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Association between serotonin transporter gene polymorphism and obsessive–compulsive disorder in the Egyptian population 埃及人血清素转运体基因多态性与强迫症之间的关系
Q3 PSYCHIATRY Pub Date : 2024-08-16 DOI: 10.1186/s43045-024-00449-y
Sara Mehrez, Mustafa Ahmed Neamatallah, Zeinab Gomaa, Abdel-Hady El-Gilany, Mohammed Shahda, Hiam F Elsaied
Obsessive–compulsive disorder (OCD) is a debilitating disorder that has multifactorial etiology including genetic, neurobiological, cognitive, and environmental influences. Genetic studies have focused on the genes of the serotonin system. This study aimed to look for the possible relation between the polymorphism in the promotor region of the serotonin transporter gene and obsessive–compulsive disorder in the Egyptian population. This study included 94 OCD patients and 116 healthy control individuals. Blood samples were collected from all participants for DNA extraction and genotyping. The assessment of patients was done by application of the structured clinical interview according to DSM-V, the dimensional Yale-Brown Obsessive–Compulsive Scale. There was an association between serotonin transporter gene polymorphism and OCD development. The carriage of the short allele was a risk factor for having OCD. Obsessive–compulsive disorder is associated with serotonin transporter gene polymorphism. This will contribute to considering the genetic information of patients for the prediction of best drug response and tolerability by personalizing the choice of treatment.
强迫症(OCD)是一种使人衰弱的疾病,其病因是多因素的,包括遗传、神经生物学、认知和环境影响。遗传学研究主要集中在血清素系统的基因上。本研究旨在寻找埃及人群中血清素转运体基因启动子区域的多态性与强迫症之间可能存在的关系。这项研究包括 94 名强迫症患者和 116 名健康对照者。研究人员采集了所有参与者的血液样本,用于 DNA 提取和基因分型。根据 DSM-V 和耶鲁-布朗强迫症量表对患者进行了结构化临床访谈评估。血清素转运体基因多态性与强迫症的发展存在关联。短等位基因携带者是患强迫症的危险因素。强迫症与血清素转运体基因多态性有关。这将有助于考虑患者的遗传信息,通过个性化治疗选择来预测最佳药物反应和耐受性。
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引用次数: 0
The impact of childhood abuse on patients with obsessive–compulsive disorder: an Egyptian study 童年虐待对强迫症患者的影响:一项埃及研究
Q3 PSYCHIATRY Pub Date : 2024-08-12 DOI: 10.1186/s43045-024-00447-0
Yasser Abo Raya, Mohammad Gamal Sehlo, Reehab Saeed Mahdy, Heba Mesbah Kotb, Abdallah Saad Ibrahim
The presence of childhood abuse is expected to have a great impact on several psychological domains on obsessive–compulsive disorder (OCD) patients. This study was designed to assess the psychological impact of history childhood abuse (emotional abuse, physical abuse, sexual abuse, and emotional and physical neglect) on five psychological domains among OCD patients (self-esteem, depression, suicidal risk, cognitive functions, and anxiety). This cross-sectional study included 101 OCD patients who were seen in the psychiatric department’s outpatient clinic at Zagazig University Hospital. They were diagnosed according to DSM-IV (SCID-I interview). All the patients were assessed using Childhood Trauma Questionnaire (CTQ-28), the Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HAM-A), Beck’s Suicide Scale, Rosenberg Self-Esteem Scale, and the MoCA scale (Montreal Cognitive Assessment Test). The prevalence of childhood abuse in the studied group was 74.3%. 24.8% with emotional abuse, 20.8% with physical abuse, 16.8% with sexual abuse, and 11.9% of patients with emotional and physical neglect. The different types of childhood abuse (emotional, physical, and sexual abuse) were significantly associated with decreased self-esteem and increased depressive symptoms, while emotional and physical neglect were associated with decreased self-esteem only among OCD patients. The most powerful and significant predictor of lower self-esteem and depression was sexual abuse, and it was also the only significant predictor of increased suicidal risk among OCD patients. History of childhood abuse was significantly associated with decreased self-esteem and increased depressive symptoms among OCD patients. Only history of sexual abuse was significantly associated with increased suicidal risk. So, evaluation of the childhood abuse history is highly important among OCD patients to be incorporated in the management plan to reduce the suffering of OCD patients and for better improvement.
