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Development of hybrid model for improving the prediction of dengue-human protein interaction for anti-viral drug discovery 开发用于改进登革热-人蛋白相互作用预测的杂交模型,用于抗病毒药物的发现
Q3 Computer Science Pub Date : 2020-09-09 DOI: 10.1504/ijiids.2020.10031590
R. Revathy, A. Fathima, S. Balamurali, G. Murugaboopathi
Dengue fever is the most common viral disease caused by mosquitoes. Due to the lack of curable drugs, there is an urgent need to develop anti-viral against dengue disease. Several innovative computational approaches were incorporated for the discovery of a new lead molecule that acts on the dengue virus target. The target can be a viral or host protein. Predicting the type of interaction between the virus and human protein will give better knowledge in developing therapeutics against the dengue disease. The main objective of this study is to propose a hybrid model which combines feed forward back propagation neural network (FFBPNN) with firefly algorithm to predict the dengue-human protein interaction. The novelty in this study is to focus on optimising the weights and bias of the artificial neural network to improve the efficiency of algorithm. While comparing with existing C4.5 and FFBPNN classification algorithms, the results show that the proposed hybrid method fitted the interaction data efficiently and predicts the interaction type which leads to the development of anti-viral drugs. The accuracy of the classification gained by C4.5 is 88%, FFBPNN is 97% and hybrid FFBPNN is 99%.
登革热是由蚊子引起的最常见的病毒性疾病。由于缺乏可治愈的药物,迫切需要开发针对登革热的抗病毒药物。在发现一种作用于登革热病毒靶点的新先导分子时,采用了几种创新的计算方法。目标可以是病毒或宿主蛋白质。预测病毒与人类蛋白质之间相互作用的类型将为开发针对登革热的治疗方法提供更好的知识。本研究的主要目的是提出一种将前馈-反向传播神经网络(FFBPNN)与萤火虫算法相结合的混合模型来预测登革热-人蛋白质相互作用。本研究的新颖之处在于着重优化人工神经网络的权值和偏置,以提高算法的效率。与现有的C4.5和FFBPNN分类算法进行比较,结果表明,该混合方法能够有效地拟合相互作用数据,并预测相互作用类型,从而促进抗病毒药物的开发。C4.5的分类准确率为88%,FFBPNN为97%,混合FFBPNN为99%。
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引用次数: 0
Optimal bag-of-features using random salp swarm algorithm for histopathological image analysis 基于随机salp群算法的最优特征袋算法用于组织病理图像分析
Q3 Computer Science Pub Date : 2020-08-28 DOI: 10.1504/ijiids.2020.10031678
V. Rachapudi, G. L. Devi
Histopathological image classification is a prominent part of medical image classification. The classification of such images is a challenging task due to the presence of several morphological structures in the tissue images. Recently, bag-of-features method has been used for image classification tasks. However, bag-of-features method uses K-means algorithm to cluster the features, which is a sensitive algorithm towards the initial cluster centres and often traps into the local optima. Therefore, in this work, an efficient bag-of-features histopathological image classification method is presented using a novel variant of salp swarm algorithm termed as random salp swarm algorithm. The efficiency of the proposed variant has been validated against 20 benchmark functions. Further, the performance of the proposed method has been studied on blue histology image dataset and the results are compared with 5 other state-of-the-art meta-heuristic based bag-of-features methods. The experimental results demonstrate that the proposed method surpassed the other considered methods.
