Quan Jing, Jijia Gu, Ziwei Li, Xuan Sun, Qiuyang Chen, Shanhong Li, Weizhang Xu
Prostate cancer is a common malignant tumor at present, and there are still adverse reactions after radical prostatectomy. As many as 30% of patients complain of urinary incontinence (UI). This review begins with the pathophysiological basis of post‐prostatectomy urinary incontinence (PPUI) and describes the maintenance of normal urine control function, anatomical changes, and urodynamic maintenance of PPUI. Then, we talk about the various influencing factors of UI, for example, the differences caused by the basic condition of the patient, the length of the membranous urinary tract, the level of prostate‐specific antigen before operation, the method and technique of operation, and so on. Last, we introduce all kinds of treatments of PPUI in detail. It includes noninvasive conservative treatment, traditional surgical treatment, emerging stem cell therapy treatment, and postoperative psychotherapy of PPUI. The present situation of the treatment of UI after prostatectomy is summarized, and the prospect of the technology is put forward.
{"title":"Prostatectomy postoperative urinary incontinence: From origin to treatment","authors":"Quan Jing, Jijia Gu, Ziwei Li, Xuan Sun, Qiuyang Chen, Shanhong Li, Weizhang Xu","doi":"10.1002/prm2.12121","DOIUrl":"https://doi.org/10.1002/prm2.12121","url":null,"abstract":"Prostate cancer is a common malignant tumor at present, and there are still adverse reactions after radical prostatectomy. As many as 30% of patients complain of urinary incontinence (UI). This review begins with the pathophysiological basis of post‐prostatectomy urinary incontinence (PPUI) and describes the maintenance of normal urine control function, anatomical changes, and urodynamic maintenance of PPUI. Then, we talk about the various influencing factors of UI, for example, the differences caused by the basic condition of the patient, the length of the membranous urinary tract, the level of prostate‐specific antigen before operation, the method and technique of operation, and so on. Last, we introduce all kinds of treatments of PPUI in detail. It includes noninvasive conservative treatment, traditional surgical treatment, emerging stem cell therapy treatment, and postoperative psychotherapy of PPUI. The present situation of the treatment of UI after prostatectomy is summarized, and the prospect of the technology is put forward.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"384 3","pages":"224 - 232"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is a fatal autosomal recessive disorder that often occurs in infants and young children, and rarely reported in adults. In this paper, we retrospectively reported an elderly woman with recurrent fever, this patient was diagnosed with familial hemophagocytic syndrome by perfecting relevant examinations after admission, improvement was observed after standard chemotherapy. In order to further determine the possible underlying genetic causes, we performed gene mutation analysis and found that there were compound heterozygous missense mutations c.133G > A (p.Gly45Arg) and c.147C > A (p.Asp49Glu) on the exon2 of PRF1 gene in this patient. According to the clinical manifestations and test results, the patient was further confirmed as late‐onset FHL‐2 type. Without a suitable donor, the patient did not perform hematopoietic stem cell transplantation. Therefore, the relevant genetic examination should be performed as early as possible in young patients with a family history of hemophagocytic lymphohistiocytosis, and it can provide a basis for etiological diagnosis and radical treatment by hematopoietic stem cell transplantation. It is essential to further study the molecular mechanism and clinical application value for late‐onset elderly FHL patients without appropriate donors.
