Background Atopic dermatitis (AD) is a common skin disease that not only severely burdens patients but also their families and society. AD is a chronic inflammatory disease that is usually detected in childhood. Objectives We aim to evaluate the quality of life of parents of children with AD and to crosscheck it with the intensity of the disease. Patients and methods This is a cross-sectional study, where the data of parents of 100 children with AD were collected from the outpatient clinic of the Dermatology, Venereology, and Andrology Department, Assiut University Hospitals, from May 2017 to May 2019. Parents answered the validated Arabic version of the Dermatitis Family Impact (DFI) questionnaire. The disease severity was assessed using the SCORAD index. Results Families of children with severe dermatitis had quite high DFI scores (16.37±3.727) compared with the families of those with dermatitis of moderate intensity (12.10±3.356) and dermatitis of low intensity (8.50±0.707) (P<0.001). It was observed that the impact of dermatitis on families had a positive significant correlation with the degree of intensity of AD (P<0.001, r=0.658). The highest-scoring DFI domains were sleep time, followed by a feeling of tiredness, emotional stability, general life, household work, and expenditure. Conclusion AD directly affects the quality of life of patients’ parents, and the adverse effects on the quality of life are significantly correlated with the disease severity.
{"title":"Impact of childhood atopic dermatitis on family: correlation with disease severity","authors":"Azza Abdel-Maguid, Esraa Abd El Salam, H. Gaber","doi":"10.4103/ejdv.ejdv_1_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_1_21","url":null,"abstract":"Background Atopic dermatitis (AD) is a common skin disease that not only severely burdens patients but also their families and society. AD is a chronic inflammatory disease that is usually detected in childhood. Objectives We aim to evaluate the quality of life of parents of children with AD and to crosscheck it with the intensity of the disease. Patients and methods This is a cross-sectional study, where the data of parents of 100 children with AD were collected from the outpatient clinic of the Dermatology, Venereology, and Andrology Department, Assiut University Hospitals, from May 2017 to May 2019. Parents answered the validated Arabic version of the Dermatitis Family Impact (DFI) questionnaire. The disease severity was assessed using the SCORAD index. Results Families of children with severe dermatitis had quite high DFI scores (16.37±3.727) compared with the families of those with dermatitis of moderate intensity (12.10±3.356) and dermatitis of low intensity (8.50±0.707) (P<0.001). It was observed that the impact of dermatitis on families had a positive significant correlation with the degree of intensity of AD (P<0.001, r=0.658). The highest-scoring DFI domains were sleep time, followed by a feeling of tiredness, emotional stability, general life, household work, and expenditure. Conclusion AD directly affects the quality of life of patients’ parents, and the adverse effects on the quality of life are significantly correlated with the disease severity.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"42 1","pages":"40 - 44"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49602067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oxidant and antioxidant status in patients with female pattern hair loss with varying severity","authors":"Fathia M Khattab, A. Al-Karamany","doi":"10.4103/ejdv.ejdv_38_19","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_38_19","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"23 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70716856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perforating folliculitis is a primary perforating disorder, characterized by the phenomenon of transepidermal elimination. It is associated with various disorders such as psoriasis, juvenile acanthosis nigricans, diabetic mellitus, renal failure, cardiac failure, and malignant neoplasia. Other primary perforating dermatoses are Kyrle’s disease, reactive perforating collagenosis, and elastosis perforans serpiginosa. Among the association of perforating dermatoses with genetic diseases like Down’s syndrome, elastosis perforans serpiginosa and very rarely reactive perforating collagenosis have been reported. We report the first case of an 11-year-old boy who is a known case of Down syndrome presented with perforating folliculitis.
