Xiyi Wei, Jinyong Tian, Jianyu Diao, Gulinuer Aibibula, Maimaitijiang Dawuti, Yiliyasi Tuerxun, Mhtaer Wubuli, Yujie Zhang, N. Song, Jie Yang
Hydatid cyst (HC) is a zoonotic parasitic disease in agricultural and pastoral areas while renal involvement without liver and lung hydatid is both less common in clinical practice and rarely described in literature. We present a case of a 40‐year‐old male from Xinjiang who complained of flank pain in the right with oliguria. Robot‐assisted laparoscopic exploration, conversion to open laparotomy and excision of internal capsule in right kidney were performed. Finally, a typical renal HC was diagnosed after complementary examinations. Isolated renal HC is very rare and can be misinterpreted as a cystic renal cell carcinoma pre‐operatively.
{"title":"Renal hydatid cyst mimicked cystic renal cell carcinoma: A case report","authors":"Xiyi Wei, Jinyong Tian, Jianyu Diao, Gulinuer Aibibula, Maimaitijiang Dawuti, Yiliyasi Tuerxun, Mhtaer Wubuli, Yujie Zhang, N. Song, Jie Yang","doi":"10.1002/prm2.12062","DOIUrl":"https://doi.org/10.1002/prm2.12062","url":null,"abstract":"Hydatid cyst (HC) is a zoonotic parasitic disease in agricultural and pastoral areas while renal involvement without liver and lung hydatid is both less common in clinical practice and rarely described in literature. We present a case of a 40‐year‐old male from Xinjiang who complained of flank pain in the right with oliguria. Robot‐assisted laparoscopic exploration, conversion to open laparotomy and excision of internal capsule in right kidney were performed. Finally, a typical renal HC was diagnosed after complementary examinations. Isolated renal HC is very rare and can be misinterpreted as a cystic renal cell carcinoma pre‐operatively.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"35 - 38"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41888260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zicheng Xu, Jianxing Wang, Hongzhou Cai, Feng Qi, Qing Zou
The purpose of this study is to evaluate the risk of developing a second primary malignancy (SPM) in oral tongue cancer (OTC) patients, and identify the characteristics and survival outcomes of OTC patients with an SPM. Patients with first primary OTC were identified from the Surveillance, Epidemiology, and End Result (SEER) database, and were further divided into the only one primary malignancy (OOPM) group and SPM group. Baseline characteristics and survival outcomes between patients in two groups were compared. Furthermore, a Fine and Gray subdistribution hazard model was utilized to investigate the cumulative risk of developing an SPM in OTC patients. Then, a multivariate competing‐risk model was performed to explore risk predictors. Patients in the SPM group had older age and lower tumor stage than those in the OOPM group. Moreover, the proportion of receiving surgery in the SPM group was significantly higher than that in the OOPM group. Lung was the most common site of SPMs in whole patients. In male patients, the second common site of SPMs was prostate, while in female patients, it was female breast. OTC patients with an SPM of lung and bronchus had the worst overall survival. Finally, older age, male sex, primary site of ventral surface and anterior 2/3 of tongue, localized diseases, and the administration of surgery were considered as risk predictors of developing an SPM in OTC patients. OTC survivors had high risk of developing an SPM, and subsequent malignancy was an important COD. Careful monitoring is warranted in OTC survivors due to the high SPM‐specific mortality.
