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Corrigendum to “HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway’[Neurochemistry International 99 (2016) 239–251] HPOB,一种HDAC6抑制剂,通过抑制线粒体GR转位和内在凋亡途径减轻皮质酮诱导的大鼠肾上腺嗜铬细胞瘤PC12细胞损伤'[Neurohemistry International 99 (2016) 239-251]的更正。
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-14 DOI: 10.1016/j.neuint.2024.105856
Zong-yang Li , Qing-zhong Li , Lei Chen , Bao-dong Chen , Ce Zhang , Xiang Wang , Wei-ping Li
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引用次数: 0
Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation 大豆卵磷脂通过抑制肠道炎症预防高盐摄入诱发的小鼠高血压和认知障碍
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-12 DOI: 10.1016/j.neuint.2024.105858
Hisayoshi Kubota , Kazuo Kunisawa , Masaya Hasegawa , Hitomi Kurahashi , Kazuhiro Kagotani , Yuki Fujimoto , Akihito Hayashi , Ryoji Sono , Takehiko Tsuji , Kuniaki Saito , Toshitaka Nabeshima , Akihiro Mouri

High salt (HS) intake induces hypertension and cognitive impairment. Preventive strategies include against dietary supplements. Soybean lecithin is a widely used phospholipid supplement. Lysolecithin is important in cell signaling, digestion, and absorption. This study aimed to investigate the effects of lysophosphatidylcholine containing >70% of the total phospholipids (LPC70), on hypertension and cognitive impairment induced in mice by HS intake. Mice were provided with HS solution (2% NaCl in drinking water) with or without LPC70 for 12 weeks. Blood pressure, cognitive function, and inflammatory response of intestine were determined. Hypertension and impaired object recognition memory induced by HS intake were implicated with increased inducible nitric oxide synthase in the small intestine and tau hyperphosphorylation in the prefrontal cortex. LPC70 treatment prevented cognitive impairment by suppressing inducible nitric oxide synthase and tau hyperphosphorylation. LPC70 may be valuable as a functional food component in preventing HS-induced cognitive impairment.

高盐(HS)摄入会诱发高血压和认知障碍。预防策略包括反对膳食补充剂。大豆卵磷脂是一种广泛使用的磷脂补充剂。卵磷脂在细胞信号传导、消化和吸收方面具有重要作用。本研究旨在探讨含磷脂总量 70% 的溶血磷脂酰胆碱(LPC70)对摄入 HS 引起的小鼠高血压和认知障碍的影响。向小鼠提供含或不含 LPC70 的 HS 溶液(饮用水中含 2% NaCl),持续 12 周。对小鼠的血压、认知功能和肠道炎症反应进行了测定。摄入 HS 引起的高血压和物体识别记忆受损与小肠中诱导型一氧化氮合酶增加和前额叶皮层中 tau 过度磷酸化有关。LPC70 治疗可抑制诱导型一氧化氮合酶和 tau 过度磷酸化,从而防止认知障碍。LPC70作为一种功能性食品成分,在预防HS诱导的认知障碍方面可能具有重要价值。
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引用次数: 0
A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology 从生物可及性和多药理角度对黄酮类化合物的老年保护活性进行严格评估
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-10 DOI: 10.1016/j.neuint.2024.105859
Roumi Naskar , Anirrban Ghosh , Raja Bhattacharya , Sandipan Chakraborty

