Mingtao Liu, Zhangkai J. Cheng, Mingshan Xue, Runpei Lin, Teng Zhang, Baoqing Sun
Abstract Interstitial lung diseases (ILDs), also known as diffuse lung diseases, pose a significant challenge to the respiratory health of individuals worldwide. Among these conditions, idiopathic pulmonary fibrosis (IPF) is one of the most prevalent, contributing substantially to morbidity and mortality. However, IPF is characterized by high heterogeneity, presenting a substantial obstacle to clinical program development and scientific research due to significant variations in disease progression, treatment response, and prognosis. Recent advances in metabolomics have enabled the identification of specific biochemical pathways and disease biomarkers, offering a beacon of hope for patients afflicted with various diseases. Remarkably, metabolomics has made significant strides in ILDs, particularly in IPF. Metabonomics, a branch of life science, provides an in‐depth analysis of metabolic pathways and the specific biological molecular composition of omics, obtained primarily from biological samples such as serum, plasma, pleural effusion, bronchoalveolar lavage fluid, lung surgical biopsy samples, urine, feces, sputum, and cerebrospinal fluid. In this review, we aim to provide a comprehensive overview of the application of metabolomics in ILDs, with a particular focus on IPF. By summarizing the current state of research in this field, we hope to shed light on the latest advances, challenges, and opportunities that metabolomics can provide in managing ILDs.
{"title":"The application of metabolomics toward idiopathic pulmonary fibrosis and potential metabolomic value of diverse samples in interstitial lung diseases","authors":"Mingtao Liu, Zhangkai J. Cheng, Mingshan Xue, Runpei Lin, Teng Zhang, Baoqing Sun","doi":"10.1002/prm2.12106","DOIUrl":"https://doi.org/10.1002/prm2.12106","url":null,"abstract":"Abstract Interstitial lung diseases (ILDs), also known as diffuse lung diseases, pose a significant challenge to the respiratory health of individuals worldwide. Among these conditions, idiopathic pulmonary fibrosis (IPF) is one of the most prevalent, contributing substantially to morbidity and mortality. However, IPF is characterized by high heterogeneity, presenting a substantial obstacle to clinical program development and scientific research due to significant variations in disease progression, treatment response, and prognosis. Recent advances in metabolomics have enabled the identification of specific biochemical pathways and disease biomarkers, offering a beacon of hope for patients afflicted with various diseases. Remarkably, metabolomics has made significant strides in ILDs, particularly in IPF. Metabonomics, a branch of life science, provides an in‐depth analysis of metabolic pathways and the specific biological molecular composition of omics, obtained primarily from biological samples such as serum, plasma, pleural effusion, bronchoalveolar lavage fluid, lung surgical biopsy samples, urine, feces, sputum, and cerebrospinal fluid. In this review, we aim to provide a comprehensive overview of the application of metabolomics in ILDs, with a particular focus on IPF. By summarizing the current state of research in this field, we hope to shed light on the latest advances, challenges, and opportunities that metabolomics can provide in managing ILDs.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135792679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Tian, K. Ding, Zhongchao Wang, L. Yin, Jianzhong Wu, Xia He
RAF1 (c‐raf) has been known as an important tumor‐promoter in many cancers. However, the regulatory mechanisms affecting RAF1 expressions are rarely reported. This study aimed to predict the candidate miRNAs of RAF1 gene and verify their functions in the progression of lung cancer. The expression of miR‐643 was detected by reverse transcription polymerase chain reaction (RT‐PCR). A dual‐luciferase report system was used to verify the relationship between miR‐643 and RAF1. RT‐PCR and Western blot were used to analyze the regulatory relationship between miR‐643 and RAF1. Transwell chamber, scratch, and monoclonal tests showed that miR‐643 affected the proliferation, migration, and radiosensitivity of H1299 and A549 cells by targeting the RAF1 gene. The expression of miR‐643 in lung cancer cells was lower than that in the bronchial epithelioid cells (CRL‐2741), and luciferase reporter experiment confirmed that miR‐643 targeted RAF1. MiR‐643 overexpression decreased the RAF1 expression, thereby decreasing cell migration, proliferation, and radiation resistance through the AKT/nuclear factor‐κB pathway. miR‐643 in lung cancer cells could inhibit cell proliferation, invasion, and metastasis and increase the radiosensitivity by downregulating RAF1.
