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Assessment of serum interleukin 6 in a sample of Egyptian patients with schizophrenia 对埃及精神分裂症患者血清白细胞介素 6 的评估
Q3 PSYCHIATRY Pub Date : 2024-03-15 DOI: 10.1186/s43045-024-00409-6
Eman Ibrahim Abo El Ella, Eman S. Rabie, Mona Mahmoud El Sheikh, Reem Hassan El Ghamry, Mostafa Salah Hotar, Fiby Fayez Gabrielle
Inflammation has been demonstrated to play a pathophysiological function in schizophrenia. Raised interleukin-6 (IL-6) levels have been the most consistently linked to schizophrenia. It was hypothesized that IL-6 contributed to the development of both adverse and beneficial symptoms. The aim of the study was to estimate the level of serum IL-6 in patients with schizophrenia and its relation to positive in addition to negative symptoms. This case–control descriptive cross-sectional study was conducted on 40 patients, divided into two groups: 20 individuals in Group A (patients group) were treatment-naive for their first episode of schizophrenia, and 20 volunteers in Group B (control group) were matched for gender and age to the patient group. Both groups were evaluated for their serum interleukin-6 levels using the ELISA method. Patients and controls were recruited from the Okasha Institute of Psychiatry, Faculty of Medicine, and Ain Shams University Hospitals. Cases with schizophrenia who were experiencing their first episode and had not yet begun any form of therapy had a considerably higher mean serum IL-6 level compared to the healthy control group. The level of serum interleukin 6 in first-episode treatment-naïve individuals with schizophrenia is higher than that of healthy controls, revealing a probable underlying immunological pathology. However, serum interleukin-6 levels were not significantly correlated with positive, negative, or general psychopathology symptoms.
炎症已被证明在精神分裂症中起着病理生理作用。白细胞介素-6(IL-6)水平的升高与精神分裂症的关系最为密切。据推测,IL-6 会导致不良症状和有益症状的出现。本研究旨在估算精神分裂症患者的血清 IL-6 水平及其与阳性症状和阴性症状的关系。这项病例对照描述性横断面研究以 40 名精神分裂症患者为对象,分为两组:A 组(患者组)的 20 名患者在精神分裂症首次发作时未经治疗;B 组(对照组)的 20 名志愿者在性别和年龄上与患者组相匹配。两组均采用 ELISA 方法评估其血清白细胞介素-6 水平。患者和对照组均从奥卡沙精神病学研究所、医学院和艾因夏姆斯大学医院招募。与健康对照组相比,首次发病且尚未开始接受任何形式治疗的精神分裂症患者的平均血清 IL-6 水平要高得多。首次发病且未接受治疗的精神分裂症患者的血清白细胞介素 6 水平高于健康对照组,这可能揭示了潜在的免疫学病理。然而,血清白细胞介素6水平与阳性、阴性或一般精神病理症状无明显相关性。
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引用次数: 0
Prevalence and pattern of psychiatric morbidity in patients with first-episode acute coronary syndrome 首发急性冠状动脉综合征患者的精神病发病率和发病模式
Q3 PSYCHIATRY Pub Date : 2024-03-11 DOI: 10.1186/s43045-024-00408-7
Nighat Akbar, Kubra Farooq, Neelofar Jan, Marya Zahoor, Yasir Hassan Rather, Ubaid Rasool Bhat
The existing body of literature extensively highlights the impact of psychological determinants on the initiation of coronary heart disease. Globally, the incidence of psychiatric disorders is increasing, and India is no stranger to this trend. However, the connection between psychiatric co-morbidities and the onset of acute coronary syndrome has been relatively understudied in this region of the world. Individuals experiencing acute coronary syndrome exhibited notably higher psychiatric morbidity compared to the control group, with an odds ratio of 4.14. Mood disorders, in particular, were the most prevalent among ACS patients, demonstrating an odds ratio of 5.023, followed by anxiety disorders with an odds ratio of 2.48. The findings revealed a substantial association underscoring the intricate interplay between mental and cardiovascular health emphasizing the importance of holistic healthcare approaches that consider both physical and psychological well-being, in the context of cardiovascular diseases. Further research in this area can contribute to a more comprehensive understanding of the links between mental health and cardiovascular outcomes, potentially informing targeted interventions and improving overall patient care.