Flavonoids, a commonly consumed natural product, elicit health-benefits such as antioxidant, anti-inflammatory, antiviral, anti-allergic, hepatoprotective, anti-carcinogenic and neuroprotective activities. Several studies have reported the beneficial role of flavonoids in improving memory, learning, and cognition in clinical settings. Their mechanism of action is mediated through the modulation of multiple signalling cascades. This polypharmacology makes them an attractive natural scaffold for designing and developing new effective therapeutics for complex neurological disorders like Alzheimer's disease and Parkinson's disease. Flavonoids are shown to inhibit crucial targets related to neurodegenerative disorders (NDDs), including acetylcholinesterase, butyrylcholinesterase, β-secretase, γ-secretase, α-synuclein, Aβ protein aggregation and neurofibrillary tangles formation. Conserved neuro-signalling pathways related to neurotransmitter biogenesis and inactivation, ease of genetic manipulation and tractability, cost-effectiveness, and their short lifespan make Caenorhabditis elegans one of the most frequently used models in neuroscience research and high-throughput drug screening for neurodegenerative disorders. Here, we critically appraise the neuroprotective activities of different flavonoids based on clinical trials and epidemiological data. This review provides critical insights into the absorption, metabolism, and tissue distribution of various classes of flavonoids, as well as detailed mechanisms of the observed neuroprotective activities at the molecular level, to rationalize the clinical data. We further extend the review to critically evaluate the scope of flavonoids in the disease management of neurodegenerative disorders and review the suitability of C. elegans as a model organism to study the neuroprotective efficacy of flavonoids and natural products.

类黄酮是一种常见的天然产品,具有抗氧化、抗炎、抗病毒、抗过敏、保肝、抗癌和保护神经等保健作用。一些研究报告称,类黄酮在临床环境中对改善记忆、学习和认知能力有益。黄酮类化合物的作用机制是通过调节多种信号级联介导的。这种多药理作用使黄酮类化合物成为一种极具吸引力的天然支架,可用于设计和开发治疗阿尔茨海默病和帕金森病等复杂神经系统疾病的新型有效疗法。黄酮类化合物可抑制与神经退行性疾病(NDDs)有关的关键靶点,包括乙酰胆碱酯酶、丁酰胆碱酯酶、β-分泌酶、γ-分泌酶、α-突触核蛋白、Aβ 蛋白聚集和神经纤维缠结的形成。与神经递质的生物发生和失活相关的神经信号通路的保守性、遗传操作的简易性和可操作性、成本效益以及短暂的寿命使 elegans 成为神经科学研究和神经退行性疾病高通量药物筛选中最常用的模型之一。在此,我们根据临床试验和流行病学数据对不同黄酮类化合物的神经保护活性进行了批判性评估。这篇综述对各类类黄酮的吸收、代谢和组织分布,以及在分子水平上观察到的神经保护活性的详细机制提供了重要的见解,从而使临床数据合理化。我们进一步扩展了综述范围,对黄酮类化合物在神经退行性疾病治疗中的应用范围进行了批判性评估,并回顾了将秀丽隐杆线虫作为模型生物来研究黄酮类化合物和天然产品的神经保护功效的适宜性。
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引用次数: 0
Activity-based anorexia (ABA) model: Effects on brain neuroinflammation, redox balance and neuroplasticity during the acute phase 基于活动的厌食症(ABA)模型:对急性期大脑神经炎症、氧化还原平衡和神经可塑性的影响。
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-06 DOI: 10.1016/j.neuint.2024.105842
Vittoria Spero , Maria Scherma , Sabrina D'Amelio , Roberto Collu , Simona Dedoni , Chiara Camoglio , Carlotta Siddi , Walter Fratta , Raffaella Molteni , Paola Fadda

Several evidences suggest that immuno-inflammatory responses are involved in the pathogenesis of anorexia nervosa (AN). Herein we investigate the possible alteration of key mediators of inflammation, redox balance, and neuroplasticity in the brain of rats showing an anorexic-like phenotype. We modeled AN in adolescent female rats using the activity-based anorexia (ABA) paradigm and measured gene expression levels of targets of interest in the prefrontal cortex (PFC) and dorsal hippocampus (DH). We observed reduced mRNA levels of pro-inflammatory cytokines IL-1β and TNF-α, the inflammasome NLRP3, and the microglial marker CD11b in both PFC and DH of ABA animals. Conversely, the mRNA of IL-6, which acts as both a pro-inflammatory and anti-inflammatory cytokine, was increased. Moreover, we observed an overall upregulation of different antioxidant enzymes in PFC, while their profile was not affected or opposite in the DH, with the exception of MT1α. Interestingly, ABA animals showed elevated levels of the neuroplasticity marker BDNF in both PFC and DH. Our data indicate that ABA induction is associated with anatomical-specific cerebral alteration of mediators of neuroinflammation, oxidative balance and neuroplasticity. Although more research should be conducted, these results add important information about the role of these systems in the complex AN etiopathogenesis.

