Aim To present real world data for the treatment of palmoplantar psoriasis with Apremilast. Objectives To study the efficacy and safety of apremilast in palmo-plantar psoriasis. Background Palmoplantar psoriasis (PPP) is a disabling condition that is refractory to treatment. Apremilast an approved oral PDE4 inhibitor was used as a twice daily dose to treat our patients. Methods 30 patients of PPP were administered apremilast tablets, along with mid potent topical steroids and emollient cream. 23 patients completed the study. Results The primary end point was the assessment of clinical response in patients achieving Palmoplantar Physicians Global Assessment 0/1 (ppPGA) at 16 weeks which was seen in 34.7% patients. Secondary end points were assessed as follows: Change in mean ppPGA from baseline to week 24, ppPGA 0/1 was seen in 48.7% patients, three patients who continued long term therapy maintained ppPGA 0/1 and adverse events (AE) reported during the course of the therapy were seen in 26% of the patients. Conclusions Apremilast is a fairly effective and safe drug for the management of PPP. It is capable of not only inducing clinically meaningful responses but also keeping PPP under control in the long run.
{"title":"Apremilast − a fairly effective drug to manage palmoplantar psoriasis","authors":"S. Parasramani, J. Pillai","doi":"10.4103/ejdv.ejdv_38_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_38_20","url":null,"abstract":"Aim To present real world data for the treatment of palmoplantar psoriasis with Apremilast. Objectives To study the efficacy and safety of apremilast in palmo-plantar psoriasis. Background Palmoplantar psoriasis (PPP) is a disabling condition that is refractory to treatment. Apremilast an approved oral PDE4 inhibitor was used as a twice daily dose to treat our patients. Methods 30 patients of PPP were administered apremilast tablets, along with mid potent topical steroids and emollient cream. 23 patients completed the study. Results The primary end point was the assessment of clinical response in patients achieving Palmoplantar Physicians Global Assessment 0/1 (ppPGA) at 16 weeks which was seen in 34.7% patients. Secondary end points were assessed as follows: Change in mean ppPGA from baseline to week 24, ppPGA 0/1 was seen in 48.7% patients, three patients who continued long term therapy maintained ppPGA 0/1 and adverse events (AE) reported during the course of the therapy were seen in 26% of the patients. Conclusions Apremilast is a fairly effective and safe drug for the management of PPP. It is capable of not only inducing clinically meaningful responses but also keeping PPP under control in the long run.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47176402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mai AbdelWahed, M. Elmogy, M. Abdelsalam, M. Zohdy
Background Psoriasis is a Th1/Th17 disease resulting from a dysregulated interplay between keratinocytes and immune cells, leading to skin hyperproliferation. Increased levels of interleukin (IL)-33 were reported in various Th1/Th17-driven autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, with correlation to disease severity. Increased levels of IL-33 have been reported in lesional skin of psoriatic patients. The authors hypothesized that keratinocyte-released IL-33 might play a role in psoriasis pathogenesis; thus, inhibiting IL-33 activity might be a breaking new therapeutic strategy in its treatment. Patients and methods Serum IL-33 levels were measured by an enzyme-linked immunosorbent assay for 30 patients with active psoriasis (group A), 30 patient with stable psoriasis (group B), and 30 healthy age-matched and sex-matched controls (group C). Results Serum IL-33 showed statistically significant higher mean value among patients with psoriasis compared with the control group. The level of IL-33 in active psoriasis was significantly higher than in inactive psoriasis. Moreover, there was a statistically significant correlation between IL-33 and psoriasis area and severity index (PASI) score. Receiver operating characteristics curve detected the validity of serum IL-33 in differentiating patients with psoriasis from controls. At the cutoff point of IL-33 as 22.72 pg//ml, psoriasis could be predicted with 96.67% sensitivity and 93.33% specificity. Serum IL-33 was a statistically significant predictor of PASI score, with 63.5% of PASI scores predicted by serum IL-33. Conclusion Serum IL-33 may represent a new marker for psoriasis diagnosis as well as a predictor of the disease severity.
