Zhuo Wang, Changwen Jing, H. Cao, Siwen Liu, Jianzhong Wu, Rong Ma
Next generation sequencing (NGS) method provided a valuable tool for a comprehensive understanding of papillary thyroid carcinoma (PTC) biology. We explored the application of NGS based detection for a panel of 15 target genes mutations and analyzed the gene spectrum in PTC.
{"title":"Next generation sequencing based detection of 15 target genes mutations in papillary thyroid carcinoma","authors":"Zhuo Wang, Changwen Jing, H. Cao, Siwen Liu, Jianzhong Wu, Rong Ma","doi":"10.1002/prm2.12028","DOIUrl":"https://doi.org/10.1002/prm2.12028","url":null,"abstract":"Next generation sequencing (NGS) method provided a valuable tool for a comprehensive understanding of papillary thyroid carcinoma (PTC) biology. We explored the application of NGS based detection for a panel of 15 target genes mutations and analyzed the gene spectrum in PTC.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"90 - 93"},"PeriodicalIF":0.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47261833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 2011, Qatar launched the First National Cancer Control Program in the GCC. The National Cancer Strategy, A Path to Excellence (2011‐2016) and the companion document, Qatar National Cancer Research Strategy (2012) transformed cancer care in Qatar. Cancer outcomes are now equivalent to countries with long established National Cancer Strategies (The Lancet, 2018). Critical to the success were robust governance structures, informed and committed leadership, comprehensive involvement of all sectors including public and private providers, charities, private sector employers, academic partners and the judicious use of expert groups and subject matter experts. Major milestones have been reached in the prevention, early detection, treatment and care of cancer throughout the period the National Cancer Strategy has been in place. Achievements have included harmonized multi‐sectoral awareness, education, and myth busting campaigns aligned to a single National Awareness Calendar. A National Breast Cancer Screening Program, a National Bowel Cancer Screening Program and an opportunistically ran Cervical Cancer Screening Program have been established, supported by a dedicated Cancer Screening Call Center and a Mobile Screening Unit for those hard to reach geographical areas in Qatar. Internationally peer reviewed cancer specific teams included new and extended roles, the introduction of forefront diagnostic and treatment modalities and a patient centered approach to the organization of care have improved clinical outcomes, patient experience, and public confidence. Future development will focus on consolidating areas of significant achievement incorporating emerging evidence and new technologies. This will include evidence‐based approaches for public engagement, prevention and early detection, particularly the use of personalized approaches. As with any successful cancer program, survivorship and transition programs need to be enhanced to include chronic illness and palliative care models. Rare cancers, further development of local faculty and maturity of Qatar's high impact Cancer Research portfolio are also a focus. Qatar provides a model that illustrates how the principles of good cancer control are internationally applicable but need to be locally owned and adapted to the country and be culturally specific. It is critical to have clear leadership and governance, as well as the right people in all partner organizations to work collaboratively in achieving a common goal. We make key policy recommendations that are applicable inside and outside of Qatar. Moreover, we share the successful cancer care framework learned from the Qatar experience.