童年受虐史预计会对强迫症(OCD)患者的多个心理领域产生重大影响。本研究旨在评估童年虐待史(情感虐待、身体虐待、性虐待以及情感和身体忽视)对强迫症患者五个心理领域(自尊、抑郁、自杀风险、认知功能和焦虑)的影响。这项横断面研究包括 101 名在扎加齐格大学医院精神科门诊就诊的强迫症患者。他们的诊断依据是 DSM-IV(SCID-I 访谈)。所有患者均接受了童年创伤问卷(CTQ-28)、汉密尔顿抑郁评定量表(HDRS)、汉密尔顿焦虑评定量表(HAM-A)、贝克自杀量表、罗森伯格自尊量表和蒙特利尔认知评估测试(MoCA)量表的评估。研究组中童年受虐待的比例为 74.3%。24.8%的患者遭受过情感虐待,20.8%的患者遭受过身体虐待,16.8%的患者遭受过性虐待,11.9%的患者遭受过情感和身体忽视。不同类型的童年虐待(情感虐待、身体虐待和性虐待)与自尊心下降和抑郁症状增加有显著关联,而情感和身体忽视仅与强迫症患者的自尊心下降有关。性虐待是导致自尊心下降和抑郁的最有力、最重要的预测因素,也是强迫症患者自杀风险增加的唯一重要预测因素。童年受虐史与强迫症患者自尊心下降和抑郁症状增加有显著相关性。只有性虐待史与自杀风险的增加有显著相关性。因此,对强迫症患者的童年虐待史进行评估是非常重要的,应将其纳入管理计划中,以减轻强迫症患者的痛苦,更好地改善病情。
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引用次数: 0
Attitude and help-seeking behavior towards suicide among medical students in Jammu and Kashmir 查谟和克什米尔医学生对自杀的态度和求助行为
Q3 PSYCHIATRY Pub Date : 2024-08-07 DOI: 10.1186/s43045-024-00448-z
Rajnish Raj, Zaid Ahmad Wani, Deeba Nazir, Inaamul Haq, Andleeba Rehman, Tanmay Jasrotia, Kulbushan Kumar, Rameez Ahmad Meer, Maajid Shafi Bhat
The ongoing training process and medical curriculum of the medical profession are crucial for equipping them with necessary knowledge and skills, but it can also be challenging to balance the demands of a busy learning schedule, making this period stressful. This study has been aimed to determining the attitude towards suicide and their help-seeking behavior among medical undergraduates in the union territory of Jammu and Kashmir (J&K). Across medical colleges of the J&K region, an online survey was conducted among 275 medical undergraduates using Attitude Towards Suicide Scale-20 and General Help-Seeking Behavior Questionnaire. An independent sample t-test and one-way ANOVA were carried out for statistical analysis in SPSS 25.0. The mean age of the participants was 22.05 years, including 116 male and 159 female students. Psychiatry posting was attended by 31.3% (N = 86) students. Students showed greater acceptability over suicide is preventable, and it is a cry for help. For personal and emotional problems, subjects preferred seeking help from informal sources, while for suicidal ideations, they exhibited inclination towards formal sources. Findings of the result should be utilized in preventing negative mental health consequences and in planning assistance to them. Medical students within the institution should receive counselling services from the psychiatry department in a non-stigmatizing manner.