{"title":"Second primary malignancies in oral tongue cancer: A Surveillance, Epidemiology, and End Result–based analysis evaluating the basic characteristics, survival outcomes, and predictive factors","authors":"Zicheng Xu, Jianxing Wang, Hongzhou Cai, Feng Qi, Qing Zou","doi":"10.1002/prm2.12056","DOIUrl":"https://doi.org/10.1002/prm2.12056","url":null,"abstract":"The purpose of this study is to evaluate the risk of developing a second primary malignancy (SPM) in oral tongue cancer (OTC) patients, and identify the characteristics and survival outcomes of OTC patients with an SPM. Patients with first primary OTC were identified from the Surveillance, Epidemiology, and End Result (SEER) database, and were further divided into the only one primary malignancy (OOPM) group and SPM group. Baseline characteristics and survival outcomes between patients in two groups were compared. Furthermore, a Fine and Gray subdistribution hazard model was utilized to investigate the cumulative risk of developing an SPM in OTC patients. Then, a multivariate competing‐risk model was performed to explore risk predictors. Patients in the SPM group had older age and lower tumor stage than those in the OOPM group. Moreover, the proportion of receiving surgery in the SPM group was significantly higher than that in the OOPM group. Lung was the most common site of SPMs in whole patients. In male patients, the second common site of SPMs was prostate, while in female patients, it was female breast. OTC patients with an SPM of lung and bronchus had the worst overall survival. Finally, older age, male sex, primary site of ventral surface and anterior 2/3 of tongue, localized diseases, and the administration of surgery were considered as risk predictors of developing an SPM in OTC patients. OTC survivors had high risk of developing an SPM, and subsequent malignancy was an important COD. Careful monitoring is warranted in OTC survivors due to the high SPM‐specific mortality.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"13 - 4"},"PeriodicalIF":0.5,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45869603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.21203/rs.3.rs-1097537/v1
Yang Gao, K. Gu, Chuanzhen Bian, Ping Yan, Yun-shan Zhao
Background Currently, the prognosis of triple-negative breast cancer (TNBC) patients remained poor mainly due to resistance, recurrence, metastasis and severe side effects. The study provided systematic insights into the patterns of TNBC distant metastases (DM), as well as investigating the related elements for the prognosis prediction of TNBC patients on the basis of on large sample. Methods We screened eligible patients with triple-negative breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. Besides, we analyzed differences in baseline characteristics among patients with diverse modes of metastasis. Meanwhile, we calculated proportional mortality ratio (PMR) and the expression of proportional trends in different patients. Subsequently, Kaplan-Meier (KM) analysis was employed to investigate the survival outcomes. Finally, the predictive and prognostic factors of DM were identified. Results In this study, we included 24,822 TNBC patients, including 1,026 DM patients and 23,796 non-DM patients. At the time of initial diagnosis, 4.1% of patients had DM, and 36.9% had multiple metastases. According to the study, the most common sites of metastasis in DM patients were bone (251 cases) and lung (244 cases), while the least common organ of metastasis was brain (37 cases). Age, tumor grade, T, N and marital status were deemed as risk elements of DM. T stage, insurance status, marital status, surgery treatment, chemotherapy, number of metastatic sites and metastatic sites also effect the diagnosis of DM significantly. Conclusion Our study showed that the most common site of metastasis in TNBC patients with DM was bone and the least common site was brain. Different modes of metastasis have different survival and prognostic characteristics. Thus, our research may have important implications for the clinical practice of TNBC patients in the future.
{"title":"Patterns of Distant Metastases in Patients With Triple-Negative Breast Cancer –– A Population-Based Study","authors":"Yang Gao, K. Gu, Chuanzhen Bian, Ping Yan, Yun-shan Zhao","doi":"10.21203/rs.3.rs-1097537/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-1097537/v1","url":null,"abstract":"\u0000 Background\u0000\u0000Currently, the prognosis of triple-negative breast cancer (TNBC) patients remained poor mainly due to resistance, recurrence, metastasis and severe side effects. The study provided systematic insights into the patterns of TNBC distant metastases (DM), as well as investigating the related elements for the prognosis prediction of TNBC patients on the basis of on large sample.\u0000Methods\u0000\u0000We screened eligible patients with triple-negative breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. Besides, we analyzed differences in baseline characteristics among patients with diverse modes of metastasis. Meanwhile, we calculated proportional mortality ratio (PMR) and the expression of proportional trends in different patients. Subsequently, Kaplan-Meier (KM) analysis was employed to investigate the survival outcomes. Finally, the predictive and prognostic factors of DM were identified.