首页 > 最新文献

Rwanda Medical Journal最新文献

英文 中文
An unusual variation in the formation and termination of the sciatic nerve - a case report 坐骨神经形成和终止的异常变异--病例报告
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.21
S. Habumuremyi, V. Archibong, J. Gashegu
The sciatic nerve (SN) presented with unusual patterns in which five smaller fibers instead of one or two nerves at the level of the Piriformis muscle. Those five fibers measured 7.5 cm from their origin to where they joined to form the SN. The SN terminated in the popliteal fossa by giving rise to three terminal branches: the tibial nerve, the common peroneal nerve, and another unusual nerve that supplied the medial head of the gastrocnemius. This case is unusual because the SN presents with different positional variations of its two components in relation to the piriformis muscle but not five fibers; in addition, the SN normally bifurcates instead of trifurcating when it reaches in the popliteal fossa. The case presented a Type A pattern of SN to the piriformis muscle. This type of pattern has been documented to be the most common in some parts of Africa. Some authors have reported two patterns of trifurcation of the SN. One is a pattern where the SN gave rise to the tibial, superficial, and deep peroneal nerves at the popliteal fossa, and another is a trifurcation pattern where it gave rise to the tibial, common peroneal, and sural nerves. The case is different as it presents an unusual unreported pattern where the SN trifurcates by giving rise to the tibial, common peroneal, and nerve that supplies the medial head of the gastrocnemius muscle. The current variation has never been reported elsewhere.
坐骨神经(SN)呈现出不寻常的形态,在梨状肌水平有五条较小的纤维,而不是一条或两条神经。这五条纤维从起源到连接形成坐骨神经的位置长达 7.5 厘米。腓总神经在腘窝处产生三个末端分支:胫神经、腓总神经和另一条供应腓肠肌内侧头的不寻常神经。该病例之所以不寻常,是因为SN的两个组成部分相对于梨状肌有不同的位置变化,但没有五根纤维;此外,SN到达腘窝时通常会分叉,而不是三叉。该病例呈现的是腹股沟肌到梨状肌的 A 型模式。据记载,这种模式在非洲一些地区最为常见。一些作者报告了两种SN三叉模式。一种是腓肠神经在腘窝处产生胫神经、腓浅神经和腓深神经,另一种是腓肠神经在腘窝处产生胫神经、腓总神经和鞍神经。本病例与众不同,因为它呈现了一种未曾报道过的不寻常模式,即腓肠神经三叉化,产生胫神经、腓总神经和供应腓肠肌内侧头的神经。目前的变异从未在其他地方报道过。
{"title":"An unusual variation in the formation and termination of the sciatic nerve - a case report","authors":"S. Habumuremyi, V. Archibong, J. Gashegu","doi":"10.4314/rmj.v81i1.21","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.21","url":null,"abstract":"The sciatic nerve (SN) presented with unusual patterns in which five smaller fibers instead of one or two nerves at the level of the Piriformis muscle. Those five fibers measured 7.5 cm from their origin to where they joined to form the SN. The SN terminated in the popliteal fossa by giving rise to three terminal branches: the tibial nerve, the common peroneal nerve, and another unusual nerve that supplied the medial head of the gastrocnemius. This case is unusual because the SN presents with different positional variations of its two components in relation to the piriformis muscle but not five fibers; in addition, the SN normally bifurcates instead of trifurcating when it reaches in the popliteal fossa. The case presented a Type A pattern of SN to the piriformis muscle. This type of pattern has been documented to be the most common in some parts of Africa. Some authors have reported two patterns of trifurcation of the SN. One is a pattern where the SN gave rise to the tibial, superficial, and deep peroneal nerves at the popliteal fossa, and another is a trifurcation pattern where it gave rise to the tibial, common peroneal, and sural nerves. The case is different as it presents an unusual unreported pattern where the SN trifurcates by giving rise to the tibial, common peroneal, and nerve that supplies the medial head of the gastrocnemius muscle. The current variation has never been reported elsewhere.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"43 182","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent primitive sciatic artery: a case report and review of the literature 持续存在的原始坐骨神经动脉:病例报告和文献综述
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.14
O. Kubwimana, E. Sindikubwabo, J. Rugambwa, J. Gashegu
A persistent sciatic artery is an anatomical variation as the artery running in the posterior thigh compartment should have regressed at the embryological level. Its persistence should be looked into the window of potential complications such as aneurysms and limb ischemia. A number of cases have previously been documented in international journals, but none locally. We present findings of a monthly resident dissection course whereby an adult male cadaver was dissected on the gluteal and posterior thigh, and we found a persistent sciatic artery arising on the lateral circumflex femoral artery, and distally, it was joining the normal popliteal artery. Persistent sciatic artery is a variation worth knowing for surgeons and anesthesiologists approaching the posterior thigh. We should foster awareness of such variations through research.
