Physics of Life Reviews最新文献

{"title":"From modelling PPST to modelling bodily self-consciousness: Comment on “Computational models of peripersonal space representation” by T. Bertoni, J.P. Noel & A. Serino","authors":"Renato Paredes , Peggy Seriès , Olaf Blanke","doi":"10.1016/j.plrev.2025.12.012","DOIUrl":"10.1016/j.plrev.2025.12.012","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 204-207"},"PeriodicalIF":14.3,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why the memory palace is mightier than the memory pharmacy","authors":"Boris N. Konrad, Martin Dresler","doi":"10.1016/j.plrev.2025.12.011","DOIUrl":"10.1016/j.plrev.2025.12.011","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 128-130"},"PeriodicalIF":14.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From adaptive networks to expanding state spaces: Comment on “Beyond networks: Toward adaptive models of biological complexity” by Pessoa","authors":"Jincan Che","doi":"10.1016/j.plrev.2025.12.010","DOIUrl":"10.1016/j.plrev.2025.12.010","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 126-127"},"PeriodicalIF":14.3,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145825506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From brain dynamics to the dynamic self - standing in the spatiotemporal architecture of the psyche: Comment on “Brain dynamics shape cognition–Spatiotemporal Neuroscience” by Northoff, Wolman & Zhang","authors":"Andrea Scalabrini","doi":"10.1016/j.plrev.2025.12.008","DOIUrl":"10.1016/j.plrev.2025.12.008","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 121-125"},"PeriodicalIF":14.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodeling of non-coding RNA regulatory networks: Decoding the pathological mechanisms and new therapeutic paradigms of cardiovascular diseases","authors":"Wangzheqi Zhang ,&nbsp;Lei Duan ,&nbsp;Changli Wang ,&nbsp;Yan Liao ,&nbsp;Rui Zhao ,&nbsp;Zhaoyu Li ,&nbsp;Haoling Zhang ,&nbsp;Zengwu Wang ,&nbsp;Jing-jing Zhang","doi":"10.1016/j.plrev.2025.12.007","DOIUrl":"10.1016/j.plrev.2025.12.007","url":null,"abstract":"<div><div>The essential role of non-coding RNAs (ncRNAs) in cardiovascular disease (CVD) research instigates a shift from empirical studies to those based on molecular mechanisms, targeted interventions, and personalized health management in the world of precision medicine. This review systematically summarizes the expression profiles and multilayered regulatory mechanisms of various ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs) in a variety of cardiovascular diseases (CVDs) ranging from congenital heart disease to atherosclerosis (AS), cardiomyopathies, heart failure (HF), and arrhythmias. The central roles of key pathological pathways like epigenetic changes, competing endogenous RNA (ceRNA), inflammation and cell fate determination will be highlighted. From a diagnostic point of view, ncRNAs have good potentials as early-stage biomarkers, in applications such as exosomal liquid biopsy, disease classification, and prognosis. Emerging technologies, notably locked nucleic acid (LNA) oligonucleotides, adeno-associated virus serotype 9 (AAV9)-based delivery systems and engineered exosomes, are unlocking new avenues for intervention on the therapeutic front. These developments, coupled with drug repurposing strategies and tissue-specific delivery platforms, can make ncRNA-targeted therapies more specific and controllable. At the same time, interdisciplinary innovations, like single-cell multi-omics, spatial transcriptomics, CRISPR-dCas9 systems, and deep learning assist clinical translation greatly. However, the real-world application of ncRNA-based therapies is constrained by many challenges like low delivery efficiency, functional redundancy, and microenvironmental dependence. Future directions must aim to create integrative platforms that can dynamically identify and modulate ncRNA functions to link mechanistic studies to personalized therapies and subsequently expedite clinical translation of ncRNA discoveries. In this sense, three cross-scale principles-network topology and ceRNA competition dynamics; spatiotemporal gradients modeled by exosome transport and tissue microenvironments; and energetic/stoichiometric constraints like Dicer processing capacity and miRNA-target ratios- provide an analytical framework that appears recurrently across diverse CVD phenotypes and tighten the mechanistic unity of this review.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 131-201"},"PeriodicalIF":14.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informational inbreeding: a useful concept to add to extant evolutionary theories: Comment on “Homo informatio” by Michael J. Walker","authors":"Héctor M. Manrique ,&nbsp;Ana Magdalena Hurtado","doi":"10.1016/j.plrev.2025.12.006","DOIUrl":"10.1016/j.plrev.2025.12.006","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 115-117"},"PeriodicalIF":14.3,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding higher-order tumor-microenvironment interactions via an innovative computational framework: Comment on “High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth” by Che et al","authors":"Yuan Zhou,&nbsp;Qing Lu","doi":"10.1016/j.plrev.2025.12.001","DOIUrl":"10.1016/j.plrev.2025.12.001","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 118-120"},"PeriodicalIF":14.3,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bodily rhythms and the Brain: Critical links to cognition in health and disease. Comment on ‘A body-brain (dis)equilibrium regulating transitions from health to pathology’ by Antonio Criscuolo, Anna Czepiel, Michael Schwartze and Sonja A. Kotz","authors":"Marzia De Lucia ,&nbsp;Andria Pelentritou ,&nbsp;Alessandro Tavano","doi":"10.1016/j.plrev.2025.12.005","DOIUrl":"10.1016/j.plrev.2025.12.005","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 109-112"},"PeriodicalIF":14.3,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unbearable hardness of inferring being: Comment on “preliminaries to artificial consciousness” by Evers et al.","authors":"Robert Chis-Ciure","doi":"10.1016/j.plrev.2025.12.004","DOIUrl":"10.1016/j.plrev.2025.12.004","url":null,"abstract":"<div><div>This commentary commends Evers et al.’s multidimensional heuristic for structuring artificial consciousness research while arguing it cannot, as stated, adjudicate the nomological possibility of phenomenal consciousness, which is at stake in current debates. Behavioral–cognitive “profiles” lack a justified principle linking function to experience, and the awareness case study illustrates how externally specified goals can just as well underwrite as-if (pseudo-intentional) control rather than original intentionality. Moreover, the proposed heuristic overlooks that substrate similarity is currently indispensable for justifiably inferring the presence of consciousness beyond the validated case of the adult human brain. Given all this, the framework seems to provide a blueprint for building a more sophisticated philosophical zombie; it does not—and cannot—tell us whether anyone is there.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 87-90"},"PeriodicalIF":14.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relating computational models and experiments in peripersonal space: Comment on “computational models of peripersonal space representation”, by Bertoni et al.","authors":"Raffaele Tucciarelli,&nbsp;Matthew R. Longo","doi":"10.1016/j.plrev.2025.12.003","DOIUrl":"10.1016/j.plrev.2025.12.003","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 82-83"},"PeriodicalIF":14.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}