Pub Date : 2022-09-21DOI: 10.31688/abmu.2022.57.3.03
Maria Cemortan, Irina Sagaidac, Olga Cernețchi, Constantin Ostrofet
bile acids, ICP = intrahepatic cholestasis of pregnancy, IVF = in vitro fertilization, LFTs = liver function tests, Me = median, UDCA = ursodeoxycholic acid, w.g. = weeks of gestation decreased, being assessed on the third day after delivery as less or equal with 5 points in 93.1% of cases, being occasional or discontinuous in 90.1% of cases. Conclusions. Pruritus is the most prevalent clinical sign of ICP and it should not be ignored, being considered as a call for follow-up.
{"title":"\"ASSESSMENT OF CLINICAL SYMPTOMS IN WOMEN WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY\"","authors":"Maria Cemortan, Irina Sagaidac, Olga Cernețchi, Constantin Ostrofet","doi":"10.31688/abmu.2022.57.3.03","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.3.03","url":null,"abstract":"bile acids, ICP = intrahepatic cholestasis of pregnancy, IVF = in vitro fertilization, LFTs = liver function tests, Me = median, UDCA = ursodeoxycholic acid, w.g. = weeks of gestation decreased, being assessed on the third day after delivery as less or equal with 5 points in 93.1% of cases, being occasional or discontinuous in 90.1% of cases. Conclusions. Pruritus is the most prevalent clinical sign of ICP and it should not be ignored, being considered as a call for follow-up.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42987009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.31688/abmu.2022.57.3.02
P. Petakh, Vitaliia Isevych, V. Griga, A. Kamyshnyi
leptospirosis in the period from 2009 to 2019 was conduct-ed. Quantitative variables in the presence of normal distribution were compared using a paired Student’s t-test, and in the case of an abnormal distribution, the Mann–Whitney U test was used. The criterion χ 2 was used for qualitative variables. A two-step cluster analysis was also performed. précoces et d’un ajustement thérapeutique. Mots-clés: la leptospirose, mortalité, prédicteurs, facteurs de risque Results. The following factors associated with death from leptospirosis have been identified: oliguria (OR, 13.5; 95% confidence interval [CI], 2.56-71.12), serum creatinine and urea levels, direct and total bilirubin, platelets, and white blood cells count. Conclusions. These „red flag” laboratory and clinical characteristics will aid medical personnel in rapidly identifying a patient at risk of death, which is critical in determining the severity of the condition and the need for early intensive care and therapy adjustment. direct toxic injury, immune-mediated responses, and circulatory collapse 19 . The results of our study suggest that risk stratifica-tion for patients with leptospirosis should not be relied on the presence of icterus. Jaundice occurs because of damage to the vessels of the hepatic capillaries without hepatocellular necrosis. There are retrospective studies that confirm 20,21 , or deny 9,10 the role of jaundice as a predictor of death in this infectious disease.
{"title":"\"THE RISK FACTORS OF SEVERE LEPTOSPIROSIS IN THE TRANSCARPATHIAN REGION OF UKRAINE – SEARCH FOR „RED FLAGS”\"","authors":"P. Petakh, Vitaliia Isevych, V. Griga, A. Kamyshnyi","doi":"10.31688/abmu.2022.57.3.02","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.3.02","url":null,"abstract":"leptospirosis in the period from 2009 to 2019 was conduct-ed. Quantitative variables in the presence of normal distribution were compared using a paired Student’s t-test, and in the case of an abnormal distribution, the Mann–Whitney U test was used. The criterion χ 2 was used for qualitative variables. A two-step cluster analysis was also performed. précoces et d’un ajustement thérapeutique. Mots-clés: la leptospirose, mortalité, prédicteurs, facteurs de risque Results. The following factors associated with death from leptospirosis have been identified: oliguria (OR, 13.5; 95% confidence interval [CI], 2.56-71.12), serum creatinine and urea levels, direct and total bilirubin, platelets, and white blood cells count. Conclusions. These „red flag” laboratory and clinical characteristics will aid medical personnel in rapidly identifying a patient at risk of death, which is critical in determining the severity of the condition and the need for early intensive care and therapy adjustment. direct toxic injury, immune-mediated responses, and circulatory collapse 19 . The results of our study suggest that risk stratifica-tion for patients with leptospirosis should not be relied on the presence of icterus. Jaundice occurs because of damage to the vessels of the hepatic capillaries without hepatocellular necrosis. There are retrospective studies that confirm 20,21 , or deny 9,10 the role of jaundice as a predictor of death in this infectious disease.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46029274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.31688/abmu.2022.57.3.10
P. Antonov, Atanas Ivanov, Pavel E. Stanchev, P. Genov
au cours des 5 dernières années. Tous les examens physiques, de laboratoire et d‘imagerie effec-tués ont montré la cause de l‘hématospermie: le coït réservé. Conclusions. L‘hématospermie est une affection relativement rare et généralement inoffensive d’étio-logie multifactorielle. Le cas présenté de coït réservé est une pratique impopulaire de rapport sexuel et une méthode contraceptive qui se manifeste cliniquement par une hématospermie. coït unpopular practice of sexual intercourse and a contraceptive method which is clinically manifested with haematospermia.