{"title":"Perforating folliculitis in Down’s syndrome − a rare case report","authors":"Aswath Rajan, V. Pai, P. Shukla","doi":"10.4103/ejdv.ejdv_60_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_60_20","url":null,"abstract":"Perforating folliculitis is a primary perforating disorder, characterized by the phenomenon of transepidermal elimination. It is associated with various disorders such as psoriasis, juvenile acanthosis nigricans, diabetic mellitus, renal failure, cardiac failure, and malignant neoplasia. Other primary perforating dermatoses are Kyrle’s disease, reactive perforating collagenosis, and elastosis perforans serpiginosa. Among the association of perforating dermatoses with genetic diseases like Down’s syndrome, elastosis perforans serpiginosa and very rarely reactive perforating collagenosis have been reported. We report the first case of an 11-year-old boy who is a known case of Down syndrome presented with perforating folliculitis.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"42 1","pages":"73 - 76"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46340397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rehab Naguib, A. El-Rifaie, ManarA Awad, L. Rashed
{"title":"Downregulation of microRNA-520 in chronic plaque psoriasis","authors":"Rehab Naguib, A. El-Rifaie, ManarA Awad, L. Rashed","doi":"10.4103/ejdv.ejdv_29_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_29_21","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70716114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Badran Aya, S. Rofaida, Abd-ElkaderS Alaa, Kamel Amira, A. Fatma, G. Ahmed
{"title":"Trappin-2/Elafin and Clusterin serum levels in pemphigus vulgaris and correlation with the severity score: a case–control study","authors":"Badran Aya, S. Rofaida, Abd-ElkaderS Alaa, Kamel Amira, A. Fatma, G. Ahmed","doi":"10.4103/ejdv.ejdv_7_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_7_21","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70717304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antiphospholipid antibody syndrome presenting as pyoderma gangrenosum","authors":"M. Abdulla","doi":"10.4103/ejdv.ejdv_12_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_12_21","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70715117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Shaker, Mohammed Hassan M, Talal Abd El-Raheem, SaraM Yasen
{"title":"Analyses of serum 25-hydroxyvitamin D levels and single nucleotide polymorphisms in the vitamin D receptor gene for acne vulgaris: a case–control study","authors":"O. Shaker, Mohammed Hassan M, Talal Abd El-Raheem, SaraM Yasen","doi":"10.4103/ejdv.ejdv_14_21","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_14_21","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70715453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Adel, G. Nassef, Mostafa M Ezzat, Marwa Khalaf, T. Abdelraheem
Background Disturbed lipid metabolism may play a role in psoriasis pathogenesis. Relationship between lipids and acne has been studied, and significant dyslipidemic findings were reported. In androgenetic alopecia (AGA), the role of androgens is not fully established, and nonandrogenic mechanisms may be involved. Objective The aim was to study lipid profile in patients with psoriasis, acne, and AGA and its relation to severity for a possible role in the etiopathogenesis of these diseases. Materials and methods The study included 25 patients with psoriasis, where the severity of psoriasis was evaluated by psoriasis area and severity index score; 25 patients with acne, where the severity of acne was evaluated by Global Acne Grading System; 25 patients with AGA, who were evaluated by the Norwood-Hamilton scale for males and Ludwig scale for females; and 25 healthy controls. Detailed history, clinical examination, BMI, and laboratory estimation of serum lipids (cholesterol, triglycerides, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol) were performed for all paricipants. Results There was a significant increase in low-density lipoprotein in each of psoriasis, acne, and AGA groups as compared with controls (P<0.05). Cholesterol and triglycerides were significantly higher only in psoriasis compared with controls (P<0.05). High-density lipoprotein was significantly lower in patients with psoriasis, acne, and AGA in comparison with controls (P<0.05), and it was negatively related to severity in psoriasis and acne. Conclusion Psoriasis, acne, and AGA are associated with atherogenic lipid profile, being more prominent in psoriasis and not related to known atherosclerotic risk factors except obesity. Patients with psoriasis and less likely acne and AGA may be at risk of atherosclerosis and consequently cardiovascular disease (CVD).
