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JANUS KINASE INHIBITORS FOR RELAPSING POLYCHONDRITIS TREATMENT: A HYPOTHESIS Janus 激酶抑制剂治疗复发性多软骨炎:假设
Pub Date : 2024-02-29 DOI: 10.47316/cajmhe.2023.4.4.04
N. Gokcen
Relapsing polychondritis (RP) is a rare autoimmune disease marked by recurrent episodes of inflammation impacting cartilaginous structures. The underlying mechanism has not been fully elucidated; however, comprehensive genetic and histopathological evaluations have revealed the involvement of specific genes, cell-mediated immunity, and humoral immunity in the pathogenesis of RP. The spectrum of symptoms associated with this condition ranges from mild manifestations to severe, life-threatening presentations. Treatment options vary depending on the disease severity. Non-steroidal anti-inflammatory drugs, colchicine, dapsone, and systemic corticosteroids are commonly utilized as first-line therapeutic options. Furthermore, cyclophosphamide, methotrexate, azathioprine, cyclosporine, and biological disease-modifying anti-rheumatic drugs are employed as second-line treatment. Nevertheless, there is insufficient data regarding the use of Janus kinase inhibitors (JAKi) in RP patients as a treatment option. This hypothesis suggests that JAKi may be a viable treatment option for relieving symptoms in these patients.
复发性多软骨炎(RP)是一种罕见的自身免疫性疾病,其特征是影响软骨结构的炎症反复发作。其基本机制尚未完全阐明;然而,全面的遗传学和组织病理学评估显示,特定基因、细胞介导免疫和体液免疫参与了 RP 的发病机制。与这种疾病相关的症状范围很广,从轻微的表现到严重的危及生命的症状都有。治疗方案因病情严重程度而异。非甾体抗炎药、秋水仙碱、达泊松和全身性皮质类固醇激素通常被用作一线治疗方案。此外,环磷酰胺、甲氨蝶呤、硫唑嘌呤、环孢素和生物改良抗风湿药物也被用作二线治疗。然而,关于在 RP 患者中使用 Janus 激酶抑制剂(JAKi)作为治疗方案的数据尚不充分。这一假设表明,JAKi 可能是缓解这些患者症状的可行治疗方案。
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引用次数: 0
PERSPECTIVES ON MALE AGING AND THERAPEUTIC IMPLICATIONS 对男性衰老的看法和治疗意义
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.01
Y. Fedorchenko, B. Koçyiğit
This article provides an in-depth analysis of the molecular and cellular alterations linked to the aging process in males. It elucidates the physiological disruptions that give rise to different diseases and a decrease in functional ability. The inquiry explores the complex correlation between aging, sexual dysfunction, and infertility in males, with a focus on the physiological alterations in spermatogonial stem cells and the impact of oxidative stress on male reproductive capacity. The function of testosterone replacement therapy and its potential advantages in enhancing sexual activity, bone density, and overall health in older males are highlighted. Nevertheless, it is prudent to exercise caution as there is a correlation between testosterone replacement therapy and heightened cardiovascular risk. The article summarizes rehabilitation options for elderly men, specifically focusing on exercise regimens and cardiac rehabilitation, as means to tackle erectile dysfunction and mitigate mortality risks. The advantages of yoga in enhancing mental and physical well-being in males, particularly those grappling with prostate cancer or infertility are mentioned. The significance of adopting a comprehensive and interdisciplinary strategy towards men's health is emphasized, with particular attention given to the contributions of primary care physicians, urologists, and nurses. The significance of customized communication tactics for males and the necessity of periodic examinations for promoting healthier aging are emphasized.
本文深入分析了与男性衰老过程相关的分子和细胞变化。它阐明了导致不同疾病和功能下降的生理紊乱。文章探讨了男性衰老、性功能障碍和不育之间的复杂关联,重点关注精原干细胞的生理改变以及氧化应激对男性生殖能力的影响。重点介绍了睾酮替代疗法的功能及其在增强老年男性的性活动、骨密度和整体健康方面的潜在优势。不过,由于睾酮替代疗法与心血管风险增加之间存在相关性,因此应谨慎行事。文章总结了老年男性的康复选择,特别侧重于运动疗法和心脏康复,以此来解决勃起功能障碍并降低死亡风险。文章还提到了瑜伽在提高男性身心健康方面的优势,尤其是那些患有前列腺癌或不育症的男性。强调了对男性健康采取全面和跨学科策略的重要性,特别关注了初级保健医生、泌尿科医生和护士的贡献。强调了为男性量身定制沟通策略的重要性,以及定期检查对促进健康老龄化的必要性。
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引用次数: 0
MY LIFE AS AN EDITOR AND CONSULTANT OF MEDICAL JOURNALS 我作为医学期刊编辑和顾问的生活
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.06
F. Habibzadeh
MY LIFE AS AN EDITOR AND CONSULTANT OF MEDICAL JOURNALS
我作为医学期刊编辑和顾问的生活
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引用次数: 0
MANUSCRIPTS WITH FAKE CHATGPT-CREATED REFERENCES: A CASE STUDY 用伪造的 Chatgpt 创建的参考文献撰写手稿:案例研究
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.05
J. A. Teixeira da Silva
As a continued theme in citation abuses and the need to reform the culture of citation in academic publishing, as well as an extension of the exploration of authors’ rights, this letter highlights a case in which an author’s name was abused in a fabricated citation in a preprints.org preprint that was ultimately retracted. As a punitive measure, the preprints’ authors were blacklisted. The first author then republished (minus the previous co-authors) a modified preprint at another preprint server, Research Square, where it was also retracted for the presence of fictitious citations. In such cases, it is argued that authors whose names are abused in fictitious citations, created by ChatGPT or otherwise, as identified by real authors or the paper’s readers, should have the right to not want to be cited in this manner, because it may carry with it negative reputational consequences. There are also negative reputational consequences for journals which appear in fictional citations.