组织病理学图像分类是医学图像分类的重要组成部分。由于组织图像中存在几种形态结构,因此对此类图像进行分类是一项具有挑战性的任务。近年来,特征袋方法被用于图像分类任务。然而,特征袋法使用K-means算法对特征进行聚类,这是一种对初始聚类中心敏感的算法,经常陷入局部最优。因此,在这项工作中,提出了一种有效的特征袋组织病理图像分类方法,该方法使用一种新的salp群算法变体,称为随机salp群算法。针对20个基准函数验证了所提出的变体的效率。此外,研究了该方法在蓝色组织学图像数据集上的性能,并将结果与其他5种最先进的基于元启发式的特征袋方法进行了比较。实验结果表明,该方法优于其他考虑的方法。
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引用次数: 5
A new software development paradigm for intelligent information systems 智能信息系统软件开发新范式
Q3 Computer Science Pub Date : 2020-08-26 DOI: 10.1504/ijiids.2020.10031608
Pooja Dehraj, Arun Sharma
The continuous growth in software management cost requires the development of self-managed software systems. Using self-managed property, a system will take intelligent decisions to make a system work properly. Autonomic computing is the technique, which is used to develop such systems. Autonomic computing systems are highly reliable software systems. To enhance the quality of software systems, implementation of autonomic computing-based software development life cycle process may be a novel idea. It involves autonomous decision making by the autonomic component during the development of software. This approach reduces the complexity of the software development process. In addition, it resolves the purpose of autonomic computing to reduce software complexity and do real-time exception handling. In this paper, the implementation of the autonomic advisor-based software development process is proposed using the cloud computing technique. Cloud computing helps the developers to develop software, applications using deliverable services such as platform, infrastructure, and software. During the implementation and usage of autonomic advisor, the database becomes heavier. Therefore, to resolve such issues, cloud computing will be a beneficiary step. Other benefits of such an autonomous software development life cycle process are discussed further in this paper.
软件管理成本的不断增长要求开发自管理软件系统。使用自我管理的属性,系统将做出明智的决策,使系统正常工作。自主计算是一种技术,用于开发这样的系统。自主计算系统是高度可靠的软件系统。为了提高软件系统的质量,实现基于自主计算的软件开发生命周期过程可能是一个新颖的想法。它涉及软件开发过程中自主组件的自主决策。这种方法降低了软件开发过程的复杂性。此外,它还解决了自主计算的目的,以降低软件的复杂性和实时异常处理。本文提出了利用云计算技术实现基于自主顾问的软件开发过程。云计算帮助开发人员使用平台、基础设施和软件等可交付服务开发软件和应用程序。在自主顾问的实现和使用过程中,数据库变得越来越重。因此,要解决这些问题,云计算将是一个受益的步骤。本文将进一步讨论这种自主软件开发生命周期过程的其他好处。
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引用次数: 2
A novel DeepCNN model for denoising analysis of MRI brain tumour images 一种新的用于MRI脑肿瘤图像去噪分析的DeepCNN模型
Q3 Computer Science Pub Date : 2020-08-26 DOI: 10.1504/ijiids.2020.10031611
B. Srinivas, G. Rao
Medical images must be introduced to the specialists or doctors with high accuracy for the diagnosis of critical diseases like a brain tumour. In this paper, a novel DeepCNN model is proposed to perform MRI brain tumour image denoising task and the results are compared with pre-trained DnCNN, Gaussian, adaptive, bilateral and guided filters. It is found that DeepCNN performs better than other filtering methods used. Different noise levels ranging from 5 to 50 and noises like salt and pepper, Poisson, Gaussian, and speckle noises are used to form the noisy images. Performance metrics like peak signal to noise ratio and structural similarity index are calculated and compared across all filters and noises. The proposed DeepCNN model performs well for denoising with the unknown and known noise levels. It speeds up the training process and also improves the denoising performance because of using 17 convolutional layers and batch normalisation.
