Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.35412
D. P. Thapa, Moushami Singh
We present a case of 45 year old female, presenting with a solitary, asymptomatic, pedunculated mass since childhood. The lesion was totally excised and was sent for histopathological evaluation and was found to be Naevus lipomatosis cutaneous superficialis which is a rare form of hamartoma in which mature adipocytes are found in the dermis.
{"title":"Rare Solitary Naevus Lipomatosis Cutaneous Superficialis: Histopathology A Diagnostic Clue","authors":"D. P. Thapa, Moushami Singh","doi":"10.3126/NJDVL.V19I1.35412","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.35412","url":null,"abstract":"We present a case of 45 year old female, presenting with a solitary, asymptomatic, pedunculated mass since childhood. The lesion was totally excised and was sent for histopathological evaluation and was found to be Naevus lipomatosis cutaneous superficialis which is a rare form of hamartoma in which mature adipocytes are found in the dermis.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"112 1","pages":"68-70"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87898346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.35955
A. Bhatta, U. Keyal, Yeqiang Liu
Congenital melanocytic nevus is a benign pigmented lesion of the skin usually present at birth. Here we report a case of a 61-year-old male who presented with a pigmented lesion on the trunk, which on biopsy showed features of both congenital melanocytic nevus and fibroepithelioma of Pinkus. We reviewed the literature for this combination and found only one case reported so far. Hence, it seems that it is very unusual to see fibroepithelioma of Pinkus in conjunction with a melanocytic lesion.
{"title":"Congenital Melanocytic Nevus and Fibroepithelioma of Pinkus: A Rare Type of Collision Tumor","authors":"A. Bhatta, U. Keyal, Yeqiang Liu","doi":"10.3126/NJDVL.V19I1.35955","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.35955","url":null,"abstract":"Congenital melanocytic nevus is a benign pigmented lesion of the skin usually present at birth. Here we report a case of a 61-year-old male who presented with a pigmented lesion on the trunk, which on biopsy showed features of both congenital melanocytic nevus and fibroepithelioma of Pinkus. We reviewed the literature for this combination and found only one case reported so far. Hence, it seems that it is very unusual to see fibroepithelioma of Pinkus in conjunction with a melanocytic lesion.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"9 1","pages":"81-83"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73888695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.35957
S. Shrestha, A. Joshi
Coronavirus disease-2019 (COVID-19) is the viral pandemic with the propensity of having several systemic manifestations. As with other viral diseases, it has been associated with varied cutaneous manifestations and they range from maculopapular eruptions, vascular lesions to the chickenpox-like lesions. However, the co-occurrence of COVID-19 and varicella has been rarely reported.
{"title":"Varicella in COVID-19: A Case Report","authors":"S. Shrestha, A. Joshi","doi":"10.3126/NJDVL.V19I1.35957","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.35957","url":null,"abstract":"Coronavirus disease-2019 (COVID-19) is the viral pandemic with the propensity of having several systemic manifestations. As with other viral diseases, it has been associated with varied cutaneous manifestations and they range from maculopapular eruptions, vascular lesions to the chickenpox-like lesions. However, the co-occurrence of COVID-19 and varicella has been rarely reported.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"14 1","pages":"65-67"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73380228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.30974
Megha Tandon
Background: Acne vulgaris is a common condition with a prevalence of over 90% among adolescents and postacne scarring is a well known sequelae. Different types of scars (ice pick, boxcar, and rolling scars) warrant a customized approach of treatment for each type. We propose a novel treatment of atrophic acne scars using combination of subcision and microneedling. Materials and Methods: Ten consecutive patients of skin types III IV with moderate and severe facial acne scarring received three sequential subcision and micro-needling treatments after informed consent over a period of three months with an interval of 4 weeks between each session. Goodman and Baron’s qualitative and quantitative acne scar grading systems along with side by side comparison of pre-operative and post-operative photographs were used for assessment at the end of three sessions of the combination procedure. Results: Estimation of improvement with Goodman and Baron’s Global qualitative acne scarring system, we found good results in patients with Grades 3 and 4 acne scars. Out of 7 patients with grade 4 scars, 29% showed improvement by 2 grades and 71% showed improvement by 1 grade and all the 3 patients with grade 3 scars showed improvement by 1 grade. Quantitative assessment showed 30% patients had minimal improvement, 50% had moderate improvement and 20% had good improvement in scars. Adverse effects were transient pain, erythema and oedema. Conclusion: Subcision and microneedling are simple and inexpensive office procedures which in combination are well tolerated and are efficacious in treatment of moderate and severe acne scars.