{"title":"miR‐643 suppresses cell invasion and radioresistant of lung cancer through RAF1","authors":"H. Tian, K. Ding, Zhongchao Wang, L. Yin, Jianzhong Wu, Xia He","doi":"10.1002/prm2.12102","DOIUrl":"https://doi.org/10.1002/prm2.12102","url":null,"abstract":"RAF1 (c‐raf) has been known as an important tumor‐promoter in many cancers. However, the regulatory mechanisms affecting RAF1 expressions are rarely reported. This study aimed to predict the candidate miRNAs of RAF1 gene and verify their functions in the progression of lung cancer. The expression of miR‐643 was detected by reverse transcription polymerase chain reaction (RT‐PCR). A dual‐luciferase report system was used to verify the relationship between miR‐643 and RAF1. RT‐PCR and Western blot were used to analyze the regulatory relationship between miR‐643 and RAF1. Transwell chamber, scratch, and monoclonal tests showed that miR‐643 affected the proliferation, migration, and radiosensitivity of H1299 and A549 cells by targeting the RAF1 gene. The expression of miR‐643 in lung cancer cells was lower than that in the bronchial epithelioid cells (CRL‐2741), and luciferase reporter experiment confirmed that miR‐643 targeted RAF1. MiR‐643 overexpression decreased the RAF1 expression, thereby decreasing cell migration, proliferation, and radiation resistance through the AKT/nuclear factor‐κB pathway. miR‐643 in lung cancer cells could inhibit cell proliferation, invasion, and metastasis and increase the radiosensitivity by downregulating RAF1.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"113 - 120"},"PeriodicalIF":0.5,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41860154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cuproptosis is a form of regulated cell death, which is characterized by the lethal accumulation of excessive copper in cells. However, its role in colon adenocarcinoma (COAD) remains elusive. Our study aimed to decipher the biological function of cuproptosis‐related genes (CRGs) in patients with COAD. The expression data were obtained from The Cancer Genome Atlas, while the Gene Expression Omnibus database was used to verify the results. A total of eight differentially expressed CRGs were selected from patients with COAD. Subsequently, patients were stratified into three subtypes with distinct clinical and biological features. In view of the huge differences in the prognosis between subtypes A and C, we selected them for further study, including the variations in clinical progressions, oncogenic pathways, and immune cell infiltration. For the sake of better evaluation, we also established a cuproptosis index (CI) to quantify the heterogeneity of CRGs expression. Enrichment analysis showed that the high‐CI group was enriched in immune activation pathways. Meanwhile, the immunosuppressive cell infiltration and immune checkpoints were elevated in the high‐CI group. The CI we constructed had its predicting function in different clinical groups. Besides, we noticed that CRGs, especially CDKN2A, were closely related to the clinical progression in patients with COAD and immune cell infiltration in tumors. Moreover, CDKN2A could become a potential novel target for immunotherapy in the setting of COAD.