\u0000Results\u0000\u0000In this study, we included 24,822 TNBC patients, including 1,026 DM patients and 23,796 non-DM patients. At the time of initial diagnosis, 4.1% of patients had DM, and 36.9% had multiple metastases. According to the study, the most common sites of metastasis in DM patients were bone (251 cases) and lung (244 cases), while the least common organ of metastasis was brain (37 cases). Age, tumor grade, T, N and marital status were deemed as risk elements of DM. T stage, insurance status, marital status, surgery treatment, chemotherapy, number of metastatic sites and metastatic sites also effect the diagnosis of DM significantly.\u0000Conclusion\u0000\u0000Our study showed that the most common site of metastasis in TNBC patients with DM was bone and the least common site was brain. Different modes of metastasis have different survival and prognostic characteristics. Thus, our research may have important implications for the clinical practice of TNBC patients in the future.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67951214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanmugapriyan Sivaraman, Gokul Gomathi Radhakrishnan, R. Manogaran, B. Cheriyan
Linezolid therapy is known to cause black hairy tongue, which is benign and reversible. A 65‐year‐old diabetic male was on treatment for diabetic nonhealing ulcer involving right foot and sole for the past 6 months. Linezolid was started based on the culture and sensitivity of the pus. Patient developed thrombocytopenia and black hairy tongue after 7 days of the drug regimen. Drug was stopped and patient was advised to maintain good oral hygiene, soft tooth brush for brushing and regular mouth wash with lukewarm water. The black hairy tongue completely resolved within a week after stopping the drug. The taste and foreign body sensation on the tongue while swallowing were also improved. The diabetic wound was treated by starting vancomycin after giving a surgical wound debridement by a general surgeon.
{"title":"An uncommon side effect of linezolid: Black hairy tongue","authors":"Shanmugapriyan Sivaraman, Gokul Gomathi Radhakrishnan, R. Manogaran, B. Cheriyan","doi":"10.1002/prm2.12053","DOIUrl":"https://doi.org/10.1002/prm2.12053","url":null,"abstract":"Linezolid therapy is known to cause black hairy tongue, which is benign and reversible. A 65‐year‐old diabetic male was on treatment for diabetic nonhealing ulcer involving right foot and sole for the past 6 months. Linezolid was started based on the culture and sensitivity of the pus. Patient developed thrombocytopenia and black hairy tongue after 7 days of the drug regimen. Drug was stopped and patient was advised to maintain good oral hygiene, soft tooth brush for brushing and regular mouth wash with lukewarm water. The black hairy tongue completely resolved within a week after stopping the drug. The taste and foreign body sensation on the tongue while swallowing were also improved. The diabetic wound was treated by starting vancomycin after giving a surgical wound debridement by a general surgeon.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"167 - 169"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46361939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myelodysplastic syndromes (MDS) are a group of malignant hematological disorders characterized by the abnormal development of hematopoietic stem cells and increased risk of acute myelogenous leukemia. Although the pathogenesis of MDS has not been fully understood, various alterations of microRNAs (miRNAs) have been reported in MDS. This study aimed to explore the molecular mechanisms of MDS by integrative bioinformatics analysis of miRNAs expression profile. The GSE81372 expression profile dataset was downloaded from Gene Expression Omnibus database. The differentially expressed miRNAs (DEMs) between MDS and normal controls were identified and targets of miRNAs were predicted. Subsequently, gene ontology (GO) functional and pathway enrichment analyses of target genes were performed. Finally, pathway relation network and miRNA–GO regulatory network were constructed and analyzed. A total of six upregulated and 35 downregulated DEMs were identified. The results showed that target genes of DEMs mainly participated in the process of signal transduction, blood coagulation, apoptotic process, cell proliferation, transmembrane transport, and angiogenesis. The significantly enriched pathways included MAPK signaling pathway, PI3K‐Akt signaling pathway, TGF‐beta signaling pathway, Hippo signaling pathway, and P53 signaling pathway. Moreover, miR‐195‐5p, miR‐4505, miR‐22‐3p, and miR‐148a‐3p were selected as hub miRNAs in miRNA–GO regulatory network and their aberrant expression might be closely associated with MDS pathogenesis. Our discovery provides a registry of miRNAs and pathways that are disrupted in MDS, which has the potential to be used in clinic for diagnosis and target therapy of MDS in future.