{"title":"\"CONTINUOUS HEMATOSPERMIA FOR 5 YEARS CAUSED BY COITUS RESERVATUS AS A METHOD OF CONTRACEPTION – A CASE REPORT\"","authors":"P. Antonov, Atanas Ivanov, Pavel E. Stanchev, P. Genov","doi":"10.31688/abmu.2022.57.3.10","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.3.10","url":null,"abstract":"au cours des 5 dernières années. Tous les examens physiques, de laboratoire et d‘imagerie effec-tués ont montré la cause de l‘hématospermie: le coït réservé. Conclusions. L‘hématospermie est une affection relativement rare et généralement inoffensive d’étio-logie multifactorielle. Le cas présenté de coït réservé est une pratique impopulaire de rapport sexuel et une méthode contraceptive qui se manifeste cliniquement par une hématospermie. coït unpopular practice of sexual intercourse and a contraceptive method which is clinically manifested with haematospermia.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47380219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.31688/abmu.2022.57.3.06
D. C. Miculas, D. M. Ţiț, P. A. Negru, A. G. Tarce, A. F. Bungau
the same time a symptomatic improvement. The effectiveness of these drugs is clearly limited, both because of several negative side effects and their inefficiency to cure the disease. The therapeutic management is therefore a major challenge in AD, and the non-adherence to treatment often constitutes a serious barrier to an effective therapy. Doctors and pharmacists play a vital role in the pharmacotherapeutic management of AD, contributing to improved clinical results and quality of life of the patient. The current review analysed the challenges in therapeutic management, especially those related to treatment adherence and pharmacist involvement.
{"title":"\"THE DRUG APPROACHES AND THE ROLE OF HEALTHCARE PROFESSIONALS IN THE MANAGEMENT OF ALZHEIMER’S DISEASE\"","authors":"D. C. Miculas, D. M. Ţiț, P. A. Negru, A. G. Tarce, A. F. Bungau","doi":"10.31688/abmu.2022.57.3.06","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.3.06","url":null,"abstract":"the same time a symptomatic improvement. The effectiveness of these drugs is clearly limited, both because of several negative side effects and their inefficiency to cure the disease. The therapeutic management is therefore a major challenge in AD, and the non-adherence to treatment often constitutes a serious barrier to an effective therapy. Doctors and pharmacists play a vital role in the pharmacotherapeutic management of AD, contributing to improved clinical results and quality of life of the patient. The current review analysed the challenges in therapeutic management, especially those related to treatment adherence and pharmacist involvement.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42273074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.31688/abmu.2022.57.3.09
H. Moldovan, O. Fronea, Claudia Nica, Mihai Cacoveanu, C. Voica, S. Preda, Marian Broască, Andra-Mădălina Sibișan, Robert Țigănașu, Sabina Safta, L. Câlmâc, Ondin Zaharia, L. Mirea, C. Diaconu, H. Suciu
{"title":"\"THE CURRENT MANAGEMENT OF END-STAGE HEART FAILURE: TWO CASE REPORTS\"","authors":"H. Moldovan, O. Fronea, Claudia Nica, Mihai Cacoveanu, C. Voica, S. Preda, Marian Broască, Andra-Mădălina Sibișan, Robert Țigănașu, Sabina Safta, L. Câlmâc, Ondin Zaharia, L. Mirea, C. Diaconu, H. Suciu","doi":"10.31688/abmu.2022.57.3.09","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.3.09","url":null,"abstract":"","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46936337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.31688/abmu.2022.57.2.07
T. Verulava, A. Jorbenadze
conséquences politiques et économiques mondiales. Par conséquent, la santé publique moderne est examinée dans un contexte mondial et nécessite des réglementations internatio-nales, des actions transnationales et des solutions ba-sées sur une coopération coordonnée entre différents pays du monde. Mots-clés: santé publique, réformes sanitaires, service sanitaire-épidémiologique, médecine préventive. having huge global political and economic consequenc-es. Therefore, modern public healthcare is reviewed in a global context and requires international regulations, transnational actions, and solutions based on coordinated cooperation among different countries of the world.
