Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.02
G. Morgunova
Aging is an urgent healthcare issue in view of the rapid growth of the proportion of older persons. Searching for reliable aging biomarkers and prolonging lifespan are increasingly important scientific directions. Experimental gerontology helps to explore fundamental facts which are not always applicable in clinical scenarios. As an example, caloric restriction is one of the key interventions that prolongs laboratory animals’ lifespan and ameliorates some, but not all, aging biomarkers in humans. Consequences of overeating such as obesity, insulin resistance, type 2 diabetes, and metabolic syndrome are taking their toll with aging, making caloric restriction a hot topic in gerontology and geriatrics. Nevertheless, caloric restriction is not widely applicable in view of poor adherence to and limitations of strict diets. Drugs mimicking caloric restrictions, the so-called caloric restriction mimetics, are developed to overcome these limitations. Caloric restriction alone is not a panacea since metabolic pathways are complex and not responsive to a single intervention. Fasting and exercising are additional options for reducing effects of excessive intake of calories. Arguably, physical activity significantly improves the quality of life at old age and delays the onset of overt insulin resistance and associated diseases. Thus, developing optimal fasting and exercising schemes is becoming increasingly important. Such interventions are confounded by a number of factors, including circadian and other biorhythms and baseline metabolic activity. It is justifiable to test fasting and exercising in experimental animals to reveal numerous confounding factors. A hypothesis in this article points to the role of complex interventions such as moderate and balanced diet, intermittent fasting, and physical exercise adjusted to circadian rhythms for prolonging life and improving quality of life. The hypothesis may shed light on fundamental mechanisms of aging and perspectives of anti-aging drug therapies.
{"title":"NOT JUST CALORIC RESTRICTION: A COMPLEX APPROACH TO PROLONG LIFESPAN AND IMPROVE QUALITY OF LIFE","authors":"G. Morgunova","doi":"10.47316/cajmhe.2021.2.4.02","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.02","url":null,"abstract":"Aging is an urgent healthcare issue in view of the rapid growth of the proportion of older persons. Searching for reliable aging biomarkers and prolonging lifespan are increasingly important scientific directions. Experimental gerontology helps to explore fundamental facts which are not always applicable in clinical scenarios. As an example, caloric restriction is one of the key interventions that prolongs laboratory animals’ lifespan and ameliorates some, but not all, aging biomarkers in humans. Consequences of overeating such as obesity, insulin resistance, type 2 diabetes, and metabolic syndrome are taking their toll with aging, making caloric restriction a hot topic in gerontology and geriatrics. Nevertheless, caloric restriction is not widely applicable in view of poor adherence to and limitations of strict diets. Drugs mimicking caloric restrictions, the so-called caloric restriction mimetics, are developed to overcome these limitations. Caloric restriction alone is not a panacea since metabolic pathways are complex and not responsive to a single intervention. Fasting and exercising are additional options for reducing effects of excessive intake of calories. Arguably, physical activity significantly improves the quality of life at old age and delays the onset of overt insulin resistance and associated diseases. Thus, developing optimal fasting and exercising schemes is becoming increasingly important. Such interventions are confounded by a number of factors, including circadian and other biorhythms and baseline metabolic activity. It is justifiable to test fasting and exercising in experimental animals to reveal numerous confounding factors. A hypothesis in this article points to the role of complex interventions such as moderate and balanced diet, intermittent fasting, and physical exercise adjusted to circadian rhythms for prolonging life and improving quality of life. The hypothesis may shed light on fundamental mechanisms of aging and perspectives of anti-aging drug therapies.","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126949444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.08
T. Georgiev
MY LIFE AS A CLINICIAN, RESEARCHER AND EDITOR
我作为临床医生，研究员和编辑的生活
{"title":"MY LIFE AS A CLINICIAN, RESEARCHER AND EDITOR","authors":"T. Georgiev","doi":"10.47316/cajmhe.2021.2.4.08","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.08","url":null,"abstract":"MY LIFE AS A CLINICIAN, RESEARCHER AND EDITOR","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114180010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.06
N. Uvais
CAN VIRTUE ETHICS BRIDGE EAST AND WEST?
美德伦理能架起东西方的桥梁吗?