{"title":"Effect of Subcision and Microneedling in the Treatment of Atrophic Acne Scars in Ten Patients: A Case Series","authors":"Megha Tandon","doi":"10.3126/NJDVL.V19I1.30974","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.30974","url":null,"abstract":"Background: Acne vulgaris is a common condition with a prevalence of over 90% among adolescents and postacne scarring is a well known sequelae. Different types of scars (ice pick, boxcar, and rolling scars) warrant a customized approach of treatment for each type. We propose a novel treatment of atrophic acne scars using combination of subcision and microneedling. Materials and Methods: Ten consecutive patients of skin types III IV with moderate and severe facial acne scarring received three sequential subcision and micro-needling treatments after informed consent over a period of three months with an interval of 4 weeks between each session. Goodman and Baron’s qualitative and quantitative acne scar grading systems along with side by side comparison of pre-operative and post-operative photographs were used for assessment at the end of three sessions of the combination procedure. Results: Estimation of improvement with Goodman and Baron’s Global qualitative acne scarring system, we found good results in patients with Grades 3 and 4 acne scars. Out of 7 patients with grade 4 scars, 29% showed improvement by 2 grades and 71% showed improvement by 1 grade and all the 3 patients with grade 3 scars showed improvement by 1 grade. Quantitative assessment showed 30% patients had minimal improvement, 50% had moderate improvement and 20% had good improvement in scars. Adverse effects were transient pain, erythema and oedema. Conclusion: Subcision and microneedling are simple and inexpensive office procedures which in combination are well tolerated and are efficacious in treatment of moderate and severe acne scars.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"42 1","pages":"74-80"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87501827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.35047
Prajwal Pudasaini, S. Neupane
Introduction: Melasma is an acquired hyper melanosis that becomes more pronounced after sun exposure. Centro facial which is the commonest pattern followed by Malar and Mandibular are three clinical patterns of Melasma. Genetic influences, exposure to UV radiation, pregnancy, hormonal therapies, contribute to the pathogenesis of melasma. Melasma may considerably have significant effect on quality of life of patients. Objectives: The present study was conducted to evaluate the effects of melasma in quality of life (QoL) in the form of DLQI (Dermatology Life Quality Index) and severity of melasma according to Melasma Area and Severity Index (MASI). Materials and Methods: This is a hospital based cross-sectional prospective study conducted in 193 Melasma patients in the Department of Dermatology, Venereology and Leprology, Gandaki Medical College and Teaching Hospital, Pokhara from November 2018 to November 2019. MASI score was calculated and the patients were provided with a Nepali version of DLQI to fill up. Results: This study included 193 patients. Mean age of patients with melasma was 29.4 ± 8.5 years with maximum reported age of 59 years. The Mean age of onset of disease was 26.5 years. The Mean age of onset of disease had little impact on DLQI. The mean DLQI score was 10.9 ± 5.9, thus indicating “very large effect on patient’s life”. The mean MASI score was 6.6 ± 5.2. It was found that there was no correlation between severity of disease and DLQI scores (p=0.317) Conclusion: Melasma commonly affected females during second and third decades of life. It had a very large effect on patient’s life as assessed by DLQI.