{"title":"A case report of adult type 2 familial hemophagocytic lymphohistiocytosis","authors":"Ding‐Ding Li, None Hong‐Zhang, Hao‐Jin Zhu, Sheng‐Mei Zhang, Shu‐Jun Jiang, Yan‐Liang Zhang","doi":"10.1002/prm2.12120","DOIUrl":"https://doi.org/10.1002/prm2.12120","url":null,"abstract":"Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is a fatal autosomal recessive disorder that often occurs in infants and young children, and rarely reported in adults. In this paper, we retrospectively reported an elderly woman with recurrent fever, this patient was diagnosed with familial hemophagocytic syndrome by perfecting relevant examinations after admission, improvement was observed after standard chemotherapy. In order to further determine the possible underlying genetic causes, we performed gene mutation analysis and found that there were compound heterozygous missense mutations c.133G > A (p.Gly45Arg) and c.147C > A (p.Asp49Glu) on the exon2 of PRF1 gene in this patient. According to the clinical manifestations and test results, the patient was further confirmed as late‐onset FHL‐2 type. Without a suitable donor, the patient did not perform hematopoietic stem cell transplantation. Therefore, the relevant genetic examination should be performed as early as possible in young patients with a family history of hemophagocytic lymphohistiocytosis, and it can provide a basis for etiological diagnosis and radical treatment by hematopoietic stem cell transplantation. It is essential to further study the molecular mechanism and clinical application value for late‐onset elderly FHL patients without appropriate donors.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"242 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135974125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract This study aimed to investigate the potential of inflammatory markers, including platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), and C‐reactive protein‐to‐lymphocyte ratio (CLR), in identifying sacroiliitis. Present retrospective study was conducted at the Abant Izzet Baysal University Hospital, including patients diagnosed with sacroiliitis between August 2020 and March 2023. Control subjects with normal sacroiliac joints were also included. Sacroiliitis patients were further categorized into active and chronic sacroiliitis groups. Demographic data and laboratory characteristics, such as erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), and various blood parameters, were recorded. Inflammatory markers were calculated, including PLR, NLR, LMR, and CLR. Statistical analyses were performed to compare the study groups and evaluate the diagnostic performance of these markers. A total of 226 subjects, including 132 sacroiliitis patients and 94 control subjects, were included in the study. Serum CRP levels were significantly higher in sacroiliitis patients compared to the control group. NLR, PLR, and CLR values were elevated in sacroiliitis patients, while LMR was decreased. There were significant correlations between these markers and established inflammatory markers. Receiver operating characteristic (ROC) analysis demonstrated moderate diagnostic performance for NLR, PLR, LMR and CLR in detecting sacroiliitis. Inflammatory markers, specifically NLR, PLR, LMR and CLR, showed significant differences between sacroiliitis patients and the control group. In addition PLR is useful in distinguishing active and chronic sacroiliitis. These markers, in conjunction with established inflammatory markers, may serve as supportive diagnostic tools for sacroiliitis.
{"title":"Which inflammatory marker might be the best indicator for sacroiliitis?","authors":"Melike Elif Kalfaoglu, Zeliha Cosgun","doi":"10.1002/prm2.12118","DOIUrl":"https://doi.org/10.1002/prm2.12118","url":null,"abstract":"Abstract This study aimed to investigate the potential of inflammatory markers, including platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), and C‐reactive protein‐to‐lymphocyte ratio (CLR), in identifying sacroiliitis. Present retrospective study was conducted at the Abant Izzet Baysal University Hospital, including patients diagnosed with sacroiliitis between August 2020 and March 2023. Control subjects with normal sacroiliac joints were also included. Sacroiliitis patients were further categorized into active and chronic sacroiliitis groups. Demographic data and laboratory characteristics, such as erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), and various blood parameters, were recorded. Inflammatory markers were calculated, including PLR, NLR, LMR, and CLR. Statistical analyses were performed to compare the study groups and evaluate the diagnostic performance of these markers. A total of 226 subjects, including 132 sacroiliitis patients and 94 control subjects, were included in the study. Serum CRP levels were significantly higher in sacroiliitis patients compared to the control group. NLR, PLR, and CLR values were elevated in sacroiliitis patients, while LMR was decreased. There were significant correlations between these markers and established inflammatory markers. Receiver operating characteristic (ROC) analysis demonstrated moderate diagnostic performance for NLR, PLR, LMR and CLR in detecting sacroiliitis. Inflammatory markers, specifically NLR, PLR, LMR and CLR, showed significant differences between sacroiliitis patients and the control group. In addition PLR is useful in distinguishing active and chronic sacroiliitis. These markers, in conjunction with established inflammatory markers, may serve as supportive diagnostic tools for sacroiliitis.