Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.44-50
Yossi Maryanti, Devi Susanti, Dhea Maulidyastuti
Ischemic stroke is neurological dysfuntion caused by focal cerebral, spinal, or retinal infarction with symptoms persistingfor more than 24 hours. Prevalence of ischemic stroke is 87% of the total stroke. This study aims to describe the riskfactors of ischemic stroke patients in neurology ward Arifin Achmad General Hospital Riau province 1 January 2018−31 December 2018 period. The cross sectional used in this study and the sampling methode was consecutive sampling.There was 150 cases in this study. The result shown that most of ischemic stroke patients at 51−65 year age group(52,0%), female (50,7%), have optimal total cholesterol levels (46,7%), optimal levels of LDL (28,0%), medium levels ofHDL (55,3%), optimal levels of trygliceryde (66,0%), normal uric acid levels (63,3), have history of hypertension(60,0%), have not history of diabetes mellitus (72,7%) and history of heart disease (89,3%).
{"title":"Gambaran Faktor Risiko Pasien Stroke Iskemik yang dirawat di Bangsal Saraf RSUD Arifin Achmad Provinsi Riau Periode 1 Januari 2018 31 Desember 2018","authors":"Yossi Maryanti, Devi Susanti, Dhea Maulidyastuti","doi":"10.26891/jik.v13i1.2019.44-50","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.44-50","url":null,"abstract":"Ischemic stroke is neurological dysfuntion caused by focal cerebral, spinal, or retinal infarction with symptoms persistingfor more than 24 hours. Prevalence of ischemic stroke is 87% of the total stroke. This study aims to describe the riskfactors of ischemic stroke patients in neurology ward Arifin Achmad General Hospital Riau province 1 January 2018−31 December 2018 period. The cross sectional used in this study and the sampling methode was consecutive sampling.There was 150 cases in this study. The result shown that most of ischemic stroke patients at 51−65 year age group(52,0%), female (50,7%), have optimal total cholesterol levels (46,7%), optimal levels of LDL (28,0%), medium levels ofHDL (55,3%), optimal levels of trygliceryde (66,0%), normal uric acid levels (63,3), have history of hypertension(60,0%), have not history of diabetes mellitus (72,7%) and history of heart disease (89,3%).","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115045114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.73-76
Andrea Valentino, Rijalun Arridho
Primary intracranial malignant melanoma is an extremely rare tumor. Most of the intracranial malignant melanoma aremetastatic from skin. Diagnosis needs multidisciplinary workup to exclude metastatic melanoma. We are reporting acase of young girl with decrease consciousness and tetraplegia. CT scan revealed a solitary tumor mass in the brain.Histopathological examination and confirmed by immunohistochemistry showed that the type of tumor was intracranialprimary malignant melanoma and by excluding metastatic melanoma. Tumor excision was performed in patient andadjuvant chemotherapy was given, but residual tumors were present multiple.
{"title":"Laporan Kasus: Melanoma Maligna Intrakranial Primer","authors":"Andrea Valentino, Rijalun Arridho","doi":"10.26891/jik.v13i1.2019.73-76","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.73-76","url":null,"abstract":"Primary intracranial malignant melanoma is an extremely rare tumor. Most of the intracranial malignant melanoma aremetastatic from skin. Diagnosis needs multidisciplinary workup to exclude metastatic melanoma. We are reporting acase of young girl with decrease consciousness and tetraplegia. CT scan revealed a solitary tumor mass in the brain.Histopathological examination and confirmed by immunohistochemistry showed that the type of tumor was intracranialprimary malignant melanoma and by excluding metastatic melanoma. Tumor excision was performed in patient andadjuvant chemotherapy was given, but residual tumors were present multiple.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115622895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.58-66
Elva Rosiana, Wiwit Ade Fidiawati, Darmawi Darmawi
Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion(reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidativestress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the celldeath. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion.This study was an experimental laboratory research with post-test-only control group design including 20male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutesischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) andtreatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathologicalcharacteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.