作为引文滥用和改革学术出版引文文化必要性的持续主题,以及作者权利探索的延伸,本信着重介绍了一个案例:在preprints.org预印本中,一位作者的名字在编造的引文中被滥用,而该预印本最终被撤回。作为惩罚措施,预印本的作者被列入了黑名单。第一作者随后在另一个预印本服务器 Research Square 上重新发表了一份修改过的预印本(去掉了之前的合著者),但也因存在虚假引文而被撤回。在这种情况下,有观点认为,如果作者的名字被滥用在由 ChatGPT 或其他方式创建的虚假引文中,被真正的作者或论文读者识别出来,那么作者应该有权不希望以这种方式被引用,因为这可能会带来负面的声誉后果。出现在虚构引文中的期刊也会带来负面声誉后果。
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引用次数: 0
ADVANTAGES AND DRAWBACKS OF CHATGPT IN THE CONTEXT OF DRAFTING SCHOLARLY ARTICLES 在起草学术论文时使用聊天工具的优缺点
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.04
B. Koçyiğit, Alikhan Zhaksylyk
Incorporating Artificial Intelligence (AI), particularly ChatGPT, in academic endeavors has attracted significant interest due to its ability to optimize procedures and enhance human capacities. ChatGPT serves as an informed partner, assisting researchers in doing literature reviews, generating ideas, and even composing scholarly articles. Nevertheless, this revolutionary technology gives rise to ethical considerations in scientific investigation, namely authorship, information-data privacy, and bias. The article thoroughly examines the advantages and disadvantages of using ChatGPT for academic purposes. The benefits are seen in its effectiveness in retrieving information, surpassing language obstacles, boosting the synthesis of literature, easing the production of ideas, and assisting in the outlining of manuscripts. On the other hand, the complicated nature of using ChatGPT in scholarly activities is emphasized by worries about scientific integrity, the possibility of spreading disinformation, excessive dependence, and security and privacy issues. Finding a middle ground between utilizing the advantages of ChatGPT and maintaining academic integrity is crucial. Analyzing the dynamics will be crucial in navigating the changing junction of AI and research activities.
人工智能(AI),尤其是 ChatGPT,因其优化程序和提高人类能力的能力而备受学术界关注。ChatGPT 可作为知情伙伴,协助研究人员进行文献综述、产生想法,甚至撰写学术文章。然而,这项革命性的技术也引发了科学研究中的伦理问题,即作者身份、信息数据隐私和偏见。本文深入探讨了将 ChatGPT 用于学术目的的利弊。其优点在于它能有效地检索信息、克服语言障碍、促进文献综述、简化构思、协助撰写手稿大纲。另一方面,在学术活动中使用 ChatGPT 的复杂性也因人们对科学诚信、传播虚假信息的可能性、过度依赖以及安全和隐私问题的担忧而凸显出来。在利用 ChatGPT 的优势和维护学术诚信之间找到一个中间点至关重要。在人工智能与研究活动不断变化的交界处,分析其动态变化将至关重要。
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引用次数: 0
PREDATORY PUBLISHING AND WASTE OF RESOURCE 掠夺性出版和资源浪费
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.07
I. Benlidayı
PREDATORY PUBLISHING AND WASTE OF RESOURCE
掠夺性出版和资源浪费
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引用次数: 0
HYPERTROPHIC OSTEOARTHROPATHY IN A PATIENT WITH HETEROZYGOUS MUTATION IN THE SLCO2A1 GENE: A CASE REPORT 一名 Slco2a1 基因杂合子突变患者的肥大性骨关节病:病例报告
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.03
I. Benlidayı, Kubra Tuncer, T. Sarpel
Hypertrophic osteoarthropathy (HOA) is a condition characterized by aberrant skin and osseous tissue proliferation in the distal extremities. Mutations in the 15-hydroxyprostaglandin dehydrogenase gene (HPGD) and the soluble carrier organic anion carrier family member 2A1 gene (SLCO2A1) were associated with primary HOA. Secondary HOA, which is also called as 'hypertrophic pulmonary osteoarthropathy' is responsible for 95-97% of cases. Herein, we present a 19-year-old female patient with primary HOA and heterozygous mutation in the SLCO2A1 gene.