坐骨神经动脉持续存在是一种解剖学变异,因为在胚胎水平上,大腿后部的动脉应该已经退化。它的持续存在应被视为动脉瘤和肢体缺血等潜在并发症的窗口。此前,国际期刊上已有一些病例记录,但没有本地病例。我们展示了每月一次的住院医师解剖课程的研究结果,在解剖一具成年男性尸体的臀部和大腿后侧时,我们发现了一条在股外侧周动脉上产生的持续性坐骨神经动脉,其远端与正常的腘动脉相接。对于接近大腿后侧的外科医生和麻醉师来说,持续性坐骨神经动脉是一个值得了解的变异。我们应通过研究提高对此类变异的认识。
{"title":"Persistent primitive sciatic artery: a case report and review of the literature","authors":"O. Kubwimana, E. Sindikubwabo, J. Rugambwa, J. Gashegu","doi":"10.4314/rmj.v81i1.14","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.14","url":null,"abstract":"A persistent sciatic artery is an anatomical variation as the artery running in the posterior thigh compartment should have regressed at the embryological level. Its persistence should be looked into the window of potential complications such as aneurysms and limb ischemia. A number of cases have previously been documented in international journals, but none locally. We present findings of a monthly resident dissection course whereby an adult male cadaver was dissected on the gluteal and posterior thigh, and we found a persistent sciatic artery arising on the lateral circumflex femoral artery, and distally, it was joining the normal popliteal artery. Persistent sciatic artery is a variation worth knowing for surgeons and anesthesiologists approaching the posterior thigh. We should foster awareness of such variations through research.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"55 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duplicated gluteus maximus muscle: rare variant anatomy: a case report - a case report 双臀大肌:罕见的变异解剖:病例报告 - 病例报告
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.20
J. Rugambwa, J. Umuhire, D. Nkusi, O. Kubwimana, J. Gashegu
The gluteal region is an important anatomical and clinical area that contains muscles and vital neurovascular bundles. The gluteus maximus is the largest and most powerful muscle in the human body. While there can be some anatomical variations in the gluteus maximus, they are generally minor and do not significantly affect its function; however, its proximity to the sciatic nerve necessitates attention. Hence, a thorough understanding of the gluteal region's anatomy is crucial. In the gluteal region of an adult male cadaver dissection for the postgraduate surgical trainees' regular cadaver dissection course, we discovered a variation of the gluteus maximus muscle that was duplicated with a superficial big portion and a deep small muscle component. The little portion was attached to the hip bone by two tendinous slips connected by a tendinous arch under which the sciatic nerve runs. With this type of anatomical disposition, the sciatic nerve may become entrapped if a small portion of the gluteus muscle hypertrophies, resulting in sciatica. Since the gluteus maximus can entrap the sciatic nerve, understanding the anatomy of the gluteal region is crucial for both anatomical and clinical reasons. Clinicians should be aware of this anatomy for successful surgeries of the gluteal region, intramuscular injections, and dealing with complaints of sciatica. Additional investigation and dissections of the gluteal region are urged for a better comprehension of human anatomy and its variability.
臀部是一个重要的解剖和临床区域,包含肌肉和重要的神经血管束。臀大肌是人体最大、最有力的肌肉。虽然臀大肌可能存在一些解剖学上的变异,但这些变异一般都很轻微,不会对其功能产生重大影响;不过,由于臀大肌靠近坐骨神经,因此有必要对其加以关注。因此,全面了解臀大肌区域的解剖结构至关重要。在外科研究生学员常规尸体解剖课程中解剖的一具成年男性尸体的臀部区域中,我们发现了臀大肌的一个变种,它由浅层的大肌肉部分和深层的小肌肉部分组成。小肌部分通过两个腱滑片连接到髋骨上,腱滑片由坐骨神经穿过的腱弓连接。在这种解剖结构下,如果臀大肌的一小部分肥大,坐骨神经就可能被卡住,导致坐骨神经痛。由于臀大肌可能会夹住坐骨神经,因此了解臀部的解剖结构对于解剖学和临床都至关重要。临床医生应了解这一解剖结构,以便成功进行臀部手术、肌肉注射和处理坐骨神经痛的主诉。为了更好地理解人体解剖学及其可变性,我们呼吁对臀部区域进行更多的研究和解剖。
{"title":"Duplicated gluteus maximus muscle: rare variant anatomy: a case report - a case report","authors":"J. Rugambwa, J. Umuhire, D. Nkusi, O. Kubwimana, J. Gashegu","doi":"10.4314/rmj.v81i1.20","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.20","url":null,"abstract":"The gluteal region is an important anatomical and clinical area that contains muscles and vital neurovascular bundles. The gluteus maximus is the largest and most powerful muscle in the human body. While there can be some anatomical variations in the gluteus maximus, they are generally minor and do not significantly affect its function; however, its proximity to the sciatic nerve necessitates attention. Hence, a thorough understanding of the gluteal region's anatomy is crucial. In the gluteal region of an adult male cadaver dissection for the postgraduate surgical trainees' regular cadaver dissection course, we discovered a variation of the gluteus maximus muscle that was duplicated with a superficial big portion and a deep small muscle component. The little portion was attached to the hip bone by two tendinous slips connected by a tendinous arch under which the sciatic nerve runs. With this type of anatomical disposition, the sciatic nerve may become entrapped if a small portion of the gluteus muscle hypertrophies, resulting in sciatica. Since the gluteus maximus can entrap the sciatic nerve, understanding the anatomy of the gluteal region is crucial for both anatomical and clinical reasons. Clinicians should be aware of this anatomy for successful surgeries of the gluteal region, intramuscular injections, and dealing with complaints of sciatica. Additional investigation and dissections of the gluteal region are urged for a better comprehension of human anatomy and its variability.