{"title":"Identification and integrative analysis of microRNAs in myelodysplastic syndromes based on microRNAs expression profile","authors":"Limin Ma, Haiping Yang, Xuewen Yang","doi":"10.1002/prm2.12054","DOIUrl":"https://doi.org/10.1002/prm2.12054","url":null,"abstract":"Myelodysplastic syndromes (MDS) are a group of malignant hematological disorders characterized by the abnormal development of hematopoietic stem cells and increased risk of acute myelogenous leukemia. Although the pathogenesis of MDS has not been fully understood, various alterations of microRNAs (miRNAs) have been reported in MDS. This study aimed to explore the molecular mechanisms of MDS by integrative bioinformatics analysis of miRNAs expression profile. The GSE81372 expression profile dataset was downloaded from Gene Expression Omnibus database. The differentially expressed miRNAs (DEMs) between MDS and normal controls were identified and targets of miRNAs were predicted. Subsequently, gene ontology (GO) functional and pathway enrichment analyses of target genes were performed. Finally, pathway relation network and miRNA–GO regulatory network were constructed and analyzed. A total of six upregulated and 35 downregulated DEMs were identified. The results showed that target genes of DEMs mainly participated in the process of signal transduction, blood coagulation, apoptotic process, cell proliferation, transmembrane transport, and angiogenesis. The significantly enriched pathways included MAPK signaling pathway, PI3K‐Akt signaling pathway, TGF‐beta signaling pathway, Hippo signaling pathway, and P53 signaling pathway. Moreover, miR‐195‐5p, miR‐4505, miR‐22‐3p, and miR‐148a‐3p were selected as hub miRNAs in miRNA–GO regulatory network and their aberrant expression might be closely associated with MDS pathogenesis. Our discovery provides a registry of miRNAs and pathways that are disrupted in MDS, which has the potential to be used in clinic for diagnosis and target therapy of MDS in future.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"142 - 150"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44757246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Zhu, Bing Wu, J. Tan, Meixiang Wang, Bainv Wu, Fang Chen, Yun-xia Zhao, Xiaoxu Zhi, Liuliu Zhang, Aifeng Meng
Along with the increasing of infections of COVID‐19, nurses are needed more in caring patients with COVID‐19. The aim of this study is to explore the real intention and influencing factors of the nurses' willingness to participate in public health emergency in facing the COVID‐19. A total of 10 nurses who volunteered to care patients with COVID‐19 were selected. Data were collected by semi‐structured interviews and analyzed by content analysis method based on the theory of planned behavior. Three main categories were attitude, subjective norms and perceived behavior control. Under the first category, two subcategories were included: nurses' personal and professional value expectation, patriotism. Two subcategories were yielded for the second category: support from family and friends, role model impact of important people. In addition, three subcategories were identified for the third category: physical condition, professional knowledge and skills, national measures and incentive policies. Nurses with high willingness have seven features: high value expectation, patriotism, generous family support, good physical condition, experienced professional knowledge and skills, awareness of national measures and incentive policies. Combined with our previous quantitative study, developing tailored training programs to improve nurses’ professional value expectation, knowledge and skills in coping with unwilling attitude and weak perceived behavior control are effective ways.