肥大性骨关节病(HOA)是一种以四肢远端皮肤和骨组织异常增生为特征的疾病。15-羟基前列腺素脱氢酶基因(HPGD)和可溶性载体有机阴离子载体家族成员2A1基因(SLCO2A1)的突变与原发性HOA有关。继发性 HOA 又称 "肥厚性肺骨关节病",占 95-97% 的病例。在此,我们介绍了一名患有原发性HOA和SLCO2A1基因杂合突变的19岁女性患者。
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引用次数: 0
JACCOUD’S ARTHROPATHY IN SYSTEMIC LUPUS ERYTHEMATOSIS: A CASE REPORT 系统性红斑狼疮的贾考德关节病:病例报告
Pub Date : 2023-12-29 DOI: 10.47316/cajmhe.2023.4.3.02
I. Benlidayı, Emre Ulutas, Ceren Ornek, Emre Tirasci
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical signs and symptoms. Musculoskeletal problems (e.g. arthralgia, inflammatory arthritis, and non-erosive arthritis) are the first symptom in roughly 80% of individuals. Jaccoud’s arthropathy, which is regarded as reversible, non-erosive, and deforming arthropathy, can be observed in patients with systemic lupus erythematosus in relation to tenosynovitis, capsule retraction, ligament laxity, and muscular imbalance. Risk factors include longer disease duration, higher titers of rheumatoid factor, and anti–double stranded deoxyribonucleic acid (anti-dsDNA) antibody positivity. In the current article, a case with SLE and associated Jaccoud’s arthropathy was presented.
系统性红斑狼疮(SLE)是一种慢性自身免疫性疾病,具有多种临床症状和体征。肌肉骨骼问题(如关节痛、炎性关节炎和非侵蚀性关节炎)是大约80%患者的首发症状。杰科德关节病被认为是可逆的、非侵蚀性和变形性关节病,可在系统性红斑狼疮患者中观察到,它与腱鞘炎、关节囊回缩、韧带松弛和肌肉失衡有关。风险因素包括病程较长、类风湿因子滴度较高以及抗双链脱氧核糖核酸(anti-dsDNA)抗体阳性。本文介绍了一个患有系统性红斑狼疮并伴有雅克德关节病的病例。
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引用次数: 0
THE ABUSE OF AUTHORSHIP IN THE BIOMEDICAL LITERATURE 生物医学文献中作者身份的滥用
Pub Date : 2023-08-26 DOI: 10.47316/cajmhe.2023.4.2.07
J. A. Teixeira da Silva
The ‘publish or perish’ culture has induced an unhealthy aspect of academic publishing in the biomedical sciences, namely of illegitimate authorship. Such a position can be obtained when an authorship slot is offered as a gift (e.g., to a sponsor, or researcher in a senior position), without their intellectual or scientific participation, or it can be hidden (ghost authorship), in which the paper (or parts thereof) is written by a third party (individual, or company). In a more industrialized setting, ghost authorship takes place via the sale of papers using “paper mills”, including of specific author slots (i.e., positions in a line of authors). While author-based persistent identifiers like ORCID, or authorship attribution schemes like CRediT, sound noble and offer some form of validation, those systems still operate on a culture of blind trust (in submitting authors). This paper debates a few of the authorship-related issues currently plaguing biomedical journals.
“要么发表,要么灭亡”的文化导致了生物医学学术出版的一个不健康方面,即非法作者。当作者身份是作为礼物(例如,给发起人或高级职位的研究人员)提供时,可以获得这样的位置,而不需要他们的智力或科学参与,或者可以隐藏(幽灵作者身份),其中论文(或其部分)由第三方(个人或公司)撰写。在工业化程度更高的环境中,代笔是通过“造纸厂”出售论文来实现的,包括特定的作者位置(即作者队列中的位置)。虽然基于作者的持久标识符(如ORCID)或作者归属方案(如CRediT)听起来很高尚,并提供了某种形式的验证,但这些系统仍然在盲目信任(提交作者)的文化中运行。本文讨论了目前困扰生物医学期刊的几个与作者身份有关的问题。
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引用次数: 0
MY LIFE AS A RESEARCHER IN PHYSICAL MEDICINE AND REHABILITATION 我作为物理医学和康复研究人员的一生
Pub Date : 2023-08-26 DOI: 10.47316/cajmhe.2023.4.2.08
S. Acer Kasman
MY LIFE AS A RESEARCHER IN PHYSICAL MEDICINE AND REHABILITATION
我作为物理医学和康复研究人员的一生
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引用次数: 0
期刊
Central Asian Journal of Medical Hypotheses and Ethics
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