一些证据表明,免疫炎症反应与神经性厌食症(AN)的发病机制有关。在此,我们研究了表现出厌食症样表型的大鼠大脑中炎症、氧化还原平衡和神经可塑性的关键介质可能发生的变化。我们使用基于活动的厌食症(ABA)范式模拟了青春期雌性大鼠的厌食症,并测量了前额叶皮层(PFC)和背侧海马(DH)中相关靶点的基因表达水平。我们观察到,在 ABA 动物的前额叶皮层和海马背侧,促炎细胞因子 IL-1β 和 TNF-α、炎性组 NLRP3 以及小胶质细胞标志物 CD11b 的 mRNA 水平均有所降低。相反,同时作为促炎和抗炎细胞因子的 IL-6 的 mRNA 则有所增加。此外,我们还观察到 PFC 中不同抗氧化酶的整体上调,而在 DH 中,除了 MT1α 外,其他抗氧化酶没有受到影响,或者相反。有趣的是,ABA动物在PFC和DH中都显示出神经可塑性标志物BDNF水平的升高。我们的数据表明,ABA诱导与大脑解剖特异性神经炎症介质、氧化平衡和神经可塑性的改变有关。尽管还需要进行更多的研究,但这些结果为这些系统在复杂的AN发病机制中的作用提供了重要信息。
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引用次数: 0
Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals 传统食用药用植物可防止鱼藤酮诱导的 SH-SY5Y 细胞毒性--中草药保健品的开发前景广阔。
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-06 DOI: 10.1016/j.neuint.2024.105855
Aruna Chanu Hijam , Yaiphabi Chanu Tongbram , Pooja Devi Nongthombam , Heikrujam Nilkanta Meitei , Arunkumar Singh Koijam , Yallapa Rajashekar , Reena Haobam

Plants are good sources of pharmacologically active compounds. The present study aimed to examine the neuroprotective potentials of the methanol extracts of Salix tetrasperma Roxb. leaf (STME) and Plantago asiatica L. (PAME), two edibles medicinal plants of Manipur, India against neurotoxicity induced by rotenone in SH-SY5Y cells. Free radical quenching activities were evaluated by ABTS and DPPH assays. The cytotoxicity of rotenone and the neuronal survival were assessed by MTT assay and MAP2 expression analysis. DCF-DA, Rhodamine 123 (Rh-123), and DAPI measured the intracellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and apoptotic nuclei, respectively. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities were also assessed. LC-QTOF-MS analysis was performed for the identification of the compounds present in STME and PAME. The study showed that both the plant extracts (STME and PAME) showed antioxidant and neuroprotective capabilities in rotenone-induced neurotoxicity by preventing oxidative stress through the reduction of intracellular ROS levels and reversing the activities of GPx, SOD, and CAT caused by rotenone. Further, both plants prevented apoptotic cell death by normalizing the steady state of MMP and protecting nuclear DNA condensation. LC-QTOF-MS analysis shows the presence of known neuroprotective compounds like uridine and gabapentin in STME and PAME respectively. The two plants might be an important source of natural antioxidants and nutraceuticals with neuroprotective abilities. This could be investigated further to formulate herbal nutraceuticals for the treatment of neurodegenerative disease like Parkinson's disease.