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"74 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and attitude towards body donation among students in Huye campus, University of Rwanda 卢旺达大学胡耶校区学生对遗体捐献的认识和态度
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.17
V. Archibong, A. Mohammed, A. Afodun, A. Okesina, S. Olurunnado, A. Ivan, K. Okesina, J. Gashegu
INTRODUCTION: Body donation is the willingness of a person to donate his body or organ to a person or organization after death. Medical schools in Western countries depend solely on human donations for medical education. However, the trend is different in Africa due to limited literature. This study aimed to measure the level of knowledge and attitude toward body donation among students at the Huye campus, University of Rwanda METHODS: A cross-sectional study involving 120 students at the Huye campus of the University of Rwanda. Data was collected using a Google format questionnaire. Knowledge and attitude were assigned scores of 0 and 1 for wrong and correct options, respectively. Knowledge of body donation was calculated as the sum of the scores of all knowledge questions, and Attitude was assessed as the mean of the sum of attitude scores. The association of age, knowledge, and attitude was assessed in bivariate analysis with the Chi-square test. The threshold for statistical significance was P ≤ 0.05 with 95% confidence intervals. RESULTS: 49.2% of the respondents had a very good knowledge score, 43.3% had a good knowledge score, 6.7% had a fair knowledge score, and 0.8% had a poor knowledge score. The positive attitude score was 85.8%, and the negative attitude score was 14.2%. However, 66.7% of the respondents showed an unwillingness towards body donation, and 84.2% showed a willingness towards organ donation. CONCLUSION: The unwillingness to donate body organs observed in this study calls for the introduction of sensitization programs or courses on body donation at the tertiary level of education in Rwanda.
导言:遗体捐献是指一个人愿意在死后将自己的遗体或器官捐献给某个人或组织。西方国家的医学院完全依靠人体捐献进行医学教育。然而,由于文献资料有限,非洲的趋势有所不同。本研究旨在测量卢旺达大学胡耶校区学生对遗体捐献的了解程度和态度 方法:横断面研究,涉及卢旺达大学胡耶校区的 120 名学生。采用谷歌格式问卷收集数据。对于错误和正确的选项,知识和态度分别以 0 分和 1 分表示。对遗体捐献知识的了解程度以所有知识问题的得分总和计算,而态度则以态度得分总和的平均值进行评估。年龄、知识和态度之间的关系通过卡方检验(Chi-square test)进行双变量分析。统计显著性的临界值为 P ≤ 0.05,置信区间为 95%。结果:49.2%的受访者知识得分很高,43.3%的受访者知识得分较高,6.7%的受访者知识得分一般,0.8%的受访者知识得分较低。态度积极的占 85.8%,态度消极的占 14.2%。然而,66.7%的受访者表示不愿意捐献遗体,84.2%的受访者表示愿意捐献器官。结论:本研究中观察到的不愿意捐献遗体器官的情况要求在卢旺达高等教育中引入有关遗体捐献的宣传计划或课程。
{"title":"Knowledge and attitude towards body donation among students in Huye campus, University of Rwanda","authors":"V. Archibong, A. Mohammed, A. Afodun, A. Okesina, S. Olurunnado, A. Ivan, K. Okesina, J. Gashegu","doi":"10.4314/rmj.v81i1.17","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.17","url":null,"abstract":"INTRODUCTION: Body donation is the willingness of a person to donate his body or organ to a person or organization after death. Medical schools in Western countries depend solely on human donations for medical education. However, the trend is different in Africa due to limited literature. This study aimed to measure the level of knowledge and attitude toward body donation among students at the Huye campus, University of Rwanda METHODS: A cross-sectional study involving 120 students at the Huye campus of the University of Rwanda. Data was collected using a Google format questionnaire. Knowledge and attitude were assigned scores of 0 and 1 for wrong and correct options, respectively. Knowledge of body donation was calculated as the sum of the scores of all knowledge questions, and Attitude was assessed as the mean of the sum of attitude scores. The association of age, knowledge, and attitude was assessed in bivariate analysis with the Chi-square test. The threshold for statistical significance was P ≤ 0.05 with 95% confidence intervals. RESULTS: 49.2% of the respondents had a very good knowledge score, 43.3% had a good knowledge score, 6.7% had a fair knowledge score, and 0.8% had a poor knowledge score. The positive attitude score was 85.8%, and the negative attitude score was 14.2%. However, 66.7% of the respondents showed an unwillingness towards body donation, and 84.2% showed a willingness towards organ donation. CONCLUSION: The unwillingness to donate body organs observed in this study calls for the introduction of sensitization programs or courses on body donation at the tertiary level of education in Rwanda.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"80 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological and immunohistochemical study of the neuroprotective potentials of trans-cinnamaldehyde in Wistar rat model of insulin resistance 反式肉桂醛对 Wistar 大鼠胰岛素抵抗模型神经保护潜力的组织学和免疫组化研究