必须向专家或医生介绍医学图像,以高精度地诊断脑肿瘤等重大疾病。本文提出了一种新的DeepCNN模型来执行MRI脑肿瘤图像去噪任务,并将结果与预训练DnCNN、高斯滤波器、自适应滤波器、双边滤波器和引导滤波器进行了比较。研究发现,DeepCNN的性能优于其他过滤方法。利用5 ~ 50级的噪声和椒盐噪声、泊松噪声、高斯噪声、散斑噪声等构成噪声图像。计算并比较了所有滤波器和噪声的峰值信噪比和结构相似性指数等性能指标。所提出的DeepCNN模型对于未知和已知噪声水平的去噪都有很好的效果。由于使用了17个卷积层和批处理归一化,它加快了训练过程,也提高了去噪性能。
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引用次数: 1
An Earth mover's distance-based undersampling approach for handling class-imbalanced data 一种用于处理类不平衡数据的基于距离的欠采样方法
Q3 Computer Science Pub Date : 2020-08-26 DOI: 10.1504/ijiids.2020.10031612
G. Rekha, V. Reddy, A. Tyagi
Imbalanced datasets typically make prediction accuracy difficult. Most of the real-world data are imbalanced in nature. The traditional classifiers assume a well-balanced class distribution for training data but in practical datasets show up an imbalance, thus obscure a classifier and degrade its capability to learn from such imbalanced datasets. Data pre-processing approaches address this concern by using either random undersampling or oversampling techniques. In this paper, we introduce Earth mover's distance (EMD), as a similarity measure, to find the samples similar in nature and eliminate them as redundant from the dataset. Earth mover's distance has received a lot of attention in wide areas such as computer vision, image retrieval, machine learning, etc. The Earth mover's distance-based undersampling approach provides a solution at the data level to eliminate the redundant instances in majority samples without any loss of valuable information. This method is implemented with five conventional classifiers and one ensemble technique respectively, like C4.5 decision tree (DT), k-nearest neighbour (k-NN), multilayer perceptron (MLP), support vector machine (SVM), naive Bayes (NB) and AdaBoost technique. The proposed method yields a superior performance on 21 datasets from Keel repository.
不平衡的数据集通常使预测的准确性变得困难。大多数真实世界的数据本质上是不平衡的。传统的分类器对训练数据的分类分布假设是很平衡的,但在实际数据集中表现出不平衡,从而模糊了分类器,降低了分类器从这种不平衡数据集中学习的能力。数据预处理方法通过使用随机欠采样或过采样技术来解决这个问题。在本文中,我们引入了土动器的距离(EMD)作为相似性度量,以发现本质上相似的样本,并从数据集中剔除冗余样本。在计算机视觉、图像检索、机器学习等广泛的领域中,推土机的距离问题受到了广泛的关注。earthmover基于距离的欠采样方法在数据层面提供了一种解决方案,可以在不丢失任何有价值信息的情况下消除大多数样本中的冗余实例。该方法分别采用C4.5决策树(DT)、k近邻(k-NN)、多层感知器(MLP)、支持向量机(SVM)、朴素贝叶斯(NB)和AdaBoost技术等5种传统分类器和1种集成技术实现。该方法在龙骨知识库的21个数据集上取得了优异的性能。
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引用次数: 4
Machine learning-based book recommender system: a survey and new perspectives 基于机器学习的图书推荐系统:综述与新视角
Q3 Computer Science Pub Date : 2020-08-25 DOI: 10.1504/ijiids.2020.10031604
Khalid Anwar, Jamshed Siddiqui, S. S. Sohail
The exponential growth of recommender systems research has drawn the attention of the scientific community recently. These systems are very useful in reducing information overload and providing users with the items of their need. The major areas where recommender systems have contributed significantly include e-commerce, online auction, and books and conference recommendation for academia and industrialists. Book recommender systems suggest books of interest to users according to their preferences and requirements. In this article, we have surveyed machine learning techniques which have been used in book recommender systems. Moreover, evaluation metrics applied to evaluate recommendation techniques is also studied. Six categories for book recommendation techniques have been identified and discussed which would enable the scientific community to lay a foundation of research in the concerned field. We have also proposed future perspectives to improve recommender system. We hope that researchers exploring recommendation technology in general and book recommendation in particular will be finding this work highly beneficial.