{"title":"Serum interleukin-33 level may serve as a new marker for psoriasis diagnosis","authors":"Mai AbdelWahed, M. Elmogy, M. Abdelsalam, M. Zohdy","doi":"10.4103/ejdv.ejdv_39_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_39_20","url":null,"abstract":"Background Psoriasis is a Th1/Th17 disease resulting from a dysregulated interplay between keratinocytes and immune cells, leading to skin hyperproliferation. Increased levels of interleukin (IL)-33 were reported in various Th1/Th17-driven autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, with correlation to disease severity. Increased levels of IL-33 have been reported in lesional skin of psoriatic patients. The authors hypothesized that keratinocyte-released IL-33 might play a role in psoriasis pathogenesis; thus, inhibiting IL-33 activity might be a breaking new therapeutic strategy in its treatment. Patients and methods Serum IL-33 levels were measured by an enzyme-linked immunosorbent assay for 30 patients with active psoriasis (group A), 30 patient with stable psoriasis (group B), and 30 healthy age-matched and sex-matched controls (group C). Results Serum IL-33 showed statistically significant higher mean value among patients with psoriasis compared with the control group. The level of IL-33 in active psoriasis was significantly higher than in inactive psoriasis. Moreover, there was a statistically significant correlation between IL-33 and psoriasis area and severity index (PASI) score. Receiver operating characteristics curve detected the validity of serum IL-33 in differentiating patients with psoriasis from controls. At the cutoff point of IL-33 as 22.72 pg//ml, psoriasis could be predicted with 96.67% sensitivity and 93.33% specificity. Serum IL-33 was a statistically significant predictor of PASI score, with 63.5% of PASI scores predicted by serum IL-33. Conclusion Serum IL-33 may represent a new marker for psoriasis diagnosis as well as a predictor of the disease severity.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46978531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-15DOI: 10.12970/2310-998X.2021.09.03
M. R. Mowla, Sabrina Shahrin, Tahmina Sonali, Papri Dutta, Mizanur Rahman, A. Ghosh, J. A. Khan, Wazed Mridha, M. Choudhury, D. Barua
{"title":"Burden of Leprosy Patients at Post-Elimination Stage: Evidence from Bangladesh","authors":"M. R. Mowla, Sabrina Shahrin, Tahmina Sonali, Papri Dutta, Mizanur Rahman, A. Ghosh, J. A. Khan, Wazed Mridha, M. Choudhury, D. Barua","doi":"10.12970/2310-998X.2021.09.03","DOIUrl":"https://doi.org/10.12970/2310-998X.2021.09.03","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83326687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-25DOI: 10.12970/2310-998X.2021.09.02
T. Quint, C. Jantschitsch, H. Maier
{"title":"Abducens Palsy Associated with Herpes Zoster Opthalmicus: Case Report","authors":"T. Quint, C. Jantschitsch, H. Maier","doi":"10.12970/2310-998X.2021.09.02","DOIUrl":"https://doi.org/10.12970/2310-998X.2021.09.02","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88001177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.26767
P. Agarwal, Ashish Jagati, P. Vadher, Malay Chaudhary
Syphilitic balanitis of Follmann is a rare presentation of primary syphilis. It can occur before or after the appearance of primary chancre and some time without any associated primary chancre. We are reporting a case of syphilitic balanitis of Follmann, in a 23 years old heterosexual male, who presented with balanitis associated with single indurated lesion over coronal sulcus and few superficial ulcers over prepuce.
{"title":"Syphilitic Balanitis of Follmann, A Rare Case Report","authors":"P. Agarwal, Ashish Jagati, P. Vadher, Malay Chaudhary","doi":"10.3126/NJDVL.V19I1.26767","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.26767","url":null,"abstract":"Syphilitic balanitis of Follmann is a rare presentation of primary syphilis. It can occur before or after the appearance of primary chancre and some time without any associated primary chancre. We are reporting a case of syphilitic balanitis of Follmann, in a 23 years old heterosexual male, who presented with balanitis associated with single indurated lesion over coronal sulcus and few superficial ulcers over prepuce.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77538597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.33534
Harendra Kumar Jha, A. Pokharel
Introduction: Skin disease is common in developing countries but the spectrum varies widely. Skin biopsy is an important tool in confirming or establishing diagnoses in cases with diagnostic dilemmas. And, there may be a discrepancy between clinical and pathological diagnoses. Objectives: To determine the spectrum of histological diagnoses in skin disease and to know the consistency between clinical and pathological diagnoses. Materials and methods: A retrospective review of histological and clinical diagnoses was done at a multi-specialty hospital. A total of 85 cases were included in the study. Clinical and histological data along with demographic details, the site of the biopsy was noted. Concordance between clinical and pathological diagnosis was determined as concordant, partially concordant and discordant. Results: There were 60% female and 40% male patients out of 85 biopsies. The most common age group was 31-40 years and the mean age was 41.24 years. The most common histological spectrum was infectious group in 29.4%, followed by papulosquamous disorders in 22.4% and eczema in 12.9% cases. The concordance between clinical and pathological diagnosis was 60%, while partial concordance was seen in 16.5% and discordance was seen in 23.5% cases. Conclusion: Infections followed by papulosquamous disease and eczema were the three most common groups of histological diagnosis. This study also found an overall concordance of 76.5% and discordance in 23.5% between clinical and histopathological diagnosis.