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136359379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Bladder cancer (BC) accounts for roughly 3% of all cancer diagnoses in developed countries. The prognosis could be improved significantly if the cancer is detected and classified as either muscle‐invasive bladder cancer (MIBC) or non‐muscle‐invasive bladder cancer (NMIBC) as promptly as possible. A potential ray of hope for the treatment of BC has emerged with the rapid development of nanomedicine and microRNAs (miRNAs), which promise to have fewer adverse effects, more tumor‐inhibitory effects, and decreased drug resistance. The complex interplay between hereditary and environmental variables is the root cause of this malignancy. Gene expression can be regulated by miRNAs, which are small, non‐coding RNAs that can either prevent the translation of protein‐coding genes or cleave RNA transcripts at certain locations. Elevated genomics has enabled a more extensive investigation of miRNAs whose expression is considerably different in BC patients compared to healthy volunteers or between BC tumor tissues and peripheral tissues. miRNAs have recently been discovered to be important regulators of BC cell carcinogenicity. Inaccurate diagnoses and prolonged treatment delays are more likely to occur due to the current diagnostic process such as lack of sensitivity and specificity and poor image quality. Patients now have access to a plethora of treatment options, including but not limited to surgery, chemotherapy, immunotherapy, gene therapy, and other innovative medicines, and in some cases, combination therapies. BC is one of the deadliest and most disabling malignancies affecting the urinary tract. Cancer of the urinary bladder has a terrible propensity for being fatal. BC is an intricate illness whose development can be affected by multiple parameters. Standard treatments for BC increase prognosis and survival, although recurrence is a major concern for patients. miRNAs are naturally occurring, small RNA molecules that have been linked to cancer through their expression being dysregulated. miRNAs modulate many cellular activities including proliferation, migration, differentiation, and apoptosis. MiRNA dysregulation is recognized in BC, and miRNAs are used as diagnostic and prognostic indicators. However, this manuscript discusses the recent progress made in nanomedicine and the function of miRNAs in the pathogenesis and targeted therapy of BC.
{"title":"<scp>miRNAs</scp> involvement in the etiology and targeted therapy of bladder cancer: Interaction between signaling pathway","authors":"Rishav Sharma, Rishabha Malviya","doi":"10.1002/prm2.12119","DOIUrl":"https://doi.org/10.1002/prm2.12119","url":null,"abstract":"Abstract Bladder cancer (BC) accounts for roughly 3% of all cancer diagnoses in developed countries. The prognosis could be improved significantly if the cancer is detected and classified as either muscle‐invasive bladder cancer (MIBC) or non‐muscle‐invasive bladder cancer (NMIBC) as promptly as possible. A potential ray of hope for the treatment of BC has emerged with the rapid development of nanomedicine and microRNAs (miRNAs), which promise to have fewer adverse effects, more tumor‐inhibitory effects, and decreased drug resistance. The complex interplay between hereditary and environmental variables is the root cause of this malignancy. Gene expression can be regulated by miRNAs, which are small, non‐coding RNAs that can either prevent the translation of protein‐coding genes or cleave RNA transcripts at certain locations. Elevated genomics has enabled a more extensive investigation of miRNAs whose expression is considerably different in BC patients compared to healthy volunteers or between BC tumor tissues and peripheral tissues. miRNAs have recently been discovered to be important regulators of BC cell carcinogenicity. Inaccurate diagnoses and prolonged treatment delays are more likely to occur due to the current diagnostic process such as lack of sensitivity and specificity and poor image quality. Patients now have access to a plethora of treatment options, including but not limited to surgery, chemotherapy, immunotherapy, gene therapy, and other innovative medicines, and in some cases, combination therapies. BC is one of the deadliest and most disabling malignancies affecting the urinary tract. Cancer of the urinary bladder has a terrible propensity for being fatal. BC is an intricate illness whose development can be affected by multiple parameters. Standard treatments for BC increase prognosis and survival, although recurrence is a major concern for patients. miRNAs are naturally occurring, small RNA molecules that have been linked to cancer through their expression being dysregulated. miRNAs modulate many cellular activities including proliferation, migration, differentiation, and apoptosis. MiRNA dysregulation is recognized in BC, and miRNAs are used as diagnostic and prognostic indicators. However, this manuscript discusses the recent progress made in nanomedicine and the function of miRNAs in the pathogenesis and targeted therapy of BC.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Ye, Jiaqi Du, Dagui Chen, Lijuan Xiu, Xuan Liu, Dazhi Sun, Xiaowei Wang
Abstract Colitis‐associated bowel cancer (CAC) is one of the most common malignancies associated with inflammation. The aim of this study was to observe a new herbal formula “Xiaotan Sanjie Fang” (XTSJF) derived from the addition and subtraction theory of traditional medicine as an alternative to CAC treatment by “Daotan Decoction” and “Xiaojianzhong Decoction”, which are famous traditional Chinese medicine prescriptions for the treatment of inflammatory diseases of the digestive tract. We constructed a DMH/DSS inflammation‐associated colorectal cancer rat model and treated CAC rats with sulfasalazine and different doses of XTSJF. The results showed that the body weight of rats treated with different doses of XTSJF increased, which was still lower than that of normal rats; AFC decreased significantly compared with the model group and the positive control group, and the final dose was superior to the low dose; histological observation revealed that it could maintain the normal structure of colon tissue, while it could inhibit the secretion of VEGF, COX2, and AQP1 and the expression of pro‐inflammatory cytokines IL‐6, IL‐1β, and TNF‐α, promote the expression of caspase‐3 and BAX and inhibit the expression of Bcl‐2. Taken together, these data suggest that XTSJF can inhibit COX‐2/VEGF expression to prevent the development of inflammation‐associated colorectal cancer.