{"title":"Identification of cuproptosis‐related subtypes and tumor microenvironment characteristics in colon cancer","authors":"Hao Han, Ye Jin, Haihao Yan, Zheng Liu","doi":"10.1002/prm2.12101","DOIUrl":"https://doi.org/10.1002/prm2.12101","url":null,"abstract":"Cuproptosis is a form of regulated cell death, which is characterized by the lethal accumulation of excessive copper in cells. However, its role in colon adenocarcinoma (COAD) remains elusive. Our study aimed to decipher the biological function of cuproptosis‐related genes (CRGs) in patients with COAD. The expression data were obtained from The Cancer Genome Atlas, while the Gene Expression Omnibus database was used to verify the results. A total of eight differentially expressed CRGs were selected from patients with COAD. Subsequently, patients were stratified into three subtypes with distinct clinical and biological features. In view of the huge differences in the prognosis between subtypes A and C, we selected them for further study, including the variations in clinical progressions, oncogenic pathways, and immune cell infiltration. For the sake of better evaluation, we also established a cuproptosis index (CI) to quantify the heterogeneity of CRGs expression. Enrichment analysis showed that the high‐CI group was enriched in immune activation pathways. Meanwhile, the immunosuppressive cell infiltration and immune checkpoints were elevated in the high‐CI group. The CI we constructed had its predicting function in different clinical groups. Besides, we noticed that CRGs, especially CDKN2A, were closely related to the clinical progression in patients with COAD and immune cell infiltration in tumors. Moreover, CDKN2A could become a potential novel target for immunotherapy in the setting of COAD.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"83 - 94"},"PeriodicalIF":0.5,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49256532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinyue Wang, Ya Lu, Yuan Zhang, Jianzhong Wu, Rong Ma, Jifeng Feng
This article is aim to investigate the functional role and potential regulatory mechanisms of solute carrier family 35 member D3 (SLC35D3) in colorectal cancer. Beyond analyzing databases, western blot was used to detect and verify the expression of SLC35D3. Cell proliferation and invasion or migration ability were detected by CCK‐8, EdU, and Transwell assays. Animal experiments were conducted to verify if the biological function of SLC35D3 in vivo is consistent with that in vitro. Beyond SLC family pathway enrichment analysis, the relationship between SLC35D3 and metabolic pathway AMPK was explored using co‐immunoprecipitation and western blot. SLC35D3 is highly expressed in colorectal cancer (CRC) tissue. The overexpression or down regulation of SLC35D3 has been shown to promote or inhibit the biological functions of colorectal cancer, and similar experimental results can be verified in vivo experiments. Based on the high correlation between the SLC family and metabolic pathways, we chose the metabolic‐related AMPK pathway as the subject of our research. Co‐immunoprecipitation and protein analysis demonstrated that SLC35D3 may bind to AMPK molecules and regulate the AMPK pathway of colorectal cancer cells. Based on the above facts, SLC35D3 promotes colorectal cancer progression through regulating AMPK signaling pathway.
{"title":"Solute carrier family 35 member D3 promotes colorectal cancer progression through AMPK signaling pathway","authors":"Xinyue Wang, Ya Lu, Yuan Zhang, Jianzhong Wu, Rong Ma, Jifeng Feng","doi":"10.1002/prm2.12108","DOIUrl":"https://doi.org/10.1002/prm2.12108","url":null,"abstract":"This article is aim to investigate the functional role and potential regulatory mechanisms of solute carrier family 35 member D3 (SLC35D3) in colorectal cancer. Beyond analyzing databases, western blot was used to detect and verify the expression of SLC35D3. Cell proliferation and invasion or migration ability were detected by CCK‐8, EdU, and Transwell assays. Animal experiments were conducted to verify if the biological function of SLC35D3 in vivo is consistent with that in vitro. Beyond SLC family pathway enrichment analysis, the relationship between SLC35D3 and metabolic pathway AMPK was explored using co‐immunoprecipitation and western blot. SLC35D3 is highly expressed in colorectal cancer (CRC) tissue. The overexpression or down regulation of SLC35D3 has been shown to promote or inhibit the biological functions of colorectal cancer, and similar experimental results can be verified in vivo experiments. Based on the high correlation between the SLC family and metabolic pathways, we chose the metabolic‐related AMPK pathway as the subject of our research. Co‐immunoprecipitation and protein analysis demonstrated that SLC35D3 may bind to AMPK molecules and regulate the AMPK pathway of colorectal cancer cells. Based on the above facts, SLC35D3 promotes colorectal cancer progression through regulating AMPK signaling pathway.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"121 - 129"},"PeriodicalIF":0.5,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45996755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xu Zhang, Qingshan Hu, Lian K. Chen, P. Shao, Jian Wang