医学专业的持续培训过程和医学课程对于培养他们掌握必要的知识和技能至关重要,但要在繁忙的学习日程表中取得平衡也是一项挑战,因此这一时期的压力很大。本研究旨在确定查谟和克什米尔地区(J&K)医学本科生对自杀的态度及其求助行为。在查谟和克什米尔地区的各所医学院校中,使用自杀态度量表-20 和一般求助行为问卷对 275 名医学本科生进行了在线调查。在 SPSS 25.0 中进行了独立样本 t 检验和单因子方差分析。参与者的平均年龄为 22.05 岁,包括 116 名男生和 159 名女生。31.3%的学生(N = 86)参加了精神病学讲座。学生们对自杀是可以预防的和自杀是一种求救信号的接受度较高。对于个人和情感问题,受试者更倾向于从非正规渠道寻求帮助,而对于自杀意念,他们则倾向于从正规渠道寻求帮助。应利用调查结果来预防负面心理健康后果,并计划为他们提供援助。院校内的医学生应以非污名化的方式接受精神科的咨询服务。
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引用次数: 0
OCD in children: phenomenology, impairment, and psychiatric co-morbidity—an experience from Kashmir 儿童强迫症:现象、障碍和精神疾病并发症--克什米尔的经验
Q3 PSYCHIATRY Pub Date : 2024-08-02 DOI: 10.1186/s43045-024-00444-3
Rajnish Raj, Syed Karrar Hussain, Zaid Ahmad Wani
Obsessions are recurrent ego-dystonic thoughts, images, or urges followed by compulsion to reduce them. The phenomenology of obsessive–compulsive disorder (OCD) along with comorbidities is essential for understanding treatment response. This study aimed to assess phenomenology, impairment, and psychiatric co-morbidity associated with OCD in children and adolescents. A cross-sectional study was done among 36 patients suffering from OCD. Socio-demographic and clinical details were collected with the application of Children’s Yale-Brown Obsessive Compulsive Scale for severity of illness, Children’s Global Assessment Scale for impairment assessment, and Kiddie-Sads-Present and Lifetime Version for comorbidity. Thirty-six patients, comprising 20 male and 16 female subjects, with a mean age ± SD of 11 ± 3.4 years and a mean duration of illness of 12.30 months, were included in the study. A positive family history was noted in 30.6% of subjects. Mean C-YBOCS score was 24.44 (moderate to severe OCD) and the mean C-GAS score was 47.86, with 55.6% of subjects suffering from other comorbidities. Fear of contamination with washing and cleaning was among the most common themes in the population. Data was analyzed and presented as mean ± SD, frequencies, and percentages. Considering the increased prevalence of OCD in children and adolescent populations, a thorough symptom evaluation and any co-morbidities related to OCD should be considered by clinicians.
强迫症是指反复出现的自我强直性思维、图像或冲动,随后会强迫自己减少这些思维、图像或冲动。强迫症(OCD)的现象学以及合并症对于了解治疗反应至关重要。本研究旨在评估与儿童和青少年强迫症相关的现象学、损伤和精神疾病合并症。本研究对 36 名强迫症患者进行了横断面研究。在收集社会人口学和临床细节的同时,还采用了儿童耶鲁-布朗强迫症量表(Children's Yale-Brown Obsessive Compulsive Scale)来评估疾病的严重程度,儿童全面评估量表(Children's Global Assessment Scale)来评估障碍程度,以及 Kiddie-Sads-Present and Lifetime Version(Kiddie-Sads-Present and Lifetime Version)来评估合并症。研究共纳入 36 名患者,其中男性 20 人,女性 16 人,平均年龄(± SD)为 11 ± 3.4 岁,平均病程为 12.30 个月。30.6%的受试者有阳性家族史。C-YBOCS平均得分为24.44分(中度至重度强迫症),C-GAS平均得分为47.86分,55.6%的受试者患有其他合并症。害怕清洗和清洁造成污染是人群中最常见的主题之一。数据以均数±标准差、频率和百分比的形式进行分析和呈现。考虑到强迫症在儿童和青少年群体中的发病率越来越高,临床医生应考虑对强迫症的症状和合并症进行全面评估。
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引用次数: 0
Gender differences in patients with corona virus disease-2019 presenting with psychiatric disturbances: a multicentre study 多中心研究:伴有精神障碍的电晕病毒病-2019 患者的性别差异
Q3 PSYCHIATRY Pub Date : 2024-07-26 DOI: 10.1186/s43045-024-00445-2
Rabab Maher, Hend Ibrahim Shousha, Nagwan Madbouly, Shimaa Afify, Suaad Sayed Moussa, Noha Asem, Amr Abdelazeem, Eslam Mohamed Youssif, Khalid Yousef Harhira, Hazem Elmorsy, Hassan Elgarem, Mohamed Hassany, Basem Eysa, Mohamed El-Kassas
The coronavirus disease known as COVID-19 (2019) pandemic may increase the likelihood of psychological symptoms that can reach the level of psychiatric disorders. We aimed to study psychiatric morbidity in patients with COVID-19 concerning gender differences and disease severity in the acute phase of infection and after 6 months. This is a multicenter follow-up study registered in ClinicalTrials.gov (NCT04459403). Patients were recruited consecutively from three quarantine hospitals in Egypt. Data were collected through a questionnaire built using Google Forms including the Arabic versions of General Health Questionnaire (GHQ-12), Beck Depression Inventory (BDI), and Taylor Manifest Anxiety Scale (TMAS). Depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms were assessed after 6 months. The