Polski Merkuriusz Lekarski最新文献

The amniotic membrane, which lacks blood vessels, lymphatic vessels and nerves, is a thin membrane with anti-inflammatory and anti-scarring properties. In the field of dentistry, it is primarily employed as a dressing following the removal of malignant or pre-malignant lesions, with the objective of ensuring haemostasis and the absence of allergic reactions. Furthermore, it is employed in the treatment of oro-auricular junctions, cleft palates and in guided bone regeneration, due to the presence of mesenchymal cells. In vestibuloplasty, it has been demonstrated to enhance vestibular deepening, accelerate epithelialisation and reduce pain. In periodontics, it has been shown to be an effective treatment for gingival recession and furcation defects, and to increase the width of keratinised gingiva around implants. In endodontics, it is employed in regenerative procedures, offering comparable results to standard methods. Furthermore, in the treatment of osteoarthritis of the temporomandibular joint, it has been observed to provide pain relief and improved joint function.

Objective: Aim: To study the complexing ability of pectins obtained from various vegetable and fruit raw materials with metal ions.

Patients and methods: Materials and Methods: The content of metals was determined by the atomic emission method (SHIMADZU ICPE-9820 spectrometer); heavy metal measurement methods used were MІ.С3.7.2.01-017 and MІ.С3.7.2.01-018. Statistical analysis of the obtained data was performed using the IBM SPSS Statistics version 29.0.0.0 program; correlation analysis was conducted using the Kendall Tau-b method.

Results: Results: It was found that the highest complexing ability towards the mixture of Cu2+, Zn2+, Cd2+, and Pb2+ ions was demonstrated by low-esterified sugar beet pectin (r=0,600; p<0.01). Citrus (r=0,312; p<0.01), quince (r=0,292; p<0.01), and apple (r=0,271; p<0.01) pectins also exhibited high complexing rates, while pumpkin (r=0,214; p<0.01) and carrot (r=0,156; p<0.01) pectins had slightly lower rates. In addition, pectin is found in smaller quantities in carrots and pumpkins than in sugar beet, citrus fruits, quince, and apples. To improve nutritional characteristics, reduce allergenicity, and maintain high complexing ability of the final product, the authors proposed a combination of raw materials from sugar beet and pumpkin, enriched with apple pectin and/or pectincontaining products and juices of pumpkin and apples.

Conclusion: Conclusions: It was established that the highest complexing ability in relation to a mixture of lead, cadmium, mercury, zinc, and copper ions is possessed by low-esterified sugar beet pectin. The addition of this pectin to apple pectin and/or pectin-containing apple products and juices increases the potential nonspecific detoxification properties of the final food product.

Objective: Aim: To assess the emotional and pain experiences of Ukrainian healthcare workers during the war to identify key targets for multidisciplinary prevention approaches.

Patients and methods: Materials and Methods: The pilot study enrolled 99 healthcare professionals (69 women, 30 men), aged 23-65 years. Participants included doctors (n=69), nurses, and physical therapists (n=30), with experience ranging from under 10 to over 25 years. A 49-item questionnaire was distributed via Google Forms. The survey assessed demographics, workload, emotional stress, pain, and attitudes toward working under wartime conditions. The variables were ranked using categorical and numerical discrete scales, and the data were analyzed using Spearman's rank correlation.

Results: Results: Emotional exhaustion was reported by nearly half of the healthcare professionals at least 2-3 times per week, and pain syndrome was common, particularly lower back pain. Emotional exhaustion showed positive correlations with job dissatisfaction, workload, anxiety, and apathy. Higher pain intensity was linked to decreased productivity and emotional strain, including depression. The impact of war correlated with emotional and physical disruption, yet professionals remained empathetic toward patients. War-induced insomnia was associated with a higher desire to leave the profession, highlighting the longterm risks to healthcare workforce sustainability.

Conclusion: Conclusions: The pilot study highlights the urgent need for preventive multidisciplinary interventions to address emotional strain and pain among healthcare workers. Tailored support strategies may enhance well-being and professional sustainability in high-stress environments.