{"title":"Nurses' willingness to participate in public health emergency: A qualitative study in China","authors":"P. Zhu, Bing Wu, J. Tan, Meixiang Wang, Bainv Wu, Fang Chen, Yun-xia Zhao, Xiaoxu Zhi, Liuliu Zhang, Aifeng Meng","doi":"10.1002/prm2.12052","DOIUrl":"https://doi.org/10.1002/prm2.12052","url":null,"abstract":"Along with the increasing of infections of COVID‐19, nurses are needed more in caring patients with COVID‐19. The aim of this study is to explore the real intention and influencing factors of the nurses' willingness to participate in public health emergency in facing the COVID‐19. A total of 10 nurses who volunteered to care patients with COVID‐19 were selected. Data were collected by semi‐structured interviews and analyzed by content analysis method based on the theory of planned behavior. Three main categories were attitude, subjective norms and perceived behavior control. Under the first category, two subcategories were included: nurses' personal and professional value expectation, patriotism. Two subcategories were yielded for the second category: support from family and friends, role model impact of important people. In addition, three subcategories were identified for the third category: physical condition, professional knowledge and skills, national measures and incentive policies. Nurses with high willingness have seven features: high value expectation, patriotism, generous family support, good physical condition, experienced professional knowledge and skills, awareness of national measures and incentive policies. Combined with our previous quantitative study, developing tailored training programs to improve nurses’ professional value expectation, knowledge and skills in coping with unwilling attitude and weak perceived behavior control are effective ways.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"151 - 158"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49077735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To explore the practical application and effect of the management plan for cancer patients with wounds/stomas based on the “Internet+” model during the coronavirus disease 2019 (COVID‐19) pandemic. Based on the specific situation during the COVID‐19 pandemic, we established the “Internet+” management team for cancer patients with wounds/stomas. After systematical literature search and brainstorming analysis, we developed a management plan for cancer patients with wounds/stomas based on the “Internet+” model. Then, we included cancer patients with wounds/stomas who needed follow‐up visits or consultations at Jiangsu Cancer Hospital from January 25 to April 30, 2020. A total of 304 patients were participated in the study. The effects of the plan were evaluated including patient satisfaction, the proportion of patients who did not need to go to the hospital for treatment, the proportion of patients with improved symptoms and the rate of the patients or nurses contracted COVID‐19. After the implementation of the plan, 56.3% of the patients mastered the relevant self‐care methods under the guidance of specialist nurses and did not need to go to the hospital for treatment. A total of 89.5% of the patients showed improvement in symptoms, and 99.4% of the patients were satisfied with the online treatment. None of the patients or nurses contracted COVID‐19. The “Internet+” management plan for cancer patients with wounds/stomas during the COVID‐19 pandemic had supported epidemic prevention and control in medical institutions and reduced the risk of cross infection. In addition, this type of plan effectively improved disease symptoms in the patients, and their level of satisfaction was high.
{"title":"Development and implementation of an “Internet+” management plan for cancer patients with wounds/stomas during the coronavirus disease 2019 pandemic","authors":"Niu Niu, Xiaoxu Zhi, Liuliu Zhang, Meixiang Wang, Yun-xia Zhao, Lifang Yang, Bing Wu, P. Zhu, Na Wang, Mao-Mao Zhang, Bainv Wu, Yinan Zhang, Aifeng Meng","doi":"10.1002/prm2.12055","DOIUrl":"https://doi.org/10.1002/prm2.12055","url":null,"abstract":"To explore the practical application and effect of the management plan for cancer patients with wounds/stomas based on the “Internet+” model during the coronavirus disease 2019 (COVID‐19) pandemic. Based on the specific situation during the COVID‐19 pandemic, we established the “Internet+” management team for cancer patients with wounds/stomas. After systematical literature search and brainstorming analysis, we developed a management plan for cancer patients with wounds/stomas based on the “Internet+” model. Then, we included cancer patients with wounds/stomas who needed follow‐up visits or consultations at Jiangsu Cancer Hospital from January 25 to April 30, 2020. A total of 304 patients were participated in the study. The effects of the plan were evaluated