{"title":"Characterization of lipid profile in psoriasis, acne vulgaris, and androgenetic alopecia: a case–control study","authors":"S. Adel, G. Nassef, Mostafa M Ezzat, Marwa Khalaf, T. Abdelraheem","doi":"10.4103/ejdv.ejdv_26_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_26_20","url":null,"abstract":"Background Disturbed lipid metabolism may play a role in psoriasis pathogenesis. Relationship between lipids and acne has been studied, and significant dyslipidemic findings were reported. In androgenetic alopecia (AGA), the role of androgens is not fully established, and nonandrogenic mechanisms may be involved. Objective The aim was to study lipid profile in patients with psoriasis, acne, and AGA and its relation to severity for a possible role in the etiopathogenesis of these diseases. Materials and methods The study included 25 patients with psoriasis, where the severity of psoriasis was evaluated by psoriasis area and severity index score; 25 patients with acne, where the severity of acne was evaluated by Global Acne Grading System; 25 patients with AGA, who were evaluated by the Norwood-Hamilton scale for males and Ludwig scale for females; and 25 healthy controls. Detailed history, clinical examination, BMI, and laboratory estimation of serum lipids (cholesterol, triglycerides, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol) were performed for all paricipants. Results There was a significant increase in low-density lipoprotein in each of psoriasis, acne, and AGA groups as compared with controls (P<0.05). Cholesterol and triglycerides were significantly higher only in psoriasis compared with controls (P<0.05). High-density lipoprotein was significantly lower in patients with psoriasis, acne, and AGA in comparison with controls (P<0.05), and it was negatively related to severity in psoriasis and acne. Conclusion Psoriasis, acne, and AGA are associated with atherogenic lipid profile, being more prominent in psoriasis and not related to known atherosclerotic risk factors except obesity. Patients with psoriasis and less likely acne and AGA may be at risk of atherosclerosis and consequently cardiovascular disease (CVD).","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"41 1","pages":"91 - 96"},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44124072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Al'Abadie, Greg P. Beer, M. Al-Rubaye, Faris Oumeish, D. Abadie
Background Cow’s milk has been shown to contribute to flare-up of atopic dermatitis, whereas breastfeeding was thought to help reduce the severity of the flare-ups of the condition. Aim To investigate whether breastfeeding or cow’s milk (bottle formula) has an influence on the course of and onset of atopic dermatitis symptoms. Three feeding modalities were evaluated. These are ‘breastfed,’ ‘bottle-fed,’ or ‘breast and bottle-fed.’ Patients and methods Medical records from general practice of patients aged 2 years or less with diagnosis of eczema, atopic dermatitis, atopic eczema, and infantile eczema were reviewed. A cohort of 131 patients was divided into three categories: (a) breastfed, (b) bottle-fed, and (c) breast and bottle-fed. These data were studied according to the data recorded at the 6-week infant health checkup. The age of the child at their first eczematous diagnosis was then calculated in accordance with their date of birth. Result New eczema diagnosis showed a similar trend in ‘breast-fed’ babies; however, onset of eczema was significantly delayed in the ‘breast and bottle-fed’ group when compared with bottle-fed alone. Most bottle-fed babies (58% of patients) were diagnosed at 31–60 days, whereas most ‘breast and bottle-fed’ babies (56%) were diagnosed at 91–120 days (P≥0.0001). Conclusion Babies from the two groups (‘breast’ and ‘breast and bottle-fed’) experienced a delayed onset of their eczema compare with ‘bottle-fed’ infant group. Breastfeeding can delay the onset of atopic dermatitis.