The predictive value of cell‐free DNA (cfDNA) integrity for lymph node metastasis and short‐term postoperative recurrence in patients with proximal gastric carcinoma (PGC) after curative gastrectomy remains unclear. From August 2019 to March 2021, the cfDNA integrity was assessed in 107 patients with proximal gastric carcinoma who underwent total gastrectomy (TG). The correlation between cfDNA integrity and lymph node metastasis was inspected, and the optimal cutoff value of cfDNA integrity for lymph node metastasis was determined. Meanwhile, the cfDNA integrity was identically detected in 91 proximal gastric cancer patients receiving proximal gastrectomy (PG), as well as 41 heathy individuals. The diagnostic value of cfDNA integrity for short‐term postoperative recurrence was assessed in both cohorts. The cfDNA integrity in healthy control was significantly higher than that in TG (p < .001) and PG (p = .0003) cohorts, but not statistically different between the latter two (p = .540). In the TG cohort, the cfDNA integrity was closely correlated to lymph node metastasis. Using the cutoff value of 0.873, the patients were stratified into the cfDNA integrity high and low groups; low cfDNA integrity was associated with a shorter disease free survival (DFS) both in the TG (p = .011) and PG (p = .041) cohorts. Moreover, cfDNA integrity was assessed to possess the most predictive value for postoperative recurrence by ROC curves in both cohorts. Therefore, the cfNDA integrity may correlate with lymph node metastasis in patients with PGC, and predict short‐term recurrence after curative gastrectomy.
{"title":"Cell‐free DNA integrity correlates with lymph node metastasis and predicts short‐term postoperative recurrence in patients with proximal gastric carcinoma after curative gastrectomy","authors":"Xu Zhang, Qingshan Hu, Lian K. Chen, P. Shao, Jian Wang","doi":"10.1002/prm2.12105","DOIUrl":"https://doi.org/10.1002/prm2.12105","url":null,"abstract":"The predictive value of cell‐free DNA (cfDNA) integrity for lymph node metastasis and short‐term postoperative recurrence in patients with proximal gastric carcinoma (PGC) after curative gastrectomy remains unclear. From August 2019 to March 2021, the cfDNA integrity was assessed in 107 patients with proximal gastric carcinoma who underwent total gastrectomy (TG). The correlation between cfDNA integrity and lymph node metastasis was inspected, and the optimal cutoff value of cfDNA integrity for lymph node metastasis was determined. Meanwhile, the cfDNA integrity was identically detected in 91 proximal gastric cancer patients receiving proximal gastrectomy (PG), as well as 41 heathy individuals. The diagnostic value of cfDNA integrity for short‐term postoperative recurrence was assessed in both cohorts. The cfDNA integrity in healthy control was significantly higher than that in TG (p < .001) and PG (p = .0003) cohorts, but not statistically different between the latter two (p = .540). In the TG cohort, the cfDNA integrity was closely correlated to lymph node metastasis. Using the cutoff value of 0.873, the patients were stratified into the cfDNA integrity high and low groups; low cfDNA integrity was associated with a shorter disease free survival (DFS) both in the TG (p = .011) and PG (p = .041) cohorts. Moreover, cfDNA integrity was assessed to possess the most predictive value for postoperative recurrence by ROC curves in both cohorts. Therefore, the cfNDA integrity may correlate with lymph node metastasis in patients with PGC, and predict short‐term recurrence after curative gastrectomy.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"170 - 176"},"PeriodicalIF":0.5,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44494938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Attention‐deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and/or hyperactivity–impulsivity. It is one of the most widespread neurodevelopmental conditions and has compound etiopathogenesis involving both environmental and genetic factors. Though the role of heavy metals on ADHD has been implicated but is less studied. Hair and urine are two non‐invasive methods which can substitute blood as a method of monitoring and assessing heavy metal levels. Twenty‐four cases of ADHD and their age matched healthy children (24) were taken as controls. Hair and urine samples were analyzed for lead, cadmium, nickel, and arsenic using inductively coupled plasma optical emission spectrometry (ICP‐OES) after acid digestion and extraction. The levels of heavy metals were significantly higher in cases; lead (p = .004, .003), cadmium (p = .020, <.001), and nickel (p = .016, <.001) of the hair and urine samples, respectively. Arsenic was below the limit of detection for all the samples. Hence, in conclusion, the heavy metal levels in hair and urine were significantly higher in ADHD cases as compared to their healthy counterparts.