植物是药理活性化合物的良好来源。本研究旨在研究印度曼尼普尔的两种食用药用植物 Salix tetrasperma Roxb. 叶(STME)和 Plantago asiatica L. (PAME)的甲醇提取物对 SH-SY5Y 细胞由鱼藤酮诱导的神经毒性的保护潜力。通过 ABTS 和 DPPH 试验评估了自由基淬灭活性。通过 MTT 试验和 MAP2 表达分析评估了鱼藤酮的细胞毒性和神经元存活率。DCF-DA、罗丹明123(Rh-123)和DAPI分别测量细胞内活性氧(ROS)水平、线粒体膜电位(MMP)和凋亡核。此外,还评估了超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)和过氧化氢酶(CAT)的活性。对 STME 和 PAME 中的化合物进行了 LC-QTOF-MS 分析鉴定。研究表明,两种植物提取物(STME 和 PAME)在鱼藤酮诱导的神经毒性中都表现出抗氧化和神经保护能力,它们通过降低细胞内 ROS 水平来防止氧化应激,并逆转鱼藤酮引起的 GPx、SOD 和 CAT 活性。此外,这两种植物还能通过使 MMP 的稳态正常化和保护核 DNA 凝聚来防止细胞凋亡。LC-QTOF-MS 分析表明,STME 和 PAME 中分别含有尿苷和加巴喷丁等已知的神经保护化合物。这两种植物可能是具有神经保护能力的天然抗氧化剂和营养保健品的重要来源。可以进一步研究这两种植物,以配制治疗帕金森病等神经退行性疾病的草药保健品。
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引用次数: 0
Generation and characterization of cortical organoids from iPSC-derived dental pulp stem cells using traditional and innovative approaches 利用传统和创新方法从 iPSC 衍生的牙髓干细胞中生成皮质类器官并确定其特征。
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-04 DOI: 10.1016/j.neuint.2024.105854
André Luíz Teles e Silva , Bruno Yukio Yokota-Moreno , Mariana Silva Branquinho , Geisa Rodrigues Salles , Thiago Cattuzo de Souza , Ronald Almeida de Carvalho , Gabriel Batista , Elisa Varella Branco , Karina Griesi-Oliveira , Maria Rita Passos Bueno , Marimélia Aparecida Porcionatto , Roberto Hirochi Herai , Lionel Fernel Gamarra , Andrea Laurato Sertié

Cortical organoids derived from human induced pluripotent stem cells (hiPSCs) represent a powerful in vitro experimental system to investigate human brain development and disease, often inaccessible to direct experimentation. However, despite steady progress in organoid technology, several limitations remain, including high cost and variability, use of hiPSCs derived from tissues harvested invasively, unexplored three-dimensional (3D) structural features and neuronal connectivity. Here, using a cost-effective and reproducible protocol as well as conventional two-dimensional (2D) immunostaining, we show that cortical organoids generated from hiPSCs obtained by reprogramming stem cells from human exfoliated deciduous teeth (SHED) recapitulate key aspects of human corticogenesis, such as polarized organization of neural progenitor zones with the presence of outer radial glial stem cells, and differentiation of superficial- and deep-layer cortical neurons and glial cells. We also show that 3D bioprinting and magnetic resonance imaging of intact cortical organoids are alternative and complementary approaches to unravel critical features of the 3D architecture of organoids. Finally, extracellular electrical recordings in whole organoids showed functional neuronal networks. Together, our findings suggest that SHED-derived cortical organoids constitute an attractive model of human neurodevelopment, and support the notion that a combination of 2D and 3D techniques to analyze organoid structure and function may help improve this promising technology.

