Suicidal ideation in patients with major depressive disorder (MDD) presents a critical challenge in mental health, with conventional antidepressants often having delayed onset. This systematic review and meta-analysis investigates the efficacy of ketamine in rapidly reducing acute suicidal ideation in this patient group. A comprehensive literature search up to June 2023 across PubMed (Medline), Scopus, Web of Science, and Embase yielded 12 studies, including 7 randomized controlled trials (RCTs). The evaluation of the impact of ketamine on Montgomery-Åsberg Depression Rating Scale-Suicidal Ideation (MADRS-SI) scores was conducted using the standardized mean difference (SMD) through the Cohen’s d method for analysis. The assessment of risk of bias was executed utilizing the Cochrane Risk of Bias Tool (RoB2). Subgroup assessments considered study period, geographic location, and follow-up duration. Ketamine administration showed a significant reduction in MADRS SI scores (mean difference, -1.16; 95% CI, -1.89, -0.23). Subgroup analysis revealed varying efficacy based on the study period, geographical location, and follow-up length. Intravenous ketamine demonstrated the most substantial reduction in suicidal thoughts. High heterogeneity among studies was observed. Ketamine offers a rapid and significant reduction in acute suicidal ideation in patients with MDD. It holds promise as an intervention during high-risk periods where conventional treatments are limited by slower onset. However, variability in study results and concerns over long-term safety necessitate further research to optimize treatment protocols and understand the implications of different administration routes. These findings have important implications for developing clinical guidelines in managing acute suicidal ideation in MDD.
{"title":"Ketamine’s efficacy in alleviating acute suicidal thoughts: a comprehensive systematic review and meta-analysis","authors":"Seyedeh Asrin Seyedoshohadaei, Ramyar Rahimi Darehbagh, Farshid Gholami, Elham Nouri, Media Babahajiani, Parisa Kohnepoushi, Yousef Moradi, Leila AzizKhani","doi":"10.1186/s43045-024-00428-3","DOIUrl":"https://doi.org/10.1186/s43045-024-00428-3","url":null,"abstract":"Suicidal ideation in patients with major depressive disorder (MDD) presents a critical challenge in mental health, with conventional antidepressants often having delayed onset. This systematic review and meta-analysis investigates the efficacy of ketamine in rapidly reducing acute suicidal ideation in this patient group. A comprehensive literature search up to June 2023 across PubMed (Medline), Scopus, Web of Science, and Embase yielded 12 studies, including 7 randomized controlled trials (RCTs). The evaluation of the impact of ketamine on Montgomery-Åsberg Depression Rating Scale-Suicidal Ideation (MADRS-SI) scores was conducted using the standardized mean difference (SMD) through the Cohen’s d method for analysis. The assessment of risk of bias was executed utilizing the Cochrane Risk of Bias Tool (RoB2). Subgroup assessments considered study period, geographic location, and follow-up duration. Ketamine administration showed a significant reduction in MADRS SI scores (mean difference, -1.16; 95% CI, -1.89, -0.23). Subgroup analysis revealed varying efficacy based on the study period, geographical location, and follow-up length. Intravenous ketamine demonstrated the most substantial reduction in suicidal thoughts. High heterogeneity among studies was observed. Ketamine offers a rapid and significant reduction in acute suicidal ideation in patients with MDD. It holds promise as an intervention during high-risk periods where conventional treatments are limited by slower onset. However, variability in study results and concerns over long-term safety necessitate further research to optimize treatment protocols and understand the implications of different administration routes. These findings have important implications for developing clinical guidelines in managing acute suicidal ideation in MDD.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141169081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-24DOI: 10.1186/s43045-024-00429-2
