Manickam Navakumar, G. Seethalakshmi, Lalu Meera, G. Kannan
We report a case of a 22-year-old male patient with angiokeratoma corporis diffusum, which is a cutaneous feature of many lysosomal storage disorders, but we diagnosed it as Fabry disease (FD) as our patient had normal intelligence associated with coarse facies, acroparesthesia, ocular changes like dilated vessels in conjunctiva, and presence of vacuolated endothelial cells in histopathological examination. It is an X-linked inborn error of the glycosphingolipid metabolic pathway that is associated with protean manifestations and is a paradigm of a multi-system condition with symptoms expressing themselves in many organs. We report this rare case mainly to stress the importance of proper clinical evaluation in the diagnosis of FD in today’s era of costly investigations like enzyme assay, which is not feasible in our setting. It also shows the importance of proper dermatological assessment, which has a highly positive predictive value in terms of assessing systemic morbidity in FD.
{"title":"Angiokeratoma corporis diffusum − a rare case report","authors":"Manickam Navakumar, G. Seethalakshmi, Lalu Meera, G. Kannan","doi":"10.4103/ejdv.ejdv_7_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_7_22","url":null,"abstract":"We report a case of a 22-year-old male patient with angiokeratoma corporis diffusum, which is a cutaneous feature of many lysosomal storage disorders, but we diagnosed it as Fabry disease (FD) as our patient had normal intelligence associated with coarse facies, acroparesthesia, ocular changes like dilated vessels in conjunctiva, and presence of vacuolated endothelial cells in histopathological examination. It is an X-linked inborn error of the glycosphingolipid metabolic pathway that is associated with protean manifestations and is a paradigm of a multi-system condition with symptoms expressing themselves in many organs. We report this rare case mainly to stress the importance of proper clinical evaluation in the diagnosis of FD in today’s era of costly investigations like enzyme assay, which is not feasible in our setting. It also shows the importance of proper dermatological assessment, which has a highly positive predictive value in terms of assessing systemic morbidity in FD.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47782601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Seborrheic keratosis is one of the most common benign epidermal tumors seen in elderly individuals. It has slow growth and presents with a varied degree of pigmentation in skin color closely resembling many other pigmented dermatoses. Dermoscopy, a noninvasive technique, could increase the accuracy of diagnosis and can differentiate it from various closest mimickers and malignancies. Aim This study aims to describe the various dermoscopic features of seborrheic keratosis in a series of cases. Patients and methods A hospital-based, descriptive study was conducted over 12 months from January 2018 to December 2018 in the Department of Dermatology, a tertiary-care center. A total of 100 patients were selected and evaluated in a prestructured proforma concerning age, sex, site of lesion, number and duration, and associated comorbidities. The lesion is observed on dermoscopy, and the dermoscopic patterns were then documented and analyzed. Result Among a total of 100 (32%) cases, the most common age group was between 41 and 50 years with females (52%) outnumbering males (48%). The most common site was the face (38%), and the common morphology was plaque (60%). Sign of Leser-Trélat was observed in five patients of which three were associated with malignancy that includes two lymphomas and one breast carcinoma. The color on dermoscopy was predominant dark brown (43%) and brownish-black (32%). The common element was clod (39%) and combined clod and dots (18%). More than three colors and more than two elements in a single lesion were observed in 15 and 11% of cases, respectively. The dermoscopic clues of seborrheic keratosis with highest to lowest prevalence were cerebriform pattern (76%), sharp demarcation (64%), comedone-like opening (56%), milia-like cyst (54%), mica-like scales (52%), moth-eaten border (46%), jelly sign (40%), fingerprint-like pattern (40%), fat fingers (36%), peripheral globules/network (34%), coral-like structure (26%), papillary structures (26%), irregular globules (12%), irregular opaque brown pigmentation (12%), and yellow-orange areas (3%). The flat seborrheic keratosis predominantly showed an irregular network-like structure, fat fingers, milia-like cyst, and accentuation of two adjacent perifollicular pigmentations forming a double ring-like structure (16%). The raised lesions predominantly showed fissures/ridges (cerebriform pattern), exophytic papillary structures, opaque pigmentation, and a mica-like pattern. Ten lesions were misinterpreted as seborrheic keratosis clinically and on dermoscopy were verruca vulgaris (2/10, 20%), melanocytic nevus (3/10, 30%), and basal cell carcinoma (5/10, 50%), which were confirmed on histopathology. Conclusion The study emphasizes the use of dermoscopy in seborrheic keratosis to improve the clinical accuracy of diagnosis and also to differentiate from its common mimickers.