{"title":"The Histopathological Spectrum and Clinico-Pathological Concordance in 85 Cases of Skin Biopsy: A Single Center Experience","authors":"Harendra Kumar Jha, A. Pokharel","doi":"10.3126/NJDVL.V19I1.33534","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.33534","url":null,"abstract":"Introduction: Skin disease is common in developing countries but the spectrum varies widely. Skin biopsy is an important tool in confirming or establishing diagnoses in cases with diagnostic dilemmas. And, there may be a discrepancy between clinical and pathological diagnoses. Objectives: To determine the spectrum of histological diagnoses in skin disease and to know the consistency between clinical and pathological diagnoses. Materials and methods: A retrospective review of histological and clinical diagnoses was done at a multi-specialty hospital. A total of 85 cases were included in the study. Clinical and histological data along with demographic details, the site of the biopsy was noted. Concordance between clinical and pathological diagnosis was determined as concordant, partially concordant and discordant. Results: There were 60% female and 40% male patients out of 85 biopsies. The most common age group was 31-40 years and the mean age was 41.24 years. The most common histological spectrum was infectious group in 29.4%, followed by papulosquamous disorders in 22.4% and eczema in 12.9% cases. The concordance between clinical and pathological diagnosis was 60%, while partial concordance was seen in 16.5% and discordance was seen in 23.5% cases. Conclusion: Infections followed by papulosquamous disease and eczema were the three most common groups of histological diagnosis. This study also found an overall concordance of 76.5% and discordance in 23.5% between clinical and histopathological diagnosis.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81430738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.35308
Vikash Paudel, S. Neupane
The Coronavirus Disease-2019 (COVID-19) pandemic has caused an unparalleled disruption in all forms of scientific learning process including medical education. It has presented a challenge for scientists, educators, and students. Widespread interruptions to medical education, scientific discussions, conference, and seminars have also been seen at times of major conflicts and pandemics in the past as well, which resulted in major changes in medical curriculum. This editorial discusses the medical education and how COVID-19 has affected medical education in Nepal. Besides, it also explores the potential implications of COVID-19 for the future of medical education.
{"title":"The Challenges of COVID-19 in Medical Education in Nepal","authors":"Vikash Paudel, S. Neupane","doi":"10.3126/NJDVL.V19I1.35308","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.35308","url":null,"abstract":"The Coronavirus Disease-2019 (COVID-19) pandemic has caused an unparalleled disruption in all forms of scientific learning process including medical education. It has presented a challenge for scientists, educators, and students. Widespread interruptions to medical education, scientific discussions, conference, and seminars have also been seen at times of major conflicts and pandemics in the past as well, which resulted in major changes in medical curriculum. This editorial discusses the medical education and how COVID-19 has affected medical education in Nepal. Besides, it also explores the potential implications of COVID-19 for the future of medical education.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89960135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.28322
Rashmi Singh, S. Pandey
Introduction: Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence. Plane wart is one of the morphological variants accounting for approximately one fifth of HPV lesions. Treatment of plane warts is difficult and recurrence quite common. Objectives: To compare the efficacy and safety of 5% 5 –fluorouracil (5 FU) and 0.05% tretinoin and electrosurgery in the treatment of plane wart. Materials and methods: Seventy-five patients, 38 males and 37 females were included in this randomized controlled comparative trial. Patients were age and sex matched and divided into three groups, GROUP A: Patients treated with 5% 5-FU, GROUP B: Patients treated with 0.05% tretinoin and GROUP C: Patients treated with electrosurgery. While topical treatments were applied once nightly for 4 weeks (5% 5-FU for four hours and tretinoin overnight), electrosurgery was done at first visit only. Result: While electrosurgery had shown faster results, results were more consistent with least recurrence in 5-FU and fair recurrence with 0.05% tretinoin. Conclusion: All three treatments i.e. 5 FU, topical tretinoin and electrosurgery showed excellent response in treatment of plane warts with minimal side effects.