{"title":"Does breastfeeding delay the onset of eczema in infants?","authors":"M. Al'Abadie, Greg P. Beer, M. Al-Rubaye, Faris Oumeish, D. Abadie","doi":"10.4103/ejdv.ejdv_47_20","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_47_20","url":null,"abstract":"Background Cow’s milk has been shown to contribute to flare-up of atopic dermatitis, whereas breastfeeding was thought to help reduce the severity of the flare-ups of the condition. Aim To investigate whether breastfeeding or cow’s milk (bottle formula) has an influence on the course of and onset of atopic dermatitis symptoms. Three feeding modalities were evaluated. These are ‘breastfed,’ ‘bottle-fed,’ or ‘breast and bottle-fed.’ Patients and methods Medical records from general practice of patients aged 2 years or less with diagnosis of eczema, atopic dermatitis, atopic eczema, and infantile eczema were reviewed. A cohort of 131 patients was divided into three categories: (a) breastfed, (b) bottle-fed, and (c) breast and bottle-fed. These data were studied according to the data recorded at the 6-week infant health checkup. The age of the child at their first eczematous diagnosis was then calculated in accordance with their date of birth. Result New eczema diagnosis showed a similar trend in ‘breast-fed’ babies; however, onset of eczema was significantly delayed in the ‘breast and bottle-fed’ group when compared with bottle-fed alone. Most bottle-fed babies (58% of patients) were diagnosed at 31–60 days, whereas most ‘breast and bottle-fed’ babies (56%) were diagnosed at 91–120 days (P≥0.0001). Conclusion Babies from the two groups (‘breast’ and ‘breast and bottle-fed’) experienced a delayed onset of their eczema compare with ‘bottle-fed’ infant group. Breastfeeding can delay the onset of atopic dermatitis.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"41 1","pages":"67 - 70"},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43535990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Serum amyloid A (SAA) is an acute-phase protein that activates immune cells and induces cytokines and chemokine. SAA levels in the blood have been reported to be elevated in case of inflammation, infections, neoplasia, and tissue injury. This study measured the SAA in patients with atopic dermatitis (AD) and evaluated the association between the severity of AD and their values. Patients and methods A total of 52 patients with AD (22 males and 30 females) were involved in our study. Subjects were characterized as having atopic eczema (eAD; n=25) extrinsic type AD or nonatopic (iAD; n=27) intrinsic AD by serum immunoglobulin E level. Serum soluble IL-2R (IL-2R) and SAA levels were measured. Results The serum SAA levels was detectable in all patients with AD, showing significantly higher levels (P=0.026) in the patients with eAD (207 pg/ml; 95% confidence interval: 172–242 pg/ml) compared with those with iAD (144 pg/ml; 95% confidence interval: 116–178 pg/ml). The serum SAA levels were significantly correlated with eosinophil counts and sIL-2R levels and showed a tendency to correlate with SCORAD index and serum immunoglobulin E levels. Conclusion These results suggest SAA level as a parameter of AD activity and may support its possible role in the pathogenesis of AD.
{"title":"Assessment of serum amyloid A level and the severity of atopic dermatitis","authors":"Fathia M Khattab, H. Ibraheem","doi":"10.4103/ejdv.ejdv_27_19","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_27_19","url":null,"abstract":"Background Serum amyloid A (SAA) is an acute-phase protein that activates immune cells and induces cytokines and chemokine. SAA levels in the blood have been reported to be elevated in case of inflammation, infections, neoplasia, and tissue injury. This study measured the SAA in patients with atopic dermatitis (AD) and evaluated the association between the severity of AD and their values. Patients and methods A total of 52 patients with AD (22 males and 30 females) were involved in our study. Subjects were characterized as having atopic eczema (eAD; n=25) extrinsic type AD or nonatopic (iAD; n=27) intrinsic AD by serum immunoglobulin E level. Serum soluble IL-2R (IL-2R) and SAA levels were measured. Results The serum SAA levels was detectable in all patients with AD, showing significantly higher levels (P=0.026) in the patients with eAD (207 pg/ml; 95% confidence interval: 172–242 pg/ml) compared with those with iAD (144 pg/ml; 95% confidence interval: 116–178 pg/ml). The serum SAA levels were significantly correlated with eosinophil counts and sIL-2R levels and showed a tendency to correlate with SCORAD index and serum immunoglobulin E levels. Conclusion These results suggest SAA level as a parameter of AD activity and may support its possible role in the pathogenesis of AD.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"41 1","pages":"71 - 74"},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44934923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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