the university parking lot, this paper formulates multiple server queueing models and assesses their performance. The “Multiple Server Finite Queue Length Infinite Queue Population Model” is most desirable where cars have to wait for less time in the queue (approximately 43.14%) and reduces the queue length by approximately 64.76% in the university parking area. Based on the findings of the queue performance, an ARENA-based simulation has been illustrated to visualize the improved condition of the university parking management system. When the findings from the performance evaluation of the queue model are applied, the simulation results show that the parking area’s capacity is more utilized (from 58.16 to 97.18%) compared to the current situation.

摘要 大学很难满足学生对停车场的需求。数据显示,某大学的注册汽车数量在过去 4 年中一直在变化,而且大部分时间都在增长,而大学停车场的数量在这 04 年中一直保持稳定。排队理论为决策评估提供了数字基础,因此日益受到重视。具有多个服务器的排队模型提供了大量的决策数据,这对于评估服务器的性能至关重要。本研究的目的是通过在 ARENA 仿真软件中模拟大学停车场,评估大学停车场管理系统的现状。为减少交通拥堵并确认大学停车场的最大利用率,本文建立了多个服务器队列模型,并对其性能进行了评估。其中,"多服务器有限队列长度无限队列人口模型 "最理想,车辆在队列中等待的时间较短(约为 43.14%),并将大学停车场的队列长度减少了约 64.76%。根据队列性能的评估结果,基于 ARENA 的模拟系统可直观地显示大学停车场管理系统的改善情况。当应用排队模型的性能评估结果时,模拟结果显示,与当前情况相比,停车区的容量利用率更高(从 58.16% 提高到 97.18%)。
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引用次数: 0
Fast Algorithm for Solving Some Three-Dimensional Inverse Problems of Magnetometry 解决某些三维反磁力测量问题的快速算法
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700030
A. S. Leonov, D. V. Lukyanenko, A. G. Yagola

Abstract

Typical three-dimensional inverse problems of magnetic prospecting are considered: determination of the vector density of magnetic dipoles in the studied area of the Earth’s crust from the components of the vector (and/or gradient tensor) of magnetic induction measured on the surface. These problems, being, as a rule, ill-posed, can be solved by standard regularization methods. However, for such a solution on sufficiently detailed grids, significant computing resources (computing clusters, supercomputers, etc.) are required to solve the problem in minutes. The article proposes a new, fast regularizing algorithm for solving such three-dimensional problems, which makes it possible to obtain an approximate solution on a personal computer of average performance in tens of seconds or in a few minutes. In addition, the approach used allows us to calculate an a posteriori error estimate of the found solution in a comparable time, and this makes it possible to evaluate the quality of the solution when interpreting the results. Algorithms for solving the inverse problem and a posteriori error estimation for the solutions found are tested in solving model inverse problems and used in the processing of experimental data.

摘要 考虑了典型的三维反磁力探矿问题:根据在地表测量的磁感应强度矢量(和/或梯度张量)的分量确定地壳研究区域的磁偶极子矢量密度。这些问题通常都是求解困难的问题,可以通过标准正则化方法解决。然而,要在足够精细的网格上解决这些问题,需要大量的计算资源(计算集群、超级计算机等),才能在几分钟内解决问题。本文提出了一种新的快速正则化算法来求解此类三维问题,这种算法可以在一台性能一般的个人电脑上在几十秒或几分钟内获得近似解。此外,所使用的方法还允许我们在相当短的时间内计算出所找到的解的后验误差估计值,这样就可以在解释结果时评估解的质量。在解决模型逆问题和处理实验数据的过程中,我们对求解逆问题的算法和求解结果的后验误差估计进行了测试。
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引用次数: 0
Estimation of Parameters in a Traffic Flow Model 交通流模型参数估计
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s207004822470008x
M. A. Pogrebnyak

Abstract

This paper studies the estimation of parameters estimation in a traffic flow model. The model is represented by a system of differential equations with a time delay. The main result of this paper is the calculation of the range of values for the parameters describing the intensity of acceleration and braking, as well as a coefficient that describes how smoothly the pursuing vehicle adjusts its speed to the one in front. The parameters of the model are estimated with analytical calculations and numerical experiments. A special computer program is developed for the numerical experiment.