源自人类诱导多能干细胞(hiPSCs)的皮质类器官是研究人类大脑发育和疾病的强大体外实验系统,通常无法直接进行实验。然而,尽管类器官技术取得了稳步进展,但仍存在一些局限性,包括成本高、可变性大、使用的hiPSCs来源于有创采集的组织、三维(3D)结构特征和神经元连接性有待探索。在这里,我们使用一种具有成本效益和可重复性的方案以及传统的二维(2D)免疫染色法,表明通过对人类脱落牙齿(SHED)干细胞进行重编程而获得的hiPSCs所生成的皮质类器官再现了人类皮质生成的关键方面,如神经祖细胞区的极化组织与外侧放射状胶质干细胞的存在,以及浅层和深层皮质神经元和胶质细胞的分化。我们还表明,三维生物打印和完整皮层有机体的磁共振成像是揭示有机体三维结构关键特征的替代和互补方法。最后,对整个有机体的细胞外电记录显示了功能性神经元网络。总之,我们的研究结果表明,SHED衍生的大脑皮层有机体是人类神经发育的一个极具吸引力的模型,并支持结合二维和三维技术来分析有机体结构和功能可能有助于改进这一前景广阔的技术的观点。
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引用次数: 0
Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer 解密 FAM72 基因家族的分子景观:对干细胞生物学和癌症的影响
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-09-03 DOI: 10.1016/j.neuint.2024.105853
Janani Ramesh , Raja Mohan Gopalakrishnan , Tuan Hoang Anh Nguyen , Soak-Kuan Lai , Hoi-Yeung Li , Pok-Son Kim , Arne Kutzner , Noriko Inoue , Klaus Heese

Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

序列相似性家族 72(FAM72)是位于人类 1 号染色体上的一个蛋白质编码基因家族,有四个独特的旁系亲属:FAM72A、FAM72B、FAM72C 和 FAM72D。虽然 FAM72 与 SLIT-ROBO Rho GTPase-activating protein 2(SRGAP2)是一对基因,但其功能作用,尤其是在神经干细胞中的功能作用,仍不完全清楚。这篇综述探讨了FAM72的独特特征,揭示了它的表达模式、在细胞周期调控、干细胞更新中的潜在作用以及在神经发生和肿瘤发生中的影响。
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引用次数: 0
Pentylenetetrazole: A review 戊烯四唑:综述。
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1016/j.neuint.2024.105841
Álefe Brito Monteiro, Alan Ferreira Alves, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Pessoa de Melo, Nayana Maria Medeiros Vilar Barbosa, Cícero Francisco Bezerra Felipe

Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to induce neurological disorders and replicate the characteristics of human epileptic seizures in animal models. This review offers a comprehensive analysis of the behavioral, neurophysiological, and neurochemical changes induced by PTZ. The epileptogenic and neurotoxic mechanisms of PTZ are associated with an imbalance between the GABAergic and glutamatergic systems. At doses exceeding 60 mg/kg, PTZ exerts its epileptic effects by non-competitively antagonizing GABAA receptors and activating NMDA receptors, resulting in an increased influx of cations such as Na+ and Ca2+. Additionally, PTZ promotes oxidative stress, microglial activation, and the synthesis of pro-inflammatory mediators, all of which are features characteristic of glutamatergic excitotoxicity. These mechanisms ultimately lead to epileptic seizures and neuronal cell death, which depend on the dosage and method of administration. The behavioral, electroencephalographic, and histological changes associated with PTZ further establish it as a valuable preclinical model for the study of epileptic seizures, owing to its simplicity, cost-effectiveness, and reproducibility.

戊四氮唑(PTZ)是一种四氮唑衍生物,常用作诱导神经系统疾病的化学制剂,并在动物模型中复制人类癫痫发作的特征。本综述全面分析了 PTZ 诱导的行为、神经生理学和神经化学变化。PTZ 的致痫和神经毒性机制与 GABA 能系统和谷氨酸能系统之间的失衡有关。当剂量超过 60 毫克/千克时,PTZ 通过非竞争性拮抗 GABAA 受体和激活 NMDA 受体,导致 Na+ 和 Ca2+ 等阳离子流入增加,从而产生癫痫效应。此外,PTZ 还会促进氧化应激、小胶质细胞活化和促炎介质的合成,所有这些都是谷氨酸能兴奋毒性的特征。这些机制最终会导致癫痫发作和神经细胞死亡,这取决于给药剂量和方法。与 PTZ 相关的行为学、脑电图和组织学变化因其简单、成本效益高和可重复性而进一步将其确立为研究癫痫发作的宝贵临床前模型。
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引用次数: 0
Post-stroke whole body vibration therapy alters the cerebral transcriptome to promote ischemic tolerance in middle-aged female rats 中风后全身振动疗法改变大脑转录组,促进中年雌性大鼠的缺血耐受性
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1016/j.neuint.2024.105843
Shahil H. Patel , Helen M. Bramlett , Ami P. Raval