study questionnaire was offered to 400 patients and 199 patients agreed to fill it. BDI and TAMS were higher in mild than moderate and severe COVID-19 (14, 8, 8, P-value = 0.009, 17, 13.5, 14, P-value = 0.04, respectively). Females showed a higher prevalence of depression, anxiety, sleep problems, and insomnia due to anxiety than males. Education level, marital status, previous psychiatric illness, and severity of COVID-19 independently affected depression. Marital status, family history of psychiatric illness, and chronic medical illness independently affected anxiety. On 6-month follow-up, BDI significantly decreased in males but not females. TMAS showed no significant changes, but the severity of anxiety was still higher in females. PTSD was more frequent in females (26 (37.1%) versus 4 (9.5%), respectively, P-value = 0.02). The prevalence and severity of depression and anxiety were higher in females than male participants, suggesting that females are more affected by the COVID-19 pandemic.
被称为COVID-19(2019年)大流行的冠状病毒疾病可能会增加出现心理症状的可能性,从而达到精神障碍的程度。我们旨在研究 COVID-19 患者在感染急性期和 6 个月后的精神疾病发病率,其中涉及性别差异和疾病严重程度。这是一项在 ClinicalTrials.gov (NCT04459403) 上注册的多中心随访研究。患者从埃及三家隔离医院连续招募。通过使用 Google Forms 制作的问卷收集数据,其中包括阿拉伯语版的一般健康问卷 (GHQ-12)、贝克抑郁量表 (BDI) 和泰勒显性焦虑量表 (TMAS)。6 个月后对抑郁、焦虑和创伤后应激障碍(PTSD)症状进行评估。研究向 400 名患者发放了调查问卷,199 名患者同意填写。轻度 COVID-19 患者的 BDI 和 TAMS 分别高于中度和重度 COVID-19 患者(分别为 14、8、8,P 值 = 0.009;17、13.5、14,P 值 = 0.04)。女性患抑郁症、焦虑症、睡眠问题和因焦虑而失眠的比例高于男性。教育程度、婚姻状况、既往精神病史和 COVID-19 的严重程度对抑郁有独立影响。婚姻状况、精神病家族史和慢性病对焦虑症有独立影响。在 6 个月的随访中,男性的 BDI 显著下降,而女性则没有。TMAS没有明显变化,但女性焦虑的严重程度仍然更高。创伤后应激障碍在女性中更为常见(分别为 26 例(37.1%)和 4 例(9.5%),P 值 = 0.02)。女性抑郁症和焦虑症的患病率和严重程度均高于男性,这表明女性受 COVID-19 大流行的影响更大。
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引用次数: 0
The prevalence and consequences of workplace violence among psychiatrists in Saudi Arabia: a cross-sectional study 沙特阿拉伯精神科医生工作场所暴力的发生率和后果:横断面研究
Q3 PSYCHIATRY Pub Date : 2024-07-22 DOI: 10.1186/s43045-024-00446-1
Afnan A. Alwabili, Nada I. AlGhammas, Hanoof H. ALkhalaf, Malak A. Almutairi
There has been increasing concern globally about the rise in workplace violence (WPV), which is considered a persistent problem generally overlooked by the public and professional organizations. WPV is a significant challenge faced by psychiatrists internationally, yet little is known about WPV among psychiatrists in Saudi Arabia. This study aims to estimate the prevalence of WPV against psychiatrists in Saudi Arabia and identify the types and sources of violence experienced as well as the associated risk factors that contribute to WPV. Among 239 psychiatrists, the prevalence of WPV in Saudi Arabia was 56.3%. The prevalence was particularly high among those working in the central region (55.4%) and in Ministry of Health hospitals, Violent behavior was exhibited mostly by patients 133 (99.3%), and the most common type of violence was verbal abuse 75 (56.0%). Respondents reported that patients’ health conditions, denial of admission to the hospital, and staff shortages were the most common triggers for violence. More than two-thirds of the psychiatrists (74.6%) did not require medical intervention after incidents of violence. The majority of psychiatrists felt either stressed (39%) or angry (22.0%) after such incidents. Reasons for not reporting violent events included feeling that violence is part of the job (76.9%) and being unaware of the violence reporting system (50.8%). This study underscores the significant prevalence of WPV among Saudi Arabian psychiatrists, especially in the central region and in Ministry of Health hospitals, notably in emergency rooms. Perpetrators are primarily psychiatric patients and their relatives. The issue is compounded by staffing shortages. WPV poses physical risks and causes psychological stress, negatively impacting productivity. Underreporting persists due to a lack of awareness or violence being perceived as part of the job. Addressing these challenges through raising awareness, providing support mechanisms, and enforcing regulations is essential to bolster workplace safety and patient care for psychiatrists.