{"title":"Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting <scp>COX</scp>‐2/<scp>VEGF</scp> expression cancer","authors":"Min Ye, Jiaqi Du, Dagui Chen, Lijuan Xiu, Xuan Liu, Dazhi Sun, Xiaowei Wang","doi":"10.1002/prm2.12116","DOIUrl":"https://doi.org/10.1002/prm2.12116","url":null,"abstract":"Abstract Colitis‐associated bowel cancer (CAC) is one of the most common malignancies associated with inflammation. The aim of this study was to observe a new herbal formula “Xiaotan Sanjie Fang” (XTSJF) derived from the addition and subtraction theory of traditional medicine as an alternative to CAC treatment by “Daotan Decoction” and “Xiaojianzhong Decoction”, which are famous traditional Chinese medicine prescriptions for the treatment of inflammatory diseases of the digestive tract. We constructed a DMH/DSS inflammation‐associated colorectal cancer rat model and treated CAC rats with sulfasalazine and different doses of XTSJF. The results showed that the body weight of rats treated with different doses of XTSJF increased, which was still lower than that of normal rats; AFC decreased significantly compared with the model group and the positive control group, and the final dose was superior to the low dose; histological observation revealed that it could maintain the normal structure of colon tissue, while it could inhibit the secretion of VEGF, COX2, and AQP1 and the expression of pro‐inflammatory cytokines IL‐6, IL‐1β, and TNF‐α, promote the expression of caspase‐3 and BAX and inhibit the expression of Bcl‐2. Taken together, these data suggest that XTSJF can inhibit COX‐2/VEGF expression to prevent the development of inflammation‐associated colorectal cancer.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135206523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiuping Zhang, Li Lin, Meiying Zou, Jing Jiang, Yaqin Wu
To investigate the effect of evidence‐based nursing on breast cancer patients during postoperative radiotherapy care. In the sample selection, 100 breast cancer patients who received postoperative radiotherapy in our hospital from January 2020 to January 2022 were selected to participate in this study. Patients in the control group received routine nursing program, while patients in the study group applied the intervention of evidence‐based nursing philosophy, the nursing effect was compared between the two groups. According to the nursing effect of the two groups, there was a significant difference under the intervention of different protocols. The patients in the study group showed significant improvements in Self‐Rating Depression Scale and Self‐Rating Anxiety Scale scores under the evidence‐based care intervention, superior to those of the control group, and the difference was significant (p < .05); from the scores of shoulder and elbow functions, the patients in the study group showed more significant intervention effects, superior to that of the control group, and the difference was significant (p < .05); from the skin injury degree of the two groups, the skin injury grade of the study group was significantly superior to that of the control group, with a significant difference (p < .05); from the patient satisfaction indexes, after the evidence‐based nursing intervention, the satisfaction indexes of the study group and the control group were 98% and 82%, respectively, and the difference was significant (p < .05). In the current nursing intervention of postoperative radiotherapy for breast cancer patients, evidence‐based nursing models can effectively relieve the adverse emotions of patients, improve patients' shoulder joint and elbow joint function, reduce the skin damage, and improve patient satisfaction, which has an important clinical spread value.