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.16
S. Olorunnado, O. Akinola
INTRODUCTION: The incidence of insulin resistance is on the increase globally. Earlier reports linked impaired insulin signaling and glucose intolerance to cognitive decline, suggesting that improving insulin signaling could enhance neuronal survival. Trans-cinnamaldehyde (TCA) is an active component of cinnamon and has many pharmacological importance. However, the effects of TCA on insulin resistance-induced neurodegenerative changes are unclear. This study, therefore, aimed at evaluating the effects of trans-cinnamaldehyde on hippocampal histoarchitecture in insulin-resistant rats. METHODS: Twenty adult Wistar rats were fed with a high-fat diet for 8 weeks and then injected with a low dose of STZ (30 mg/kg body weight intraperitoneally). 60mg/kg of TCA was orally administered once daily for 4 weeks. Histological and immunohistochemical techniques were used to investigate the ameliorative potentials of TCA on the hippocampus of Wistar Rats. RESULTS: TCA administration to insulin-resistant rats histologically and immunohistochemically reduced pyknosis, astrogliosis, and neurodegenerative changes in the hippocampus when compared with untreated insulin-resistant rats. CONCLUSION: TCA prospect as a novel therapy in insulin-resistant subjects with neurogenerative diseases could be further explored.
简介:胰岛素抵抗的发病率在全球范围内呈上升趋势。早前有报告称,胰岛素信号传递受损和葡萄糖不耐受与认知能力下降有关,这表明改善胰岛素信号传递可提高神经元的存活率。反式肉桂醛(TCA)是肉桂的一种活性成分,具有许多重要的药理作用。然而,TCA 对胰岛素抵抗引起的神经退行性变化的影响尚不清楚。因此,本研究旨在评估反式肉桂醛对胰岛素抵抗大鼠海马组织结构的影响。方法:20 只成年 Wistar 大鼠以高脂肪饮食喂养 8 周,然后腹腔注射低剂量 STZ(30 毫克/千克体重)。每天一次口服 60 毫克/千克三氯乙酸,连续 4 周。采用组织学和免疫组化技术研究 TCA 对 Wistar 大鼠海马的改善潜力。结果:与未经治疗的胰岛素抵抗大鼠相比,给胰岛素抵抗大鼠服用 TCA 从组织学和免疫组化角度减少了海马中的细胞凋亡、星形胶质细胞增多和神经退行性变化。结论:三氯乙酸有望作为一种新型疗法用于患有神经退行性疾病的胰岛素抵抗受试者,这种疗法有待进一步探索。
{"title":"Histological and immunohistochemical study of the neuroprotective potentials of trans-cinnamaldehyde in Wistar rat model of insulin resistance","authors":"S. Olorunnado, O. Akinola","doi":"10.4314/rmj.v81i1.16","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.16","url":null,"abstract":"INTRODUCTION: The incidence of insulin resistance is on the increase globally. Earlier reports linked impaired insulin signaling and glucose intolerance to cognitive decline, suggesting that improving insulin signaling could enhance neuronal survival. Trans-cinnamaldehyde (TCA) is an active component of cinnamon and has many pharmacological importance. However, the effects of TCA on insulin resistance-induced neurodegenerative changes are unclear. This study, therefore, aimed at evaluating the effects of trans-cinnamaldehyde on hippocampal histoarchitecture in insulin-resistant rats. METHODS: Twenty adult Wistar rats were fed with a high-fat diet for 8 weeks and then injected with a low dose of STZ (30 mg/kg body weight intraperitoneally). 60mg/kg of TCA was orally administered once daily for 4 weeks. Histological and immunohistochemical techniques were used to investigate the ameliorative potentials of TCA on the hippocampus of Wistar Rats. RESULTS: TCA administration to insulin-resistant rats histologically and immunohistochemically reduced pyknosis, astrogliosis, and neurodegenerative changes in the hippocampus when compared with untreated insulin-resistant rats. CONCLUSION: TCA prospect as a novel therapy in insulin-resistant subjects with neurogenerative diseases could be further explored.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant status and acute phase reactants in pregnant women infected with Plasmodium falciparum 感染恶性疟原虫孕妇的抗氧化状态和急性期反应物
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.2
D. Atere Adedeji, A. Kosamat Yekeen, O. Oluwatuyi Precious, E. Chukwuemeka Cinderella