工作场所暴力(WPV)的增加在全球范围内引起了越来越多的关注,这被认为是一个长期存在的问题,通常被公众和专业组织所忽视。WPV 是精神科医生在国际上面临的一个重大挑战,但人们对沙特阿拉伯精神科医生中的 WPV 却知之甚少。本研究旨在估算沙特阿拉伯精神科医生遭受 WPV 的发生率,并确定遭受暴力的类型和来源以及导致 WPV 的相关风险因素。在沙特阿拉伯的 239 名精神科医生中,WPV 的发生率为 56.3%。在中部地区(55.4%)和卫生部下属医院工作的精神科医生中,暴力行为发生率尤其高。暴力行为的主要施暴者是患者,有 133 人(99.3%),最常见的暴力行为类型是辱骂,有 75 人(56.0%)。受访者称,病人的健康状况、拒绝入院和人手短缺是最常见的暴力诱因。超过三分之二的精神科医生(74.6%)在暴力事件发生后不需要医疗干预。大多数精神科医生在此类事件发生后感到压力(39%)或愤怒(22.0%)。不报告暴力事件的原因包括觉得暴力是工作的一部分(76.9%)和不了解暴力报告系统(50.8%)。这项研究强调了沙特阿拉伯精神科医生中 WPV 的严重普遍性,特别是在中部地区和卫生部医院,尤其是急诊室。施暴者主要是精神病患者及其亲属。人员短缺使问题更加复杂。WPV 带来身体风险并造成心理压力,对工作效率产生负面影响。由于缺乏认识或认为暴力是工作的一部分,报告不足的现象一直存在。通过提高认识、提供支持机制和执行法规来应对这些挑战,对于加强精神科医生的工作场所安全和患者护理至关重要。
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引用次数: 0
Effect of a nursing educational program on competency and parenting practices among parents having children with attention deficit hyperactivity disorder: a randomized controlled trial 护理教育计划对有注意力缺陷多动障碍儿童的父母的能力和养育方法的影响:随机对照试验
Q3 PSYCHIATRY Pub Date : 2024-07-19 DOI: 10.1186/s43045-024-00443-4
Alaa El Din Moustafa Hamed Abd Elaleem, Zeinab Abd El Halim Osman, Wafaa Osman Abd El-Fatah
Attention deficit hyperactivity disorder is a common condition most prevalent among children worldwide. When it comes to parenting, parents of children with attention deficit hyperactivity disorder exhibit lower competency and more negative parenting behaviors than parents of children without the disease. This randomized controlled trial aimed to assess the effect of a nursing educational program on competency and practices among parents of children with attention deficit hyperactivity disorder. A total of 50 parents, most of whom were mothers with children aged between 5 and 10 years and previously diagnosed with attention deficit hyperactivity disorder, were chosen at random and split into equal study and control groups. The study group received eight sessions of the nursing educational program, with each session lasting 60 to 90 min, while the control group only received routine interventions. The results of the current study show statistically significant differences between the study group and control group in terms of positive parenting practices, negative parenting practices, over-reactive practices, functional family practices, interactive practices, satisfactory parenting sense of competency, and effectiveness of parenting sense of competency. The nursing educational program presents benefits in improving parenting practices and enhancing parenting sense of competency among parents of children with attention deficit hyperactivity disorder.