{"title":"Role of dermoscopy in diagnosing and differentiating seborrheic keratoses: a case study of 100 patients","authors":"Aswath Rajan, P. Shukla, V. Pai","doi":"10.4103/ejdv.ejdv_39_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_39_21","url":null,"abstract":"Background Seborrheic keratosis is one of the most common benign epidermal tumors seen in elderly individuals. It has slow growth and presents with a varied degree of pigmentation in skin color closely resembling many other pigmented dermatoses. Dermoscopy, a noninvasive technique, could increase the accuracy of diagnosis and can differentiate it from various closest mimickers and malignancies. Aim This study aims to describe the various dermoscopic features of seborrheic keratosis in a series of cases. Patients and methods A hospital-based, descriptive study was conducted over 12 months from January 2018 to December 2018 in the Department of Dermatology, a tertiary-care center. A total of 100 patients were selected and evaluated in a prestructured proforma concerning age, sex, site of lesion, number and duration, and associated comorbidities. The lesion is observed on dermoscopy, and the dermoscopic patterns were then documented and analyzed. Result Among a total of 100 (32%) cases, the most common age group was between 41 and 50 years with females (52%) outnumbering males (48%). The most common site was the face (38%), and the common morphology was plaque (60%). Sign of Leser-Trélat was observed in five patients of which three were associated with malignancy that includes two lymphomas and one breast carcinoma. The color on dermoscopy was predominant dark brown (43%) and brownish-black (32%). The common element was clod (39%) and combined clod and dots (18%). More than three colors and more than two elements in a single lesion were observed in 15 and 11% of cases, respectively. The dermoscopic clues of seborrheic keratosis with highest to lowest prevalence were cerebriform pattern (76%), sharp demarcation (64%), comedone-like opening (56%), milia-like cyst (54%), mica-like scales (52%), moth-eaten border (46%), jelly sign (40%), fingerprint-like pattern (40%), fat fingers (36%), peripheral globules/network (34%), coral-like structure (26%), papillary structures (26%), irregular globules (12%), irregular opaque brown pigmentation (12%), and yellow-orange areas (3%). The flat seborrheic keratosis predominantly showed an irregular network-like structure, fat fingers, milia-like cyst, and accentuation of two adjacent perifollicular pigmentations forming a double ring-like structure (16%). The raised lesions predominantly showed fissures/ridges (cerebriform pattern), exophytic papillary structures, opaque pigmentation, and a mica-like pattern. Ten lesions were misinterpreted as seborrheic keratosis clinically and on dermoscopy were verruca vulgaris (2/10, 20%), melanocytic nevus (3/10, 30%), and basal cell carcinoma (5/10, 50%), which were confirmed on histopathology. Conclusion The study emphasizes the use of dermoscopy in seborrheic keratosis to improve the clinical accuracy of diagnosis and also to differentiate from its common mimickers.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41674009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roma Dhande, Bhushan Madke, A. Singh, Sugat A Jawade, Praveen Maheshwari
Aim To study the involvement of terminal and vellus hair follicle in dermatophytic infections. Objectives Methodology A 4mm punch biopsy was collected from the active border involving the hairy part of the skin and stained with Hematyoxylin and Eosin and Periodic acid schiff stain . Hair follicle portions were examined to check if there are any fungal elements in the follicle. Result It was found that there was correlation between duration of disease and involvement of hair follicle. Conclusion Chronicity is associated with hair follicle involvement, requiring longer duration of oral Antifungals for complete clearance of infection.