Low-frequency whole body vibration (WBV; 40 Hz) therapy after stroke reduces ischemic brain damage, motor, and cognitive deficits in middle-aged rats of both sexes. However, the underlying mechanisms responsible for WBV induced ischemic protections remain elusive. In the current study, we hypothesize that post-stroke WBV initiates transcriptional reprogramming in the cortex of middle-aged female rats which is responsible for the observed reduced stroke consequences. Middle-aged female Sprague-Dawley rats that remained in constant diestrus (reproductively senescent) were randomized to either sham or transient middle cerebral artery occlusion (tMCAO; 90 min) surgery. A day after induction of tMCAO, animals received either WBV or no-WBV treatment for 15 min twice a day for five days for a week. Post-treatment, cortical tissue was analyzed for gene expression using RNA sequencing (RNAseq) and gene enrichment analysis via Enrichr. The RNAseq data analysis revealed significant changes in gene expression due to WBV therapy and the differentially expressed genes are involved in variety of biological processes like neurogenesis, angiogenesis, excitotoxicity, and cell death. Specifically, observed significant up-regulation of 116 and down-regulation of 258 genes after WBV in tMCAO exposed rats as compared to the no-WBV group. The observed transcriptional reprogramming will identify the possible mechanism(s) responsible for post-stroke WBV conferred ischemic protection and future studies will be needed to confirm the role of the genes identified in the current study.

中风后的低频全身振动(WBV;40Hz)疗法可减少中年雌雄大鼠缺血性脑损伤、运动和认知障碍。然而,WBV诱导缺血性保护作用的潜在机制仍不明确。在目前的研究中,我们假设中风后 WBV 在中年雌性大鼠的大脑皮层中启动了转录重编程,这是观察到的中风后果减轻的原因。中年雌性 Sprague-Dawley 大鼠一直处于发情期(生殖衰老),我们随机对其进行假手术或瞬时大脑中动脉闭塞(tMCAO;90 分钟)手术。诱导 tMCAO 一天后,动物接受 WBV 或无 WBV 治疗,每天两次,每次 15 分钟,连续五天,为期一周。治疗后,使用 RNA 测序(RNAseq)和 Enrichr 基因富集分析对大脑皮层组织进行基因表达分析。RNAseq 数据分析显示,WBV 治疗导致基因表达发生了显著变化,差异表达的基因参与了神经发生、血管生成、兴奋毒性和细胞死亡等多种生物过程。具体而言,与无 WBV 组相比,观察到暴露于 tMCAO 的大鼠在接受 WBV 治疗后,116 个基因明显上调,258 个基因明显下调。观察到的转录重编程将确定脑卒中后 WBV 给予缺血保护的可能机制,未来的研究将需要确认当前研究中确定的基因的作用。
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引用次数: 0
Corrigendum to “Pharmacological inhibition of cGAS ameliorates postoperative cognitive dysfunction by suppressing caspase-3/GSDME-dependent pyroptosis” [Neurochem. Int. 178 (2024) 105788] 更正:"药理抑制 cGAS 可通过抑制 caspase-3/GSDME 依赖性脓毒症改善术后认知功能障碍" [Neurochem.
IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-25 DOI: 10.1016/j.neuint.2024.105838
Xueshan Bu , Ping Gong , Lei Zhang , Wenqin Song , Jiabao Hou , Qingwen Li , Wei Wang , Zhongyuan Xia
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引用次数: 0
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