注意缺陷多动障碍是一种常见疾病,在全球儿童中最为普遍。在养育子女方面,注意力缺陷多动障碍患儿的父母比非患儿的父母表现出更低的能力和更消极的养育行为。这项随机对照试验旨在评估护理教育计划对注意力缺陷多动障碍儿童家长的能力和行为的影响。试验随机选取了 50 名家长,将他们分成人数相等的研究组和对照组,其中大部分是母亲,其子女年龄在 5 到 10 岁之间,曾被诊断患有注意缺陷多动障碍。研究组接受八节护理教育课程,每节课 60 至 90 分钟,而对照组只接受常规干预。本次研究结果显示,研究组与对照组在积极养育实践、消极养育实践、过度反应实践、家庭功能性实践、互动实践、满意的养育胜任感和养育胜任感的有效性等方面存在统计学意义上的显著差异。护理教育计划在改善注意缺陷多动障碍儿童家长的养育实践和提高养育能力方面带来了益处。
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引用次数: 0
Sensory processing patterns among children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) using short sensory profile and evoked potentials: a case–control study 自闭症谱系障碍(ASD)和注意缺陷多动障碍(ADHD)儿童的感觉处理模式:一项病例对照研究
Q3 PSYCHIATRY Pub Date : 2024-07-12 DOI: 10.1186/s43045-024-00441-6
Alaa Salah, Mostafa Amr, Mohamed El-Sayed, Mohamed ElWasify, Khaled Eltoukhy, Samer Salama, Salwa Tobar
Both autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are early neurodevelopmental disorders that present notable diagnostic problems and share clinical features. The current research intends to clarify the sensory profile, visual-evoked potential (VEP), and auditory-evoked potential of children diagnosed with autism spectrum disorder (ASD), ADHD, and typically developing children (TD). We have observed sensory processing problems in 42–88% of children diagnosed with autism and approximately 50% of children diagnosed with ADHD. The parents of 37 children diagnosed with ASD, 41 children diagnosed with ADHD, and 43 children who were typically developing completed the short sensory profile (SSP) along with standardized questionnaires used to assess the symptoms and autistic behaviors. We assessed intellectual functioning and evoked potential in all the groups. There were more sensory problems in the ASD and ADHD groups than in the control group (P < 0.001); however, autism and ADHD differed in all subscales except unresponsiveness, auditory filtering, and visual/auditory subscales. Also, the ASD group and ADHD group showed a more significant delay in visual-evoked potential VEP than the control group (mean and SD of right eye p100 latency 150.85 ± 48.70 in ASD vs 119.28 ± 18.06 in ADHD vs 103.42 ± 5.19 in typically developing group, left p100 latency 141.09 in ASD ± 32.55 vs 116.51 ± 10.1 in ADHD vs 103.0 ± 5.91 typically developing group). Additionally, the ASD group significantly deviated from norms in the absolute latency of waves I, III, and V, as well as the inter-wave intervals of I–III and III–V in the auditory-evoked potential. Furthermore, there was a statistically significant distinction between the ADHD and the TD groups in terms of left wave III and V latency and left interpeak latency between I–III and III–V. Children diagnosed with ASD and ADHD have a greater likelihood than typically developing children to experience sensory processing abnormalities; as a result, we recommend basic assessment, follow-up, and designing the most appropriate intervention.