A case of a 40-year-old patient who presented to the clinic due to carpal tunnel syndrome of the left hand was presented. Four years earlier, the same patient underwent four-finger amputation of his right dominant hand due to fulminant necrosis caused by Streptococcus pyogenes infection. Descriptive history and the results of examination indicated that the patient adapted very good to significant disability of the hand. He had no constant pain, but only when the weather changed, which he rated at 3-4 points on the Numeric Rank Scale. The hand function examined by the DASH questionnaire showed a significant impairment - 42 points, but the patient declared that he functioned well in everyday life and even found a permanent job in a security company.

Objective: Aim: Assessment of the risk of soil and groundwater contamination by triazine herbicides to reduce anthropogenic environment pollution and decrease the potential negative impact on public health in Ukraine and the EU.

Patients and methods: Materials and Methods: 14 preparations containing 5 active substances of the triazine class and its environmental fate in soil and water considering Ukraine and EU climatic conditions. Methods of in-field hygienic experiment, gas-liquid chromatography, analytical and statistical methods, hygienic modelling using Experimental Leaching Index (ELI), (GUS), (RLPI), (LIX), (DT50) and (KOC), SCI-GROW, LEACHmod.

Results: Results: Analysis of the physicochemical properties of studied substances showed that they were classified as mobile or moderately mobile by migration ability. Calculated T50 for studied substances allowed us to determine the hazard classes for them. Substances pertain to 2-3 classes (promethrin and terbuthylazine - class 2, moderately persistent (30-100 days), tribenuron-methyl, thifensulfuron-methyl and metribuzin - class 3, weak persistency (less than 30 days)). The determination coefficient (R2) values ranged from 0.704 to 0.995.

Conclusion: Conclusions: According to the GUS, most of the studied substances have a moderate possibility of leaching into groundwater, except for thifensulfuron-methyl. While in EU soils the index for promethrin is very low, tribenuron-methyl is low, terbuthylazine and metribuzin are moderate, and thifensulfuron-methyl is high. The SCI-GROW assessment showed that most of them have significantly lower values in Ukraine than international values (except for promethrin), which can be explained by significant dissimilarities in maximum application rates, number of treatments, and in some cases - different resistance of substances in Ukrainian and EU soils.

Objective: Aim: To evaluate clinical applicability of immune mediator's interleukin-16, immunoglobulin E along with eosinophil count in diagnosing COVID-19 and determining its severity.

Patients and methods: Materials and Methods: Cross-sectional case-control study was conducted at Al-Najaf General Hospital, Najaf, Iraq between March and August 2024. 120 participants: 60 confirmed COVID-19 cases and 60 healthy controls which matched cases in terms of age and sex. Data collected through direct interviews and hospital records; laboratory investigations were performed following standard protocols. Serum analysis: Serum levels of IgE and IL-16 were determined using an automated system and enzyme-linked immune sorbent assay (ELISA).

Results: Results: A significant difference in levels of immune markers between COVID-19 group and healthy controls. Eosinophil count significantly higher in patients than in controls (105±64 cells/ml vs. 78±22 cells/ml, P<0.001). IgE levels in patients were markedly elevated compared to controls (788±98 UI/ml vs. 204±122 UI/ml, P<0.001). IL-16 levels in patients were double of controls (12.8±3.9 pg/ml vs. 6.2±2.9 pg/ml, P<0.01). Logistic regression analysis indicated that elevated levels of IL-16, IgE, and eosinophils were significantly associated with an increased risk of severe COVID-19, with IL-16 showing a particularly strong association (odds ratio=1.7, P<0.001). Sensitivity values were 0.74, 0.48, and 0.85 for eosinophils, IgE, and IL-16, while specificity values were 0.66, 0.58, and 0.72.

Conclusion: Conclusions: Findings underscore probable implication of immune mediators in respect, more especially IL-6, as biomarkers for COVID-19 severity and diagnosis.

Objective: Aim: The aim is to investigate the impact of an experimental judo training program on the morphofunctional state and physical fitness of healthy adolescents.

Patients and methods: Materials and Methods: The study involved 54 male adolescents aged 16-17, who were divided into an experimental group (EG, n=27) and a control group (CG, n=27). The morphofunctional state of the students was evaluated based on the indicators of muscular, cardiovascular, and respiratory system activities, while physical fitness was assessed using physical education tests.

