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Pengaruh Pemberian Asam Alfa Lipoat terhadap Kadar Kolesterol Total pada Tikus Diabetes Melitus Tipe 2 2型糖尿病小鼠的总胆固醇水平受阿尔法酸影响
Pub Date : 2018-11-22 DOI: 10.26891/JIK.V11I2.2017.18-23
Uliana Sinaga, Ismawati Ismawati, Enikarmila Asni
Hypercholesterolemia is complication in type 2 diabetes. Alpha lipoic acid (ALA) reduced total cholesterol by modulatingcholesterol synthesis pathway and reduced cholesterol biosynthesis genes expression. The goal of this research wasto investigate the prohibition of hypercholesterolemia in type 2 diabetes rat by ALA. Fifteen adult male wistar rats (2-3 months, 200-250 g body weight) were segregated into three groups (standard, type 2 diabetes and type 2 diabetes +ALA). Type 2 diabetes induced by streptozotocin 65 mg/kg and nicotinamide 110 mg/kg. ALA was given for 3 weeksafter type 2 diabetes induced.After 31 days total cholesterol of groups labelled is measured. The result showed therewas significant difference between ALA and type 2 diabetes groups (p= 0.012), and there was no significant differencebetween ALA and standard groups (p= 0.591). As the conclusion, this study proves that ALA has effects on totalcholesterol in type 2 diabetes rats.
高胆固醇血症是2型糖尿病的并发症。α硫辛酸(ALA)通过调节胆固醇合成途径和降低胆固醇生物合成基因表达来降低总胆固醇。本研究旨在探讨ALA对2型糖尿病大鼠高胆固醇血症的抑制作用。将15只2 ~ 3月龄、体重200 ~ 250 g的成年雄性wistar大鼠分为标准组、2型糖尿病组和2型糖尿病+ALA组。链脲佐菌素65 mg/kg、烟酰胺110 mg/kg诱导2型糖尿病。2型糖尿病诱导后给予ALA 3周。31天后测量标记组的总胆固醇。结果显示,ALA组与2型糖尿病组之间差异有统计学意义(p= 0.012), ALA组与标准组之间差异无统计学意义(p= 0.591)。综上所述,本研究证明ALA对2型糖尿病大鼠的总胆固醇有影响。
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引用次数: 1
Eosinophilic Ascites Due to Eosinophilic Gastroenteritis – Cytological Approach 嗜酸性胃肠炎所致嗜酸性腹水-细胞学方法
Pub Date : 2018-11-22 DOI: 10.26891/jik.v11i2.2017.47-51
I. Romus
Eosinophilic ascites (EA) merupakan kasus yang sangat jarang. EA merupakan gejala yang paling jarang dari penyakitgastroenteritis eosinofilik (EGE). EA terjadi karena adanya edema dan peradangan eosinofilik dari lapisan serosa usushalus dan dapat melibatkan segmen lain pada saluran gastrointestinal. Kami melaporkan kasus seorang wanita berusia19 tahun dengan gambaran mikroskopik sitologi cairan asites tampak eosinofil yang cukup padat dan pemeriksaanhistopatologi dari biopsi lambung menunjukkan infiltrasi eosinofil. Data klinis menunjukkan adanya nyeri abdomendifus, mual, distensi abdomen, ascites sedang, dan diare. Hasil Magnetic Resonance Imaging (MRI) menunjukkanadanya penebalan dinding usus halus difus dan tidak mendeteksi keganasan primer. Hasil tes laboratorium menunjukkaneosinofilia pada pemeriksaan darah tepi, kadar IgE serum meningkat dan negatif untuk infeksi parasit. Pasien mendapatkanterapi SLE selama 1 tahun tanpa perbaikan yang nyata. Pengobatan dengan kortikosteroid menormalkan hasil teslaboratorium dan asites teratasi segera. EGE merupakan kasus yang langka dan harus diingat pada pasien dengangejala ascites yang tidak diketahui penyebabnya.