简介:黄褐斑是一种后天的高度黑化，在阳光照射后变得更加明显。面部中心是最常见的类型，其次是颧部和下颌骨，是黄褐斑的三种临床类型。遗传影响，暴露于紫外线辐射，怀孕，激素治疗，有助于黄褐斑的发病机制。黄褐斑对患者的生活质量有显著影响。目的:采用DLQI (Dermatology life quality Index，皮肤病生活质量指数)和melasma Area and severity Index (MASI)评价黄褐斑对患者生活质量(QoL)的影响。材料与方法:这是一项基于医院的横断面前瞻性研究，于2018年11月至2019年11月在博卡拉Gandaki医学院和教学医院皮肤、性病和麻风科进行了193例黄褐斑患者。计算MASI评分，并提供尼泊尔版DLQI进行填写。结果:本研究纳入193例患者。黄褐斑患者平均年龄29.4±8.5岁，最大报道年龄59岁。平均发病年龄为26.5岁。平均发病年龄对DLQI的影响较小。DLQI平均评分为10.9±5.9分，对患者生活影响非常大。平均MASI评分为6.6±5.2。结论:女性黄褐斑多发生在二、三十岁。根据DLQI评估，它对患者的生活有很大的影响。
{"title":"An Observational Study to Evaluate Quality of Life in Patients with Melasma in A Tertiary Level Hospital of Pokhara","authors":"Prajwal Pudasaini, S. Neupane","doi":"10.3126/NJDVL.V19I1.35047","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.35047","url":null,"abstract":"Introduction: Melasma is an acquired hyper melanosis that becomes more pronounced after sun exposure. Centro facial which is the commonest pattern followed by Malar and Mandibular are three clinical patterns of Melasma. Genetic influences, exposure to UV radiation, pregnancy, hormonal therapies, contribute to the pathogenesis of melasma. Melasma may considerably have significant effect on quality of life of patients. Objectives: The present study was conducted to evaluate the effects of melasma in quality of life (QoL) in the form of DLQI (Dermatology Life Quality Index) and severity of melasma according to Melasma Area and Severity Index (MASI). Materials and Methods: This is a hospital based cross-sectional prospective study conducted in 193 Melasma patients in the Department of Dermatology, Venereology and Leprology, Gandaki Medical College and Teaching Hospital, Pokhara from November 2018 to November 2019. MASI score was calculated and the patients were provided with a Nepali version of DLQI to fill up. Results: This study included 193 patients. Mean age of patients with melasma was 29.4 ± 8.5 years with maximum reported age of 59 years. The Mean age of onset of disease was 26.5 years. The Mean age of onset of disease had little impact on DLQI. The mean DLQI score was 10.9 ± 5.9, thus indicating “very large effect on patient’s life”. The mean MASI score was 6.6 ± 5.2. It was found that there was no correlation between severity of disease and DLQI scores (p=0.317) Conclusion: Melasma commonly affected females during second and third decades of life. It had a very large effect on patient’s life as assessed by DLQI.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"1 1","pages":"37-41"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91388538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-02DOI: 10.3126/NJDVL.V19I1.34693
M. Pradhan, Vikash Paudel
Introduction: Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. It is the most common of the superficial fungal infections. Nowadays, these fungal infections are at a rise and run a prolonged course despite of treatment due to resistance to conventional antifungal agents. There is a felt need to conduct an epidemiological studies to know the change in the pattern and causes of widespread resistance. Objectives: This study was aimed at identifying clinico-mycological patterns of dermatophytic infections in patients attending the dermatology outpatient department of a tertiary care hospital in Birgunj and the adjoining areas. Materials and Methods: The study included cases of clinically diagnosed dermatophytosis from the outpatient department of Dermatology of National Medical College, Birgunj. Clinical and epidemiological data were collected as per proforma and skin scraping, hair plucking, and nail clipping were done and materials were examined microscopically by KOH mount then cultured on Sabouraud dextrose agar and antifungal susceptibility were done by disk diffusion test. Results: There were 349 patients recruited in the study, with a male: female ratio of 1.6:1. The most commonly affected age group was 20–29 years (27.3%). Tinea corporis was the most common type observed (38.1%). Potassium hydroxide positivity was seen in 228 samples (65.3%) and culture positivity was found in 202 samples (57.9%). The most common species identified was Trichophyton rubrum (55%). The most sensitive drug was itraconazole, and more number of resistances was noted with fluconazole. Conclusion: Dermatophytic infection is ecumenical in distribution with increased frequency in tropical and subtropical countries with variable epidemiology. Inadequate and irregular use of antifungal drugs has led to the emergence of resistant strains, which cause poor treatment outcomes. Thus, it is essential to test for antifungal sensitivity to check for resistance to antifungals.
