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AN OVERVIEW OF MONKEYPOX OUTBREAK 猴痘疫情概述
Pub Date : 2023-05-13 DOI: 10.47316/cajmhe.2023.4.1.01
Erhan Kaya, Musa Şahin, Yavuzalp Solak, O. Acar, Celal Kuş, M. Kuş, Muhammed Mustafa Beyoğlu, B. Koçyiğit
The proceeding 2022 multicountry epidemic of Monkeypox emerges as a global health concern. The first death outside of Africa appeared in Brazil on July 29, 2022, and the first death in Europe occurred in Spain on July 29, 2022. As a result, the World Health Organization announced the monkeypox epidemic as a global public health emergency on July 2022. Therefore, we aimed to present a review in light of contemporary facts. We conducted a review of current details on Monkeypox. Close contact is the best-known risk factor for human-to-human transmission; a pregnant woman can pass the virus to the fetus. The approximative incubation period is 10-14 days. Prodromal symptoms are fever, malaise, chills, and lymphadenopathy. Then clinicians observe that rash develops in most patients. Monkeypox usually takes 2-4 weeks on its own. The plurality of monkeypox patients recovers without treatment. However, some patients with complications may need treatment. Children, pregnant women, and immunocompromised individuals may develop a longer disease because of eye infections, pneumonia, and encephalitis. Physicians use anamnesis, clinical signs, and laboratory tests to diagnose infection. Infected animals and patients should be quarantined. There is no specific vaccine still. Nevertheless, the smallpox vaccine protects 85% against monkeypox, according to early reports. Antiviral drugs, Tecovirimat, Cidofovir, Brincidofovir, and Human Vaccinia Immune Globulin, can potentially treat. Our review centers on clinical knowledge for the efficacious management, prevention, and guidance of monkeypox responders and patients globally.
即将到来的2022年猴痘多国流行成为一个全球卫生问题。非洲以外的首例死亡病例于2022年7月29日出现在巴西,欧洲的首例死亡病例于2022年7月29日出现在西班牙。因此,世界卫生组织于2022年7月宣布猴痘疫情为全球突发公共卫生事件。因此,我们的目的是根据当代的事实进行回顾。我们对猴痘的当前细节进行了审查。密切接触是最广为人知的人际传播风险因素;孕妇可以将病毒传染给胎儿。潜伏期约为10-14天。前驱症状为发热、不适、寒战和淋巴结肿大。然后临床医生观察到大多数患者出现皮疹。猴痘本身通常需要2-4周。多数猴痘患者无需治疗即可痊愈。然而,一些有并发症的患者可能需要治疗。儿童、孕妇和免疫功能低下的个体可能因眼部感染、肺炎和脑炎而发展为长期疾病。医生使用记忆、临床症状和实验室检查来诊断感染。受感染的动物和病人应被隔离。目前还没有专门的疫苗。然而,根据早期的报告,天花疫苗对猴痘的保护率为85%。抗病毒药物,如替科维莫、西多福韦、布林多福韦和人牛痘免疫球蛋白,都有潜在的治疗作用。我们的综述集中在有效管理、预防和指导全球猴痘应答者和患者的临床知识。
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引用次数: 0
ACADEMIA SHOULD STOP USING BEALL’S LISTS AND REVIEW THEIR USE IN PREVIOUS STUDIES 学术界应该停止使用beall的列表,并回顾它们在以前研究中的使用情况
Pub Date : 2023-05-13 DOI: 10.47316/cajmhe.2023.4.1.04
J. A. Teixeira da Silva, G. Kendall
Academics (should) strive to submit to journals which are academically sound and scholarly. To achieve this, they could either submit to journals that appear exclusively on safelists (occasionally referred to as whitelists, although this term tends to be avoided), or avoid submitting to journals on watchlists (occasionally referred to as blacklists, although this term tends to be avoided). The most well-known of these lists was curated by Jeffrey Beall. Beall’s Lists (there are two, one for stand-alone journals and one for publishers) were taken offline by Beall himself in January 2017. Prior to 2017, Beall’s Lists were widely cited and utilized, including to make quantitative claims about scholarly publishing. Even after Beall’s Lists became obsolete (they have not been maintained for the past six years), they continue to be widely cited and used. This paper argues that the use of Beall’s Lists, pre- and post-2017, may constitute a methodological error and, even if papers carry a disclaimer or limitations section noting this weakness, their conclusions cannot always be relied upon. This paper also argues for the need to conduct a detailed post-publication assessment of reports in the literature that used Beall’s Lists to validate their findings and conclusions, assuming that it becomes accepted that Beall’s Lists are not a reliable resource for scientific investigation. Finally, this paper contends that any papers that have identified methodological errors should be corrected. Several lists that were cloned from Beall’s Lists have also emerged and are also being cited. These should also be included in any post-publication investigation that is conducted.