肠阴藤壶(EA)是一个非常罕见的例子。EA是肠内炎(EGE)最罕见的症状。EA是由于肠道真皮真菌层的水肿和炎症而发生的,可能涉及胃肠道的其他部分。我们报道了一名19岁的女性的病例,她的胃部活检显示出非常致密的eoxifil和检验胃活检显示对eoxifil的渗透。临床数据显示存在腹部病变、恶心、腹部扩张、中度风湿和腹泻。磁核磁共振成像(MRI)显示肠壁增厚,没有发现主动脉瘤。实验室检测结果显示,周边血液检测显示,IgE血清水平升高,寄生虫感染呈阴性。病人进行了一年的SLE治疗,没有进行任何明显的改善。皮质类固醇治疗立即纠正了试验结果和参与。EGE是罕见的病例,患者必须记住dengangejala是水肿的原因不明。
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引用次数: 0
Gambaran Histopatologi Paru Mencit (Mus musculus) Setelah Pemaparan Paraquat 妊娠毒血症的症状
Pub Date : 2018-11-22 DOI: 10.26891/JIK.v11i2.2017.7-11
Aulia Wiradi, Wiwit Ade Fidiawati, Sri Melati Munir
Paraquat destroys organs including lung. Purpose of this study was to determine the effect of paraquat on histopathologyof lung, exspecially fibrosis in mice (Mus musculus). This study was an experimental study with post-test only withcontrol design and using 15 mice as sample. Samples were divided into 5 groups consist of one control group and fourdifferent doses of paraquat treatment group (25 mg / kg / day, 50 mg / kg / day, 75 mg / kg / day and 100 mg / kg / day for7 days with spraying). Analysis of the data have used One-Way ANOVA then post-hoc test with tukey to assesseddifferences of each groups. The results showed increasing of lung fibrosis with increasing doses and have significantcorrelations (p = 0.000). In conclusion, there are significant changes in lung histopathology of mice (Mus musculus)after paraquat exposure for 7 days.
百草枯破坏器官,包括肺。本研究旨在探讨百草枯对小鼠肺组织病理学,尤其是肺纤维化的影响。本研究为仅后验的实验研究,采用对照设计,以15只小鼠为样本。将样品分为5组,分别为1个对照组和4个不同剂量的百草枯处理组(25 mg / kg / d、50 mg / kg / d、75 mg / kg / d和100 mg / kg / d,喷施7 d)。数据分析使用单因素方差分析,然后用随机检验来评估各组的差异。结果显示,肺纤维化随剂量增加而增加,并具有显著相关性(p = 0.000)。综上所述,百草枯暴露7天后,小鼠(小家鼠)肺组织病理学发生了显著变化。
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引用次数: 1
Mekanisme Kerja dan Target Molekuler Interleukin-1 receptor antagonist (Anakinra) pada Aterosklerosis
Pub Date : 2018-11-22 DOI: 10.26891/JIK.V11I2.2017.1-6
M. Hamidy
Inflammation plays an important role in the development and progression of a variety of cardiovascular conditions,most notably coronary atherosclerosis and congestive heart failure. A number of inflammatory molecules have beenimplicated in these processes, including interleukin-1 (IL-1). IL-1 receptor antagonist is an endogenous inhibitor of IL-1, which competitively binds to the IL-1 type I receptor without activating it. Anakinra is a nonglycosylated, recombinantform of human IL-1ra that, like endogenous IL-1ra, competitively inhibits IL-1 by binding the IL-1 type I receptor.
炎症在多种心血管疾病的发生和发展中起着重要作用,最显著的是冠状动脉粥样硬化和充血性心力衰竭。许多炎症分子参与了这些过程,包括白细胞介素-1 (IL-1)。IL-1受体拮抗剂是一种内源性IL-1抑制剂,它与IL-1 I型受体竞争性结合而不激活它。Anakinra是人IL-1ra的非糖基化重组形式,与内源性IL-1ra一样,通过结合IL-1 I型受体竞争性地抑制IL-1。
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引用次数: 0
Profil Ergonomis dan Proporsi Keluhan Muskuloskeletal pada Tenaga Kerja Bongkar Muat di Pelabuhan Bongkar Muat Kota Pekanbaru
Pub Date : 2018-11-22 DOI: 10.26891/jik.v11i2.2017.40-46
M LaodeBurhanuddin, S. Suyanto, Z. Zulfikar
Ergonomics deals with optimization, efficiency, health, safety, and comfort in the workplace. One ofthis ergonomics principle approach is important for unloading workers in the harbour, because theirworkplace and work-system have high risk of workplace accidents if the principles of ergonomics isnot applied. So, the effectivity, efficiency, productivity, comfort, and health of workers in the harbourneed to be maintained and improved with ergonomics approach. This research was held on harbourin Pekanbaru city , with descriptive observasional method to describe risk of work ergonomy causedby bad application of ergonomics at work and musculosceletal symptoms proportion of 19 unloadingworkers by Nordic Body Map (NBM) questionnaire. The result is all unloading workers (100%) havemusculosceletal injury with various grade of injury. When being observed, none of all unloadingworkers lift the load with the right method and no special technique had been used by unloadingworkers to lift the load.