Dedi Kurniawan, Akbar Satria Fitriawan, Brigitta Ayu Dwi Susanti, Insanul Firdaus, Gatot Suparmanto, Raisa Farida Kafil, Apri Nur Wulandari, W. Setyaningsih, Zenni Puspitarini, Eriyono Budi Wijoyo
{"title":"Predictors of suicidal behaviors among school-going adolescents: a cross sectional study in Indonesia","authors":"Dedi Kurniawan, Akbar Satria Fitriawan, Brigitta Ayu Dwi Susanti, Insanul Firdaus, Gatot Suparmanto, Raisa Farida Kafil, Apri Nur Wulandari, W. Setyaningsih, Zenni Puspitarini, Eriyono Budi Wijoyo","doi":"10.1186/s43045-024-00429-2","DOIUrl":"https://doi.org/10.1186/s43045-024-00429-2","url":null,"abstract":"","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-22DOI: 10.1186/s43045-024-00426-5
R. M. Naguib, Ghada Refaat Amin, D. E. Serafi, Hend Adel Hamed Naga, S. Sallam
{"title":"Psychiatric impact of the novel coronavirus disease 2019 on previously mentally healthy survivors","authors":"R. M. Naguib, Ghada Refaat Amin, D. E. Serafi, Hend Adel Hamed Naga, S. Sallam","doi":"10.1186/s43045-024-00426-5","DOIUrl":"https://doi.org/10.1186/s43045-024-00426-5","url":null,"abstract":"","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141111301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.1186/s43045-024-00427-4
Doaa Riad Ayoub, Yasim Ramadan, D. Afifi, R. Kamel
{"title":"Digital addiction in children with end-stage kidney disease on regular hemodialysis: a cross-sectional study","authors":"Doaa Riad Ayoub, Yasim Ramadan, D. Afifi, R. Kamel","doi":"10.1186/s43045-024-00427-4","DOIUrl":"https://doi.org/10.1186/s43045-024-00427-4","url":null,"abstract":"","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.1186/s43045-024-00425-6
Ahmad Feras AlSamhori, J. Alsamhori, Abdel Rahman Feras AlSamhori, Julia Abuaun, Nada AlAwamleh, Rnad Saleh, Ayham Mohammad Hussein, Hamzah Ibrahim Yousef Abu Mahmoud, Radwan A BaniMustafa, Abdallah Barjas Qaswal
{"title":"The stigma towards seeking help among university students: a cross-sectional study in Jordan","authors":"Ahmad Feras AlSamhori, J. Alsamhori, Abdel Rahman Feras AlSamhori, Julia Abuaun, Nada AlAwamleh, Rnad Saleh, Ayham Mohammad Hussein, Hamzah Ibrahim Yousef Abu Mahmoud, Radwan A BaniMustafa, Abdallah Barjas Qaswal","doi":"10.1186/s43045-024-00425-6","DOIUrl":"https://doi.org/10.1186/s43045-024-00425-6","url":null,"abstract":"","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.1186/s43045-024-00424-7
Christian-Joseph El Zouki, Abdallah Chahine, Nathalie El Tawil, Karolina Jaalouk, Souheil Hallit, Sahar Obeid
This study aims to investigate the moderating influence of social support and religiosity in the association between child abuse and entrapment during adulthood. This cross-sectional study recruited 352 Lebanese adults between November 2022 and January 2023. The survey included several sociodemographic items and validated instruments like the Child Abuse Self Report Scale, the Entrapment Scale Short Form, the Centrality of Religiosity Scale, and the Multidimensional Scale of Perceived Social Support. The moderation analysis indicates that there is a positive relationship between physical abuse, sexual abuse, and neglect with entrapment, and the intensity of this correlation may vary depending on various levels of social support and religiosity. Religiosity and social support may help mitigate the intensity of entrapment experienced, making it less severe when support or religiosity is high but not enough to lead to a negative relationship between child abuse and entrapment. This study is crucial as it recognizes the long-lasting impact of child abuse and its potential relationship with feelings of entrapment in adulthood, especially that it stresses long-term follow-up and support for survivors with regular assessments of coping strategies to help individuals navigate challenges and promote continued healing.