自闭症谱系障碍(ASD)和注意力缺陷多动障碍(ADHD)都是早期神经发育障碍,存在显著的诊断问题和共同的临床特征。目前的研究旨在阐明被诊断为自闭症谱系障碍(ASD)、注意力缺陷多动障碍(ADHD)和发育典型儿童(TD)的感官特征、视觉诱发电位(VEP)和听觉诱发电位。我们在 42-88% 的自闭症儿童和大约 50% 的多动症儿童中发现了感觉处理问题。37 名被诊断为自闭症的儿童、41 名被诊断为多动症的儿童和 43 名发育正常的儿童的家长填写了简短感觉档案 (SSP),以及用于评估症状和自闭症行为的标准化问卷。我们评估了所有组别的智力功能和诱发电位。与对照组相比,自闭症多动症组和多动症组存在更多的感官问题(P < 0.001);然而,除反应迟钝、听觉过滤和视觉/听觉分量表外,自闭症多动症组和多动症组在所有分量表上都存在差异。此外,与对照组相比,ASD 组和 ADHD 组的视觉诱发电位 VEP 出现了更明显的延迟(ASD 组右眼 p100 潜伏期的平均值和标度为 150.85 ± 48.70 vs ADHD 组为 119.28 ± 18.06 vs 典型发育组为 103.42 ± 5.19,ASD 组左眼 p100 潜伏期的平均值和标度为 141.09 ± 32.55 vs ADHD 组为 116.51 ± 10.1 vs 典型发育组为 103.0 ± 5.91)。此外,在听觉诱发电位中,ASD 组的 I 波、III 波和 V 波的绝对潜伏期以及 I-III 波和 III-V 波的波间间隔均明显偏离常模。此外,在左波 III 和 V 波潜伏期以及左波 I-III 和 III-V 波间潜伏期方面,ADHD 组与 TD 组之间存在统计学意义上的显著差异。被诊断为自闭症和多动症的儿童比发育正常的儿童更有可能出现感觉处理异常;因此,我们建议进行基本评估、跟踪和设计最合适的干预措施。
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引用次数: 0
The association between screen time exposure, parent depression, and development of social communication skills among preschool children in Qassim Region 屏幕时间暴露、父母抑郁与卡西姆地区学龄前儿童社交沟通能力发展之间的关系
Q3 PSYCHIATRY Pub Date : 2024-07-08 DOI: 10.1186/s43045-024-00439-0
Abdullah Alqifari, Raghad Ibrahim Albarrak, Yaqeen Fahad Alrubaish, Mayadah Assaf Alawaji, Reghd Husain Alkhalifah, Hana Nasser Alqifari, Mohammed Suleiman
Screen exposure among children continues to increase worldwide. It has negative effects on children of developmental age, including obesity, poor attention, sleep disorders, vision problems, language delays, and deficits in communication skills. It has been reported that parental depression is associated with both increased screen time for children and poor function and skills in children. However, other studies have reported no association between screen time and parental depression. A cross-sectional study was conducted using a convenience sample of 340 parents of 4- to 6-year-old children in the Qassim Region of Saudi Arabia. Data were collected from the primary health care vaccination clinic by contacting parents of children aged 4 to 6 years to fill out the Social Communication Questionnaire (SCQ) for the child and the Patient Health Questionnaire-9 (PHQ9) for the parents. We conducted a regression analysis to assess the influence of screen time exposure on social communication skills (SCQ score). The results of this study indicated that there was no significant effect observed (B = 0.283, P > 0.05), indicating that a positive correlation between screen time usage and SCQ score may not apply to the entire population. Conversely, we discovered a crucial link between screen time exposure and parental depression (PHQ), as it displayed noteworthy impact values (B = 1.136, P < 0.05), indicating an affirmative correlation between them. In addition, our results also indicated apparent positive associations between parental depression and SCQ scores (B = 0.229, P < 0.05). Our findings revealed that there was a significant association between parental depression and both screen time exposure and SCQ score, while there was no correlation between screen time exposure and SCQ score.