现有文献广泛强调了心理因素对冠心病发病的影响。在全球范围内,精神疾病的发病率不断上升,印度也不例外。然而,世界上这一地区对精神疾病并发症与急性冠状动脉综合征发病之间的联系研究相对不足。与对照组相比,急性冠脉综合征患者的精神疾病发病率明显更高,几率比为 4.14。尤其是情绪障碍,在急性冠状动脉综合征患者中最为普遍,几率比为 5.023,其次是焦虑症,几率比为 2.48。研究结果表明,心理障碍与心血管健康之间存在着巨大的关联,强调了在心血管疾病的背景下,考虑身心健康的整体医疗保健方法的重要性。在这一领域开展进一步的研究有助于更全面地了解心理健康与心血管疾病结果之间的联系,从而有可能为有针对性的干预措施提供依据,并改善对患者的整体护理。
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引用次数: 0
Assessment of brain-derived neurotrophic factor levels in serum of children with autism spectrum disorders 评估自闭症谱系障碍儿童血清中的脑源性神经营养因子水平
Q3 PSYCHIATRY Pub Date : 2024-03-08 DOI: 10.1186/s43045-024-00403-y
Salwa Amin Abd Elhamid, Mohammad Mostafa Alkherkhisy, Rania Elsayed Kasem
The autism spectrum disorder (ASD) has no identified biomarker for early detection or for its severity. As for the brain-derived neurotrophic factor (BDNF), it is a crucial neurotropic factor that regulates the plasticity and maturing of neuronal synapses. Accordingly, it might influence how children with autism develop. To evaluate the BDNF serum levels in autistic children and their relationship with the illness severity as well as with the common drugs received by autistic patients, 60 patients with autism along with another 60 normally developing children were involved in the study. Using the Childhood Autism Rating Scale (CARS), the severity of autism was then evaluated. The ELISA method was used to measure the BDNF level. It was seen that the BDNF concentrations were higher in autism patients (P < 0.001). There was also a highly strong positive association between the CARS score and the BDNF (P < 0.001). Using the cut-off value of > 2.8 of BDNF helped to distinguish between well-developing and autistic children, with the aspects of “sensitivity” and “specificity” being 88.3% and 80%, respectively. Moreover, children with autism who received omega-3 had statistically lower levels of BDNF than those who did not take any (P = 0.040). The serum BDNF concentration is higher in autism; this proposes that the BDNF may contribute to the onset or progress of autism. Therefore, it may be used as a noninvasive biomarker for the illness severity because of its greater occurrence in autistic children who have severe social impairment.