including patient satisfaction, the proportion of patients who did not need to go to the hospital for treatment, the proportion of patients with improved symptoms and the rate of the patients or nurses contracted COVID‐19. After the implementation of the plan, 56.3% of the patients mastered the relevant self‐care methods under the guidance of specialist nurses and did not need to go to the hospital for treatment. A total of 89.5% of the patients showed improvement in symptoms, and 99.4% of the patients were satisfied with the online treatment. None of the patients or nurses contracted COVID‐19. The “Internet+” management plan for cancer patients with wounds/stomas during the COVID‐19 pandemic had supported epidemic prevention and control in medical institutions and reduced the risk of cross infection. In addition, this type of plan effectively improved disease symptoms in the patients, and their level of satisfaction was high.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"159 - 166"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47696232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the misclassification rates of Asian‐American patients with low‐risk prostate cancer (PCa). Patients diagnosed with low‐risk PCa treated with radical prostatectomy between 2010 and 2015 in the Surveillance, Epidemiology, and End Results database were included in this study. Then, basic characteristics and pathological outcomes of the enrolled patients were retrospectively extracted. We compared the rates of upgrading and/or upstaging between Asian‐American patients and White/Black patients. Moreover, temporal trend analyses were performed to explore the changes in upgrading and upstaging rates in each race over time. Finally, logistic regression models were constructed to explore the role of Asian race in upgrading and upstaging and to screen out potential risk factors for predicting upgrading and upstaging in Asian‐American patients. Asian‐Americans had a significantly higher rate of upgrading than Whites (P < .001), while no statistical difference was found in the comparison of upstaging rate (P = .536). Moreover, Asian‐Americans were more likely to upgrade to diseases with higher ISUP grade than Whites (P = .010). The rate of upgrading increased significantly over time in White and Black patients, but not in Asian‐American patients. Finally, race seemed to be an independent risk factor for predicting upgrading, while the racial differences seemed to be more pronounced between White and Black patients. Asian‐American patients had a significantly higher rate of upgrading than White patients. Moreover, Asian‐American patients were more likely to upgrade to diseases with higher ISUP grade. Further risk assessment before clinical decision for low‐risk PCa patients with the help of significant clinical variables is required.
{"title":"Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer","authors":"Xiao Li, Zicheng Xu, Wenbo Xu, Feng Qi, Qing Zou","doi":"10.1002/prm2.12098","DOIUrl":"https://doi.org/10.1002/prm2.12098","url":null,"abstract":"To investigate the misclassification rates of Asian‐American patients with low‐risk prostate cancer (PCa). Patients diagnosed with low‐risk PCa treated with radical prostatectomy between 2010 and 2015 in the Surveillance, Epidemiology, and End Results database were included in this study. Then, basic characteristics and pathological outcomes of the enrolled patients were retrospectively extracted. We compared the rates of upgrading and/or upstaging between Asian‐American patients and White/Black patients. Moreover, temporal trend analyses were performed to explore the changes in upgrading and upstaging rates in each race over time. Finally, logistic regression models were constructed to explore the role of Asian race in upgrading and upstaging and to screen out potential risk factors for predicting upgrading and upstaging in Asian‐American patients. Asian‐Americans had a significantly higher rate of upgrading than Whites (P < .001), while no statistical difference was found in the comparison of upstaging rate (P = .536). Moreover, Asian‐Americans were more likely to upgrade to diseases with higher ISUP grade than Whites (P = .010). The rate of upgrading increased significantly over time in White and Black patients, but not in Asian‐American patients. Finally, race seemed to be an independent risk factor for predicting upgrading, while the racial differences seemed to be more pronounced between White and Black patients. Asian‐American patients had a significantly higher rate of upgrading than White patients. Moreover, Asian‐American patients were more likely to upgrade to diseases with higher ISUP grade. Further risk assessment before clinical decision for low‐risk PCa patients with the help of significant clinical variables is required.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"103 - 95"},"PeriodicalIF":0.5,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48989824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaodong Xie, Lingling Gu, Zhen Guo, H. Tao, Yiqin Zhou, W. Shen, Zhengyang Zhou