{"title":"Application of evidence‐based nursing in postoperative radiotherapy care for breast cancer","authors":"Qiuping Zhang, Li Lin, Meiying Zou, Jing Jiang, Yaqin Wu","doi":"10.1002/prm2.12117","DOIUrl":"https://doi.org/10.1002/prm2.12117","url":null,"abstract":"To investigate the effect of evidence‐based nursing on breast cancer patients during postoperative radiotherapy care. In the sample selection, 100 breast cancer patients who received postoperative radiotherapy in our hospital from January 2020 to January 2022 were selected to participate in this study. Patients in the control group received routine nursing program, while patients in the study group applied the intervention of evidence‐based nursing philosophy, the nursing effect was compared between the two groups. According to the nursing effect of the two groups, there was a significant difference under the intervention of different protocols. The patients in the study group showed significant improvements in Self‐Rating Depression Scale and Self‐Rating Anxiety Scale scores under the evidence‐based care intervention, superior to those of the control group, and the difference was significant (p < .05); from the scores of shoulder and elbow functions, the patients in the study group showed more significant intervention effects, superior to that of the control group, and the difference was significant (p < .05); from the skin injury degree of the two groups, the skin injury grade of the study group was significantly superior to that of the control group, with a significant difference (p < .05); from the patient satisfaction indexes, after the evidence‐based nursing intervention, the satisfaction indexes of the study group and the control group were 98% and 82%, respectively, and the difference was significant (p < .05). In the current nursing intervention of postoperative radiotherapy for breast cancer patients, evidence‐based nursing models can effectively relieve the adverse emotions of patients, improve patients' shoulder joint and elbow joint function, reduce the skin damage, and improve patient satisfaction, which has an important clinical spread value.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"177 - 181"},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44521445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Gao, Chuanzhen Bian, Kang Gu, Haiyan Wang, Shan Zhuang, Xiaowen Tang, Yunian Zhao
Abstract This study provided systematic insights into the patterns of triple‐negative breast cancer (TNBC) distant metastases (DM) and investigated the related elements for the prognosis prediction of TNBC patients based on a large sample. We reviewed eligible patients with TNBC from the SEER database between 2010 and 2015. We also analyzed differences in baseline characteristics among patients with diverse modes of metastasis. Meanwhile, we calculated proportional mortality ratio and expression of proportional trends in different patients. Subsequently, KM analysis was employed to investigate the survival outcomes. Finally, the predictive and prognostic factors of DM were identified. In this study, we included 24 822 TNBC patients, including 1026 DM patients and 23 796 non‐DM patients. At the time of initial diagnosis, 4.1% of patients had DM, and 36.9% had multiple metastases. According to the study, the most common sites of metastasis in DM patients were bone (251 cases) and lung (244 cases), while the least common organ of metastasis was brain (37 cases). Age, grade, T, N, and marital status were deemed as risk elements of DM. T stage, insurance status, marital status, surgery treatment, chemotherapy, number of metastatic sites, and metastatic sites also significantly affected the diagnosis of DM. Our study showed that the most common site of metastasis in TNBC patients with DM was bone and the least common site was brain. Different modes of metastasis have different survival and prognostic characteristics. Thus, our research may have important implications for the clinical practice of TNBC patients in the future.
{"title":"Patterns of distant metastases in patients with triple‐negative breast cancer—A population‐based study","authors":"Yang Gao, Chuanzhen Bian, Kang Gu, Haiyan Wang, Shan Zhuang, Xiaowen Tang, Yunian Zhao","doi":"10.1002/prm2.12107","DOIUrl":"https://doi.org/10.1002/prm2.12107","url":null,"abstract":"Abstract This study provided systematic insights into the patterns of triple‐negative breast cancer (TNBC) distant metastases (DM) and investigated the related elements for the prognosis prediction of TNBC patients based on a large sample. We reviewed eligible patients with TNBC from the SEER database between 2010 and 2015. We also analyzed differences in baseline characteristics among patients with diverse modes of metastasis. Meanwhile, we calculated proportional mortality ratio and expression of proportional trends in different patients. Subsequently, KM analysis was employed to investigate the survival outcomes. Finally, the predictive and prognostic factors of DM were identified. In this study, we included 24 822 TNBC patients, including 1026 DM patients and 23 796 non‐DM patients. At the time of initial diagnosis, 4.1% of patients had DM, and 36.9% had multiple metastases. According to the study, the most common sites of metastasis in DM patients were bone (251 cases) and lung (244 cases), while the least common organ of metastasis was brain (37 cases). Age, grade, T, N, and marital status were deemed as risk elements of DM. T stage, insurance status, marital status, surgery treatment, chemotherapy, number of metastatic sites, and metastatic sites also significantly affected the diagnosis of DM. Our study showed that the most common site of metastasis in TNBC patients with DM was bone and the least common site was brain. Different modes of metastasis have different survival and prognostic characteristics. Thus, our research may have important implications for the clinical practice of TNBC patients in the future.