自闭症谱系障碍(ASD)尚无可用于早期检测或判断其严重程度的生物标志物。至于脑源性神经营养因子(BDNF),它是一种重要的神经营养因子,可调节神经元突触的可塑性和成熟。因此,它可能会影响自闭症儿童的发育。为了评估自闭症儿童血清中的 BDNF 水平及其与病情严重程度和自闭症患者常用药物的关系,研究人员对 60 名自闭症患者和另外 60 名发育正常的儿童进行了调查。然后使用儿童自闭症评定量表(CARS)评估自闭症的严重程度。研究采用 ELISA 方法测量 BDNF 水平。结果显示,自闭症患者的 BDNF 浓度更高(P 2.8),BDNF 有助于区分发育良好的儿童和自闭症儿童,其 "灵敏度 "和 "特异性 "分别为 88.3% 和 80%。此外,从统计学角度看,服用欧米伽-3 的自闭症儿童的 BDNF 水平低于未服用欧米伽-3 的儿童(P = 0.040)。自闭症儿童血清中的 BDNF 浓度较高,这表明 BDNF 可能是自闭症发病或进展的原因之一。因此,BDNF 可用作衡量疾病严重程度的非侵入性生物标志物,因为自闭症儿童有严重的社交障碍。
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引用次数: 0
Autistic, schizotypal traits, and insight level in patients with obsessive–compulsive disorder 强迫症患者的自闭症、分裂型特质和洞察力水平
Q3 PSYCHIATRY Pub Date : 2024-03-04 DOI: 10.1186/s43045-024-00402-z
M. Farouk, M. Nasr, M. Khalil, I. Dozebik, S. El Makawi, W. Fakher, D. R. Ayoub
Comorbid personality disorders and obsessive–compulsive disorder (OCD) range between 33 and 87%. Patients having OCD more commonly receive cluster A (the odd and eccentric cluster) compared with other nonpsychotic patients. Poor insight levels within OCD increase disease severity and impair neuropsychological factors, where OCD patients exhibit poorer speech learning and memory. To assess schizotypal, autistic traits, and insight levels in patients with OCD. Forty subjects with OCD were recruited from outpatient clinics of Kasr Alainy Psychiatry and Addiction Prevention Hospital and assessed using the Dimensional Yale-Brown Obsessive–Compulsive Scale (DYBOCS), Schizotypal Personality Questionnaire-Brief Revised (SPQ-BR), and Autism Spectrum Quotient (AQ) while insight level was assessed using Brown Assessment of Beliefs Scale (BABS). Total DY-BOCS score was positively correlated with the AQ score and SPQ score. Global distress and interference subdomains of DY-BOCS were positively correlated with AQ, SPQ score, and Insight level (BABS). Indicating that the worse the insight the higher the distress and interference in daily life. Global distress and interference were also positively correlated to all subscales of SPQ. Aggressive obsessions were correlated with SPQ score, cognitive-perceptual (CP) traits, ideas of reference, and magical thinking. Contamination/cleaning obsessions were positively correlated with the level of insight (BABS). While sexual and religious obsessions were negatively correlated with the level of insight. Increased severity of OCD is associated with more autistic symptoms, schizotypal symptoms, and poorer insight. No gender differences in OCD patients regarding severity, autistic symptoms, schizotypal symptoms, or insight.
并发人格障碍和强迫症(OCD)的比例在 33% 到 87% 之间。与其他非精神病患者相比,强迫症患者更常见于A群(古怪和偏心群)。强迫症患者的洞察力较差,会增加疾病的严重程度并损害神经心理学因素,强迫症患者的言语学习和记忆能力较差。评估强迫症患者的精神分裂症、自闭症特征和洞察力水平。研究人员从 Kasr Alainy 精神病与成瘾预防医院的门诊部招募了 40 名强迫症患者,使用耶鲁-布朗强迫症量表(DYBOCS)、分裂型人格问卷简明修订版(SPQ-BR)和自闭症谱系商数(AQ)对其进行评估,并使用布朗信念评估量表(BABS)对其洞察力水平进行评估。DY-BOCS 总分与 AQ 分数和 SPQ 分数呈正相关。DY-BOCS 的总体痛苦和干扰子域与 AQ、SPQ 分数和洞察力水平(BABS)呈正相关。这表明洞察力越差,日常生活中的困扰和干扰就越大。总体痛苦和干扰与 SPQ 的所有分量表也呈正相关。攻击性强迫与 SPQ 分数、认知-感知(CP)特征、参照观念和魔幻思维相关。污染/清洁强迫症与洞察力水平(BABS)呈正相关。性强迫和宗教强迫则与洞察力水平呈负相关。强迫症严重程度的增加与更多的自闭症症状、分裂型症状和更差的洞察力有关。强迫症患者在严重程度、自闭症症状、精神分裂症状或洞察力方面没有性别差异。
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引用次数: 0
Turkish reliability and validity study of Barkley’s BAARS-IV self-report current symptoms 土耳其巴克利 BAARS-IV 自我报告当前症状的可靠性和有效性研究