To examine the feasibility of quantitative dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in the early assessment of the therapeutic response to concurrent chemoradiotherapy (CRT) in esophageal cancer (EC) patients and to determine its value in predicting HIF‐1α expression. EC patients underwent DCE‐MRI 1 week pre‐CRT and 3 weeks post‐CRT (3w‐CRT). According to tumor regression post‐treatment, patients were divided into sensitive group (SG) and resistant group (RG). HIF‐1α expression was assessed by immunohistochemistry (IHC). Quantitative parameters (ktrans, kep, and ve) were compared between the SG and RG groups, as well as between the HIF‐1α(+) and HIF‐1α(−) groups. Receiver operating characteristic (ROC) curve analysis was performed to detect the best predictor of the above parameters in the therapeutic response and in predicting HIF‐1α expression. Totally 34 and 5 patients were included in the SG and RG, respectively. Pre‐ktrans and pre‐kep were decreased significantly in the SG at 3w‐CRT (p < .01), whereas only pre‐kep was decreased in the RG (p = .037). Pre‐ktrans was higher in the SG compared with the RG (p < .01). Meanwhile, absolute Δktrans (post‐ktrans–pre‐ktrans) was reduced more substantially in the SG compared with the RG. Δktrans also had the highest area under the curve (AUC = 0.929) in distinguishing SG from RG. Based on IHC, 13 and 11 patients were HIF‐1α(+) and HIF‐1α(−), respectively. At 3w‐CRT, post‐ktrans was markedly lower than pre‐ktrans in the HIF‐1α(+) group (p < .01); however, both ktrans and kep in the HIF‐1α(−) group were dramatically reduced than pre‐treatment values (both p < .01). Pre‐ktrans was significantly higher in the HIF‐1α(−) group compared with the HIF‐1α(+) group (p = .002) and constituted an excellent parameter for predicting HIF‐1α expression (AUC = 0.881). DCE‐MRI is effective in the early assessment of the therapeutic response after CRT, offering a novel noninvasive method for predicting HIF‐1α expression in advanced EC patients.
{"title":"DCE‐MRI for early evaluation of therapeutic response in esophageal cancer after concurrent chemoradiotherapy and its values in predicting HIF‐1α expression","authors":"Xiaodong Xie, Lingling Gu, Zhen Guo, H. Tao, Yiqin Zhou, W. Shen, Zhengyang Zhou","doi":"10.1002/prm2.12049","DOIUrl":"https://doi.org/10.1002/prm2.12049","url":null,"abstract":"To examine the feasibility of quantitative dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in the early assessment of the therapeutic response to concurrent chemoradiotherapy (CRT) in esophageal cancer (EC) patients and to determine its value in predicting HIF‐1α expression. EC patients underwent DCE‐MRI 1 week pre‐CRT and 3 weeks post‐CRT (3w‐CRT). According to tumor regression post‐treatment, patients were divided into sensitive group (SG) and resistant group (RG). HIF‐1α expression was assessed by immunohistochemistry (IHC). Quantitative parameters (ktrans, kep, and ve) were compared between the SG and RG groups, as well as between the HIF‐1α(+) and HIF‐1α(−) groups. Receiver operating characteristic (ROC) curve analysis was performed to detect the best predictor of the above parameters in the therapeutic response and in predicting HIF‐1α expression. Totally 34 and 5 patients were included in the SG and RG, respectively. Pre‐ktrans and pre‐kep were decreased significantly in the SG at 3w‐CRT (p < .01), whereas only pre‐kep was decreased in the RG (p = .037). Pre‐ktrans was higher in the SG compared with the RG (p < .01). Meanwhile, absolute Δktrans (post‐ktrans–pre‐ktrans) was reduced more substantially in the SG compared with the RG. Δktrans also had the highest area under the curve (AUC = 0.929) in distinguishing SG from RG. Based on IHC, 13 and 11 patients were HIF‐1α(+) and HIF‐1α(−), respectively. At 3w‐CRT, post‐ktrans was markedly lower than pre‐ktrans in the HIF‐1α(+) group (p < .01); however, both ktrans and kep in the HIF‐1α(−) group were dramatically reduced than pre‐treatment values (both p < .01). Pre‐ktrans was significantly higher in the HIF‐1α(−) group compared with the HIF‐1α(+) group (p = .002) and constituted an excellent parameter for predicting HIF‐1α expression (AUC = 0.881). DCE‐MRI is effective in the early assessment of the therapeutic response after CRT, offering a novel noninvasive method for predicting HIF‐1α expression in advanced EC patients.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"118 - 126"},"PeriodicalIF":0.5,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42015445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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