{"title":"Gambaran Histopatologi Pankreas Tikus Putih (Rattus norvegicus) Pasca Perlakuan Iskemia-Reperfusi Ginjal","authors":"Elva Rosiana, Wiwit Ade Fidiawati, Darmawi Darmawi","doi":"10.26891/jik.v13i1.2019.58-66","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.58-66","url":null,"abstract":"Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion(reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidativestress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the celldeath. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion.This study was an experimental laboratory research with post-test-only control group design including 20male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutesischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) andtreatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathologicalcharacteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116835093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.23-27
Yolazenia Yolazenia, H. Harianto, Iqbal Teguh Riady
Allergic rhinitis should be considered as a serious condition because it can affect the quality of life of patients. In manycases, the most common allergen is house dust mites (HDM). The purpose of this study was to describe the density ofhouse dust mites as triggers of allergic rhinitis in Pekanbaru orphanage children. This is a descriptive study with across sectional approach. Data obtained from interviews using the modified International Study of Asthma and Allergiesof Childhood (ISAAC) questionnaire to know the allergic rhinitis status and examination of house dust samples toidentify HDM in the parasitology laboratory. Sampling was carried out in 4 orphanages Pekanbaru. Allergic rhinitissymptoms were experienced by 81.2% of children in the orphanages and HDM was found with the mean density 9.11/g of dust. HDM was found in all four orphanages and was found to have a high incidence of allergic rhinitis.
{"title":"Gambaran Kepadatan Tungau Debu Rumah Sebagai Pencetus Rinitis Alergi pada Anak Panti Asuhan Pekanbaru","authors":"Yolazenia Yolazenia, H. Harianto, Iqbal Teguh Riady","doi":"10.26891/jik.v13i1.2019.23-27","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.23-27","url":null,"abstract":"Allergic rhinitis should be considered as a serious condition because it can affect the quality of life of patients. In manycases, the most common allergen is house dust mites (HDM). The purpose of this study was to describe the density ofhouse dust mites as triggers of allergic rhinitis in Pekanbaru orphanage children. This is a descriptive study with across sectional approach. Data obtained from interviews using the modified International Study of Asthma and Allergiesof Childhood (ISAAC) questionnaire to know the allergic rhinitis status and examination of house dust samples toidentify HDM in the parasitology laboratory. Sampling was carried out in 4 orphanages Pekanbaru. Allergic rhinitissymptoms were experienced by 81.2% of children in the orphanages and HDM was found with the mean density 9.11/g of dust. HDM was found in all four orphanages and was found to have a high incidence of allergic rhinitis.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114408729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.51-57
Ilhami Romus, Ina Farida Rangkuti, Vini Jum’atur Rahmah
Ascites is abnormal accumulation fluid in the peritoneal cavity. Many underlying disease can be responsiblefor causing ascites. Peritoneal fluid cytology remains the gold standard for detection of malignant cells inascites which is useful in determining staging, treatment and prognosis. This aim of this study is to describethe characteristic of the result ascitic cytology examination at Anatomical Pathology Department of ArifinAchmad Hospital Period January 2013 – December 2018. This study reviewed the anatomy pathology data.A total of 171 cases consisted of 91.8% were females and males were 8.2%. The highest number caseswere in the age group of 41-50 years (26.9%). Most ascitic fluid came from Department of Obstetric andGynecology (81.9%). The more frequent clinical diagnosis were ovarian carcinoma (19.3%) and ovariancyst (18.7%). Most ascitic cytology examination results was positive cytology (64,9%). Adenocarcinomawas commonest positive cytology (46,2%).