{"title":"\"DEVELOPMENT OF PUBLIC HEALTH IN GEORGIA: CHALLENGES AND POLICY ISSUES\"","authors":"T. Verulava, A. Jorbenadze","doi":"10.31688/abmu.2022.57.2.07","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.2.07","url":null,"abstract":"conséquences politiques et économiques mondiales. Par conséquent, la santé publique moderne est examinée dans un contexte mondial et nécessite des réglementations internatio-nales, des actions transnationales et des solutions ba-sées sur une coopération coordonnée entre différents pays du monde. Mots-clés: santé publique, réformes sanitaires, service sanitaire-épidémiologique, médecine préventive. having huge global political and economic consequenc-es. Therefore, modern public healthcare is reviewed in a global context and requires international regulations, transnational actions, and solutions based on coordinated cooperation among different countries of the world.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48515929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.31688/abmu.2022.57.2.08
Diana N. Gheorghita, Claudiu Filimon, Deniz Gunșahin, A. Kozma, V. D. Miron
{"title":"A NEW EPIDEMIC IN CHILDREN: PEDIATRIC OBESITY","authors":"Diana N. Gheorghita, Claudiu Filimon, Deniz Gunșahin, A. Kozma, V. D. Miron","doi":"10.31688/abmu.2022.57.2.08","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.2.08","url":null,"abstract":"","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43208124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.31688/abmu.2022.57.2.06
Diana R. Ungureanu, M. Moga, S.I. Badila, S. Casap, C. Anastasiu, D. Feștilă
objective of our paper was to evaluate the role of antenatal interventions in preventing premature births and their complications. Our paper is a narrative review and we selected studies from PubMed database from January 2000 to January 2021 using the following Medical Subject Headings: The results of the studies show there is an improvement of fetal and maternal outcomes when certain drugs are used such as tocolytic agents, antibiotherapy or corticosteroids. Every class of drug we presented in our paper aim to reduce the mortality and morbidity of main role is to delay the delivery for at least 48 hours, to administrate antenatal corticosteroids for enhancing fetal lung maturity. Uterine contractions involve the interaction between actin and myosin with myometrial cells, medi-ated by myosin light-chain kinase 2,3 . The mechanism of action of tocolytic agents involves the regulation of the myosin light-chain kinase activity: calcium and cyclic adenosine monophosphate (AMP). Many agents are used to inhibit these contractions, including magnesium sulphate, calcium channel blockers, oxytocin antagonists, nonsteroidal an-ti-inflammatory drugs (NSAIDs) and beta-adrenergic receptor agonists. No evidence exists that tocolytic therapy has any direct favorable effect on neonatal outcomes or that any prolongation of pregnancy afforded by tocolytics is translated to significant médicaments notre article à réduire la mortalité et la morbidité des nouveau-nés et administrées de elles préviennent la plupart des issues im-probables. Les qui ces stratégies sont limitées en termes de nombre d’études publiées, cependant, toutes les études que nous incluses soutiennent l’administration de ces médicaments Mots-clés: prématurité, anténatal, tocolyse, antibiothérapie, corticothérapie. they the data that support these are limited in terms of the number of published studies, however, all the studies we included support the administration of tocolytic agents, and corticosteroids as well as vitamin
{"title":"\"PREVENTIVE ANTENATAL INTERVENTIONS TO REDUCE PREMATURE BIRTHS\"","authors":"Diana R. Ungureanu, M. Moga, S.I. Badila, S. Casap, C. Anastasiu, D. Feștilă","doi":"10.31688/abmu.2022.57.2.06","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.2.06","url":null,"abstract":"objective of our paper was to evaluate the role of antenatal interventions in preventing premature births and their complications. Our paper is a narrative review and we selected studies from PubMed database from January 2000 to January 2021 using the following Medical Subject Headings: The results of the studies show there is an improvement of fetal and maternal outcomes when certain drugs are used such as tocolytic agents, antibiotherapy or corticosteroids. Every class of drug we presented in our paper aim to reduce the