近年来,推荐系统的研究呈指数级增长,引起了科学界的关注。这些系统在减少信息过载和为用户提供他们需要的项目方面非常有用。推荐系统做出重大贡献的主要领域包括电子商务、在线拍卖、为学术界和实业家推荐书籍和会议。图书推荐系统根据用户的喜好和需求,向用户推荐他们感兴趣的图书。在这篇文章中,我们调查了在图书推荐系统中使用的机器学习技术。此外,还研究了用于评价推荐技术的评价指标。已经确定并讨论了六类推荐书籍的技术,这将使科学界能够为有关领域的研究奠定基础。我们还提出了未来改进推荐系统的观点。我们希望研究推荐技术,特别是书籍推荐的研究人员会发现这项工作非常有益。
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引用次数: 15
A new weighted two-dimensional vector quantisation encoding method in bag-of-features for histopathological image classification 一种新的特征袋加权二维矢量量化编码方法用于组织病理图像分类
Q3 Computer Science Pub Date : 2020-08-25 DOI: 10.1504/ijiids.2020.10031594
Raju Pal, M. Saraswat
Automated histopathological image analysis is a challenging problem due to the complex morphological structure of histopathology images. Bag-of-features is one of the prominent image representation methods which has been successfully applied in histopathological image analysis. There are four phases in the bag-of-features method, namely feature extraction, codebook construction, feature encoding, and classification. Out of which feature encoding is one of the prime phases. In feature encoding phase, images are represented in terms of visual words before feeding into support vector machine classifier. However, the feature encoding phase of the bag-of-features framework considers the one feature to encode each image in terms of visual words due to which the system can not use the merits of other features. Therefore, to improve the efficacy of the bag-of-features framework, a new weighted two-dimensional vector quantisation encoding method is proposed in this work. The proposed method is tested on two histopathological image datasets for classification. The experimental results show that the combination of SIFT and ORB features with two dimensional vector quantisation encoding method returns 80.13% and 77.13% accuracy on ADL and Blue Histology datasets respectively which is better than other considered encoding methods.
由于组织病理图像复杂的形态结构,自动组织病理图像分析是一个具有挑战性的问题。特征袋表示是一种突出的图像表示方法,已成功应用于组织病理学图像分析。特征袋方法分为特征提取、码本构建、特征编码和分类四个阶段。其中特征编码是主要阶段之一。在特征编码阶段,图像在输入到支持向量机分类器之前,先用视觉词表示。然而,特征袋框架的特征编码阶段考虑用视觉词来编码每个图像的一个特征,因此系统无法利用其他特征的优点。因此,为了提高特征袋框架的有效性,本文提出了一种新的加权二维矢量量化编码方法。在两个组织病理图像数据集上进行了分类测试。实验结果表明,SIFT和ORB特征结合二维矢量量化编码方法在ADL和Blue组织学数据集上的准确率分别为80.13%和77.13%,优于其他考虑的编码方法。
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引用次数: 6
Security, privacy and trust: privacy preserving model for internet of things 安全、隐私和信任:物联网的隐私保护模型
Q3 Computer Science Pub Date : 2020-08-25 DOI: 10.1504/ijiids.2020.10031591
S. K. Jain, N. Kesswani, Basant Agarwal
Internet of things (IoT) has emerged as one of the dominant technologies. The IoT systems provide significant number of opportunities in solving many real-time problems such as in healthcare, transport, smart cities, etc. However, ensuring privacy protection is challenging as sensitive and personal information is communicated through the IoT devices. In this paper, we propose a privacy preserving model called as security, privacy and trust (SPT) that ensures data privacy in IoT devices through lightweight data collection and data access protocols in resource constrained IoT ecosystem. We have conducted the experiments on small scale dataset (1,000 data points) and large scale dataset (10,000 data points). The experimental results show that in the proposed SPT model, there is an improvement of 3.63% for small scale dataset and 12.87% improvement for large scale dataset in terms of average effective time. We also provide a case study of the proposed approach on the healthcare-based IoT system.