{"title":"CAN VIRTUE ETHICS BRIDGE EAST AND WEST?","authors":"N. Uvais","doi":"10.47316/cajmhe.2021.2.4.06","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.06","url":null,"abstract":"CAN VIRTUE ETHICS BRIDGE EAST AND WEST?","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"24 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116407984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.01
B. Koçyiğit, A. Akyol, Serkan Usgu
Fibromyalgia syndrome (FMS) is a chronic rheumatic disease in which pain is predominant and accompanied by fatigue, anxiety, depression, sleep disturbance and cognitive dysfunction. Although there are numerous pharmacological and non-pharmacological therapeutic alternatives, symptom control is frequently problematic. Manual therapy covers manipulating soft tissue and various joints using the hands. It is organized by mapping of soft tissue structures with rhythmically applied pressure to improve physical function, facilitate daily activities, promote rehabilitation procedures and decrease pain. Massage is generally accepted as an essential component of manual therapy. Stretching and mobilizations are also part of manual therapy. Although numerous beneficial effects of manual therapy and massage on the musculoskeletal system and pain have been proven, the data in FMS patients studies are inconclusive. We hypothesize that manual therapy and massage are beneficial therapeutic options for the control of symptoms of FMS patients. Furthermore, these strategies can be employed in conjunction with well-established and high-evidence therapeutic procedures. Future research should focus on establishing standardized protocols for manual therapy and massage, which is one of the major limitations. To ensure a high level of evidence, research studies with large sample sizes, long follow-up periods and methodologically complete are needed.
{"title":"ROLE OF MANUAL THERAPY AND MASSAGE IN THE TREATMENT OF FIBROMYALGIA: TESTING THE HYPOTHESIS","authors":"B. Koçyiğit, A. Akyol, Serkan Usgu","doi":"10.47316/cajmhe.2021.2.4.01","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.01","url":null,"abstract":"Fibromyalgia syndrome (FMS) is a chronic rheumatic disease in which pain is predominant and accompanied by fatigue, anxiety, depression, sleep disturbance and cognitive dysfunction. Although there are numerous pharmacological and non-pharmacological therapeutic alternatives, symptom control is frequently problematic. Manual therapy covers manipulating soft tissue and various joints using the hands. It is organized by mapping of soft tissue structures with rhythmically applied pressure to improve physical function, facilitate daily activities, promote rehabilitation procedures and decrease pain. Massage is generally accepted as an essential component of manual therapy. Stretching and mobilizations are also part of manual therapy. Although numerous beneficial effects of manual therapy and massage on the musculoskeletal system and pain have been proven, the data in FMS patients studies are inconclusive. We hypothesize that manual therapy and massage are beneficial therapeutic options for the control of symptoms of FMS patients. Furthermore, these strategies can be employed in conjunction with well-established and high-evidence therapeutic procedures. Future research should focus on establishing standardized protocols for manual therapy and massage, which is one of the major limitations. To ensure a high level of evidence, research studies with large sample sizes, long follow-up periods and methodologically complete are needed.","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132091263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.03
B. Koçyiğit, Ahmet Akyol
Introduction: Publons is the most prestigious and well-organized platform that allows to evaluate peer review metrics. It also provides publication and citation data as it is synchronized with the Web of Science. There are socio-cultural ties between Central Asian countries and Turkey, and these countries can take Turkey as a model for scientific development. Therefore, it will be useful for Central Asian countries to summarize Turkey's Publons activities. In this study, we used Publons database to list the top institutions, researchers and reviewers in Turkey. Methods: Publons database was used to export the data on October 10, 2021. The top 20 researchers were identified in terms of the number of verified reviews. Additionally, the top 20 institutions were determined in terms of the number of researchers, number of verified reviews and top reviewers. Results: On Publons, 57464 registered researchers from Turkey were found (ranked 7th) and 484 of these researchers had top reviewer status (ranked 16th). A total of 175644 verified reviews were detected from Turkey-based researchers (ranked 16th) and of which 45835 were performed in the last 12 months (ranked 14th). Based on the total number of researchers, four institutions from Turkey were in the top 100 in the world rankings (Hacettepe University, Istanbul Technical University, Istanbul University-Cerrahpasa, and Cukurova University). There were no institutions from Turkey among the top 100 in the lists created according to the number of verified reviews and top reviewers. Conclusion: Turkey has a considerable number of researchers registered with Publons. However, Turkey should follow a scientific route in terms of verified reviews. Turkey and Central Asian countries can create scientific collaborations and cooperative projects. Thus, Central Asian countries will benefit from Turkey's experiences.