学者(应)努力提交学术上健全和学术性强的期刊。要做到这一点,他们可以向只出现在安全名单上的期刊投稿(偶尔被称为白名单,尽管往往避免使用这个术语),或者避免向监视名单上的期刊投稿(偶尔被称为黑名单,尽管往往避免使用这个术语)。这些名单中最著名的是由杰弗里·比尔策划的。Beall 's Lists(有两个,一个用于独立期刊,一个用于出版商)于2017年1月被Beall本人下线。在2017年之前,Beall’s Lists被广泛引用和使用,包括对学术出版做出定量声明。即使在比尔清单过时之后(在过去的六年里,它们没有被维护),它们仍然被广泛引用和使用。本文认为,在2017年之前和之后使用Beall’s Lists可能构成方法学上的错误,即使论文有免责声明或限制部分指出这一弱点,它们的结论也并不总是可靠的。本文还认为,有必要对使用Beall’s Lists的文献中的报告进行详细的出版后评估,以验证他们的发现和结论,假设Beall’s Lists不是科学调查的可靠资源这一观点已被接受。最后,本文认为,任何论文,发现了方法上的错误,应予以纠正。一些从比尔的榜单中克隆出来的榜单也出现了,并被引用。这些也应该包括在任何发表后的调查中。
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引用次数: 6
POST-PUBLICATION REVIEW 出版审查
Pub Date : 2023-05-13 DOI: 10.47316/cajmhe.2023.4.1.06
I. Benlidayı
POST-PUBLICATION REVIEW
出版审查
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引用次数: 1
OPEN ACCESS PUBLISHING — “SO NEAR AND YET SO FAR” 开放获取出版——“如此近而又如此远”
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.05
S. Santhanam, M. Goyal
Scientific knowledge needs to be widely disseminated across the globe, for it to be critically analyzed or to be built upon for future studies. The conventional publication model has been less accessible due to prohibitive subscription costs and hence the need arose for the open access model where the readers would have free access. The Open Science movement is not only about open-access journals but also includes open source, open data and methodology, open peer review, open-access indexing, and archiving. The prototype open access model is the gold model where researchers (themselves or supported by grants or funding agencies) pay certain article processing charges and the readers have free access to the content without any restrictions. Additionally, there is a need for free-to-use open-access platforms or repositories like PubMed Central to archive the open-access content. Institutional repository is another way for collecting, archiving, and distributing the scholarly contents of an academic institution. Preprint servers allow archiving manuscripts before they are submitted to or undergo review for publication, and they offer an important platform for freely sharing knowledge. While open-access model looks attractive, it has its challenges. Currently, the change to open-access model has meant the transfer of the financial burden, earlier borne by the readers, to the authors in the form of APCs. Irrespective of the model, there is a need to reconsider the high subscription costs and the article processing charges which are often prohibitive for many. Science must be accessible to the researchers and the public at a reasonable cost without delay.