物联网(IoT)已成为主导技术之一。物联网系统为解决许多实时问题提供了大量机会,例如医疗保健、交通、智慧城市等。然而,确保隐私保护具有挑战性,因为敏感和个人信息是通过物联网设备交流的。在本文中,我们提出了一种称为安全、隐私和信任(SPT)的隐私保护模型,该模型通过资源受限的物联网生态系统中轻量级的数据收集和数据访问协议来确保物联网设备中的数据隐私。我们在小规模数据集(1000个数据点)和大规模数据集(10000个数据点)上进行了实验。实验结果表明,在SPT模型中,小尺度数据集的平均有效时间提高了3.63%,大尺度数据集的平均有效时间提高了12.87%。我们还提供了一个基于医疗保健的物联网系统的拟议方法的案例研究。
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引用次数: 5
Hierarchical clustering on metric lattice 度量格上的层次聚类
Q3 Computer Science Pub Date : 2020-06-26 DOI: 10.1504/ijiids.2020.10030210
Xiangyan Meng, Muyan Liu, Jingyi Wu, Huiqiu Zhou, F. Xu, Qiufeng Wu
This work proposes a new clustering algorithm named 'fuzzy interval number hierarchical clustering' (FINHC) by converting original data into fuzzy interval number (FIN) firstly, then it proves F that denotes the collection of FINs is a lattice and introduces a novel metric distance based on the results from lattice theory, as well as combining them with hierarchical clustering. The relevant mathematical background about lattice theory and the specific algorithm which is used to construct FIN have been presented in this paper. Three evaluation indexes including compactness, recall and F1-measure are applied to evaluate the performance of FINHC, hierarchical clustering (HC) k-means, k-medoids, density-based spatial clustering of applications with noise (DBSCAN) in six experiments used UCI public datasets and one experiment used KEEL public dataset. The FINHC algorithm shows better clustering performance compared to other traditional clustering algorithms and the results are also discussed specifically.
本文首先将原始数据转换为模糊区间数(FIN),提出了一种新的聚类算法“模糊区间数分层聚类”(FINHC),然后证明了表示FIN集合的F是一个格,并在格理论结果的基础上引入了一种新的度量距离,并将它们与分层聚类相结合。本文介绍了格理论的相关数学背景和构造网格的具体算法。在UCI公共数据集和KEEL公共数据集的6个实验和1个实验中,采用紧凑性、召回率和f1测度3个评价指标对FINHC、分层聚类(HC)、k-means、k-medoids、基于密度的空间聚类(DBSCAN)进行了性能评价。FINHC算法与其他传统聚类算法相比具有更好的聚类性能,并对结果进行了具体讨论。
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引用次数: 1
Quality materialised view selection using quantum inspired artificial bee colony optimisation 使用量子启发的人工蜂群优化的质量物化视图选择
Q3 Computer Science Pub Date : 2020-06-26 DOI: 10.1504/ijiids.2020.10030204
B. Arun
The availability of huge volumes of digital data and powerful computers has facilitated the extraction of information, knowledge and wisdom for decision support system. The information value is solely dependent on data quality. Data warehouse provides quality data; it is required that it responds to queries within seconds. But on account of steadily growing data warehouse, the query response time is generally in hours and weeks. Materialised view is an efficient approach to facilitate timely extraction of information and knowledge for strategic business decision making. Selecting an optimal set of views for materialisation, referred to as view selection, is a NP complete problem. In this paper, a quantum inspired artificial bee colony algorithm is proposed to address the view selection problem. Experimental results show that the proposed algorithm significantly outperforms the fundamental algorithm for view selection, HRUA and other view selection algorithms like ABC, MBO, HBMO, BCOc, BCOi and BBMO.
海量的数字数据和强大的计算机为决策支持系统的信息、知识和智慧的提取提供了便利。信息的价值完全取决于数据的质量。数据仓库提供高质量的数据;它需要在几秒钟内响应查询。但是由于数据仓库的稳定增长,查询响应时间通常以小时和周为单位。物化视图是一种有效的方法,可以方便地及时提取信息和知识,为战略业务决策提供依据。选择一组最优的视图进行具体化,称为视图选择,是一个NP完全问题。本文提出了一种量子启发的人工蜂群算法来解决视图选择问题。实验结果表明,该算法在视图选择、HRUA等基本算法以及ABC、MBO、HBMO、BCOc、BCOi、BBMO等视图选择算法上均有显著优于。
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引用次数: 0
期刊
International Journal of Intelligent Information and Database Systems
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