{"title":"PUBLONS BASED PROFILING OF TURKISH REVIEWERS AND ACADEMIC INSTITUTIONS","authors":"B. Koçyiğit, Ahmet Akyol","doi":"10.47316/cajmhe.2021.2.4.03","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.03","url":null,"abstract":"Introduction: Publons is the most prestigious and well-organized platform that allows to evaluate peer review metrics. It also provides publication and citation data as it is synchronized with the Web of Science. There are socio-cultural ties between Central Asian countries and Turkey, and these countries can take Turkey as a model for scientific development. Therefore, it will be useful for Central Asian countries to summarize Turkey's Publons activities. In this study, we used Publons database to list the top institutions, researchers and reviewers in Turkey. \u0000Methods: Publons database was used to export the data on October 10, 2021. The top 20 researchers were identified in terms of the number of verified reviews. Additionally, the top 20 institutions were determined in terms of the number of researchers, number of verified reviews and top reviewers. \u0000Results: On Publons, 57464 registered researchers from Turkey were found (ranked 7th) and 484 of these researchers had top reviewer status (ranked 16th). A total of 175644 verified reviews were detected from Turkey-based researchers (ranked 16th) and of which 45835 were performed in the last 12 months (ranked 14th). Based on the total number of researchers, four institutions from Turkey were in the top 100 in the world rankings (Hacettepe University, Istanbul Technical University, Istanbul University-Cerrahpasa, and Cukurova University). There were no institutions from Turkey among the top 100 in the lists created according to the number of verified reviews and top reviewers. \u0000Conclusion: Turkey has a considerable number of researchers registered with Publons. However, Turkey should follow a scientific route in terms of verified reviews. Turkey and Central Asian countries can create scientific collaborations and cooperative projects. Thus, Central Asian countries will benefit from Turkey's experiences.","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116395430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.47316/cajmhe.2021.2.4.09
I. Benlidayı
WAYS TO IMPROVE VISIBILITY OF PUBLICATIONS
提高出版物可见度的方法
{"title":"WAYS TO IMPROVE VISIBILITY OF PUBLICATIONS","authors":"I. Benlidayı","doi":"10.47316/cajmhe.2021.2.4.09","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.4.09","url":null,"abstract":"WAYS TO IMPROVE VISIBILITY OF PUBLICATIONS","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115185595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-05DOI: 10.47316/cajmhe.2021.2.3.05
J. A. Teixeira da Silva
The Directory of Open Access Journals (DOAJ) is a leading whitelist of open access journals (OAJs), that is, OAJs that are presumably safe to publish in, or scholarly, because they follow best practices established by COPE/DOAJ/OASPA/WAME. Academics rely on the DOAJ to select OAJs of choice, and filter for particular needs, for example, English-only or no article processing charges. A search of DOAJ-indexed OAJs publishing work on ornamental research identified five OAJs, but 60% of them had incorrect and thus misleading information. The ‘last update’ of all five OAJs were outdated. The DOAJ must ensure that indexed OAJs have updated information. The Editors of OAJs also bear responsibility.
{"title":"UPDATES ON INFORMATION REGARDING THE DIRECTORY OF OPEN ACCESS JOURNALS PLATFORM MAY INCREASE ITS RELIABILITY","authors":"J. A. Teixeira da Silva","doi":"10.47316/cajmhe.2021.2.3.05","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.3.05","url":null,"abstract":"The Directory of Open Access Journals (DOAJ) is a leading whitelist of open access journals (OAJs), that is, OAJs that are presumably safe to publish in, or scholarly, because they follow best practices established by COPE/DOAJ/OASPA/WAME. Academics rely on the DOAJ to select OAJs of choice, and filter for particular needs, for example, English-only or no article processing charges. A search of DOAJ-indexed OAJs publishing work on ornamental research identified five OAJs, but 60% of them had incorrect and thus misleading information. The ‘last update’ of all five OAJs were outdated. The DOAJ must ensure that indexed OAJs have updated information. The Editors of OAJs also bear responsibility.","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127784819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-05DOI: 10.47316/cajmhe.2021.2.3.06
T. Velikova
MY LIFE AS A RESEARCHER AND EDUCATOR
我的研究和教育生涯
{"title":"MY LIFE AS A RESEARCHER AND EDUCATOR","authors":"T. Velikova","doi":"10.47316/cajmhe.2021.2.3.06","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.3.06","url":null,"abstract":"MY LIFE AS A RESEARCHER AND EDUCATOR","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114068005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-05DOI: 10.47316/cajmhe.2021.2.3.01
Marlen Yessirkepov, A. Gasparyan
EMBRACING SOCIAL MEDIA FOR GENERATING AND TESTING HYPOTHESES
利用社交媒体来产生和测试假设
{"title":"EMBRACING SOCIAL MEDIA FOR GENERATING AND TESTING HYPOTHESES","authors":"Marlen Yessirkepov, A. Gasparyan","doi":"10.47316/cajmhe.2021.2.3.01","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.3.01","url":null,"abstract":"EMBRACING SOCIAL MEDIA FOR GENERATING AND TESTING HYPOTHESES","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"466 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116342538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-05DOI: 10.47316/cajmhe.2021.2.3.07
I. Benlidayı
ONLINE MEETINGS DURING THE ERA OF THE COVID-19 PANDEMIC
COVID-19大流行时期的在线会议
{"title":"ONLINE MEETINGS DURING THE ERA OF THE COVID-19 PANDEMIC","authors":"I. Benlidayı","doi":"10.47316/cajmhe.2021.2.3.07","DOIUrl":"https://doi.org/10.47316/cajmhe.2021.2.3.07","url":null,"abstract":"ONLINE MEETINGS DURING THE ERA OF THE COVID-19 PANDEMIC","PeriodicalId":388483,"journal":{"name":"Central Asian Journal of Medical Hypotheses and Ethics","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115652357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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