{"title":"Gambaran Hasil Pemeriksaan Sitologi Cairan Asites di Instalasi Patologi Anatomi RSUD Arifin Achmad Provinsi Riau Periode Januari 2013 – Desember 2017","authors":"Ilhami Romus, Ina Farida Rangkuti, Vini Jum’atur Rahmah","doi":"10.26891/jik.v13i1.2019.51-57","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.51-57","url":null,"abstract":"Ascites is abnormal accumulation fluid in the peritoneal cavity. Many underlying disease can be responsiblefor causing ascites. Peritoneal fluid cytology remains the gold standard for detection of malignant cells inascites which is useful in determining staging, treatment and prognosis. This aim of this study is to describethe characteristic of the result ascitic cytology examination at Anatomical Pathology Department of ArifinAchmad Hospital Period January 2013 – December 2018. This study reviewed the anatomy pathology data.A total of 171 cases consisted of 91.8% were females and males were 8.2%. The highest number caseswere in the age group of 41-50 years (26.9%). Most ascitic fluid came from Department of Obstetric andGynecology (81.9%). The more frequent clinical diagnosis were ovarian carcinoma (19.3%) and ovariancyst (18.7%). Most ascitic cytology examination results was positive cytology (64,9%). Adenocarcinomawas commonest positive cytology (46,2%).","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128184869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.4-13
Ekarini Daroedono
Communication in the health sector plays an important role in the context of educating people and the society. Theemphasis is rely primarily on promoting health so that behavior changes occur. One of the example is a governmentprogram “GEMARIKAN” which was designated to increase fish consumption in the community. Unfortunately, thetriumph upon this programme is overshadowed by the potential transmission of zoonotic infections of the nematodeworm named Anisakis spp. This worm can caused a potentially fatal and deadly disease called anisakiasis. This risk canbe reduced by re-conducting numerous education in the community regarding these parasites, their life cycles, its hostbehaviors and lifestyles that can facilitate transmission such as eating fish in raw conditions and the need of goodhandling practices of fish to avoid transmission to occur.
{"title":"Konsumsi Ikan dan Potensi Anisakiasis: Aspek Komunikasi Kesehatan Masyarakat Suatu Program Pemerintah","authors":"Ekarini Daroedono","doi":"10.26891/jik.v13i1.2019.4-13","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.4-13","url":null,"abstract":"Communication in the health sector plays an important role in the context of educating people and the society. Theemphasis is rely primarily on promoting health so that behavior changes occur. One of the example is a governmentprogram “GEMARIKAN” which was designated to increase fish consumption in the community. Unfortunately, thetriumph upon this programme is overshadowed by the potential transmission of zoonotic infections of the nematodeworm named Anisakis spp. This worm can caused a potentially fatal and deadly disease called anisakiasis. This risk canbe reduced by re-conducting numerous education in the community regarding these parasites, their life cycles, its hostbehaviors and lifestyles that can facilitate transmission such as eating fish in raw conditions and the need of goodhandling practices of fish to avoid transmission to occur.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127462871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.67-72
Sri Wahdini, Anita D. Shanti, Hans M. Sinaga
Knowledge and behaviour about properly handle and maintain contact lens is essential to prevent infection. Thepurpose of this study was to determine the knowledge and behaviour of medical students in one of university in Jakartaabout the use and care of contact lens in contact lenses users. This study uses cross-sectional design. Data wascollected in January-June 2015 in one of university in Jakarta using specific questionnaire containing 10 questions.Respondents were the students in the first, second, and third years who use the contact lens. There were 97 respondentsand the percentage of respondent with good, fair, and poor knowledge level about the use and care of contact lens were40 (41.2%), 29 (29.9%), and 28 (28.9%). The number of respondents with good, fair, and poor behavior level about thecare of contact lens were 63 (64.9%), 31 (32.0%), and 3 (3.1%). The knowledge and behaviour among medical studentswearing contact lenses about the use and care of contact lens were in good level.
{"title":"Pengetahuan dan Perilaku Mahasiswa Kedokteran di Sebuah Universitas di Jakarta tentang Penggunaan dan Perawatan Lensa Kontak","authors":"Sri Wahdini, Anita D. Shanti, Hans M. Sinaga","doi":"10.26891/jik.v13i1.2019.67-72","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.67-72","url":null,"abstract":"Knowledge and behaviour about properly handle and maintain contact lens is essential to prevent infection. Thepurpose of this study was to determine the knowledge and behaviour of medical students in one of university in Jakartaabout the use and care of contact lens in contact lenses users. This study uses cross-sectional design. Data wascollected in January-June 2015 in one of university in Jakarta using specific questionnaire containing 10 questions.Respondents were the students in the first, second, and third years who use the contact lens. There were 97 respondentsand the percentage of respondent with good, fair, and poor knowledge level about the use and care of contact lens were40 (41.2%), 29 (29.9%), and 28 (28.9%). The number of respondents with good, fair, and poor behavior level about thecare of contact lens were 63 (64.9%), 31 (32.0%), and 3 (3.1%). The knowledge and behaviour among medical studentswearing contact lenses about the use and care of contact lens were in good level.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132906172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26891/jik.v13i1.2019.14-22
F. Siregar
Immune function will decrease with age. The weakening of immune system is known as immunosenescence.Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergoaging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomereshortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decreasenumber of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changingmacrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissueregeneration.