{"title":"Study of involvement of terminal and vellus hair follicle in dermatophytic infections","authors":"Roma Dhande, Bhushan Madke, A. Singh, Sugat A Jawade, Praveen Maheshwari","doi":"10.4103/ejdv.ejdv_5_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_5_22","url":null,"abstract":"Aim To study the involvement of terminal and vellus hair follicle in dermatophytic infections. Objectives Methodology A 4mm punch biopsy was collected from the active border involving the hairy part of the skin and stained with Hematyoxylin and Eosin and Periodic acid schiff stain . Hair follicle portions were examined to check if there are any fungal elements in the follicle. Result It was found that there was correlation between duration of disease and involvement of hair follicle. Conclusion Chronicity is associated with hair follicle involvement, requiring longer duration of oral Antifungals for complete clearance of infection.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43567209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Coronavirus disease 2019 (COVID-19) pandemic has resulted in remarkable changes in the profiles of diseases including dermatologic conditions. Aim To investigate the patterns of skin diseases in Egypt during the COVID-19 pandemic. Patients and methods In this cross-sectional study, we reviewed the data of patients who visited dermatology clinics between August 2020 and January 2021 and compared them with the data from the same clinics in the previous year. Results The total number of patients who attended the dermatology clinics between August 2020 and January 2021 was 803 as compared with 1611 patients in the corresponding period of the previous year (49.84% reduction). During the COVID-19 pandemic, there was a significant increase in the frequency of allergic contact dermatitis, irritant contact dermatitis, pityriasis rosea, alopecia areata, erythema multiforme, vasculitis, herpes zoster, and chicken pox (P<0.05). On the contrary, some dermatological conditions such as urticaria and nonscarring hair loss had significantly decreased frequencies during the COVID-19 pandemic (P<0.05). Several skin diseases had unchanged frequencies during the COVID-19 pandemic. These included skin infections (other than viral infections), bullous disorders, some eczematous skin diseases, papulosquamous disorders, and disorders of skin pigmentation. Conclusion This study indicates a significant reduction in the total number of patients attending dermatology clinics in Egypt during the COVID-19 pandemic. The frequency of some skin diseases increased significantly, whereas other skin diseases decreased significantly or remained unchanged during the pandemic. Periodic evaluation of the epidemiologic characteristics of skin diseases is required at different stages of evolution of the COVID-19 pandemic.
{"title":"Frequency of skin diseases in Egyptian population during coronavirus disease 2019 pandemic: a hospital-based cross-sectional study","authors":"M. Mohamed, N. Mohammed, R. Saleh","doi":"10.4103/ejdv.ejdv_38_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_38_21","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19) pandemic has resulted in remarkable changes in the profiles of diseases including dermatologic conditions. Aim To investigate the patterns of skin diseases in Egypt during the COVID-19 pandemic. Patients and methods In this cross-sectional study, we reviewed the data of patients who visited dermatology clinics between August 2020 and January 2021 and compared them with the data from the same clinics in the previous year. Results The total number of patients who attended the dermatology clinics between August 2020 and January 2021 was 803 as compared with 1611 patients in the corresponding period of the previous year (49.84% reduction). During the COVID-19 pandemic, there was a significant increase in the frequency of allergic contact dermatitis, irritant contact dermatitis, pityriasis rosea, alopecia areata, erythema multiforme, vasculitis, herpes zoster, and chicken pox (P<0.05). On the contrary, some dermatological conditions such as urticaria and nonscarring hair loss had significantly decreased frequencies during the COVID-19 pandemic (P<0.05). Several skin diseases had unchanged frequencies during the COVID-19 pandemic. These included skin infections (other than viral infections), bullous disorders, some eczematous skin diseases, papulosquamous disorders, and disorders of skin pigmentation. Conclusion This study indicates a significant reduction in the total number of patients attending dermatology clinics in Egypt during the COVID-19 pandemic. The frequency of some skin diseases increased significantly, whereas other skin diseases decreased significantly or remained unchanged during the pandemic. Periodic evaluation of the epidemiologic characteristics of skin diseases is required at different stages of evolution of the COVID-19 pandemic.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49459436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum interleukin-33 level and psoriasis diagnosis","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.4103/ejdv.ejdv_48_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_48_21","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Median canaliform dystrophy of Heller is a rare entity characterized by median or midline split of nails in one or both thumb nails. Treatment of median canaliform dystrophy is at times challenging as no successful therapy is available till date. Recently reported treatments include topical steroids, calcineurin inhibitor tacrolimus 0.1%, and tazarotene 0.05% ointment. We report the case of a 30-year-old man who came to our institute with complaints of nail lesions over both thumb nails and great toe nails from the past 5 years, which was causing cosmetic disfigurement.