摘要 本文研究了交通流模型中的参数估计。该模型由带有时间延迟的微分方程系统表示。本文的主要成果是计算了描述加速和制动强度的参数的取值范围,以及描述追尾车辆根据前方车辆调整速度的平稳程度的系数。该模型的参数是通过分析计算和数值实验估算出来的。为数值实验开发了专门的计算机程序。
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引用次数: 0
Churn Prediction Using Mathematical Programming via a Linear Classification Algorithm 通过线性分类算法使用数学编程进行流失预测
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700182
Mohamed Barhdadi, Badreddine Benyacoub, Mohamed Ouzineb

Abstract

The initial idea in developing customer churn prediction was to use statistical analysis of a sample of previous customers to help operators predict which existing customers were likely migrate to other operators. In this paper, a nonstatistical approach to this problem can also be envisaged by formulating the problem as a linear program. The main concept of our proposed algorithm is to hybridize the Jackknife resampling technique with an efficient heuristic based on a variable neighborhood search algorithm to construct a new approach that can present an alternative to black-box machine learning methods. The goal is to find possible solutions (or weights) to minimize error distances and the number of misclassified points. We tested the suggested algorithm with an imbalanced instance and the comparisons show that the proposed model outperforms the most existing machine learning classifiers, both in terms of the solution quality and the execution time. The numerical results indicate that the best solution is achieved in 85% over G-mean of all instances tested. The average gap between our solution and the best solution is still quite small (1.15%).

摘要 开发客户流失预测的最初想法是利用对以往客户样本的统计分析,帮助运营商预测哪些现有客户可能会迁移到其他运营商。在本文中,通过将该问题表述为线性程序,还可以设想一种非统计方法来解决该问题。我们提出的算法的主要概念是将积刀重采样技术与基于变量邻域搜索算法的高效启发式算法相结合,从而构建出一种可替代黑盒机器学习方法的新方法。我们的目标是找到可能的解决方案(或权重),使误差距离和误分类点的数量最小化。我们用不平衡实例测试了所建议的算法,比较结果表明,所建议的模型在解决方案质量和执行时间方面都优于大多数现有的机器学习分类器。数值结果表明,在所有测试实例中,85% 的 G-mean 都能获得最佳解决方案。我们的解决方案与最佳解决方案之间的平均差距仍然很小(1.15%)。
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引用次数: 0
Modelling Typhoid Fever Transmission with Treatment Relapse Response: Optimal Control and Cost-Effectiveness Analysis 伤寒传播与治疗复发反应建模:最佳控制和成本效益分析
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700169
Kazeem A. Tijani, Chinwendu E. Madubueze, Reuben I. Gweryina

Abstract

Typhoid fever has become a public health concern, especially in developing countries where sanitation and personal hygiene are not taken seriously, coupled with the non-availability of safe drinking water. Despite the antibiotic treatment, about 2–5% of recovered humans still harbour the typhoid bacteria in their bodies and shed it via their faeces in the population, making it difficult to eradicate the disease. Thus, the effect of limited clinical efficacy of the antibiotics with corresponding relapse response to treatment on infected humans is examined in this paper by formulating a deterministic mathematical model for direct and indirect transmission mode of Typhoid infection. The basic reproduction number is analytically derived and used to implement the global sensitivity analysis of the model’s parameters that employed Latin hypercube Sampling (LHS) with Partial Rank Correlation Coefficient (PRCC). Regarding the sensitivity analysis result, the optimal control and cost-effectiveness analysis are analysed and simulated numerically with four controls, the water, sanitation and hygiene (WASH) practice and awareness campaign control, the sterilisation and disinfection control, the potency of antibiotics control and the screening control. The optimal control analysis applied Pontrygin’s maximum principle to the optimal control problem. The limited efficacy of antibiotics with corresponding relapse response to treatment is shown to influence the spread of typhoid infection in the population. Furthermore, the cost-effectiveness analysis employed Infected Averted Ratio (IAR), Average Cost-effectiveness Ratio (ACER) and Increment Cost-effectiveness Ratio (ICER) techniques to four cases (I–IV) that compared fifteen strategies. The results indicate that the WASH practice and awareness campaign (Strategy 1) is good to implement for single control implementation, while for double control implementation, the WASH practice and awareness campaign and the potency of antibiotics administered to typhoid patients (Strategy 6) is the best to consider. Combining Strategy 6 and screening control is the most cost-effective for triple controls. Furthermore, the overall computation of cost-effectiveness among all the most cost-effective with all the controls combined suggests that Strategy 1 is the most cost-effective strategy to implement for eradicating typhoid infection in the population.