{"title":"Immunosenescence : Penuaan Pada Sel Makrofag","authors":"F. Siregar","doi":"10.26891/jik.v13i1.2019.14-22","DOIUrl":"https://doi.org/10.26891/jik.v13i1.2019.14-22","url":null,"abstract":"Immune function will decrease with age. The weakening of immune system is known as immunosenescence.Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergoaging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomereshortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decreasenumber of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changingmacrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissueregeneration.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127456703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-22DOI: 10.26891/jik.v11i2.2017.30-33
Eka Bebasari, D. P. Nugraha
The nutritional status is a factor that related with blood pressure. The nutritional status that indicated by body massindex (BMI) needs to be considered in management of hypertension. This study was a cross-sectional analytic thatassess relationship between BMI and hypertension controlled. The subjects of the study were hypertension patientsthat visit outpatient clinic of Arifin Ahmad General Hospital, Riau Province. Datas were analyzed by unpaired t-test.The results showed that patients with obesity grade 1 were more frequent in controlled hypertension group comparedto uncontrolled hypertension (43.8% vs 32.5%). The BMI average in patients with controlled hypertension group was24.2, while in uncontrolled hypertension group was 24.8 (p>0.05). There was no statistically significant differencebetween BMI in both groups patients.
营养状况是与血压有关的一个因素。在高血压的治疗中，需要考虑身体质量指数(BMI)所指示的营养状况。本研究采用横断面分析评估BMI与高血压控制之间的关系。研究对象为在廖内省阿里芬艾哈迈德总医院门诊就诊的高血压患者。数据分析采用非配对t检验。结果显示，高血压控制组1级肥胖患者发生率高于高血压不控制组(43.8% vs 32.5%)。高血压控制组BMI平均值为24.2，高血压未控制组BMI平均值为24.8 (p>0.05)。两组患者BMI差异无统计学意义。
{"title":"Perbandingan Indeks Massa Tubuh Pada Pasien Hipertensi Dengan Tekanan Darah Yang Terkontrol dan Tidak Terkontrol di RSUD Arifin Achmad Provinsi Riau","authors":"Eka Bebasari, D. P. Nugraha","doi":"10.26891/jik.v11i2.2017.30-33","DOIUrl":"https://doi.org/10.26891/jik.v11i2.2017.30-33","url":null,"abstract":"The nutritional status is a factor that related with blood pressure. The nutritional status that indicated by body massindex (BMI) needs to be considered in management of hypertension. This study was a cross-sectional analytic thatassess relationship between BMI and hypertension controlled. The subjects of the study were hypertension patientsthat visit outpatient clinic of Arifin Ahmad General Hospital, Riau Province. Datas were analyzed by unpaired t-test.The results showed that patients with obesity grade 1 were more frequent in controlled hypertension group comparedto uncontrolled hypertension (43.8% vs 32.5%). The BMI average in patients with controlled hypertension group was24.2, while in uncontrolled hypertension group was 24.8 (p>0.05). There was no statistically significant differencebetween BMI in both groups patients.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116730643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-22DOI: 10.26891/jik.v11i2.2017.24-29
Desby Juananda, D. C. R. Sari, M. Ar-Rochmah, N. Arfian, M. M. Romi