{"title":"Hair and urine lead, cadmium, nickel, and arsenic levels in children with attention‐deficit hyperactivity disorder: A case–control study in a tertiary care hospital in eastern India","authors":"Saurav Nayak, S. Sahu, Joseph John, Suravi Patra","doi":"10.1002/prm2.12103","DOIUrl":"https://doi.org/10.1002/prm2.12103","url":null,"abstract":"Attention‐deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and/or hyperactivity–impulsivity. It is one of the most widespread neurodevelopmental conditions and has compound etiopathogenesis involving both environmental and genetic factors. Though the role of heavy metals on ADHD has been implicated but is less studied. Hair and urine are two non‐invasive methods which can substitute blood as a method of monitoring and assessing heavy metal levels. Twenty‐four cases of ADHD and their age matched healthy children (24) were taken as controls. Hair and urine samples were analyzed for lead, cadmium, nickel, and arsenic using inductively coupled plasma optical emission spectrometry (ICP‐OES) after acid digestion and extraction. The levels of heavy metals were significantly higher in cases; lead (p = .004, .003), cadmium (p = .020, <.001), and nickel (p = .016, <.001) of the hair and urine samples, respectively. Arsenic was below the limit of detection for all the samples. Hence, in conclusion, the heavy metal levels in hair and urine were significantly higher in ADHD cases as compared to their healthy counterparts.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"153 - 158"},"PeriodicalIF":0.5,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46315473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pâmella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, T. B. Scandolara, Janoário Athanázio de Souza, D. Rech, Janaína Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, D. Venturini, C. Panis
To investigate the clinical meaning of systemic nitric oxide metabolites (NOx) by comparing eutrophic and overweight/obese patients with breast cancer, considering clinical factors determinant of disease prognosis. A total of 61 women diagnosed with breast cancer were included in the study. NOx estimative was performed on plasma samples using the cadmium–copper‐Griess method. It was then categorized according to the age at diagnosis, body mass index, menopausal status, tumor histological features, molecular subtype lymph nodal invasion, and emboli presence, considering p ≤ 0.05 as significant. A significant augment was observed in NOx levels from overweight patients carrying Luminal B tumors concerning the Luminal B eutrophic ones. There was a considerable reduction in NOx levels in eutrophic postmenopausal patients compared to the overweight postmenopausal ones. Patients bearing tumor sizes between 2 and 5 cm in the eutrophic group had lower levels of NOx, concerning the overweight patients carrying tumors of the same size interval. Circulating NOx levels change significantly according to the trophic‐adipose status of breast cancer patients, and it is further affected by prognostic factors related to poor disease prognosis.