{"title":"Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study","authors":"M. Pradhan, Vikash Paudel","doi":"10.3126/NJDVL.V19I1.34693","DOIUrl":"https://doi.org/10.3126/NJDVL.V19I1.34693","url":null,"abstract":"Introduction: Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. It is the most common of the superficial fungal infections. Nowadays, these fungal infections are at a rise and run a prolonged course despite of treatment due to resistance to conventional antifungal agents. There is a felt need to conduct an epidemiological studies to know the change in the pattern and causes of widespread resistance. Objectives: This study was aimed at identifying clinico-mycological patterns of dermatophytic infections in patients attending the dermatology outpatient department of a tertiary care hospital in Birgunj and the adjoining areas. Materials and Methods: The study included cases of clinically diagnosed dermatophytosis from the outpatient department of Dermatology of National Medical College, Birgunj. Clinical and epidemiological data were collected as per proforma and skin scraping, hair plucking, and nail clipping were done and materials were examined microscopically by KOH mount then cultured on Sabouraud dextrose agar and antifungal susceptibility were done by disk diffusion test. Results: There were 349 patients recruited in the study, with a male: female ratio of 1.6:1. The most commonly affected age group was 20–29 years (27.3%). Tinea corporis was the most common type observed (38.1%). Potassium hydroxide positivity was seen in 228 samples (65.3%) and culture positivity was found in 202 samples (57.9%). The most common species identified was Trichophyton rubrum (55%). The most sensitive drug was itraconazole, and more number of resistances was noted with fluconazole. Conclusion: Dermatophytic infection is ecumenical in distribution with increased frequency in tropical and subtropical countries with variable epidemiology. Inadequate and irregular use of antifungal drugs has led to the emergence of resistant strains, which cause poor treatment outcomes. Thus, it is essential to test for antifungal sensitivity to check for resistance to antifungals.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"108 1","pages":"30-36"},"PeriodicalIF":0.4,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75305986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.22541/AU.161556028.81077251/V1
M. El-Hamd, Hasan Mohamed Ibrahim, Abdallah Elaiw Mohammed, Eisa Mohammed
Objective This study aimed to assess the clinical efficiency of narrowband–ultraviolet B (NB–UVB) phototherapy and methotrexate (MTX) therapy and their effects on serum tumor necrosis factor-alpha (TNF-α) in patients with cutaneous lichen planus (CLP). Patients and methods The present prospective cohort study was carried out on 60 patients with CLP. The included patients were indiscriminately classified into two treatment groups: group A (30 patients) received NB–UVB phototherapy for three months and group B (30 patients) received MTX therapy for 3 months. All the patients were assessed clinically and TNF-α before and after treatments. Results There were no statistically significant differences between the two groups of treatment with regard to clinical improvement after treatment (P=0.149). Regarding the levels of TNF-α, there was a statistically significant difference between the two treatment groups after treatment (P=0.024). There was a statistically significant reduction in TNF-α level after treatment in the MTX group. Conclusion This study concluded that NB–UVB phototherapy and MTX therapy were clinically effective in the treatment of patients with CLP. MTX therapy was more efficient in the reduction of TNF-α level than NB–UVB phototherapy in patients with CLP.