Beberapa penelitian menunjukkan bahwa stres kronis meningkatkan produksi reactive oxygen species (ROS), dan /atau menekan mekanisme pertahanan antioksidan. Efek neuroprotektif dari Centella asiatica (L.). Urb telah dilaporkandapat melindungi neuron dari kerusakan oksidatif. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstraketanol C. asiatica leaf terhadap ekspresi superoxide dismutase-2 sel (SOD- 2) pada sel Purkinje serebelum tikussetelah diberikan kejutan kronis di kaki. Sebanyak 25 tikus Sprague Dawley jantan dewasa muda diacak ke dalam limakelompok. Kelompok kontrol negatif terdiri dari tikus yang tidak stres; kelompok kontrol stres menerima aquadest; dankelompok lain diobati dengan dosis yang berbeda (mg / kg berat badan / hari, p.o.) ekstrak etanol daun C. asiatica: 150,300 dan 600, masing-masing diikuti oleh pemberian kejutan kronis di kaki selama dua puluh delapan hari. Ekspresi SOD-2 dari lapisan sel Purkinje diukur menggunakan metode imunohistokimia. Data dianalisis dengan one-way ANOVA (p<0,05). Kami menemukan bahwa ekspresi SOD-2 (%) dari lapisan sel Purkinje untuk kelompok kontrol negatif, kelompokkontrol stres, CeA150, CeA300 dan CeA600 kelompok adalah 22,38 ± 9,73, 9,81 ± 2,21, 10,29 ± 3,60, 14,72 ± 6,65, dan22,75 ± 10,93, masing-masing (p <0,05). Analisis post-hoc menunjukkan perbedaan yang signifikan antara kelompokkontrol negatif dan kelompok kontrol stres (p <0,05). Ada juga perbedaan yang signifikan antara kelompok kontrolstres dan kelompok CeA600 (p <0,05), tetapi tidak ada perbedaan yang signifikan antara kelompok perlakuan (p> 0,05).Penelitian ini menunjukkan bahwa ekstrak etanol daun C. asiatica meningkatkan ekspresi SOD-2 pada sel Purkinjecerebellar tikus setelah stres kronis.
{"title":"Ethanol Extracts of Centella asiatica (L.) Urb. Leaf Increase Superoxide Dismutase-2 (SOD-2) Expression on Rat Cerebellar Purkinje Cells After Chronic Stress","authors":"Desby Juananda, D. C. R. Sari, M. Ar-Rochmah, N. Arfian, M. M. Romi","doi":"10.26891/jik.v11i2.2017.24-29","DOIUrl":"https://doi.org/10.26891/jik.v11i2.2017.24-29","url":null,"abstract":"Beberapa penelitian menunjukkan bahwa stres kronis meningkatkan produksi reactive oxygen species (ROS), dan /atau menekan mekanisme pertahanan antioksidan. Efek neuroprotektif dari Centella asiatica (L.). Urb telah dilaporkandapat melindungi neuron dari kerusakan oksidatif. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstraketanol C. asiatica leaf terhadap ekspresi superoxide dismutase-2 sel (SOD- 2) pada sel Purkinje serebelum tikussetelah diberikan kejutan kronis di kaki. Sebanyak 25 tikus Sprague Dawley jantan dewasa muda diacak ke dalam limakelompok. Kelompok kontrol negatif terdiri dari tikus yang tidak stres; kelompok kontrol stres menerima aquadest; dankelompok lain diobati dengan dosis yang berbeda (mg / kg berat badan / hari, p.o.) ekstrak etanol daun C. asiatica: 150,300 dan 600, masing-masing diikuti oleh pemberian kejutan kronis di kaki selama dua puluh delapan hari. Ekspresi SOD-2 dari lapisan sel Purkinje diukur menggunakan metode imunohistokimia. Data dianalisis dengan one-way ANOVA (p<0,05). Kami menemukan bahwa ekspresi SOD-2 (%) dari lapisan sel Purkinje untuk kelompok kontrol negatif, kelompokkontrol stres, CeA150, CeA300 dan CeA600 kelompok adalah 22,38 ± 9,73, 9,81 ± 2,21, 10,29 ± 3,60, 14,72 ± 6,65, dan22,75 ± 10,93, masing-masing (p <0,05). Analisis post-hoc menunjukkan perbedaan yang signifikan antara kelompokkontrol negatif dan kelompok kontrol stres (p <0,05). Ada juga perbedaan yang signifikan antara kelompok kontrolstres dan kelompok CeA600 (p <0,05), tetapi tidak ada perbedaan yang signifikan antara kelompok perlakuan (p> 0,05).Penelitian ini menunjukkan bahwa ekstrak etanol daun C. asiatica meningkatkan ekspresi SOD-2 pada sel Purkinjecerebellar tikus setelah stres kronis.","PeriodicalId":385518,"journal":{"name":"Jurnal Ilmu Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132736256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：