{"title":"Median canaliform nail dystrophy involving thumb nails and great toe nails: a rare entity","authors":"Vikram Arragudla, A. Parthasaradhi","doi":"10.4103/ejdv.ejdv_30_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_30_21","url":null,"abstract":"Median canaliform dystrophy of Heller is a rare entity characterized by median or midline split of nails in one or both thumb nails. Treatment of median canaliform dystrophy is at times challenging as no successful therapy is available till date. Recently reported treatments include topical steroids, calcineurin inhibitor tacrolimus 0.1%, and tazarotene 0.05% ointment. We report the case of a 30-year-old man who came to our institute with complaints of nail lesions over both thumb nails and great toe nails from the past 5 years, which was causing cosmetic disfigurement.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49208750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acne patients demonstrate high levels of social, psychological, and emotional impairment including suicidal ideation. 1 The global pandemic bought with it high levels of psychological distress, and it is well known that stress influences the activity of the pilosebaceous unit leading to acne. 2 Further, “do it yourself” (DIY) solutions flooding the internet meant that it was pertinent that the dermatologist not only initiate care, but administer due counselling and “on-going” care for acne patients at this time. The continuation of care of acne is possible via teledermatology, and it appears to be a common issue for which patients seek video consultations and are satisfied with their initial consult, 3 however video consultation has its limitations.
{"title":"Optimizing acne care via teledermatology − where do we stand?","authors":"Rajat Kandhari","doi":"10.4103/ejdv.ejdv_44_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_44_21","url":null,"abstract":"Acne patients demonstrate high levels of social, psychological, and emotional impairment including suicidal ideation. 1 The global pandemic bought with it high levels of psychological distress, and it is well known that stress influences the activity of the pilosebaceous unit leading to acne. 2 Further, “do it yourself” (DIY) solutions flooding the internet meant that it was pertinent that the dermatologist not only initiate care, but administer due counselling and “on-going” care for acne patients at this time. The continuation of care of acne is possible via teledermatology, and it appears to be a common issue for which patients seek video consultations and are satisfied with their initial consult, 3 however video consultation has its limitations.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48827793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rehab Naguib, A. El-Rifaie, Abd-ElA El-Taweel, M. Dahab
Background Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Circular RNAs (circRNAs) are regulatory noncoding RNAs. They play an important role in multiple physiological and pathological processes, such as cancer, cardiovascular diseases, and neuronal diseases. Some circRNAs are involved in regulating immunity, inflammation, and cell proliferation in many types of cells. Aim To detect the expression of circRNA (Circ0061012) in psoriatic skin of diseased patients as compared with normal control persons to investigate the possible role of circRNA in psoriasis pathogenesis and its correlation with disease severity. Patients and methods The present study included 30 psoriatic patients and 30 healthy controls. A 4-mm punch skin biopsy was taken from patients (psoriatic lesion) and controls, and it was kept in the lysis solution for the stability of the studied parameters and was kept frozen at ‑80°Celsius till analysis of circRNA by real-time polymerase chain reaction. Results The tissue level of circRNA (Circ0061012) was significantly higher among patients with psoriasis as compared with normal control individuals. Conclusion circRNA could contribute to psoriasis pathogenesis through its immunomodulatory role, so it might be a therapeutic target in the future.
{"title":"An insight into the value of circular RNA in psoriasis pathogenesis and its correlation with PASI score","authors":"Rehab Naguib, A. El-Rifaie, Abd-ElA El-Taweel, M. Dahab","doi":"10.4103/ejdv.ejdv_36_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_36_21","url":null,"abstract":"Background Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Circular RNAs (circRNAs) are regulatory noncoding RNAs. They play an important role in multiple physiological and pathological processes, such as cancer, cardiovascular diseases, and neuronal diseases. Some circRNAs are involved in regulating immunity, inflammation, and cell proliferation in many types of cells. Aim To detect the expression of circRNA (Circ0061012) in psoriatic skin of diseased patients as compared with normal control persons to investigate the possible role of circRNA in psoriasis pathogenesis and its correlation with disease severity. Patients and methods The present study included 30 psoriatic patients and 30 healthy controls. A 4-mm punch skin biopsy was taken from patients (psoriatic lesion) and controls, and it was kept in the lysis solution for the stability of the studied parameters and was kept frozen at ‑80°Celsius till analysis of circRNA by real-time polymerase chain reaction. Results The tissue level of circRNA (Circ0061012) was significantly higher among patients with psoriasis as compared with normal control individuals. Conclusion circRNA could contribute to psoriasis pathogenesis through its immunomodulatory role, so it might be a therapeutic target in the future.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48838439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rehab Naguib, Abd-ElAziz El-Rifaie, EmanA.Z. Eissa, L. Rashed
Background Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. Dysregulation of autophagy-related genes has been recognized to increase susceptibility to diseases, such as inflammation, cancer, and autoimmune disorders. Aim Our study aimed to detect the expression of the autophagy-related gene 16L1 (ATG 16L) in psoriasis patients compared with normal controls to investigate the role of autophagy in the pathogenesis of this disease. Patients and methods This case–control study included 30 psoriasis patients and 30 healthy controls. Punch skin biopsies of 4 mm were taken from psoriatic lesions and then from the controls and they were kept in a lysis solution for the stability of the studied parameters and were kept frozen at –80°C till analysis of ATG 16L using real-time PCR. Results The level of the ATG 16L1 in the lesional skin of psoriasis was significantly increased compared with normal controls (P<0.001). Limitation Limited number of patients were included in this study (30 patients). Conclusion Autophagy process may play an important role in the pathogenesis of psoriasis disease.