{"title":"Clinical efficiency of narrowband-ultraviolet B phototherapy and methotrexate therapy and their effects on serum tumor necrosis factor-alpha in patients with cutaneous lichen planus","authors":"M. El-Hamd, Hasan Mohamed Ibrahim, Abdallah Elaiw Mohammed, Eisa Mohammed","doi":"10.22541/AU.161556028.81077251/V1","DOIUrl":"https://doi.org/10.22541/AU.161556028.81077251/V1","url":null,"abstract":"Objective This study aimed to assess the clinical efficiency of narrowband–ultraviolet B (NB–UVB) phototherapy and methotrexate (MTX) therapy and their effects on serum tumor necrosis factor-alpha (TNF-α) in patients with cutaneous lichen planus (CLP). Patients and methods The present prospective cohort study was carried out on 60 patients with CLP. The included patients were indiscriminately classified into two treatment groups: group A (30 patients) received NB–UVB phototherapy for three months and group B (30 patients) received MTX therapy for 3 months. All the patients were assessed clinically and TNF-α before and after treatments. Results There were no statistically significant differences between the two groups of treatment with regard to clinical improvement after treatment (P=0.149). Regarding the levels of TNF-α, there was a statistically significant difference between the two treatment groups after treatment (P=0.024). There was a statistically significant reduction in TNF-α level after treatment in the MTX group. Conclusion This study concluded that NB–UVB phototherapy and MTX therapy were clinically effective in the treatment of patients with CLP. MTX therapy was more efficient in the reduction of TNF-α level than NB–UVB phototherapy in patients with CLP.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"164 - 170"},"PeriodicalIF":0.4,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41435978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-02DOI: 10.12970/2310-998X.2021.09.01
K. Asare, Justice Afrifa, Y. Opoku
{"title":"Mechanisms Underlying Induced Pseudo-Scleroderma among Patients with Phenylketonuria Metabolic Disorder","authors":"K. Asare, Justice Afrifa, Y. Opoku","doi":"10.12970/2310-998X.2021.09.01","DOIUrl":"https://doi.org/10.12970/2310-998X.2021.09.01","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"130 1","pages":"1-8"},"PeriodicalIF":0.4,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76408180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interrelationship between head lice infestation and nutritional status of Thai preschool nursery children in a remote community near Thailand-Cambodia international border: an observation","authors":"B. Joob, V. Wiwanitkit","doi":"10.4103/ejdv.ejdv_8_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_8_20","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"41 1","pages":"51 - 52"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45287064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Bullous systemic lupus erythematosus (BSLE) has rarely been described in pediatric lupus population, and the real prevalence of childhood-onset BSLE has not been reported. BSLE is a rare manifestation of systemic lupus erythematosus and is very rare in children. BSLE affects women more often than men, reflecting the female preponderance in systemic lupus erythematosus. It most often manifests in the second through fourth decades of life, but it has also been reported in children and older adults. Patients and methods Herein, we describe a case of a 10-year-old female patient who presented with a 1-year history of recurrent itchy urticated skin eruption, which was followed 2 months later (after the first year) by a generalized blistering eruption with photosensitivity. Results Histopathologic examination revealed a subepidermal blister and papillary-tip neutrophil microabscesses. Immunofluorescence studies showed linear immunoglobulin G (IgG) and IgC deposition along the BMZ with weaker staining of IgA and IgM. Laboratory tests revealed positive ANA, dsDNA, anti-SM antibodies, elevated erythrocyte sedimentation rate, and proteinuria. Conclusion Although the course of BSLE is often remitting, but not in our case, treatment with dapsone is successful in most cases of BSLE.
{"title":"Childhood bullous systemic lupus erythematosus: unusual prognosis","authors":"K. Gharib","doi":"10.4103/ejdv.ejdv_2_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_2_20","url":null,"abstract":"Background Bullous systemic lupus erythematosus (BSLE) has rarely been described in pediatric lupus population, and the real prevalence of childhood-onset BSLE has not been reported. BSLE is a rare manifestation of systemic lupus erythematosus and is very rare in children. BSLE affects women more often than men, reflecting the female preponderance in systemic lupus erythematosus. It most often manifests in the second through fourth decades of life, but it has also been reported in children and older adults. Patients and methods Herein, we describe a case of a 10-year-old female patient who presented with a 1-year history of recurrent itchy urticated skin eruption, which was followed 2 months later (after the first year) by a generalized blistering eruption with photosensitivity. Results Histopathologic examination revealed a subepidermal blister and papillary-tip neutrophil microabscesses. Immunofluorescence studies showed linear immunoglobulin G (IgG) and IgC deposition along the BMZ with weaker staining of IgA and IgM. Laboratory tests revealed positive ANA, dsDNA, anti-SM antibodies, elevated erythrocyte sedimentation rate, and proteinuria. Conclusion Although the course of BSLE is often remitting, but not in our case, treatment with dapsone is successful in most cases of BSLE.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"41 1","pages":"16 - 21"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43643918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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