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single‐tube two‐pronged approach using both cell‐free DNA and RNA for multimodal biomarker tests at the time of biopsy","authors":"S. Lin, H. Lai, Chen Yeh","doi":"10.1002/prm2.12115","DOIUrl":"https://doi.org/10.1002/prm2.12115","url":null,"abstract":"","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42606000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Duman, Eray Erge, Burcin Meryem Atak Tel, Cagri Kiziltunc, G. Aktas
{"title":"De Ritis score as an inflammatory marker in Hashimoto's thyroiditis","authors":"T. Duman, Eray Erge, Burcin Meryem Atak Tel, Cagri Kiziltunc, G. Aktas","doi":"10.1002/prm2.12114","DOIUrl":"https://doi.org/10.1002/prm2.12114","url":null,"abstract":"","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49430063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Mary, Srinivasan Sivannan, Karthikeyan Elumalai, Helan Williams, Vijayan Abhilash, Sivaneswari Srinivasan, B. Cheriyan, Mahalakshmi Devaraji
The study's primary aim was to examine how a stroke affects health‐related quality of life (QoL), and a secondary aim was to link this event with clinical and sociodemographic factors. Stroke patients were included in the study. First, 94 patients underwent a quantitative analytical cross‐sectional study 3 months after starting medication. Using multivariable linear regression, relationships between the severity of the initial stroke were investigated. From the raw data, we determined the standard deviation and the standard error of the mean. If the p‐value is less than .05, it is considered significant, and if it's less than .0001, it is extremely significant. The majority 94.68% were diagnosed with ischemic stroke, and only 5.32% were hemorrhagic stroke; 56.32% of the patients were male, and 43.68% were female; one‐third of the patients were found to be smokers and alcoholics; 9.57% of the patients had a family history of stroke; and 9.5% of the patients had a history of stroke. Patients with stroke comorbidities, including high blood pressure 88.19%, diabetes 51.06%, high cholesterol 22.34%, coronary artery disease 23.40%, smoking 30.85%, and alcoholism 24.46%. Significant dangers were posed by both hypertension and smoking. There was a statistically significant improvement in quality of life between the two groups, with the intervention group showing a mean difference of 112. The p‐value for this improvement was less than .0001. The quality of life of stroke survivors can be improved through direct screening, monitoring of the patient, planned therapy, and management.
{"title":"An assessment of quality of life among stroke survivors at tertiary care teaching hospital in South India: A randomized clinical trial","authors":"P. Mary, Srinivasan Sivannan, Karthikeyan Elumalai, Helan Williams, Vijayan Abhilash, Sivaneswari Srinivasan, B. Cheriyan, Mahalakshmi Devaraji","doi":"10.1002/prm2.12113","DOIUrl":"https://doi.org/10.1002/prm2.12113","url":null,"abstract":"The study's primary aim was to examine how a stroke affects health‐related quality of life (QoL), and a secondary aim was to link this event with clinical and sociodemographic factors. Stroke patients were included in the study. First, 94 patients underwent a quantitative analytical cross‐sectional study 3 months after starting medication. Using multivariable linear regression, relationships between the severity of the initial stroke were investigated. From the raw data, we determined the standard deviation and the standard error of the mean. If the p‐value is less than .05, it is considered significant, and if it's less than .0001, it is extremely significant. The majority 94.68% were diagnosed with ischemic stroke, and only 5.32% were hemorrhagic stroke; 56.32% of the patients were male, and 43.68% were female; one‐third of the patients were found to be smokers and alcoholics; 9.57% of the patients had a family history of stroke; and 9.5% of the patients had a history of stroke. Patients with stroke comorbidities, including high blood pressure 88.19%, diabetes 51.06%, high cholesterol 22.34%, coronary artery disease 23.40%, smoking 30.85%, and alcoholism 24.46%. Significant dangers were posed by both hypertension and smoking. There was a statistically significant improvement in quality of life between the two groups, with the intervention group showing a mean difference of 112. The p‐value for this improvement was less than .0001. The quality of life of stroke survivors can be improved through direct screening, monitoring of the patient, planned therapy, and management.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"196 - 201"},"PeriodicalIF":0.5,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49665701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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