mortality and morbidity of main role is to delay the delivery for at least 48 hours, to administrate antenatal corticosteroids for enhancing fetal lung maturity. Uterine contractions involve the interaction between actin and myosin with myometrial cells, medi-ated by myosin light-chain kinase 2,3 . The mechanism of action of tocolytic agents involves the regulation of the myosin light-chain kinase activity: calcium and cyclic adenosine monophosphate (AMP). Many agents are used to inhibit these contractions, including magnesium sulphate, calcium channel blockers, oxytocin antagonists, nonsteroidal an-ti-inflammatory drugs (NSAIDs) and beta-adrenergic receptor agonists. No evidence exists that tocolytic therapy has any direct favorable effect on neonatal outcomes or that any prolongation of pregnancy afforded by tocolytics is translated to significant médicaments notre article à réduire la mortalité et la morbidité des nouveau-nés et administrées de elles préviennent la plupart des issues im-probables. Les qui ces stratégies sont limitées en termes de nombre d’études publiées, cependant, toutes les études que nous incluses soutiennent l’administration de ces médicaments Mots-clés: prématurité, anténatal, tocolyse, antibiothérapie, corticothérapie. they the data that support these are limited in terms of the number of published studies, however, all the studies we included support the administration of tocolytic agents, and corticosteroids as well as vitamin","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42190922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.31688/abmu.2022.57.2.11
Theodoros Kyrkoudis, G. Tsoucalas, V. Thomaidis, N. Papavramidou, A. Fiska
{"title":"\"THE GREEK ANATOMIST IOANNIS KALLIAS. AN IMPORTANT FIGURE OF THE IMPERIAL SCHOOL OF MEDICINE IN THE OTTOMAN CONSTANTINOPLE\"","authors":"Theodoros Kyrkoudis, G. Tsoucalas, V. Thomaidis, N. Papavramidou, A. Fiska","doi":"10.31688/abmu.2022.57.2.11","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.2.11","url":null,"abstract":"","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47230640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.31688/abmu.2022.57.2.05
A. Blajin, Cristina Tănase, A. Popa, Vlad Filimon, F. Grama, T. Burcoș
favourable outcomes and poten-tial advantages, this treatment approach can result in significant toxicity. The watch-and-wait (WW) strategy is an alternative approach and has been accepted as an alternative treatment in patients with rectal cancer who have had a complete clinical response (cCR) after neoadjuvant therapy. However, there are several open questions and concerns about this strategy, including the methods of patient selection, criteria to accurately determine cCR, both clinical and radiological, optimal duration of neoadjuvant treatment, optimal follow-up strategies and fu-ture possible perspectives of this approach. The aim of this review is to summarize the current available data and evidence on the WW strategy and the proven bene-fits this approach may have in patients with rectal cancer.
{"title":"\"WATCH AND WAIT POLICY – A PATHWAY TO A BETTER QUALITY OF LIFE FOR PATIENTS WITH RECTAL CANCER: A REVIEW\"","authors":"A. Blajin, Cristina Tănase, A. Popa, Vlad Filimon, F. Grama, T. Burcoș","doi":"10.31688/abmu.2022.57.2.05","DOIUrl":"https://doi.org/10.31688/abmu.2022.57.2.05","url":null,"abstract":"favourable outcomes and poten-tial advantages, this treatment approach can result in significant toxicity. The watch-and-wait (WW) strategy is an alternative approach and has been accepted as an alternative treatment in patients with rectal cancer who have had a complete clinical response (cCR) after neoadjuvant therapy. However, there are several open questions and concerns about this strategy, including the methods of patient selection, criteria to accurately determine cCR, both clinical and radiological, optimal duration of neoadjuvant treatment, optimal follow-up strategies and fu-ture possible perspectives of this approach. The aim of this review is to summarize the current available data and evidence on the WW strategy and the proven bene-fits this approach may have in patients with rectal cancer.","PeriodicalId":40057,"journal":{"name":"Archives of the Balkan Medical Union","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46930549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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