{"title":"Relationship between a history of child abuse and feelings of entrapment in Lebanese adults: the co-moderating effect of social support and religiosity","authors":"Christian-Joseph El Zouki, Abdallah Chahine, Nathalie El Tawil, Karolina Jaalouk, Souheil Hallit, Sahar Obeid","doi":"10.1186/s43045-024-00424-7","DOIUrl":"https://doi.org/10.1186/s43045-024-00424-7","url":null,"abstract":"This study aims to investigate the moderating influence of social support and religiosity in the association between child abuse and entrapment during adulthood. This cross-sectional study recruited 352 Lebanese adults between November 2022 and January 2023. The survey included several sociodemographic items and validated instruments like the Child Abuse Self Report Scale, the Entrapment Scale Short Form, the Centrality of Religiosity Scale, and the Multidimensional Scale of Perceived Social Support. The moderation analysis indicates that there is a positive relationship between physical abuse, sexual abuse, and neglect with entrapment, and the intensity of this correlation may vary depending on various levels of social support and religiosity. Religiosity and social support may help mitigate the intensity of entrapment experienced, making it less severe when support or religiosity is high but not enough to lead to a negative relationship between child abuse and entrapment. This study is crucial as it recognizes the long-lasting impact of child abuse and its potential relationship with feelings of entrapment in adulthood, especially that it stresses long-term follow-up and support for survivors with regular assessments of coping strategies to help individuals navigate challenges and promote continued healing.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.1186/s43045-024-00423-8
Doaa El Basiouny, Hana I. Habib, Sally Moore, Mohamed A. Khalil
Body image appreciation is an important psychological aspect for all individuals of all ages which affects their psychological, personal, and social well-being. Examining the relationship between disordered eating tendencies, body appreciation, body mass index (BMI), and emotional distress among individuals who follow and seek psychological services from the non-profit entitative Egyptian eating disorders initiative EEDI and an online therapy platform. A cross-sectional study including 301 healthy participants with no past medical or psychiatric history was conducted. Participants completed an online survey including demographic data, BMI, and three measures: The Eating Attitudes Test (EAT-26), the Body Appreciation Scale (BAS), and the Depression Anxiety and Stress Scale (DASS-21) questionnaires. Participants with disordered eating tendencies — according to EAT-26 — had lower BAS scores (p < 0.001) and higher DASS depression, anxiety, and stress scores (p < 0.001). EAT-26 was negatively correlated with age (p = 0.003) and BAS (p < 0.001). Meanwhile, it was positively correlated with the three DASS scales (p < 0.001). BAS was negatively correlated with body mass index and the three DASS scales (p < 0.001). Body appreciation decreases with increased disordered eating tendencies and BMI. Depression, anxiety, and stress are associated with a decrease in body appreciation.
{"title":"Relation between body appreciation, eating disorder risk, emotional distress, and BMI among a group of Egyptian subjects","authors":"Doaa El Basiouny, Hana I. Habib, Sally Moore, Mohamed A. Khalil","doi":"10.1186/s43045-024-00423-8","DOIUrl":"https://doi.org/10.1186/s43045-024-00423-8","url":null,"abstract":"Body image appreciation is an important psychological aspect for all individuals of all ages which affects their psychological, personal, and social well-being. Examining the relationship between disordered eating tendencies, body appreciation, body mass index (BMI), and emotional distress among individuals who follow and seek psychological services from the non-profit entitative Egyptian eating disorders initiative EEDI and an online therapy platform. A cross-sectional study including 301 healthy participants with no past medical or psychiatric history was conducted. Participants completed an online survey including demographic data, BMI, and three measures: The Eating Attitudes Test (EAT-26), the Body Appreciation Scale (BAS), and the Depression Anxiety and Stress Scale (DASS-21) questionnaires. Participants with disordered eating tendencies — according to EAT-26 — had lower BAS scores (p < 0.001) and higher DASS depression, anxiety, and stress scores (p < 0.001). EAT-26 was negatively correlated with age (p = 0.003) and BAS (p < 0.001). Meanwhile, it was positively correlated with the three DASS scales (p < 0.001). BAS was negatively correlated with body mass index and the three DASS scales (p < 0.001). Body appreciation decreases with increased disordered eating tendencies and BMI. Depression, anxiety, and stress are associated with a decrease in body appreciation.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140883745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.1186/s43045-024-00422-9
Razan Numan Alkhatib, Samir Jabra Dukmak, Faris El-Dahiyat, Amjed Ahmed Abojedi
In this research, the first Arabic quality of life (A-QoLA) measure for the mothers and fathers of children with autism is translated and validated. While there have been several translations of the QoLA scale, to the best of our knowledge, there are no Arabic version of this scale. To translate and validate the QoLA, 407 family members (mostly parents) participated in this research. Item total correlation and confirmatory factor analysis (CFA) were used for the scale validation process. The results show that like QoLA, all the items in Part A of the A-QoLA were positively correlated with the total score except items 2, 4, 17, and 22 (which were deleted). In addition, the Part B outcome of the item total correlation showed that all the items had a positive correlation with the overall score. The CFA results show high internal validity and consistency confirmed the two-domain structure for QoLA after it was translated into Arabic. Our results have very important implications as autism is quite common in the Arab world, and the scale can be used across several Arabic-speaking countries to understand the impact of autism on families.