INTRODUCTION: Malaria during pregnancy remains a public health issue. The most deadly plasmodium, Plasmodium falciparum, kills about 40% of the world's population, especially pregnant women and children under five. In pregnant women infected with Plasmodium falciparum, MDA, CAT, H2O2, SOD, and GPx were measured as oxidative stress markers and SAA and CRP as acute-phase proteins. METHODS: A total of 90 subjects were recruited for this study, which was subdivided into 30 pregnant women infected with malaria (PWM), 35 pregnant women not infected with malaria (PWN), and 25 healthy women without pregnancy (WWP) who served as the control groups. 5mls of venous blood was collected and dispensed into appropriate bottles for malaria parasite assessment using a rapid diagnostic test (RDT) and MDA, CAT, H2O2, SOD, GPx, SAA, and CRP analysis using conventional laboratory techniques. Statistical analysis was done, and P values under 0.05 were significant. RESULTS: The PWM and PWN groups had significantly higher MDA and H2O2 values, but SOD, GPx, and CAT values were significantly lower (p<0.05). When comparing CRP and SAA levels between PWM, PWN, and control groups, both groups with pregnancy had significantly greater levels (p<0.05). A negative correlation (r = -0.442, p<0.05) was found between MDA and SAA, while positive correlations were seen between CAT and CRP, and SOD and SAA in pregnant women with malaria. CONCLUSION: This study found that malaria during pregnancy increases oxidants and decreases antioxidant enzymes, causing oxidative stress. This study showed that CRP and SAA may indicate malaria infections.
导言:孕期疟疾仍然是一个公共卫生问题。最致命的疟原虫--恶性疟原虫杀死了全球约 40% 的人口,尤其是孕妇和五岁以下儿童。在感染了恶性疟原虫的孕妇中,测量了氧化应激标记物 MDA、CAT、H2O2、SOD 和 GPx,以及急性期蛋白 SAA 和 CRP。方法:本研究共招募了 90 名受试者,分为 30 名感染疟疾的孕妇(PWM)、35 名未感染疟疾的孕妇(PWN)和 25 名未怀孕的健康妇女(WWP)作为对照组。采集 5 毫升静脉血并装入适当的瓶中,使用快速诊断检测(RDT)对疟原虫进行评估,并使用常规实验室技术对 MDA、CAT、H2O2、SOD、GPx、SAA 和 CRP 进行分析。进行了统计分析,P 值小于 0.05 为显著。结果:PWM 组和 PWN 组的 MDA 和 H2O2 值明显较高,但 SOD、GPx 和 CAT 值明显较低(P<0.05)。在比较 PWM 组、PWN 组和对照组的 CRP 和 SAA 水平时,妊娠组和对照组的 CRP 和 SAA 水平都明显更高(P<0.05)。疟疾孕妇的 MDA 与 SAA 之间呈负相关(r = -0.442,p<0.05),而 CAT 与 CRP、SOD 与 SAA 之间呈正相关。结论:本研究发现,妊娠期疟疾会增加氧化剂,降低抗氧化酶,导致氧化应激。该研究表明,CRP和SAA可能预示着疟疾感染。
{"title":"Antioxidant status and acute phase reactants in pregnant women infected with Plasmodium falciparum","authors":"D. Atere Adedeji, A. Kosamat Yekeen, O. Oluwatuyi Precious, E. Chukwuemeka Cinderella","doi":"10.4314/rmj.v81i1.2","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.2","url":null,"abstract":"INTRODUCTION: Malaria during pregnancy remains a public health issue. The most deadly plasmodium, Plasmodium falciparum, kills about 40% of the world's population, especially pregnant women and children under five. In pregnant women infected with Plasmodium falciparum, MDA, CAT, H2O2, SOD, and GPx were measured as oxidative stress markers and SAA and CRP as acute-phase proteins. \u0000METHODS: A total of 90 subjects were recruited for this study, which was subdivided into 30 pregnant women infected with malaria (PWM), 35 pregnant women not infected with malaria (PWN), and 25 healthy women without pregnancy (WWP) who served as the control groups. 5mls of venous blood was collected and dispensed into appropriate bottles for malaria parasite assessment using a rapid diagnostic test (RDT) and MDA, CAT, H2O2, SOD, GPx, SAA, and CRP analysis using conventional laboratory techniques. Statistical analysis was done, and P values under 0.05 were significant. \u0000RESULTS: The PWM and PWN groups had significantly higher MDA and H2O2 values, but SOD, GPx, and CAT values were significantly lower (p<0.05). When comparing CRP and SAA levels between PWM, PWN, and control groups, both groups with pregnancy had significantly greater levels (p<0.05). A negative correlation (r = -0.442, p<0.05) was found between MDA and SAA, while positive correlations were seen between CAT and CRP, and SOD and SAA in pregnant women with malaria. \u0000CONCLUSION: This study found that malaria during pregnancy increases oxidants and decreases antioxidant enzymes, causing oxidative stress. This study showed that CRP and SAA may indicate malaria infections.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"85 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140706956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sciatic nerve loop engulfing perforator arteries - a case report 坐骨神经环吞噬穿孔动脉--病例报告
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.15
O. Kubwimana, J. Rugambwa, J. Gashegu
The sciatic nerve is the thickest in the human body; however, it is susceptible to a wide range of anatomical variations with potential clinical implications. Some variations are very rare and unreported in the existing literature We present a case of a middle-aged male cadaver with a sciatic nerve giving a loop where 3 perforator arteries from the profunda femoris artery pass; the loop bundles were reforming the main nerve distally. A sciatic nerve loop engulfing muscular perforator arteries is a scarce anatomical variation worth knowing for clinical, academic, and research interests.