Q3 PSYCHIATRY Pub Date : 2024-02-26 DOI: 10.1186/s43045-024-00406-9
Tansu Eda Topaloglu, Bilge Dogan, Doga Sevincok, Levent Sevincok
Recall bias of patients and their relatives, low reliability of the history, changes in attention deficit hyperactivity disorder (ADHD) symptoms or compensatory behaviors, and various comorbidities may be associated with difficulties in diagnosing ADHD in adults. Barkley Adult Attention Deficit Hyperactivity Disorder Rating Scale-IV (BAARS-IV), a relatively new scale, needs to be studied for validity and reliability in different societies and cultures. In this study, we investigated whether the Turkish version of BAARS-IV: Present Symptoms Section is valid and reliable in the medical students who constituted the sample. Adult Attention Deficit Hyperactivity Disorder Self-Report Scale and BAARS-IV: Present Symptoms Section were administered to 402 fifth- and sixth-year medical students. We performed exploratory and confirmatory factor analyzes. Cronbach’s alpha and inter-item correlation were evaluated. Pearson correlation test was used in inter-scale correlation analyses. For ADHD items, Kaiser-Meyer-Olkin (KMO) (0.882), Measuring of Sampling Adequacy MSA (0.819), chi-square (2512.455), and p (< 0.001) values showed that the data were suitable for factor analysis. A three-factor structure with an eigenvalue above 1 and explaining 53.14% of the total variance was obtained. In the correlation matrix reconstructed with eight Sluggish Cognitive Tempo (SCT) items, the determinant of the correlation matrix was 0.025, the KMO determinant was 0.852, the lowest MSA value was 0.750, and the residual rate was 14%. A two-factor structure was obtained explaining 67.451% of the variance. Cronbach’s alpha values of the inattention and impulsivity subscales were 0.839 and 0.752, respectively. Cronbach’s alpha value of 8 questions in the SCT scale was found to be 0.871. The results of our study indicate that the BAARS-IV Self-report Present Symptoms scale is valid and reliable among medical students.
患者及其亲属的回忆偏差、病史的低可靠性、注意力缺陷多动障碍(ADHD)症状或代偿行为的变化以及各种合并症可能与诊断成人注意力缺陷多动障碍的困难有关。巴克利成人注意缺陷多动障碍评定量表-IV(BAARS-IV)是一个相对较新的量表,它在不同社会和文化中的有效性和可靠性有待研究。在本研究中,我们调查了土耳其版 BAARS-IV:目前症状部分对构成样本的医科学生是否有效和可靠。我们对 402 名五年级和六年级医学生进行了成人注意缺陷多动障碍自评量表和 BAARS-IV:目前症状部分的测试。我们进行了探索性和确认性因子分析。对 Cronbach's alpha 和项目间相关性进行了评估。在量表间相关分析中使用了皮尔逊相关检验。对于ADHD项目,Kaiser-Meyer-Olkin(KMO)(0.882)、MSA(0.819)、chi-square(2512.455)和p(< 0.001)值显示数据适合进行因子分析。得出了特征值大于 1 的三因素结构,解释了总方差的 53.14%。在用 8 个慢速认知节奏(SCT)项目重建的相关矩阵中,相关矩阵的行列式为 0.025,KMO 行列式为 0.852,最低 MSA 值为 0.750,残差率为 14%。得出的双因素结构解释了 67.451%的方差。注意力不集中分量表和冲动分量表的 Cronbach's alpha 值分别为 0.839 和 0.752。SCT 量表中 8 个问题的 Cronbach's alpha 值为 0.871。我们的研究结果表明,BAARS-IV 现象自评量表在医学生中是有效和可靠的。
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引用次数: 0
Depression, anxiety, and hopelessness in a sample of Egyptian children diagnosed with cystic fibrosis 被诊断患有囊性纤维化的埃及儿童样本中的抑郁、焦虑和绝望情绪
Q3 PSYCHIATRY Pub Date : 2024-02-23 DOI: 10.1186/s43045-024-00407-8
Fadia Zyada, Hala Hamdy, N. El Basha, Mohamed Refaey, Fatma M. Atia, Somaya H. Shaheen