科学知识需要在全球范围内广泛传播,以便对其进行批判性分析或为未来的研究奠定基础。由于高昂的订阅费用,传统的出版模式已经不太容易获得,因此需要开放获取模式,读者可以免费获取。开放科学运动不仅涉及开放获取期刊,还包括开放源代码、开放数据和方法、开放同行评审、开放获取索引和存档。原型开放获取模式是黄金模式,研究人员(自己或由资助机构或资助机构支持)支付一定的文章处理费,读者可以不受任何限制地免费访问内容。此外,还需要免费使用的开放存取平台或像PubMed Central这样的存储库来存档开放存取内容。机构存储库是收集、归档和分发学术机构的学术内容的另一种方式。预印本服务器允许在手稿提交或接受出版审查之前对其进行存档,它们为自由分享知识提供了重要的平台。虽然开放获取模式看起来很有吸引力,但它也有自己的挑战。目前,向开放获取模式的转变意味着将原先由读者承担的经济负担以apc的形式转移到作者身上。无论采用哪种模式,我们都需要重新考虑高昂的订阅费用和文章处理费,这对许多人来说往往是令人望而却步的。科研人员和公众必须能够以合理的成本毫不拖延地获得科学。
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引用次数: 0
DYSTOPIAN CASES OF ORCID IDENTIFIERS: ANIMAL-ASSOCIATED ACCOUNTS orcid标识符的反乌托邦案例:与动物相关的账户
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.06
J. A. Teixeira da Silva
DYSTOPIAN CASES OF ORCID IDENTIFIERS: ANIMAL-ASSOCIATED ACCOUNTS
orcid标识符的反乌托邦案例:与动物相关的账户
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引用次数: 2
MY LIFE AS A VITAMIN D RESEARCHER 我作为维生素d研究人员的生活
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.08
W. Grant
MY LIFE AS A VITAMIN D RESEARCHER
我作为维生素d研究人员的生活
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引用次数: 0
FDA-APPROVED INDICATIONS OF ADRENOCORTICOTROPIC HORMONE (ACTH) AS A DRUG: DOES IT HAVE A PLACE IN DISEASE MANAGEMENT TODAY? 促肾上腺皮质激素(acth)作为药物的适应症:它在今天的疾病管理中有一席之地吗?
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.01
G. Iliopoulos, D. Daoussis
ACTH is a pituitary hormone important for proper function of adrenal glands, cortisol production as well as human physiology in general.  It is involved in the pathogenesis of several endocrine disorders like Cushing syndrome and can be a useful diagnostic tool for diseases like primary adrenal insufficiency.  Although popular as a hormone in endocrine system physiology and testing, ACTH has been used as a drug since the 1950s.  Except for steroid-releasing properties, its mechanism of action involves a steroid-independent anti-inflammatory and possible immune-modulatory effect.  Pharmaceutic ACTH has a wide range of indications approved by FDA and usually comes in the form of subcutaneous injections.  In this narrative review, we accumulated what we considered as important data from reviews, cases and trials involving the most basic FDA-approved ACTH indications.  A special emphasis was given on rheumatologic indications of ACTH.  More large data studies need to be performed to assess ACTH usefulness, efficacy, safety and cost-effectiveness as a drug.  
ACTH是一种垂体激素,对肾上腺的正常功能、皮质醇的产生以及人体生理都很重要。它参与了库欣综合征等几种内分泌疾病的发病机制,可以作为原发性肾上腺功能不全等疾病的有用诊断工具。虽然ACTH作为一种激素在内分泌系统生理学和测试中很受欢迎,但自20世纪50年代以来,ACTH一直被用作药物。除了类固醇释放特性外,其作用机制涉及类固醇非依赖性抗炎和可能的免疫调节作用。药物ACTH具有广泛的适应症,经FDA批准,通常以皮下注射的形式出现。在这篇叙述性综述中,我们从涉及fda批准的最基本ACTH适应症的综述、病例和试验中积累了我们认为重要的数据。特别强调了ACTH的风湿病适应症。需要进行更多的大数据研究来评估促肾上腺皮质激素作为一种药物的有效性、有效性、安全性和成本效益。
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引用次数: 0
GROUND GLASS OPACITIES: SIGN OF CAUTION IN TYPICAL INTERSTITIAL PNEUMONIA 磨玻璃影:典型间质性肺炎的警告征象
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.03
M. Tezcan, S. A. Kasman
Typical interstitial pneumonia (IP) is mainly the fibrotic form of interstitial lung disease. In some cases with typical IP, a certain amount of ground-glass opacity (GGO) can be detected on high-resolution computed tomography, however, some important issues, such as the co-existence of GGO and typical IP, still require further investigation by biopsy. After the diagnosis of typical IP, anti-fibrosis treatment is usually considered. Here, we hypothesized that GGO in typical IP could be a manifestation of an acute inflammatory attack requiring immunosuppressive therapy or an indicator of ongoing contact with trigger factors that initiate pathological reactions in typical IP.