坐骨神经是人体中最粗的神经,但它很容易发生各种解剖变异,对临床有潜在影响。我们展示了一例中年男性尸体,其坐骨神经在股深动脉的三条穿孔动脉穿过的地方形成了一个环;环束在远端对主神经进行改造。坐骨神经环吞噬肌肉穿孔动脉是一种罕见的解剖变异,值得临床、学术和研究人员了解。
{"title":"Sciatic nerve loop engulfing perforator arteries - a case report","authors":"O. Kubwimana, J. Rugambwa, J. Gashegu","doi":"10.4314/rmj.v81i1.15","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.15","url":null,"abstract":"The sciatic nerve is the thickest in the human body; however, it is susceptible to a wide range of anatomical variations with potential clinical implications. Some variations are very rare and unreported in the existing literature We present a case of a middle-aged male cadaver with a sciatic nerve giving a loop where 3 perforator arteries from the profunda femoris artery pass; the loop bundles were reforming the main nerve distally. A sciatic nerve loop engulfing muscular perforator arteries is a scarce anatomical variation worth knowing for clinical, academic, and research interests.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"72 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of the Zipgrade app in marking and data analysis in the Human Anatomy Department of the School of Medicine and Pharmacy at the University of Rwanda Zipgrade 应用程序在卢旺达大学医学和药学院人体解剖学系的评分和数据分析中的有效性
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.23
P. Ndahimana, V. Archibong, J. Gashegu
INTRODUCTION: Introduction: ZipGrade is a free online app, and that helps to grade student assessments in multiple-choice formats. It is an effective tool to analyze the student’s performance within a short time. This study was conducted to determine the effectiveness of the Zipgrade app in electronic marking and data analysis. METHODS: The study used the Anatomy III answer sheets of 71 students from Pharmacy Level 2. The Zipgrade App was used to prepare and mark the answer sheets at the end of the assessment. Within 15 minutes, 69 out of the 71 answer sheets were scanned and marked electronically on the mobile Zipgrade app using a smartphone. The Zipgrade mobile app analyzes the performance of the students on each question. RESULTS: The Zipgrade App provided results in the form of percentages, tables, and graphs. The minimum score was 38/80 (47.5%), while the maximum score was 71/80 (88.8%). The average score was 58.4/80 (73.1%). The median is 60 (75%), while the standard deviation was found to be 0.09. Six students scored 85-90%, ten students scored 80-85%, nineteen scored 75-80%, and seventeen students obtained 70-75%. Seven students got 65-70%, and three students scored 6065%. Five students scored between 50 and 60%, and two students failed the assessment by scoring 45-49%. Item analysis of questions showed that question 63 was the easiest, where 100% of students passed, and the most difficult was question 10, where only 10.1% of students passed the question. CONCLUSION: Zipgrade is an important technology in marking and grading, and it is a more efficient tool for a data-driven education system in today’s world.