Even though current therapeutic approaches have significantly increased the longevity and standard of living for children suffering from cystic fibrosis (CF), the crucial psychological components of this illness have not received the same level of attention as other chronic illnesses. The aim of the research was to assess depression, anxiety, and hopelessness in cystic fibrosis-affected children and their relation to the duration of illness. In this study, we compared 40 healthy control children between the ages of 7 and 12 with 40 cystic fibrosis children who were matched for age and sex. All patients had detailed clinical and psychometric evaluations using the Children’s Depression Inventory (CDI), the Anxiety Scale for Children (ASC), and the Hopelessness Scale for Children (HSC). The CDI, ASC, and HSC revealed a significant difference between both groups. Positive correlations between depression, anxiety, and hopelessness and disease duration were found. Patients with CF experienced significantly increased depression, anxiety, and hopelessness, and there is an association between these symptoms and the duration of the illness. We advise making psychiatric screening a standard part of evaluating and monitoring CF patients.
尽管目前的治疗方法大大延长了囊性纤维化(CF)患儿的寿命并提高了他们的生活水平,但这种疾病的关键心理因素却没有像其他慢性疾病那样受到同等程度的关注。研究的目的是评估受囊性纤维化影响的儿童的抑郁、焦虑和绝望情绪及其与病程的关系。在这项研究中,我们将 40 名 7 至 12 岁的健康对照组儿童与 40 名囊性纤维化儿童进行了比较,这 40 名儿童的年龄和性别均匹配。所有患者都接受了详细的临床和心理测量评估,评估使用了儿童抑郁量表(CDI)、儿童焦虑量表(ASC)和儿童无望量表(HSC)。儿童抑郁量表(CDI)、儿童焦虑量表(ASC)和儿童无望量表(HSC)显示,两组患者之间存在显著差异。抑郁、焦虑和绝望与病程呈正相关。CF患者的抑郁、焦虑和绝望情绪明显增加,这些症状与病程有关联。我们建议将精神病筛查作为评估和监测 CF 患者的标准部分。
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引用次数: 0
Psychometric validation of the Dysmorphic Concern Questionnaire (DCQ) into Arabic 阿拉伯语畸形关注问卷(DCQ)的心理计量验证
Q3 PSYCHIATRY Pub Date : 2024-02-19 DOI: 10.1186/s43045-024-00401-0
Feten Fekih-Romdhane, Rabih Hallit, Vanessa Azzi, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Tabassum Rashid, Toni Sawma, Sahar Obeid, Souheil Hallit
Research on dysmorphic concerns (DC) in Arabic-speaking contexts is hampered by the lack of validated tools. Because DC are culturally dependent, psychometrically sound measures are needed at the national level to closely and accurately investigate the construct in specific societies and populations. The purpose of the current research was to investigate the psychometric properties of Dysmorphic Concern Questionnaire (DCQ) in its Arabic translation in Lebanese adults. The study involved 515 participants (69.9% females, mean age of 27.55 ± 10.92 years) who completed a self-report, web-based questionnaire. Confirmatory factor analysis indicated excellent construct validity, as the one-factor structure of the Arabic DCQ fits well with the data. McDonald’s omega was 0.89 in our sample, evidencing an excellent level of internal consistency. Furthermore, the results from the multigroup analysis showed that the DCQ holds similar structural model between genders at the metric, configural, and scalar levels. Finally, DC levels correlated inversely with body appreciation and self-esteem and positively with disordered eating symptoms, thus supporting the concurrent and convergent validity of the Arabic DCQ. The DCQ translated into Arabic appears to have a valid self-assessment measure to capture the presence of DC manifestations. It is anticipated that the Arabic DCQ will be advantageous for healthcare professionals and researchers working with Arabic-speaking people around the world.