{"title":"Impact of body mass index on the circulating levels of nitric oxide metabolites in clinicopathological features from women with breast cancer","authors":"Pâmella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, T. B. Scandolara, Janoário Athanázio de Souza, D. Rech, Janaína Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, D. Venturini, C. Panis","doi":"10.1002/prm2.12104","DOIUrl":"https://doi.org/10.1002/prm2.12104","url":null,"abstract":"To investigate the clinical meaning of systemic nitric oxide metabolites (NOx) by comparing eutrophic and overweight/obese patients with breast cancer, considering clinical factors determinant of disease prognosis. A total of 61 women diagnosed with breast cancer were included in the study. NOx estimative was performed on plasma samples using the cadmium–copper‐Griess method. It was then categorized according to the age at diagnosis, body mass index, menopausal status, tumor histological features, molecular subtype lymph nodal invasion, and emboli presence, considering p ≤ 0.05 as significant. A significant augment was observed in NOx levels from overweight patients carrying Luminal B tumors concerning the Luminal B eutrophic ones. There was a considerable reduction in NOx levels in eutrophic postmenopausal patients compared to the overweight postmenopausal ones. Patients bearing tumor sizes between 2 and 5 cm in the eutrophic group had lower levels of NOx, concerning the overweight patients carrying tumors of the same size interval. Circulating NOx levels change significantly according to the trophic‐adipose status of breast cancer patients, and it is further affected by prognostic factors related to poor disease prognosis.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"62 - 68"},"PeriodicalIF":0.5,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43082759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To study the role of Body Mass Index (BMI) and serum lipid profile molecules, as well as their derivative indexes in primary pterygium patients. The patient group consisted of 110 patients with primary pterygium diagnosed in our center between January 2019 and December 2020, while the control group consisted of 144 healthy persons of similar age and sex diagnosed during the same time period. The BMI, serum lipid profile molecules and their derivative indexes of both groups were analyzed retrospectively. In the patient group, 62 patients were overweight or obesity and 104 patients with dyslipidemia. Among them, body mass index (BMI), serum triglycerides (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (Apo‐B) levels were significantly higher than those in the control group (p < 0.05). The difference in Apo‐B/ApoAl ratio, TC/LDL‐C ratio, HDL‐C/LDL‐C ratio was statistically significant (p < 0 .05), while the serum high‐density lipoprotein cholesterol (HDL‐C), apolipoprotein A1 (ApoA1) and TG/LDL‐C ratio were not significantly different in the patient group compared with control group (p > 0.05). Logistic analysis indicated that obesity, TC and HDL‐C/LDL‐C ratio are independent risk factors influencing the onset of pterygium (p < .05). BMI and serum lipid level are both significantly associated with primary pterygium. Obesity and abnormal serum lipid metabolism are independent risk factors for pterygium and play a critical role in the development of pterygium. Obesity and serum lipid level can significantly affect clinical management of pterygium. These characteristics are simple to use in clinical practice and may aid in the identification of pterygium high‐risk populations.
{"title":"The role of serum lipids and BMI in China patients with primary pterygium","authors":"Yu‐ying Sun, Wei‐peng Liang, Yanzhang Zeng, Shu-Ai Luo, Chun-Yu Huang, Yu-Ying Liu","doi":"10.1002/prm2.12097","DOIUrl":"https://doi.org/10.1002/prm2.12097","url":null,"abstract":"To study the role of Body Mass Index (BMI) and serum lipid profile molecules, as well as their derivative indexes in primary pterygium patients. The patient group consisted of 110 patients with primary pterygium diagnosed in our center between January 2019 and December 2020, while the control group consisted of 144 healthy persons of similar age and sex diagnosed during the same time period. The BMI, serum lipid profile molecules and their derivative indexes of both groups were analyzed retrospectively. In the patient group, 62 patients were overweight or obesity and 104 patients with dyslipidemia. Among them, body mass index (BMI), serum triglycerides (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (Apo‐B) levels were significantly higher than those in the control group (p < 