简介:简介:ZipGrade 是一款免费的在线应用程序,可帮助以多项选择形式对学生的评估进行评分。它是在短时间内分析学生成绩的有效工具。本研究旨在确定 Zipgrade 应用程序在电子评分和数据分析方面的有效性。方法:研究使用了 71 名药剂学二级学生的解剖学 III 答卷。使用 Zipgrade 应用程序在评估结束时准备和批改答卷。在 15 分钟内,71 份答卷中有 69 份使用智能手机在 Zipgrade 移动应用程序上进行了电子扫描和批改。Zipgrade 移动应用程序可分析学生在每道题上的表现。结果:Zipgrade 应用程序以百分比、表格和图表的形式提供结果。最低分是 38/80(47.5%),最高分是 71/80(88.8%)。平均分为 58.4/80(73.1%)。中位数为 60(75%),标准差为 0.09。六名学生的得分率为 85-90%,十名学生的得分率为 80-85%,十九名学生的得分率为 75-80%,十七名学生的得分率为 70-75%。七名学生得分 65-70%,三名学生得分 60-65%。五名学生的得分在 50-60% 之间,两名学生的得分在 45-49% 之间,未能通过评估。对问题的项目分析显示,第 63 题最简单,100% 的学生都通过了;第 10 题最难,只有 10.1%的学生通过了该题。结论:Zipgrade 是一种重要的阅卷和评分技术,是当今世界数据驱动教育系统的一种更有效的工具。
{"title":"Effectiveness of the Zipgrade app in marking and data analysis in the Human Anatomy Department of the School of Medicine and Pharmacy at the University of Rwanda","authors":"P. Ndahimana, V. Archibong, J. Gashegu","doi":"10.4314/rmj.v81i1.23","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.23","url":null,"abstract":"INTRODUCTION: Introduction: ZipGrade is a free online app, and that helps to grade student assessments in multiple-choice formats. It is an effective tool to analyze the student’s performance within a short time. This study was conducted to determine the effectiveness of the Zipgrade app in electronic marking and data analysis. METHODS: The study used the Anatomy III answer sheets of 71 students from Pharmacy Level 2. The Zipgrade App was used to prepare and mark the answer sheets at the end of the assessment. Within 15 minutes, 69 out of the 71 answer sheets were scanned and marked electronically on the mobile Zipgrade app using a smartphone. The Zipgrade mobile app analyzes the performance of the students on each question. RESULTS: The Zipgrade App provided results in the form of percentages, tables, and graphs. The minimum score was 38/80 (47.5%), while the maximum score was 71/80 (88.8%). The average score was 58.4/80 (73.1%). The median is 60 (75%), while the standard deviation was found to be 0.09. Six students scored 85-90%, ten students scored 80-85%, nineteen scored 75-80%, and seventeen students obtained 70-75%. Seven students got 65-70%, and three students scored 6065%. Five students scored between 50 and 60%, and two students failed the assessment by scoring 45-49%. Item analysis of questions showed that question 63 was the easiest, where 100% of students passed, and the most difficult was question 10, where only 10.1% of students passed the question. CONCLUSION: Zipgrade is an important technology in marking and grading, and it is a more efficient tool for a data-driven education system in today’s world.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"26 102","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference percentiles for mid-upper arm circumference, upper arm muscle and fat areas of Nigerian children and adolescent population aged 0 – 19 years 尼日利亚 0 - 19 岁儿童和青少年上臂中围、上臂肌肉和脂肪面积的参考百分位数
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.4
M. Nwankwo, B. Danborno, S. A. Musa, A. S. Akuyam
INTRODUCTION: Mid-upper arm circumference (MUAC) has commonly been used for many years as an alternative nutritional status index in field settings, yet estimates of percentile range for healthy children and adolescents have not been documented in Nigeria. We construct reference curves for MUAC and its derived measures of upper arm muscle area (UAMA), upper arm fat area (UAFA) and present sex- and age-specific MUAC, UAMA and UAFA values for children and adolescents. METHODS: Natural cubic splines were fitted by maximum penalized likelihood to develop centile curves for MUAC, UAMA and UAFA and the LMS coefficients necessary to estimate the z-score specific to each age and gender were presented. MUAC, UAMA and UAFA reference curves of US children and adolescents were used for comparison. RESULTS: The centiles of MUAC, UAMA and UAFA increased with age. However, these centile curves show significant sex-specific differences for boys and girls aged ≥ 10, ≥ 14.5 and ≥ 4.5 years of age, respectively. Compared to the US reference, the percentiles of MUAC, UAMA and MUAC are generally lower. CONCLUSION: In this study, we have presented a reference set of curves and tables for MUAC and its measures for healthy children and adolescents.