由于缺乏有效的工具,在阿拉伯语环境中对畸形关注(DC)的研究受到了阻碍。由于 "畸形关注 "具有文化依赖性,因此需要在全国范围内使用心理计量学上可靠的测量方法,以便在特定的社会和人群中密切而准确地研究这一问题。本研究旨在调查 "畸形关注问卷"(Dysmorphic Concern Questionnaire,DCQ)阿拉伯语译本在黎巴嫩成年人中的心理测量特性。研究涉及 515 名参与者(69.9% 为女性,平均年龄为 27.55 ± 10.92 岁),他们填写了一份自我报告的网络问卷。确认性因素分析表明,阿拉伯语 DCQ 的单因素结构与数据非常吻合,因此具有很好的建构效度。在我们的样本中,麦当劳欧米茄系数为 0.89,证明了极好的内部一致性。此外,多组分析的结果表明,DCQ 在度量、构型和标度层面上与性别间的结构模型相似。最后,DC水平与身体欣赏和自尊成反比,与饮食失调症状成正比,从而支持了阿拉伯语DCQ的并发和收敛效度。翻译成阿拉伯语的 DCQ 似乎是一种有效的自我评估测量方法,可以捕捉到存在的 DC 表现。预计阿拉伯语 DCQ 将为世界各地从事阿拉伯语工作的医护人员和研究人员提供便利。
{"title":"Psychometric validation of the Dysmorphic Concern Questionnaire (DCQ) into Arabic","authors":"Feten Fekih-Romdhane, Rabih Hallit, Vanessa Azzi, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Tabassum Rashid, Toni Sawma, Sahar Obeid, Souheil Hallit","doi":"10.1186/s43045-024-00401-0","DOIUrl":"https://doi.org/10.1186/s43045-024-00401-0","url":null,"abstract":"Research on dysmorphic concerns (DC) in Arabic-speaking contexts is hampered by the lack of validated tools. Because DC are culturally dependent, psychometrically sound measures are needed at the national level to closely and accurately investigate the construct in specific societies and populations. The purpose of the current research was to investigate the psychometric properties of Dysmorphic Concern Questionnaire (DCQ) in its Arabic translation in Lebanese adults. The study involved 515 participants (69.9% females, mean age of 27.55 ± 10.92 years) who completed a self-report, web-based questionnaire. Confirmatory factor analysis indicated excellent construct validity, as the one-factor structure of the Arabic DCQ fits well with the data. McDonald’s omega was 0.89 in our sample, evidencing an excellent level of internal consistency. Furthermore, the results from the multigroup analysis showed that the DCQ holds similar structural model between genders at the metric, configural, and scalar levels. Finally, DC levels correlated inversely with body appreciation and self-esteem and positively with disordered eating symptoms, thus supporting the concurrent and convergent validity of the Arabic DCQ. The DCQ translated into Arabic appears to have a valid self-assessment measure to capture the presence of DC manifestations. It is anticipated that the Arabic DCQ will be advantageous for healthcare professionals and researchers working with Arabic-speaking people around the world.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139927411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are there links between Alzheimer’s disease and ADHD? The efficacy of acetylcholinesterase inhibitors and NMDA receptor antagonists in controlling ADHD symptoms: a systematic review 阿尔茨海默病与多动症之间有联系吗?乙酰胆碱酯酶抑制剂和 NMDA 受体拮抗剂对控制多动症症状的疗效:系统综述
Q3 PSYCHIATRY Pub Date : 2024-02-15 DOI: 10.1186/s43045-024-00405-w
Ramin Abdi Dezfouli, Sara Akbariforoud, Ensieh Esmaeilidezfouli