Results: Results: It was found that during the experiment, adolescents' morphofunctional state and physical fitness indicators improved in both groups. However, in the EG, the difference between the initial and final data was significant (p 0.05). Moreover, at the end of the experiment, all the studied indicators in the EG were significantly better than in the CG. The most pronounced impact of judo training was observed on the strength index, Ruffier index, Stange index, Genchi index, Robinson index, and the results in the long jump, pull-ups, push-ups, and trunk lifts.

Conclusion: Conclusions: It was proven that extracurricular judo training sessions, provided that adolescents consciously choose the sport and are motivated to participate, as well as the rational planning of training sessions, are more effective compared to traditional physical education lessons in high school for improving the morphofunctional state and physical fitness of healthy adolescents. The high level of the studied indicators in adolescents will enhance their health and improve their future educational and professional activities.

Cardiac rehabilitation is a comprehensive approach aimed at preventing heart disease, supporting treatment and improving the quality of life of patients and their functional abilities. Its goals include slowing the progression of cardiovascular diseases and reducing mortality associated with these diseases. Physiotherapy is a key element of cardiac rehabilitation, complemented by appropriate pharmacological treatment, psychotherapy, nutritional counseling, patient education about the cardiovascular system and lifestyle modifications tailored to individual needs. Cardiac rehabilitation in the prevention of the occurrence, in addition to other forms of treatment, has an additional impact on reducing mortality and morbidity of patients with sequelae, especially patients after myocardial infarction. The importance of cardiac rehabilitation has increased in recent years due to the increasing number of patients successfully treated for acute coronary syndromes. Rehabilitation in this group of patients helps to alleviate the immediate negative effects of myocardial infarction and reduces the risk of re-hospitalization. Combining pharmacotherapy with well-structured physical training and lifestyle changes improves the efficiency of the cardiovascular system, improves the quality of life and reduces the occurrence of adverse cardiovascular events. The importance and benefits of cardiac rehabilitation in patients after a heart attack have been known for many years. Physiotherapists play a significant role in these activities, their work is related to helping patients in taking preventive measures - both from risk groups and after cardiac incidents.The role of the physiotherapist is also to persuade the patient to change their lifestyle.

Objective: Aim: to assess the functionality of mHealth apps with a Ukrainian interface and their compliance with personal data processing requirements.

Patients and methods: Matherials and Methods: we employed methods such as Overview, Data Retrieval and Analysis. The study is also based on overviewing and analyzing data of 40 mHealth apps.

Results: Results: a study of 40 Ukrainian-language mHealth apps was conducted: 27.5% work only on Android, 72.5% on Android and iOS. There were identified 24 functions, among which the most common are arranging an appointment with a doctor (in 17 apps), online doctor consultation (in 12 apps), searching and reserving medicines (in 12 apps). Only 20 apps have a privacy policy, but most do not provide sufficient details on data processing. Only 9 apps have requirements for user data deletion, and 12 have mechanisms for withdrawing consent to data processing.

Conclusion: Conclusions: as a result of the study, there were detected risks for users of mHealth apps due to insufficient transparency of privacy policies, the lack of precise mechanisms for transferring personal data to third parties, withdrawal of personal data processing consent, and data deletion requirements.

Objective: Aim: To investigate the morphology of the rat diaphragmatic pedicles in the normal state and to evaluate the changes that occur under modelled carboxyperitoneum of different durations.

Patients and methods: Materials and Methods: The study was conducted on sexually mature rats of the reproductive period, housed in an accredited vivarium. The animals were divided into six groups: intact, control, and four main groups. In the main groups, carboxyperitoneum at standard pressure was modelled for one, three, and five hours.

Results: Results: The study of microdissections revealed the destruction of the basal membranes of muscle fibres, which, upon histological examination, appeared as a continuous, heterogeneous, structureless mass. The mass also contained single or grouped preserved pyknotic nuclei and macrophages. The muscle fibres were deformed and fragmented in large areas, and transverse striations were absent. The myofibrils were uncoiled and partially lysed or coagulated, acquiring an intense homogeneous eosinophilic colour. The nuclei in the areas of fibre lysis were absent. The capillaries present in the endomysium were full-blooded, while the arterioles in the perimysium contained plasma or a small number of erythrocytes.

Conclusion: Conclusions: The assessment of the intensity of the noted changes in the experimental groups with varying durations of carboxyperitoneum revealed a direct correlation between the observed histological changes and the duration of pneumoperitoneum, with notable implications for the morphology of the right and left crus of diaphragm.