简介:多年来,中上臂围(MUAC)一直被用作野外环境下的另一种营养状况指数,但尼日利亚尚未记录健康儿童和青少年的百分位数范围。我们构建了MUAC及其衍生测量指标上臂肌肉面积(UAMA)和上臂脂肪面积(UAFA)的参考曲线,并给出了儿童和青少年不同性别和年龄的MUAC、UAMA和UAFA值。方法:采用最大似然法拟合自然三次样条,绘制出上臂长、上臂宽和上臂脂肪面积的百分位曲线,并给出估算各年龄和性别特定 z 分数所需的 LMS 系数。并使用美国儿童和青少年的 MUAC、UAMA 和 UAFA 参考曲线进行比较。结果:MUAC、UAMA 和 UAFA 的百分位数随年龄增长而增加。然而,这些百分位数曲线显示,年龄≥ 10 岁、≥ 14.5 岁和≥ 4.5 岁的男孩和女孩分别存在显著的性别差异。与美国参考值相比,中位体重、上腹围和中位体重的百分位数普遍较低。结论:在这项研究中,我们为健康儿童和青少年的 MUAC 及其测量值提供了一套参考曲线和表格。
{"title":"Reference percentiles for mid-upper arm circumference, upper arm muscle and fat areas of Nigerian children and adolescent population aged 0 – 19 years","authors":"M. Nwankwo, B. Danborno, S. A. Musa, A. S. Akuyam","doi":"10.4314/rmj.v81i1.4","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.4","url":null,"abstract":"INTRODUCTION: Mid-upper arm circumference (MUAC) has commonly been used for many years as an alternative nutritional status index in field settings, yet estimates of percentile range for healthy children and adolescents have not been documented in Nigeria. We construct reference curves for MUAC and its derived measures of upper arm muscle area (UAMA), upper arm fat area (UAFA) and present sex- and age-specific MUAC, UAMA and UAFA values for children and adolescents. \u0000METHODS: Natural cubic splines were fitted by maximum penalized likelihood to develop centile curves for MUAC, UAMA and UAFA and the LMS coefficients necessary to estimate the z-score specific to each age and gender were presented. MUAC, UAMA and UAFA reference curves of US children and adolescents were used for comparison. \u0000RESULTS: The centiles of MUAC, UAMA and UAFA increased with age. However, these centile curves show significant sex-specific differences for boys and girls aged ≥ 10, ≥ 14.5 and ≥ 4.5 years of age, respectively. Compared to the US reference, the percentiles of MUAC, UAMA and MUAC are generally lower. \u0000CONCLUSION: In this study, we have presented a reference set of curves and tables for MUAC and its measures for healthy children and adolescents.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"96 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney malrotation with aberrant renal arteries and extra-renal calyces - case report 肾错构瘤伴异常肾动脉和肾外盏--病例报告
Q4 Medicine Pub Date : 2024-04-13 DOI: 10.4314/rmj.v81i1.12
S. Habumuremyi, C. Niyibigira, V. Archibong, J. Gashegu, Mr. Schadrack Habumuremyi
Variations in the ureteral patterning, venous, and arterial of the kidneys are common; however, concomitant involvement with two systems is rare. The current case was discovered during a routine dissection course that took place in the Human Anatomy laboratory of the University of Rwanda. While dissecting the retroperitoneal space of one specimen, it was realized that the right kidney was mal-rotated with a ureter connected to the anterior side. That right kidney also had two aberrant arteries in addition to the main renal artery, those two aberrant arteries emerged from the inferior pole of the kidney. Renal arterial variants may be grouped as supernumerary, multiple, and aberrant, in the current case it is aberrant. It is expected that the kidney rotates from anterior to medial around the longitudinal axis during development, and the renal hilum turns toward the medial direction. However, in the current case, the hilum faced anteriorly.
肾脏输尿管形态、静脉和动脉的变异很常见,但同时涉及两个系统的情况却很少见。本病例是在卢旺达大学人体解剖实验室的一次例行解剖课程中发现的。在解剖一个标本的腹膜后间隙时,发现右肾旋转不良,输尿管与前侧相连。除主肾动脉外,该右肾还有两条畸形动脉,这两条畸形动脉从肾脏下极出现。肾动脉变异可分为特异性、多发性和异常性,本病例的肾动脉变异属于异常性。肾脏在发育过程中会围绕纵轴从前方向内侧旋转,肾门也会转向内侧。然而,在本病例中,肾门朝向前方。
{"title":"Kidney malrotation with aberrant renal arteries and extra-renal calyces - case report","authors":"S. Habumuremyi, C. Niyibigira, V. Archibong, J. Gashegu, Mr. Schadrack Habumuremyi","doi":"10.4314/rmj.v81i1.12","DOIUrl":"https://doi.org/10.4314/rmj.v81i1.12","url":null,"abstract":"Variations in the ureteral patterning, venous, and arterial of the kidneys are common; however, concomitant involvement with two systems is rare. The current case was discovered during a routine dissection course that took place in the Human Anatomy laboratory of the University of Rwanda. While dissecting the retroperitoneal space of one specimen, it was realized that the right kidney was mal-rotated with a ureter connected to the anterior side. That right kidney also had two aberrant arteries in addition to the main renal artery, those two aberrant arteries emerged from the inferior pole of the kidney. Renal arterial variants may be grouped as supernumerary, multiple, and aberrant, in the current case it is aberrant. It is expected that the kidney rotates from anterior to medial around the longitudinal axis during development, and the renal hilum turns toward the medial direction. However, in the current case, the hilum faced anteriorly.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Rwanda Medical Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1