{"title":"Pathway to excellence in cancer care: learning from Qatar's experience","authors":"M. Qoronfleh","doi":"10.1002/prm2.12027","DOIUrl":"https://doi.org/10.1002/prm2.12027","url":null,"abstract":"In 2011, Qatar launched the First National Cancer Control Program in the GCC. The National Cancer Strategy, A Path to Excellence (2011‐2016) and the companion document, Qatar National Cancer Research Strategy (2012) transformed cancer care in Qatar. Cancer outcomes are now equivalent to countries with long established National Cancer Strategies (The Lancet, 2018). Critical to the success were robust governance structures, informed and committed leadership, comprehensive involvement of all sectors including public and private providers, charities, private sector employers, academic partners and the judicious use of expert groups and subject matter experts. Major milestones have been reached in the prevention, early detection, treatment and care of cancer throughout the period the National Cancer Strategy has been in place. Achievements have included harmonized multi‐sectoral awareness, education, and myth busting campaigns aligned to a single National Awareness Calendar. A National Breast Cancer Screening Program, a National Bowel Cancer Screening Program and an opportunistically ran Cervical Cancer Screening Program have been established, supported by a dedicated Cancer Screening Call Center and a Mobile Screening Unit for those hard to reach geographical areas in Qatar. Internationally peer reviewed cancer specific teams included new and extended roles, the introduction of forefront diagnostic and treatment modalities and a patient centered approach to the organization of care have improved clinical outcomes, patient experience, and public confidence. Future development will focus on consolidating areas of significant achievement incorporating emerging evidence and new technologies. This will include evidence‐based approaches for public engagement, prevention and early detection, particularly the use of personalized approaches. As with any successful cancer program, survivorship and transition programs need to be enhanced to include chronic illness and palliative care models. Rare cancers, further development of local faculty and maturity of Qatar's high impact Cancer Research portfolio are also a focus. Qatar provides a model that illustrates how the principles of good cancer control are internationally applicable but need to be locally owned and adapted to the country and be culturally specific. It is critical to have clear leadership and governance, as well as the right people in all partner organizations to work collaboratively in achieving a common goal. We make key policy recommendations that are applicable inside and outside of Qatar. Moreover, we share the successful cancer care framework learned from the Qatar experience.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"51 - 61"},"PeriodicalIF":0.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41704040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuchang Lou, D. Xu, Xiaodong Li, Yan Huan, Jun Li
To investigate psychological state of hospitalized cancer patients undergoing radiation therapy and evaluate effects of customized psychological intervention on patients' psychological state during novel Coronavirus (COVID‐19) outbreak.
{"title":"Study of psychological state of cancer patients undergoing radiation therapy during novel coronavirus outbreak and effects of nursing intervention","authors":"Shuchang Lou, D. Xu, Xiaodong Li, Yan Huan, Jun Li","doi":"10.1002/prm2.12026","DOIUrl":"https://doi.org/10.1002/prm2.12026","url":null,"abstract":"To investigate psychological state of hospitalized cancer patients undergoing radiation therapy and evaluate effects of customized psychological intervention on patients' psychological state during novel Coronavirus (COVID‐19) outbreak.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"83 - 89"},"PeriodicalIF":0.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46424875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sunil Kumar, Karthikeyan Elumalai, Kalpana Eluri, Manogaran Elumalai, Keerthana Mallu, Sivaneswari Srinivasan, C. Ranjan, Srinivasan Sivannan
Maculopapular rashes could even be an assortment of hasty characterized by grade, ruddy region on the skin that is secured with little intersecting bumps. During this case, a 55‐year‐old woman patient has developed maculopapular rashes over the body. It is a medical reaction caused because of the hydroxychloroquine, which the patient has taken for her joint pains. Simultaneous development of blisters over the forehead, scalp, upper and lower limbs, which eventually get ruptured and formed various erosions. This episode was once severe because of the repeated intake of hydroxychloroquine as a daily regimen. This hydroxychloroquine resulted in pustules that were investigated and excision biopsy of the ruptured erosion was once administered and verified as maculopapular rashes. The patient was treated with immunosuppression, systemic, and topical corticosteroids for a month for the management and treatment of the rashes.
{"title":"A case report on hydroxychloroquine induced maculopapular rashes: The immunosuppressant and corticosteroid therapy","authors":"S. Sunil Kumar, Karthikeyan Elumalai, Kalpana Eluri, Manogaran Elumalai, Keerthana Mallu, Sivaneswari Srinivasan, C. Ranjan, Srinivasan Sivannan","doi":"10.1002/prm2.12024","DOIUrl":"https://doi.org/10.1002/prm2.12024","url":null,"abstract":"Maculopapular rashes could even be an assortment of hasty characterized by grade, ruddy region on the skin that is secured with little intersecting bumps. During this case, a 55‐year‐old woman patient has developed maculopapular rashes over the body. It is a medical reaction caused because of the hydroxychloroquine, which the patient has taken for her joint pains. Simultaneous development of blisters over the forehead, scalp, upper and lower limbs, which eventually get ruptured and formed various erosions. This episode was once severe because of the repeated intake of hydroxychloroquine as a daily regimen. This hydroxychloroquine resulted in pustules that were investigated and excision biopsy of the ruptured erosion was once administered and verified as maculopapular rashes. The patient was treated with immunosuppression, systemic, and topical corticosteroids for a month for the management and treatment of the rashes.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"101 - 98"},"PeriodicalIF":0.5,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49561931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Xiaodong, Shuchang Lou, Jun Li, Ya-Xiang Wang, Dejing Xu
To explore the inner feelings and experiences of patients with precision radiotherapy for nasopharyngeal carcinoma after discharge on continue nursing needs, and to provide theoretical basis for the development of continuing nursing service for patients with nasopharyngeal carcinoma.
