Physics of Life Reviews最新文献

{"title":"A promising new foundation for conflict and control: Bridging the gap to verification. Comment on “Active inference and cognitive control: Balancing deliberation and habits through precision optimization” by Riccardo Proietti, Thomas Parr, Alessia Tessari, Karl Friston, & Giovanni Pezzulo","authors":"Antonino Visalli","doi":"10.1016/j.plrev.2025.11.008","DOIUrl":"10.1016/j.plrev.2025.11.008","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 61-63"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The limits of information: comment on “informational embodiment: computational role of information structure in codes and robots” by Alexandre Pitti, Max Austin, Kohei Nakajima, Yasuo Kuniyoshi","authors":"Anna Loi , Vicente Raja","doi":"10.1016/j.plrev.2025.11.004","DOIUrl":"10.1016/j.plrev.2025.11.004","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 1-3"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why the memory palace is mightier than the memory pharmacy","authors":"Boris N. Konrad, Martin Dresler","doi":"10.1016/j.plrev.2025.12.011","DOIUrl":"10.1016/j.plrev.2025.12.011","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 128-130"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General integration theory of cognitive emergent: Comment on \"Brain dynamics shape cognition–spatiotemporal neuroscience\" by Georg Northoff, Angelika Wolman and Jianfeng Zhang","authors":"Feiyan Chen , Fan Liu , Jingcheng Wang , Rengqin Sun , Hongjian He , Xi-Nian Zuo","doi":"10.1016/j.plrev.2026.01.004","DOIUrl":"10.1016/j.plrev.2026.01.004","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 223-226"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On implementation of nonlocal terms in models in ecology and evolution. Comment on ‘Nonlocal models in biology and life sciences: Sources, developments, and applications’ by S. Pal & R. Melnick","authors":"Andrew Yu Morozov","doi":"10.1016/j.plrev.2025.12.013","DOIUrl":"10.1016/j.plrev.2025.12.013","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 208-211"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodeling of non-coding RNA regulatory networks: Decoding the pathological mechanisms and new therapeutic paradigms of cardiovascular diseases","authors":"Wangzheqi Zhang ,&nbsp;Lei Duan ,&nbsp;Changli Wang ,&nbsp;Yan Liao ,&nbsp;Rui Zhao ,&nbsp;Zhaoyu Li ,&nbsp;Haoling Zhang ,&nbsp;Zengwu Wang ,&nbsp;Jing-jing Zhang","doi":"10.1016/j.plrev.2025.12.007","DOIUrl":"10.1016/j.plrev.2025.12.007","url":null,"abstract":"<div><div>The essential role of non-coding RNAs (ncRNAs) in cardiovascular disease (CVD) research instigates a shift from empirical studies to those based on molecular mechanisms, targeted interventions, and personalized health management in the world of precision medicine. This review systematically summarizes the expression profiles and multilayered regulatory mechanisms of various ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs) in a variety of cardiovascular diseases (CVDs) ranging from congenital heart disease to atherosclerosis (AS), cardiomyopathies, heart failure (HF), and arrhythmias. The central roles of key pathological pathways like epigenetic changes, competing endogenous RNA (ceRNA), inflammation and cell fate determination will be highlighted. From a diagnostic point of view, ncRNAs have good potentials as early-stage biomarkers, in applications such as exosomal liquid biopsy, disease classification, and prognosis. Emerging technologies, notably locked nucleic acid (LNA) oligonucleotides, adeno-associated virus serotype 9 (AAV9)-based delivery systems and engineered exosomes, are unlocking new avenues for intervention on the therapeutic front. These developments, coupled with drug repurposing strategies and tissue-specific delivery platforms, can make ncRNA-targeted therapies more specific and controllable. At the same time, interdisciplinary innovations, like single-cell multi-omics, spatial transcriptomics, CRISPR-dCas9 systems, and deep learning assist clinical translation greatly. However, the real-world application of ncRNA-based therapies is constrained by many challenges like low delivery efficiency, functional redundancy, and microenvironmental dependence. Future directions must aim to create integrative platforms that can dynamically identify and modulate ncRNA functions to link mechanistic studies to personalized therapies and subsequently expedite clinical translation of ncRNA discoveries. In this sense, three cross-scale principles-network topology and ceRNA competition dynamics; spatiotemporal gradients modeled by exosome transport and tissue microenvironments; and energetic/stoichiometric constraints like Dicer processing capacity and miRNA-target ratios- provide an analytical framework that appears recurrently across diverse CVD phenotypes and tighten the mechanistic unity of this review.