{"title":"Efficacy of Topical 5% 5-Fluorouracil and 0.05% Tretinoin and Electrosurgery in the Treatment of Plane Warts: A Randomized Controlled Comparative Trial","authors":"Rashmi Singh, S. Pandey","doi":"10.3126/NJDVL.V19I1.28322","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.28322","url":null,"abstract":"Introduction: Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence. Plane wart is one of the morphological variants accounting for approximately one fifth of HPV lesions. Treatment of plane warts is difficult and recurrence quite common. Objectives: To compare the efficacy and safety of 5% 5 –fluorouracil (5 FU) and 0.05% tretinoin and electrosurgery in the treatment of plane wart. Materials and methods: Seventy-five patients, 38 males and 37 females were included in this randomized controlled comparative trial. Patients were age and sex matched and divided into three groups, GROUP A: Patients treated with 5% 5-FU, GROUP B: Patients treated with 0.05% tretinoin and GROUP C: Patients treated with electrosurgery. While topical treatments were applied once nightly for 4 weeks (5% 5-FU for four hours and tretinoin overnight), electrosurgery was done at first visit only. Result: While electrosurgery had shown faster results, results were more consistent with least recurrence in 5-FU and fair recurrence with 0.05% tretinoin. Conclusion: All three treatments i.e. 5 FU, topical tretinoin and electrosurgery showed excellent response in treatment of plane warts with minimal side effects.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88641316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.34551
B. Amatya, S. Joshi
Introduction: Hair loss is one of the most frequent complaints for which patients see a dermatologist. The three most common causes of hair loss in women are telogen effluvium, alopecia areata and female pattern hair loss. Objectives: The aim of this study was to investigate haemoglobin, iron profile and thyroid function tests in women with telogen effluvium, alopecia areata and female pattern hair loss. Materials and Methods: This was a hospital based cross sectional study conducted at the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital (NMCTH). We recruited female patients with telogen effluvium, alopecia areata or female pattern hair loss who presented to our outpatient department between June 2019 and July 2020. Clinical and demographic data were collected and haemoglobin, serum iron profile and thyroid function investigated. Results: A total of 80 patients were recruited in the study period. The most common diagnosis was telogen effluvium (49, 61.25%) followed by alopecia areata (18, 22.5%) and female pattern hair loss (13, 16.25%). Although mean haemoglobin levels were within normal limits, inadequate ferritin levels for normal hair cycle were found in 77.55% of patients with telogen effluvium, 88.89% with alopecia areata and 84.61% with female pattern hair loss. Thyroid abnormalities were less commonly observed with more than 75% of the patients being euthyroid. Conclusion: Haemoglobin levels are not representative of true iron status in females with acquired alopecia. We therefore recommend investigating iron profile in all females with telogen effluvium, alopecia areata or female pattern hair loss.
{"title":"A Hospital Based Cross Sectional Study Evaluating Haemoglobin, Iron Profile and Thyroid Function Tests in Women with Telogen Effluvium, Female Pattern Hair Loss, and Alopecia Areata","authors":"B. Amatya, S. Joshi","doi":"10.3126/NJDVL.V19I1.34551","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.34551","url":null,"abstract":"Introduction: Hair loss is one of the most frequent complaints for which patients see a dermatologist. The three most common causes of hair loss in women are telogen effluvium, alopecia areata and female pattern hair loss. Objectives: The aim of this study was to investigate haemoglobin, iron profile and thyroid function tests in women with telogen effluvium, alopecia areata and female pattern hair loss. Materials and Methods: This was a hospital based cross sectional study conducted at the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital (NMCTH). We recruited female patients with telogen effluvium, alopecia areata or female pattern hair loss who presented to our outpatient department between June 2019 and July 2020. Clinical and demographic data were collected and haemoglobin, serum iron profile and thyroid function investigated. Results: A total of 80 patients were recruited in the study period. The most common diagnosis was telogen effluvium (49, 61.25%) followed by alopecia areata (18, 22.5%) and female pattern hair loss (13, 16.25%). Although mean haemoglobin levels were within normal limits, inadequate ferritin levels for normal hair cycle were found in 77.55% of patients with telogen effluvium, 88.89% with alopecia areata and 84.61% with female pattern hair loss. Thyroid abnormalities were less commonly observed with more than 75% of the patients being euthyroid. Conclusion: Haemoglobin levels are not representative of true iron status in females with acquired alopecia. We therefore recommend investigating iron profile in all females with telogen effluvium, alopecia areata or female pattern hair loss.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86210830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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