{"title":"Autophagy-related gene 16L1 value in chronic plaque psoriasis","authors":"Rehab Naguib, Abd-ElAziz El-Rifaie, EmanA.Z. Eissa, L. Rashed","doi":"10.4103/ejdv.ejdv_34_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_34_21","url":null,"abstract":"Background Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. Dysregulation of autophagy-related genes has been recognized to increase susceptibility to diseases, such as inflammation, cancer, and autoimmune disorders. Aim Our study aimed to detect the expression of the autophagy-related gene 16L1 (ATG 16L) in psoriasis patients compared with normal controls to investigate the role of autophagy in the pathogenesis of this disease. Patients and methods This case–control study included 30 psoriasis patients and 30 healthy controls. Punch skin biopsies of 4 mm were taken from psoriatic lesions and then from the controls and they were kept in a lysis solution for the stability of the studied parameters and were kept frozen at –80°C till analysis of ATG 16L using real-time PCR. Results The level of the ATG 16L1 in the lesional skin of psoriasis was significantly increased compared with normal controls (P<0.001). Limitation Limited number of patients were included in this study (30 patients). Conclusion Autophagy process may play an important role in the pathogenesis of psoriasis disease.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48860153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Mohamad, Samar El-Tahlawy, Naglaa A. El Sherbiny, Eman Ebrahim
Background Acanthosis nigricans (AN) is characterized by pigmented velvety thickening of the intertriginous body areas and neck. Many studies linked it to metabolic syndrome. Aim To detect the prevalence of AN among primary school children and to identify the associated risk factors. Patients and methods We included 2060 primary school students who were selected from two rural and four urban schools. The data were collected by questionnaire sheets that were fulfilled from each student in which present and past history for any disease were taken. Results The prevalence of AN was 17.7% of all examined students, higher in females (18.6%) than males (16.3%), but it was not statistically significant. More than half of the students 55.0% were of normal weight, 23.3% were overweight, and 21.7% were obese. In the current study, 69.1% of obese children were having AN. Conclusions Regular dermatologic examination for early identification of AN is required. AN in the knuckles should be considered as a classic site and highly prevalent. It should be borne in mind that coordinated efforts of medical professional teams may be required aiming to correct the underlying disease to improve the skin symptoms. Strict follow-up of patients with AN for early detection and management of insulin resistance and metabolic syndrome.
{"title":"Prevalence and risk factors associated with acanthosis nigricans in primary school children","authors":"N. Mohamad, Samar El-Tahlawy, Naglaa A. El Sherbiny, Eman Ebrahim","doi":"10.4103/ejdv.ejdv_16_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_16_21","url":null,"abstract":"Background Acanthosis nigricans (AN) is characterized by pigmented velvety thickening of the intertriginous body areas and neck. Many studies linked it to metabolic syndrome. Aim To detect the prevalence of AN among primary school children and to identify the associated risk factors. Patients and methods We included 2060 primary school students who were selected from two rural and four urban schools. The data were collected by questionnaire sheets that were fulfilled from each student in which present and past history for any disease were taken. Results The prevalence of AN was 17.7% of all examined students, higher in females (18.6%) than males (16.3%), but it was not statistically significant. More than half of the students 55.0% were of normal weight, 23.3% were overweight, and 21.7% were obese. In the current study, 69.1% of obese children were having AN. Conclusions Regular dermatologic examination for early identification of AN is required. AN in the knuckles should be considered as a classic site and highly prevalent. It should be borne in mind that coordinated efforts of medical professional teams may be required aiming to correct the underlying disease to improve the skin symptoms. Strict follow-up of patients with AN for early detection and management of insulin resistance and metabolic syndrome.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41372002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：