0.05). The difference in Apo‐B/ApoAl ratio, TC/LDL‐C ratio, HDL‐C/LDL‐C ratio was statistically significant (p < 0 .05), while the serum high‐density lipoprotein cholesterol (HDL‐C), apolipoprotein A1 (ApoA1) and TG/LDL‐C ratio were not significantly different in the patient group compared with control group (p > 0.05). Logistic analysis indicated that obesity, TC and HDL‐C/LDL‐C ratio are independent risk factors influencing the onset of pterygium (p < .05). BMI and serum lipid level are both significantly associated with primary pterygium. Obesity and abnormal serum lipid metabolism are independent risk factors for pterygium and play a critical role in the development of pterygium. Obesity and serum lipid level can significantly affect clinical management of pterygium. These characteristics are simple to use in clinical practice and may aid in the identification of pterygium high‐risk populations.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"69 - 75"},"PeriodicalIF":0.5,"publicationDate":"2023-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chaomin Pan, Zhuoyu Ding, Jingping Dai, Li Yang, Yiyi Wei, Xinke Wang
Circular RNAs (circRNAs) have been implicated in cancer proliferation, migration, and invasion. Among various circRNAs, circSMARAC5 attracted our great attention. The research aimed at broadening the knowledge on circSMARCA5 and exploring its function in clinicopathology and therapy in solid tumors. The incorporated research was explored via Web of Science, PubMed, Embase, and Cochrane Library, consisting of 1048 patients. This study was calculated using STATA 12.0 and Review Manager 5.3 software. Clinicopathological characteristics and therapeutic targets were analyzed using pooled odd ratios (ORs) with 95% confidence intervals (CIs). And the ceRNA network of circSMARCA5 was constructed via Cytoscape 3.9.0. Eventually, there were eight studies included in conducting clinicopathological characteristics and four literature used in exploring therapeutic targets. Patients with low expression of circSMARCA5 were closely associated with gender (OR = 1.367, 95% CI = 1.003–1.862, p = .048) and pathological differentiation (OR = 1.627, 95% CI = 1.130–2.343, p = .009). Among these modulating axes, the most commonly microRNA was miR‐432. In the near future, circSMARCA5 may be a promising diagnostic biomarker and a new therapeutic target.
环状rna (circRNAs)与癌症的增殖、迁移和侵袭有关。在众多circrna中，circSMARAC5引起了我们的极大关注。本研究旨在拓宽对circSMARCA5的认识，探索其在实体瘤临床病理和治疗中的功能。纳入的研究通过Web of Science, PubMed, Embase和Cochrane Library进行了探索，包括1048名患者。本研究使用STATA 12.0和Review Manager 5.3软件进行计算。临床病理特征和治疗靶点分析采用合并奇数比(or)和95%可信区间(ci)。利用Cytoscape 3.9.0构建circSMARCA5的ceRNA网络。最终有8项研究被纳入临床病理特征，4篇文献被用于探索治疗靶点。circSMARCA5低表达患者与性别(OR = 1.367, 95% CI = 1.003 ~ 1.862, p = 0.048)和病理分化(OR = 1.627, 95% CI = 1.130 ~ 2.343, p = 0.009)密切相关。在这些调节轴中，最常见的microRNA是miR‐432。在不久的将来，circSMARCA5可能成为一种有前景的诊断生物标志物和新的治疗靶点。
{"title":"CircSMARCA5 functions as a potential biomarker for clinicopathology and therapy in solid tumors: A systematic review and meta‐analysis","authors":"Chaomin Pan, Zhuoyu Ding, Jingping Dai, Li Yang, Yiyi Wei, Xinke Wang","doi":"10.1002/prm2.12100","DOIUrl":"https://doi.org/10.1002/prm2.12100","url":null,"abstract":"Circular RNAs (circRNAs) have been implicated in cancer proliferation, migration, and invasion. Among various circRNAs, circSMARAC5 attracted our great attention. The research aimed at broadening the knowledge on circSMARCA5 and exploring its function in clinicopathology and therapy in solid tumors. The incorporated research was explored via Web of Science, PubMed, Embase, and Cochrane Library, consisting of 1048 patients. This study was calculated using STATA 12.0 and Review Manager 5.3 software. Clinicopathological characteristics and therapeutic targets were analyzed using pooled odd ratios (ORs) with 95% confidence intervals (CIs). And the ceRNA network of circSMARCA5 was constructed via Cytoscape 3.9.0. Eventually, there were eight studies included in conducting clinicopathological characteristics and four literature used in exploring therapeutic targets. Patients with low expression of circSMARCA5 were closely associated with gender (OR = 1.367, 95% CI = 1.003–1.862, p = .048) and pathological differentiation (OR = 1.627, 95% CI = 1.130–2.343, p = .009). Among these modulating axes, the most commonly microRNA was miR‐432. In the near future, circSMARCA5 may be a promising diagnostic biomarker and a new therapeutic target.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"144 - 152"},"PeriodicalIF":0.5,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47870861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：