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 131-201"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological models with nonlocal terms: Future scopes of research: Comment on “Nonlocal models in biology and life sciences: Sources, developments, and applications” by S. Pal & R. Melnick","authors":"Malay Banerjee ,&nbsp;Kalyan Manna ,&nbsp;Indrajyoti Gaine","doi":"10.1016/j.plrev.2025.11.005","DOIUrl":"10.1016/j.plrev.2025.11.005","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 29-32"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural cellular automata: Applications to biology and beyond classical AI","authors":"Benedikt Hartl ,&nbsp;Michael Levin ,&nbsp;Léo Pio-Lopez","doi":"10.1016/j.plrev.2025.11.010","DOIUrl":"10.1016/j.plrev.2025.11.010","url":null,"abstract":"<div><div>Neural Cellular Automata (NCA) represent a powerful framework for modeling biological self-organization, extending classical rule-based systems with trainable, differentiable (or evolvable) update rules that capture the adaptive self-regulatory dynamics of living matter. By embedding Artificial Neural Networks (ANNs) as local decision-making centers and interaction rules between localized agents, NCA can simulate processes across molecular, cellular, tissue, and system-level scales, offering a multiscale competency architecture perspective on evolution, development, regeneration, aging, morphogenesis, and robotic control. These models not only reproduce canonical, biologically inspired target patterns but also generalize to novel conditions, demonstrating robustness to perturbations and the capacity for open-ended adaptation and reasoning through embodiment. Given their immense success in recent developments, we here review current literature of NCAs that are relevant primarily for biological or bioengineering applications. Moreover, we emphasize that beyond biology, NCAs display robust and generalizing goal-directed dynamics without centralized control, e.g., in controlling or regenerating composite robotic morphologies or even on cutting-edge reasoning tasks such as ARC-AGI-1. In addition, the same principles of iterative state-refinement is reminiscent to modern generative Artificial Intelligence (AI), such as probabilistic diffusion models. Their governing self-regulatory behavior is constraint to fully localized interactions, yet their collective behavior scales into coordinated system-level outcomes. We thus argue that NCAs constitute a unifying computationally lean paradigm that not only bridges fundamental insights from multiscale biology with modern generative AI, but have the potential to design truly bio-inspired collective intelligence capable of hierarchical reasoning and control.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 94-108"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From modelling PPST to modelling bodily self-consciousness: Comment on “Computational models of peripersonal space representation” by T. Bertoni, J.P. Noel & A. Serino","authors":"Renato Paredes ,&nbsp;Peggy Seriès ,&nbsp;Olaf Blanke","doi":"10.1016/j.plrev.2025.12.012","DOIUrl":"10.1016/j.plrev.2025.12.012","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 204-207"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spatiotemporal structure of neural activities shapes cognitive functions: Comment on “brain dynamics shape cognition–spatiotemporal neuroscience” by Georg Northoff, Angelika Wolman, and Jianfeng Zhang","authors":"Yuzhu Tang,&nbsp;Mengxiao Sun,&nbsp;Yifeng Wang,&nbsp;Xiujuan Jing","doi":"10.1016/j.plrev.2025.12.002","DOIUrl":"10.1016/j.plrev.2025.12.002","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 84-86"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}