{"title":"Developing the first Arabic quality of life for parents of children with autism (QoLA) scale: translation, cultural adaptation and psychometric validation","authors":"Razan Numan Alkhatib, Samir Jabra Dukmak, Faris El-Dahiyat, Amjed Ahmed Abojedi","doi":"10.1186/s43045-024-00422-9","DOIUrl":"https://doi.org/10.1186/s43045-024-00422-9","url":null,"abstract":"In this research, the first Arabic quality of life (A-QoLA) measure for the mothers and fathers of children with autism is translated and validated. While there have been several translations of the QoLA scale, to the best of our knowledge, there are no Arabic version of this scale. To translate and validate the QoLA, 407 family members (mostly parents) participated in this research. Item total correlation and confirmatory factor analysis (CFA) were used for the scale validation process. The results show that like QoLA, all the items in Part A of the A-QoLA were positively correlated with the total score except items 2, 4, 17, and 22 (which were deleted). In addition, the Part B outcome of the item total correlation showed that all the items had a positive correlation with the overall score. The CFA results show high internal validity and consistency confirmed the two-domain structure for QoLA after it was translated into Arabic. Our results have very important implications as autism is quite common in the Arab world, and the scale can be used across several Arabic-speaking countries to understand the impact of autism on families.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Potentially inappropriate medications (PIMs) are defined as drugs whose adverse effects outweigh the benefits or when more efficacious alternatives are present. This study aims to assess the overall prevalence of PIMs according to Beers 2019 and 2023 among older adult patients with serious mental illnesses (such as schizophrenia), and factors associated with PIMs while examining the difference between the two versions. This cross-sectional study included chronic patients aged 65 years and above, hospitalized at the Psychiatric Hospital of the Cross (Lebanon), and taking at least one medication daily. Sociodemographic characteristics, medications, and clinical information were obtained from patients’ medical records. SPSS version 26 was used for data analysis. Descriptive statistics were used to describe independent variables, while bivariate analysis was used to assess associations between PIM use and different factors. A two-tailed p value < 0.05 was considered statistically significant. Ninety-seven patients were included with a mean age of 71.21 (± 4.63) years. 52.6% were female. 44.3% were on polypharmacy (5–9 medications). 97.9% had at least one PIM according to both versions with the majority being anticholinergics (84.5%). Polypharmacy was significantly correlated to PIM use. Hospital stay length and the presence of comorbid neurological disorders were negatively associated with PIM use. PIMs were extremely prevalent among hospitalized psychiatric older adult patients. Raising awareness among physicians on the Beers criteria or making them mandatory could help diminish PIM use among this vulnerable population.
{"title":"Assessment of potentially inappropriate medications among long-stay older adult patients with serious mental illnesses: findings from a low-resource setting","authors":"Ghinwa Abilmona, Feten Fekih-Romdhane, Souheil Hallit","doi":"10.1186/s43045-024-00419-4","DOIUrl":"https://doi.org/10.1186/s43045-024-00419-4","url":null,"abstract":"Potentially inappropriate medications (PIMs) are defined as drugs whose adverse effects outweigh the benefits or when more efficacious alternatives are present. This study aims to assess the overall prevalence of PIMs according to Beers 2019 and 2023 among older adult patients with serious mental illnesses (such as schizophrenia), and factors associated with PIMs while examining the difference between the two versions. This cross-sectional study included chronic patients aged 65 years and above, hospitalized at the Psychiatric Hospital of the Cross (Lebanon), and taking at least one medication daily. Sociodemographic characteristics, medications, and clinical information were obtained from patients’ medical records. SPSS version 26 was used for data analysis. Descriptive statistics were used to describe independent variables, while bivariate analysis was used to assess associations between PIM use and different factors. A two-tailed p value < 0.05 was considered statistically significant. Ninety-seven patients were included with a mean age of 71.21 (± 4.63) years. 52.6% were female. 44.3% were on polypharmacy (5–9 medications). 97.9% had at least one PIM according to both versions with the majority being anticholinergics (84.5%). Polypharmacy was significantly correlated to PIM use. Hospital stay length and the presence of comorbid neurological disorders were negatively associated with PIM use. PIMs were extremely prevalent among hospitalized psychiatric older adult patients. Raising awareness among physicians on the Beers criteria or making them mandatory could help diminish PIM use among this vulnerable population.","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140835145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A prospective open-label study to evaluate the effectiveness of intravenous ketamine as an adjunct in treating severe depression","authors":"Pavan Kumar Thatisetti Venkata, Divya Bolla, R. Donthu, Anzory Pathak, Amrutha Gudimetla","doi":"10.1186/s43045-024-00420-x","DOIUrl":"https://doi.org/10.1186/s43045-024-00420-x","url":null,"abstract":"","PeriodicalId":38653,"journal":{"name":"Middle East Current Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140670563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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