{"title":"Qualitative study of continuing nursing needs in patients with precision radiotherapy for nasopharyngeal carcinoma","authors":"Li Xiaodong, Shuchang Lou, Jun Li, Ya-Xiang Wang, Dejing Xu","doi":"10.1002/prm2.12006","DOIUrl":"https://doi.org/10.1002/prm2.12006","url":null,"abstract":"To explore the inner feelings and experiences of patients with precision radiotherapy for nasopharyngeal carcinoma after discharge on continue nursing needs, and to provide theoretical basis for the development of continuing nursing service for patients with nasopharyngeal carcinoma.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"62 - 67"},"PeriodicalIF":0.5,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47361837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Essâdi, Issam Lalya, M. Kaakoua, A. Arsalane, A. Elomrani, M. Khouchani, R. Belbaraka
Hepatocellular carcinoma (HCC) revealed by skull metastasis is very rare situation. This would mean that the patient was probably misdiagnosed allowing the disease to progress to an advanced stage, for which no curative treatment can be envisaged.
{"title":"Skull metastases revealing a hepatocellular carcinoma: Case report and literature review","authors":"I. Essâdi, Issam Lalya, M. Kaakoua, A. Arsalane, A. Elomrani, M. Khouchani, R. Belbaraka","doi":"10.1002/prm2.12011","DOIUrl":"https://doi.org/10.1002/prm2.12011","url":null,"abstract":"Hepatocellular carcinoma (HCC) revealed by skull metastasis is very rare situation. This would mean that the patient was probably misdiagnosed allowing the disease to progress to an advanced stage, for which no curative treatment can be envisaged.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"94 - 97"},"PeriodicalIF":0.5,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45799650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present research was to formulate chitosan‐kheri gum polyelectrolyte complex (CKGPEC) stabilized etoricoxib containing cubic nanoparticles and evaluate against various human cancer cell lines.
{"title":"Efficiency of self‐assembled etoricoxib containing polyelectrolyte complex stabilized cubic nanoparticles against human cancer cells","authors":"R. Malviya, P. Sharma, S. Dubey","doi":"10.1002/prm2.12004","DOIUrl":"https://doi.org/10.1002/prm2.12004","url":null,"abstract":"The aim of the present research was to formulate chitosan‐kheri gum polyelectrolyte complex (CKGPEC) stabilized etoricoxib containing cubic nanoparticles and evaluate against various human cancer cell lines.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"22 - 9"},"PeriodicalIF":0.5,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42785833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuxiao Zheng, Yang Gao, Yifei Cheng, Feng Qi, Qing Zou
To compare non‐extended pelvic lymph node dissection (nePLND) with extended pelvic lymph node dissection (ePLND) in outcomes and complications of patients with prostate cancer (PCa).
{"title":"Whether extended pelvic lymph node dissection should be performed in prostate cancer: The present evidence from a systematic review and meta‐analysis","authors":"Yuxiao Zheng, Yang Gao, Yifei Cheng, Feng Qi, Qing Zou","doi":"10.1002/prm2.12005","DOIUrl":"https://doi.org/10.1002/prm2.12005","url":null,"abstract":"To compare non‐extended pelvic lymph node dissection (nePLND) with extended pelvic lymph node dissection (ePLND) in outcomes and complications of patients with prostate cancer (PCa).","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"23 - 30"},"PeriodicalIF":0.5,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47262485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospect and prospect of precision medical sciences","authors":"Jifeng Feng","doi":"10.1002/prm2.12010","DOIUrl":"https://doi.org/10.1002/prm2.12010","url":null,"abstract":"","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44730457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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