Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0161
Z. Abdulrahman, M. V. Poelgeest, M. Welters, S. H. Burg
{"title":"161 Single-cell spatial in situ transcriptomics unravels vulvar HSIL composition associated with complete response to therapeutic vaccination","authors":"Z. Abdulrahman, M. V. Poelgeest, M. Welters, S. H. Burg","doi":"10.1136/jitc-2022-sitc2022.0161","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0161","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121228490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1016
Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack
Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.
{"title":"1016 IL-2 expanded tumor infiltrated Natural Killer (TINK) cells from canine sarcomas possess potent anti-tumor cytotoxicity","authors":"Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack","doi":"10.1136/jitc-2022-sitc2022.1016","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1016","url":null,"abstract":"Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121235335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0832
Hong Jiang
{"title":"832 Antigen spread mediated by oncolytic adenovirus Delta-24-RGDOX during intratumoral adoptive T cell therapy in immunocompetent mice with disseminated tumors","authors":"Hong Jiang","doi":"10.1136/jitc-2022-sitc2022.0832","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0832","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121310320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0781
O. Yeku, D. Olson, J. Ward, S. Patel, J. Aycock, Amber C. Donahue, Yi-zhou Jiang, J. Gall, Z. Roberts, Rubén Álvarez-Rodríguez, Judy Seng, Tong Shen, N. Kothari
{"title":"781 DELTA-2: A phase 1, open-label, multicenter study of ITIL-168, an autologous tumor-infiltrating lymphocyte (TIL) cell therapy, with pembrolizumab in patients with advanced solid tumors","authors":"O. Yeku, D. Olson, J. Ward, S. Patel, J. Aycock, Amber C. Donahue, Yi-zhou Jiang, J. Gall, Z. Roberts, Rubén Álvarez-Rodríguez, Judy Seng, Tong Shen, N. Kothari","doi":"10.1136/jitc-2022-sitc2022.0781","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0781","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127056542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0228
Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Elizabeth G. Leitner, Priscilla Wong, Ronni Ponek, Enping Hong, Manan Shah, Andrew Banicki, Lawrence Naitmazi, Kelly Lee, W. Gorman, Russell M. Gordley, Philip Lee, Timothy Lu
{"title":"228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors","authors":"Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Elizabeth G. Leitner, Priscilla Wong, Ronni Ponek, Enping Hong, Manan Shah, Andrew Banicki, Lawrence Naitmazi, Kelly Lee, W. Gorman, Russell M. Gordley, Philip Lee, Timothy Lu","doi":"10.1136/jitc-2022-sitc2022.0228","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0228","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1208
Jordan M. Blum, V. Spires, G. Masters, Christina Yu, S. Burm, Matt Hancock, O. Jabado, Brandon Higgs, A. Muik, K. Nuermberger, Friederike Gieseke, T. Ahmadi, K. Sasser, Ozlem Tureci, M. Jure-Kunkel, U. Şahin, M. Fereshteh, N. Pencheva
{"title":"1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustionin vitro","authors":"Jordan M. Blum, V. Spires, G. Masters, Christina Yu, S. Burm, Matt Hancock, O. Jabado, Brandon Higgs, A. Muik, K. Nuermberger, Friederike Gieseke, T. Ahmadi, K. Sasser, Ozlem Tureci, M. Jure-Kunkel, U. Şahin, M. Fereshteh, N. Pencheva","doi":"10.1136/jitc-2022-sitc2022.1208","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1208","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124832897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0692
Renzo Perales, A. Perales-Puchalt, G. Bartha, Josette M. Northcott, Richard O. Chen, J. Lyle, D. Norton, Neil Cooch, E. Gane, M. Yarchoan, T. Marron, Sarah Rochestie, J. Peters, I. Csiki, Jian Yan, N. Sardesai