To assess the effectiveness, safety, and tolerability of anti-Alzheimer agents (memantine, galantamine, rivastigmine, and donepezil) in controlling ADHD symptoms in children, adolescents, and adults. Following the PRISMA guideline, clinical trials assessing the potency of anti-Alzheimer medications in managing ADHD symptoms were imported from PubMed, Web of Science, and Scopus (until February 2023). Screening stages were conducted by two independent researchers. Two independent researchers also extracted data from clinical trials reporting the outcomes as the reduction in scores of ADHD questionnaires. The risk of bias within the included studies was assessed using the Cochrane Collaboration tool, while the certainty of outcomes was evaluated based on the GRADE criteria. Of the initial 1597 studies, 11 studies were included. No studies were available for rivastigmine, and only a single study was conducted for galantamine. The results of the other two medications had a slight inconsistency. While both memantine and donepezil were reported to be effective in several studies, they were reported to be ineffective in some other studies. Side effects were mostly reduced appetite and headache. The tolerability of memantine, donepezil, and galantamine was all convincing. While galantamine did not demonstrate a promising efficacy in ADHD, memantine and donepezil showed effectiveness. However, future studies are needed to confirm their efficacy in ADHD since there was some inconsistency.
评估抗阿尔茨海默病药物(美金刚、加兰他敏、利伐斯的明和多奈哌齐)控制儿童、青少年和成人多动症症状的有效性、安全性和耐受性。按照 PRISMA 指南,从 PubMed、Web of Science 和 Scopus(截止到 2023 年 2 月)中导入了评估抗阿尔茨海默氏症药物在控制多动症症状方面疗效的临床试验。筛选阶段由两名独立研究人员进行。两名独立研究人员还从报告结果的临床试验中提取了数据,报告结果为ADHD问卷得分的降低。使用 Cochrane 协作工具评估了纳入研究的偏倚风险,并根据 GRADE 标准评估了结果的确定性。在最初的 1597 项研究中,有 11 项研究被纳入。没有关于利伐斯的明的研究,只有一项关于加兰他敏的研究。其他两种药物的研究结果略有不一致。据报道,美金刚和多奈哌齐在几项研究中均有效,但在另一些研究中却无效。副作用主要是食欲减退和头痛。美金刚、多奈哌齐和加兰他敏的耐受性都令人信服。虽然加兰他敏对多动症的疗效并不乐观,但美金刚和多奈哌齐显示出了疗效。不过,由于存在一些不一致之处,还需要今后的研究来确认它们对多动症的疗效。
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引用次数: 0
Training of a robot-based psychological intervention program to prevent inappropriate touching of children 培训基于机器人的心理干预程序,防止不当触摸儿童
Q3 PSYCHIATRY Pub Date : 2024-02-12 DOI: 10.1186/s43045-024-00404-x
Mohammad Tahan, Gholamali Afrooz, Jafar Bolhari
This study aimed to evaluate the effect of a robot-based psychological intervention on the prevention of inappropriate touching of children. The trial was registered in the International Clinical Trial Registry Platform with the registration id of ISRCTN17186302. In this study, the intervention had a positive effect on inappropriate sexual care in elementary school children (P < 0.01). Moreover, education on sexual care heightened children’s knowledge about inappropriate touch (P < 0.01). According to the results, the robot-based psychological intervention had an impact on children’s sexual care. It is suggested that this method be applied by counselors and psychologists as a therapeutic approach.