摘要 伤寒已成为一个公共卫生问题,特别是在发展中国家,由于这些国家不重视环境卫生和个人卫生,再加上没有安全的饮用水,伤寒已成为一个公共卫生问题。尽管经过抗生素治疗,但约有 2-5% 的康复者体内仍携带伤寒杆菌,并通过粪便在人群中传播,因此很难根除该疾病。因此,本文通过建立伤寒直接和间接传播模式的确定性数学模型,研究了抗生素的有限临床疗效和相应的治疗复发反应对受感染人类的影响。通过分析得出了基本繁殖数,并利用拉丁超立方采样(LHS)和部分等级相关系数(PRCC)对模型参数进行了全局敏感性分析。关于敏感性分析结果,对最佳控制和成本效益分析进行了分析,并通过四种控制方法进行了数值模拟,即水、环境卫生和个人卫生(WASH)实践和宣传活动控制、消毒和灭菌控制、抗生素效力控制和筛查控制。最优控制分析在最优控制问题上应用了庞特莱金的最大原则。结果表明,抗生素的有限效力和相应的复发治疗反应会影响伤寒感染在人群中的传播。此外,成本效益分析采用了感染避免率(IAR)、平均成本效益比(ACER)和增量成本效益比(ICER)技术,对四种情况(I-IV)的 15 种策略进行了比较。结果表明,在实施单一控制时,讲卫生运动和提高认识运动(策略 1)是很好的选择,而在实施双重控制时,讲卫生运动和提高认识运动以及对伤寒患者使用抗生素的效力(策略 6)是最好的选择。在三重控制中,将策略 6 与筛查控制相结合最具成本效益。此外,在所有最具成本效益的控制措施中,综合计算成本效益表明,策略 1 是根除人群中伤寒感染的最具成本效益的策略。
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引用次数: 0
Modification of a Cross Type Scheme to Eliminate a “Chessboard” Error 修改交叉类型方案以消除 "棋盘 "错误
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700042
Yu. V. Yanilkin, O. O. Toporova, A. M. Erofeev

Abstract

This paper shows that the cross-type difference schemes used to approximate gas dynamic equations have an error caused by the “chessboard” distribution of thermodynamic quantities. A modification of the two-dimensional (2D) scheme is proposed to eliminate this error. The results of test computations demonstrating the advantages of the new scheme are presented.

摘要 本文指出,用于近似气体动力学方程的交叉型差分方案会因热力学量的 "棋盘式 "分布而产生误差。为消除这一误差,提出了一种二维(2D)方案的改进方法。试验计算结果证明了新方案的优势。
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引用次数: 0
Comparative Analysis of Algebraic Models of Laminar-Turbulent Transition 层流-湍流转换代数模型的比较分析
Q3 Mathematics Pub Date : 2024-06-25 DOI: 10.1134/s2070048224700091
A. S. Stabnikov, A. V. Garbaruk, A. A. Matyushenko

Abstract

This paper presents the results of extensive testing of four recently proposed algebraic laminar-turbulent transition (LTT) models, which are significantly more computationally effective than differential models, while being potentially equally accurate. The models chosen for evaluation, namely, SST KD, SST kγ, SST alg-γ, and SA BCM, are implemented in the in-house code NTS and verified by comparing the obtained results with those published by the models’ authors. The experimental database used for the evaluation of the models includes transitional boundary layers at different free-flow turbulence intensities with and without the pressure gradient, four airfoil flows with different LTT scenarios, and a tandem of two airfoils. It is found that at low levels of turbulence, the results of the SA BCM and SST kγ models may depend on the initial approximation, which does not allow them to be recommended for engineering applications. The best results, comparable in accuracy to those of differential models, are obtained using the SST alg-γ model.

摘要 本文介绍了对最近提出的四个代数层流-湍流转换(LTT)模型的广泛测试结果。选择用于评估的模型,即 SST KD、SST kγ、SST alg-γ 和 SA BCM,是在内部代码 NTS 中实现的,并通过将获得的结果与模型作者发表的结果进行比较来验证。用于评估模型的实验数据库包括有压力梯度和无压力梯度的不同自由流湍流强度下的过渡边界层、不同 LTT 情景下的四个机翼流以及两个机翼的串联流。研究发现,在低湍流水平下,SA BCM 和 SST kγ 模型的结果可能取决于初始近似值,因此不能推荐用于工程应用。使用 SST alg-γ 模型得到的结果最好,精度与差分模型相当。
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引用次数: 0
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