人体工程学涉及工作场所的优化、效率、健康、安全和舒适。其中一个人体工程学原理方法对港口卸货工人很重要,因为如果不应用人体工程学原理,他们的工作场所和工作系统就有很高的工作事故风险。因此,港口工人的效率、效率、生产力、舒适度和健康都需要通过人体工程学的方法来维持和改善。本研究以港口城市北干巴鲁为研究对象,采用描述性观察法,采用北欧人体图(NBM)问卷,描述19名卸车工人因工作中不良应用人体工程学而导致的工作人机工程学风险及肌肉骨骼症状比例。结果表明,所有卸荷工人(100%)均有不同程度的肌肉损伤。经观察,没有一个卸车工人用正确的方法吊起货物,也没有卸车工人使用特殊的技术吊起货物。
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引用次数: 0
E-Reading Vs Traditional Reading: Can Internet, Social media and Gadgets Bridge the Gap between Reading and Learning among Medical Students? 电子阅读与传统阅读:互联网、社交媒体和电子设备能弥合医学生阅读与学习之间的鸿沟吗?
Pub Date : 2018-11-22 DOI: 10.26891/JIK.V11I2.2017.52-59
F. E. Siagian, Esy Maryanti
Membaca menjadi dasar dalam belajar dan dengan perkembangan teknologi komunikasi informasi (TIK), membacasecara modern sekarang ini menjadi pengalaman yang lebih menarik dibanding sebelumnya ( misalnya membaca secaratradisional); akibat ketersediaan bahan bacaan elektronik di internet. Meski terdapat potensi efek yang tidak diinginkan,hampir tidak mungkin membatasi penetrasi TIK dalam hidup keseharian kita. Pilihannya lebih kepada kendali atas efekyang tidak dibutuhkan dan disisi lain memaksimalisasi potensi e-reading di internet untuk keuntungan pembaca.
阅读成为学习和信息通信技术发展的基础(TIK),现代阅读成为一种前所未有的有趣体验(如传统阅读);由于互联网上的电子阅读材料的可用性。虽然它有潜在的不良影响,但几乎不可能限制我们日常生活中的智力渗透。选择更多的是控制不必要的有效性,同时提高在线电子阅读的潜力,使读者受益。
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引用次数: 5
Analisis Penggunaan Antibiotik pada Pasien Sepsis Neonatus di RSUD Arifin Ahmad Provinsi Riau
Pub Date : 2018-11-22 DOI: 10.26891/JIK.V11I2.2017.12-17
Nazardi Oyong, Inayah Inayah, Yuni Novita, Rizki Giofani
Sepsis that is commonly caused by bacterial infection may cause death in neonates. The appropiate antibioticadministered will increase the life expectancy of neonates with sepsis. Objective of this study was to know the patternof antibiotic use and appropriateness of antibiotic use based on sensitivity test. The study used observational methodwith cross sectional design. The collected data were retrospective. The study population were neonates with sepsis inperinatal ward from Januari – December 2014. The criteria of inclusion were positive blood culture with sensitivity testsand use of antibiotics. The percentage of particular antibiotics used in neonates with sepsis before sensitivity testwere amikacin 64,3%; meropenem 62,9% and piperazine/tazobactam 50% with suitability of 27,1%. However, aftersensitivity test there were meropenem 38,6%, amikacin 30%, vancomycin 14,3% and piperaciline/tazobactam 14,3%with appropriateness of 64,3%. The most number of antibiotic used before and after sensitivity test were amikacin andmeropenem, respectively. There was a suitability enhancement between the use of antibiotics and sensitivity testresults.