本研究旨在评估基于机器人的心理干预对预防不当触摸儿童的效果。该试验已在国际临床试验注册平台注册,注册编号为ISRCTN17186302。在这项研究中,干预对小学生的不当性照顾有积极影响(P < 0.01)。此外,性保健教育还提高了儿童对不当触摸的认识(P < 0.01)。结果表明,基于机器人的心理干预对儿童的性关怀有一定的影响。建议辅导员和心理学家将此方法作为一种治疗方法加以应用。
{"title":"Training of a robot-based psychological intervention program to prevent inappropriate touching of children","authors":"Mohammad Tahan, Gholamali Afrooz, Jafar Bolhari","doi":"10.1186/s43045-024-00404-x","DOIUrl":"https://doi.org/10.1186/s43045-024-00404-x","url":null,"abstract":"This study aimed to evaluate the effect of a robot-based psychological intervention on the prevention of inappropriate touching of children. The trial was registered in the International Clinical Trial Registry Platform with the registration id of ISRCTN17186302. In this study, the intervention had a positive effect on inappropriate sexual care in elementary school children (P < 0.01). Moreover, education on sexual care heightened children’s knowledge about inappropriate touch (P < 0.01). According to the results, the robot-based psychological intervention had an impact on children’s sexual care. It is suggested that this method be applied by counselors and psychologists as a therapeutic approach.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139765353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of cranial electrotherapy stimulation (CES) in treatment of premature ejaculation: a randomized clinical trial 头颅电疗刺激(CES)治疗早泄的效果:随机临床试验
Q3 PSYCHIATRY Pub Date : 2024-02-09 DOI: 10.1186/s43045-024-00399-5
Hadi Delpasand, Azadeh Mazaheri, Ali Kheradmand, Mahdi Ghorbani, Amir Reza Abedi, Mohsen Khosroabadi
Premature ejaculation is one of the most common male sexual dysfunction, affecting approximately 30% of men. The aim of this study is to evaluate the efficacy and at the same time the safety of the cranial electrotherapy stimulation (CES) device in treatment of premature ejaculation disorder. Based on a randomized clinical trial, two groups were included in the study, so that the first group was treated with sertraline along with an ATANG (AT-9 model) CES, and the second group with sertraline and inactive the CES device (as the placebo group). The state of premature ejaculation after treatment (using the Premature Ejaculation Diagnostic Tool (PEDT) questionnaire) was evaluated and compared for both groups. In the intervention and placebo groups, the average score of the PEDT questionnaire before the intervention did not differ significantly between the two groups (p-value equal to 0.93). However, the average score of the PEDT questionnaire after the intervention for CES group and placebo group was 10.28 ± 1.93 and 13.23 ± 3.05, respectively, which demonstrated a significant decrease in the intervention group (p-value equal to 0.01). The use of CES device as a complementary treatment along with routine drug treatment (sertraline) is associated with a significant improvement in the condition of premature ejaculation of patients. Name of the registry: IRCT Iranian Registry of Clinical Trials. Trial registration number: IRCT20210621051657N1. Date of registration: December 11, 2022. URL of trial registry record: https://en.irct.ir/trial/57201 .
早泄是最常见的男性性功能障碍之一,约有 30% 的男性受到影响。本研究旨在评估头颅电疗刺激(CES)装置治疗早泄障碍的有效性和安全性。研究采用随机临床试验的方法,分为两组,第一组使用舍曲林和 ATANG(AT-9 型)CES,第二组使用舍曲林,不使用 CES 设备(安慰剂组)。对两组患者治疗后的早泄状况(使用早泄诊断工具(PEDT)问卷)进行了评估和比较。在干预组和安慰剂组中,干预前的 PEDT 问卷平均得分在两组之间没有显著差异(P 值等于 0.93)。然而,干预后 CES 组和安慰剂组的 PEDT 问卷平均得分分别为(10.28 ± 1.93)和(13.23 ± 3.05),这表明干预组的得分显著下降(P 值等于 0.01)。在常规药物治疗(舍曲林)的同时使用CES装置作为辅助治疗,可显著改善患者的早泄状况。登记处名称:IRCT 伊朗临床试验登记处。试验注册号:IRCT20210621051657N1。注册日期:2022 年 12 月 11 日:2022 年 12 月 11 日。试验登记记录的网址:https://en.irct.ir/trial/57201 。
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Middle East Current Psychiatry
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