典型间质性肺炎主要是肺间质性疾病的纤维化形式。在一些典型IP的病例中,高分辨率计算机断层扫描可以检测到一定量的磨玻璃不透明(GGO),然而,一些重要的问题,如GGO与典型IP的共存,仍需要进一步的活检研究。诊断为典型IP后,通常考虑抗纤维化治疗。在这里,我们假设典型IP中的GGO可能是需要免疫抑制治疗的急性炎症发作的表现,或者是与典型IP中引发病理反应的触发因素持续接触的指标。
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引用次数: 0
SOCIAL MEDIA IN SCIENCE 科学中的社交媒体
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.07
C. Gialouri, G. Fragoulis
Day by day, social media are entering our lives changing our every-day life and habits. This could not leave science unaffected. Over the last years, a lot of scientists have started using social media, exchanging ideas and sharing knowledge. Scientific journals have also followed being active participators in the social media world. In this opinion article we provide some arguments about the positive role of social media in the life of a scientist, highlighting at the same time the caveats that are encountered.  
社交媒体日复一日地进入我们的生活,改变着我们的日常生活和习惯。科学不可能不受影响。在过去的几年里,许多科学家开始使用社交媒体,交换想法和分享知识。科学期刊也成为社交媒体世界的积极参与者。在这篇观点文章中,我们提供了一些关于社交媒体在科学家生活中的积极作用的论点,同时强调了遇到的警告。
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引用次数: 0
AN EXPLORATORY FACTOR ANALYSIS OF LONG COVID 长冠肺炎探索性因素分析
Pub Date : 2022-12-30 DOI: 10.47316/cajmhe.2022.3.4.04
Joseph A. Dorri, Leonard A. Jason
An exploratory factor analysis (EFA) can provide a window into the latent dimensions of a disease, such as Long COVID. Discovering the latent factors of Long COVID  enables researchers and clinicians to better conceptualize, study and treat this disease. In this study, participants were recruited from social media sites dedicated to COVID and Long COVID. Among the 480 participants, those who completed at least 90% of the survey, reported symptoms for two or more months since COVID-19 symptom onset, and had not been hospitalized for COVID were used in the EFA. The mean duration since initial symptom onset was 74.0 (37.3) weeks. A new questionnaire called The DePaul Symptom Questionnaire-COVID was used to assess self-reports of the frequency and severity of 38 Long COVID symptoms experienced over the most recent month. The most burdensome symptoms were “Symptoms that get worse after physical or mental activities (also known as Post-Exertional Malaise),” “Fatigue/extreme tiredness,” “Difficulty thinking and/or concentrating,” “Sleep problems,” and “Muscle aches.” The EFA resulted in a three-factor model with factors labeled General, PEM/Fatigue/Cognitive Dysfunction, and Psychological, consisting of 16, 6, and 3 items respectively (25 items in total). The reliability of the items in the EFA was .90 using a split-half reliability test. Finally, participant self-reported level of functional impairment was analyzed across the three EFA factors. Interpretations and applications to research and practice are provided.
探索性因素分析(EFA)可以提供一个窗口,以了解疾病的潜在维度,例如长冠状病毒。发现Long COVID的潜在因素使研究人员和临床医生能够更好地概念化,研究和治疗这种疾病。在这项研究中,参与者是从专门针对COVID和Long COVID的社交媒体网站上招募的。在480名参与者中,完成至少90%的调查,自COVID-19症状出现以来报告症状两个月或更长时间,并且未因COVID而住院的人被纳入EFA。自首次症状出现以来的平均持续时间为74.0(37.3)周。一份名为“德保罗症状问卷-COVID”的新问卷用于评估最近一个月出现的38种长COVID症状的频率和严重程度的自我报告。最沉重的症状是“身体或精神活动后症状加重(也称为劳累后不适)”、“疲劳/极度疲劳”、“思维困难和/或注意力集中”、“睡眠问题”和“肌肉疼痛”。EFA的结果是一个三因素模型,其中一般、PEM/疲劳/认知功能障碍和心理因素分别由16项、6项和3项组成(共25项)。采用劈半信度检验,EFA项目的信度为0.90。最后,通过三个EFA因素分析参与者自我报告的功能损害水平。本文提供了对研究和实践的解释和应用。
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引用次数: 2
期刊
Central Asian Journal of Medical Hypotheses and Ethics
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