Renzo Perales, Alfredo Perales-Puchalt, Gabor Bartha, Josette Northcott, Richard Chen, John Lyle, Dan Norton, Neil Cooch, Edward Gane, Mark Yarchoan, Thomas Marron, Sarah Rochestie, Joann Peters, Ildiko Csiki, Jian Yan*, Niranjan Sardesai. Geneos Therapeutics, Plymouth Meeting, PA, USA; Personalis, Inc, Menlo Park, CA, USA; The University of Auckland, Auckland, New Zealand; The Johns Hopkins Hospital, Baltimore, MD, USA; The Tisch Cancer Institute, New York, NY, USA
{"title":"692 Circulating tumor DNA analysis of advanced hepatocellular cancer (HCC) patients treated with neoantigen targeted personalized cancer DNA vaccine (GNOS-PV02) in combination with plasmid IL-12 (pIL12) and anti-PD1 (pembrolizumab)","authors":"Renzo Perales, A. Perales-Puchalt, G. Bartha, Josette M. Northcott, Richard O. Chen, J. Lyle, D. Norton, Neil Cooch, E. Gane, M. Yarchoan, T. Marron, Sarah Rochestie, J. Peters, I. Csiki, Jian Yan, N. Sardesai","doi":"10.1136/jitc-2022-sitc2022.0692","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0692","url":null,"abstract":"Renzo Perales, Alfredo Perales-Puchalt, Gabor Bartha, Josette Northcott, Richard Chen, John Lyle, Dan Norton, Neil Cooch, Edward Gane, Mark Yarchoan, Thomas Marron, Sarah Rochestie, Joann Peters, Ildiko Csiki, Jian Yan*, Niranjan Sardesai. Geneos Therapeutics, Plymouth Meeting, PA, USA; Personalis, Inc, Menlo Park, CA, USA; The University of Auckland, Auckland, New Zealand; The Johns Hopkins Hospital, Baltimore, MD, USA; The Tisch Cancer Institute, New York, NY, USA","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125000349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0312
Rachel Abbott, Okba Alassadi, M. Davies, Magdaléna von Essen, Verónica Freire-Benéitez, Vicki Jefferson, S. Kundu, P. Kurupati, Ralf Leonhardt, Samuel L. Lukowski, Fabio Marino, G. Masi, R. Queiroz, Hayden J. Selvadurai, J. Senra, E. Tye, J. Dukes
{"title":"312 Identification of novel NSC lung cancer Dark Antigens™ with expression in multiple tumor types, as promising targets for immunotherapies","authors":"Rachel Abbott, Okba Alassadi, M. Davies, Magdaléna von Essen, Verónica Freire-Benéitez, Vicki Jefferson, S. Kundu, P. Kurupati, Ralf Leonhardt, Samuel L. Lukowski, Fabio Marino, G. Masi, R. Queiroz, Hayden J. Selvadurai, J. Senra, E. Tye, J. Dukes","doi":"10.1136/jitc-2022-sitc2022.0312","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0312","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125065776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0006
C. Weipert, L. Drusbosky, L. Bucheit, K. Chang, Shaun P. Forbes, S. Gordon
{"title":"6 Use of real-world (RW) data to assess the ability of circulating cell-free tumor DNA (ctDNA) molecular response to assess therapeutic outcomes in patients with non-small cell lung cancer (NSCLC)","authors":"C. Weipert, L. Drusbosky, L. Bucheit, K. Chang, Shaun P. Forbes, S. Gordon","doi":"10.1136/jitc-2022-sitc2022.0006","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0006","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125087469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0454
E. Nadler, C. Black, K. Ramakrishnan, Wan-Yu Tseng, Charles Wentworth, John Murphy, N. Fulcher, Liya Wang, M. Alexander, G. Patton
{"title":"454 Real-world treatment patterns among patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC) in a community oncology setting","authors":"E. Nadler, C. Black, K. Ramakrishnan, Wan-Yu Tseng, Charles Wentworth, John Murphy, N. Fulcher, Liya Wang, M. Alexander, G. Patton","doi":"10.1136/jitc-2022-sitc2022.0454","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0454","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126030379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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