脓毒症通常由细菌感染引起,可导致新生儿死亡。给予适当的抗生素将增加脓毒症新生儿的预期寿命。本研究的目的是通过药敏试验了解抗生素的使用模式和使用的适宜性。本研究采用横断面设计的观察方法。收集的数据是回顾性的。研究对象为2014年1 - 12月围产病房脓毒症新生儿。纳入标准为血培养阳性及敏感试验和使用抗生素。新生儿败血症敏感性试验前使用特殊抗生素的比例为阿米卡星64.3%;美罗培南62.9%,哌嗪/他唑巴坦50%,适宜性27.1%。美罗培南38.6%,阿米卡星30%,万古霉素14.3%,哌拉西林/他唑巴坦14.3%,适宜性为64.3%。药敏试验前后使用抗生素最多的分别是阿米卡星和美罗培南。抗生素使用与药敏试验结果之间的适宜性增强。
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引用次数: 0
Gambaran Hasil Pemeriksaan Monofilamen pada Pasien Diabetes Melitus (DM) yang Berkunjung ke Poliklinik Penyakit Dalam RSUD Arifin Achmad Provinsi Riau 这是对廖内病毒性RSUD Arifin Achmad地区临床疾病Melitus (DM)单丝检查的结果
Pub Date : 2018-11-22 DOI: 10.26891/JIK.V11I2.2017.34-39
Viona Ayu Safitri, Dani Rosdiana, Riezky Valentina Astari
Diabetes mellitus in increasing at an alarming rate and has become a global challenge. Diabetes mellitus type 2 is agroup of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin actionor both. One of the most complications of diabetes is diabetic neuropathy. Diabetic neuropathy refers to damage ofmotor nerves, sensory, and autonomic system. The aim of this study is to identify patients at risk for diabetic neuropathywith monofilament examination in internist polyclinic Arifin Achmad General Hospital from May to July 2017.Monofilament is an inexpensive, practical tool in everyday use and can be used in early detection of sensation loss inthe foot to prevent diabetic ulcer. This study is descriptive research with direct examination of patient diabetes type 2.There were 73 samples that fulfilled the inclusion criteria. Profile patients with diabetes in the polyclinic are female morethan male is 60,3%. The age group 56-65 years is the most age group of DM patients in the polyclinic is 52.1%.Duration of diabetes is 5-10 years (52.1%). The results of monofilament examination in patients with type 2 DM arescore 0-3 as many as 19 people (26%), score of 3.5-5 as many as 27 people (37%), and score> 5,5 as many as 27 people(37%).
糖尿病正以惊人的速度增长,并已成为全球性的挑战。2型糖尿病是一组以高血糖为特征的代谢性疾病,由胰岛素分泌、胰岛素作用或两者的缺陷引起。糖尿病最常见的并发症之一是糖尿病性神经病变。糖尿病性神经病变是指运动神经、感觉神经和自主神经系统的损害。本研究的目的是通过2017年5月至7月在Arifin ahmad总医院内科综合诊所进行的单丝检查来识别糖尿病神经病变的高危患者。单丝是一种廉价、实用的日常工具,可用于早期检测足部感觉丧失以预防糖尿病溃疡。本研究为直接检查2型糖尿病患者的描述性研究。有73个样本符合纳入标准。综合医院的糖尿病患者中女性多于男性为63.3%。56 ~ 65岁是本院DM患者最多的年龄组,占52.1%。糖尿病病程5 ~ 10年(52.1%)。2型糖尿病患者单丝检查结果0 ~ 3分者19人(26%),3.5 ~ 5分者27人(37%),> 5、5分者27人(37%)。
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引用次数: 1
Gambaran Komplikasi Kehamilan dengan Penyakit Jantung di RSUD Arifin Achmad Provinsi Riau Periode 2013-2017 2011 -2017年廖内阿克马省心脏病怀孕并发症的图片
Pub Date : 1900-01-01 DOI: 10.26891/jik.v13i2.2019.27-35
M. Syafei
Heart disease is the major non-obstetric cause of morbidity and mortality in pregnancy Several studies showed thatpregnancy with heart diseases are related to maternal and perinatal complications such as mortality, heart failure,arrhytmias, pulmonary oedema, low birth weight, and prematurity. The aim of this study is to know the incidence,characteristic, and complications of pregnancy with heart disease. This study was using descriptive retrospectivedesign with total sampling technique. The sources of data were medical records of patients in January 2013 – December2017 with number of sample is 37 patients. Cardiac complications was found in 19 (57,6%) cases that was composed ofarrhytmias (24,2%), prematurity (21,2%), pulmonary oedema and low birth weight both 15,2%, and heart failure (9,1%).
心脏病是妊娠期发病率和死亡率的主要非产科原因,一些研究表明,患有心脏病的妊娠与孕产妇和围产期并发症有关,如死亡率、心力衰竭、心律失常、肺水肿、低出生体重和早产。本研究的目的是了解妊娠合并心脏病的发生率、特点和并发症。本研究采用全抽样的描述性回顾性设计。数据来源为2013年1月- 2017年12月患者的病历,样本数量为37例。心脏并发症19例(57.6%),包括心律失常(24.2%)、早产(21.2%)、肺水肿和低出生体重(15.2%)以及心力衰竭(9.1%)。
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引用次数: 0
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