全球儿童接触屏幕的人数持续增加。它对处于发育年龄的儿童有负面影响,包括肥胖、注意力不集中、睡眠障碍、视力问题、语言障碍和沟通能力缺陷。据报道,父母抑郁与儿童屏幕时间增加以及儿童功能和技能低下有关。然而,其他研究报告称,屏幕时间与父母抑郁之间没有关联。我们在沙特阿拉伯卡西姆地区对 340 名 4-6 岁儿童的父母进行了方便抽样的横断面研究。我们从初级卫生保健疫苗接种诊所收集数据,联系了 4-6 岁儿童的父母,让他们填写儿童社会沟通问卷 (SCQ) 和父母患者健康问卷-9 (PHQ9)。我们进行了回归分析,以评估接触屏幕时间对社交沟通能力(SCQ 分数)的影响。研究结果表明,没有观察到明显的影响(B = 0.283,P > 0.05),这表明屏幕时间的使用与 SCQ 分数之间的正相关可能不适用于所有人群。相反,我们发现了屏幕时间暴露与父母抑郁(PHQ)之间的重要联系,因为它显示了值得注意的影响值(B = 1.136,P < 0.05),表明两者之间存在肯定的相关性。此外,我们的研究结果还表明,父母抑郁与 SCQ 分数之间存在明显的正相关(B = 0.229,P < 0.05)。我们的研究结果表明,父母抑郁与接触屏幕时间和 SCQ 分数之间存在显著关联,而接触屏幕时间与 SCQ 分数之间没有关联。
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引用次数: 0
Symptomatic remission and its associated factors among patients with schizophrenia on risperidone or olanzapine at Amanuel mental specialized hospital, Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴 Amanuel 精神专科医院服用利培酮或奥氮平的精神分裂症患者的症状缓解及其相关因素
Q3 PSYCHIATRY Pub Date : 2024-07-05 DOI: 10.1186/s43045-024-00440-7
Melak Gedamu Beyene, Solomon Teferra, Teferi Gedif Fenta
Schizophrenia is a debilitating condition that affects 1% of the global population. Understanding the prevalence and the factors predicting schizophrenia remission is crucial for healthcare providers. This study aimed to determine the prevalence of remission and factors affecting the remission. Cross-sectional study was conducted at the Amanuel Mental Specialized Hospital from 3 October, 2022, to 31 August, 2023, and included 271 participants. Remission was measured using Remission in Schizophrenia Working Group (RSWG) symptom severity-based criteria. Data analysis was done using SPSS V.25. The mean age of participants was 34.2 with standard deviation (SD) of 10.5 years. Most were male (90%), unmarried (63.8%), lived with their relatives (91.9%), and were unemployed (56.5%). Fifty-two percent achieved symptomatic remission. Remission in patients with medication switched to SGAs increased by 1.9 times compared to patients without medication switch (AOR 1.9, 95% CI: 1.1, 1.2). Adherent patients had 2.7 times higher odds of symptomatic remission as compared to non-adherent patients (AOR 2.7, 95% CI: 1.5,4.9), and for each unit increase in body mass index (BMI), the odds of achieving symptomatic remission were increased by 13% (AOR 1.13, 95% CI: 1.04, 1.23). The odds of symptomatic remission decreased by 71% in patients experiencing moderate-to-severe side effects compared to their counterparts (AOR 0.29, 95% CI: 0.1, 0.6). Our study revealed a symptomatic remission was achieved in 141 (52%) of the subjects. There is a possibility to improve symptomatic remission with counseling on the importance of adherence, monitoring and managing side effects, and switching medication to either risperidone or olanzapine. Measuring remission using RSWG time-based criteria is recommended.
精神分裂症是一种使人衰弱的疾病,影响着全球 1%的人口。了解精神分裂症的患病率和预测其缓解的因素对于医疗服务提供者来说至关重要。本研究旨在确定缓解率和影响缓解的因素。横断面研究于 2022 年 10 月 3 日至 2023 年 8 月 31 日在阿曼努埃尔精神病专科医院进行,共纳入 271 名参与者。研究采用精神分裂症缓解工作组(RSWG)基于症状严重程度的标准来衡量缓解程度。数据分析使用 SPSS V.25 进行。参与者的平均年龄为 34.2 岁,标准差(SD)为 10.5 岁。大多数参与者为男性(90%),未婚(63.8%),与亲属同住(91.9%),失业(56.5%)。52%的患者症状得到缓解。与未更换药物的患者相比,更换为 SGAs 药物的患者缓解率增加了 1.9 倍(AOR 1.9,95% CI:1.1,1.2)。与未坚持用药的患者相比,坚持用药的患者症状缓解的几率增加了 2.7 倍(AOR 2.7,95% CI:1.5,4.9),体重指数(BMI)每增加一个单位,症状缓解的几率增加 13%(AOR 1.13,95% CI:1.04,1.23)。与中重度副作用患者相比,中重度副作用患者症状缓解的几率降低了 71%(AOR 0.29,95% CI:0.1,0.6)。我们的研究显示,141 名受试者(52%)的症状得到缓解。通过提供关于坚持治疗的重要性、监测和控制副作用以及将药物更换为利培酮或奥氮平等方面的咨询,有可能改善症状缓解情况。建议使用 RSWG 基于时间的标准来衡量缓解程度。
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引用次数: 0
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Middle East Current Psychiatry
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