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1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record最新文献

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A dedicated PET scanner for breast cancer 专门用于乳腺癌的PET扫描仪
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500255
R. Freifelder, J. Karp
The authors present a design of a PET scanner dedicated to breast imaging. The scanner uses two 2-dimensional position sensitive NaI(Tl) detectors, each with 16 PMTs, placed above and below the breast to detect tumors. The design combines high spatial resolution (3.5 mm) to detect small tumors (/spl ap/0.1 cc), high sensitivity and good energy resolution to suppress scatter background and to detect low contrast masses. Additional views of the breast and lymph nodes will be possible. Simulations show that the proposed design has better lesion detectability than a general purpose whole-body PET scanner. Detector thickness, position algorithms, surface treatments of the NaI(Tl) and PMT arrangements will ensure good performance under high countrate conditions and particularly at the edges of the detector closest to the body. A preliminary investigation of different iterative reconstruction algorithms with limited angle datasets show promise in obtaining good image quality and tumor detectability, the scanner's primary design goals. Simulation results are compared to preliminary phantom measurements.
作者提出了一种专用于乳房成像的PET扫描仪的设计。扫描仪使用两个二维位置敏感的NaI(Tl)探测器,每个有16个pmt,放置在乳房的上方和下方来检测肿瘤。该设计结合了高空间分辨率(3.5 mm)来检测小肿瘤(/spl ap/0.1 cc),高灵敏度和良好的能量分辨率来抑制散射背景和检测低对比度的肿块。可能会对乳房和淋巴结进行额外的检查。仿真结果表明,该设计比一般的全身PET扫描仪具有更好的病灶检测能力。探测器的厚度、位置算法、NaI(Tl)和PMT排列的表面处理将确保在高状态条件下的良好性能,特别是在最靠近机身的探测器边缘。对不同的迭代重建算法在有限角度数据集上的初步研究表明,获得良好的图像质量和肿瘤可检测性是扫描仪的主要设计目标。仿真结果与初步模拟测量结果进行了比较。
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引用次数: 7
Small cryostem for operation of visible light photon counters (VLPC) 用于可见光光子计数器操作的小型系统
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510369
B. Baumbaugh, J. Bishop, N. Biswas, L. Coney, J. Marchant, E. Masterson, R. Ruchti, T. Stavish, J. Warchoł, M. Wayne
We have designed, constructed, and operated a small cryostem which supports the operation of 32 channels of visible light photon counters (HISTE-IV VLPCs). The VLPCs are situated within a small enclosure which can be lowered into a 30-100 liter dewar. The enthalpy of the boil-off helium keeps the VLPCs cold, and allows the system to be operated with stability for many days within the desired temperature range of 6.0 K-7.5 K. The cryostem is instrumented with clear fiber waveguides which transport the light from an optical connector situated at the top of the cryostem and outside of the dewar to the photosensors at cryogenic temperatures within the dewar. Electrical signals from the VLPCs are amplified at room temperature using QPA02 preamplifiers. Details of design and performance are reviewed.
我们设计、构建并运行了一个支持32通道可见光光子计数器(hste - iv vlpc)操作的小型系统。vlpc位于一个小的外壳内,可以降低到30-100升杜瓦瓶。蒸发氦的焓使vlpc保持低温,并允许系统在6.0 K-7.5 K的期望温度范围内稳定运行许多天。该系统配备了透明光纤波导,它将光从位于系统顶部和杜瓦瓶外部的光学连接器传输到杜瓦瓶内低温下的光传感器。来自vlpc的电信号在室温下使用QPA02前置放大器进行放大。详细的设计和性能进行了审查。
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引用次数: 3
A low noise amplifier-shaper with tail correction for the STAR detector 用于STAR探测器的带尾部校正的低噪声放大整形器
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504323
E. Beuville, P. Barale, F. Bieser, W. Hearn, S. Klein, M. Lisa, T. Noggle, H. Ritter, C. Vu, H. Wieman
A 16 channel low noise amplifier shaper has been designed for the STAR particle detector of the RHIC accelerator. The STAR Amplifier-Shaper (SAS) includes a pole/zero network which cancels the long tail of the Time Projection Chamber (TPC) signal. The tail correction can be adjusted depending on the type of gas used in the TPC. The SAS equivalent noise charge is 900 e/sub RMS//sup -/,, with 25 pf detector capacitance (the test board having 7.7 pF of parasitic capacitance), and with 80 ns shaping time (step response). The measured noise slope is 13.7 e/sub RMS//sup -//pF. The shaper pulse FWHM is adjusted at 180 ns (detector response) with /spl plusmn/4% variation over the entire dynamic range. The shaping time and the tail correction are adjusted with external voltages using MOS resistors. The gain is 16 mV/fC with a linearity of 4%. The crosstalk is about 0.36% which have a negligible effect on the position resolution. The circuit also includes an on-chip calibration system in which the test input charge is controlled by a DC voltage. The output buffer drives a 2 V swing on 50 pF output load for a total power consumption of less than 750 mW (/spl plusmn/5 Volt supply). On-chip protection diodes have also been integrated. The full custom chip has been integrated in the CMOS ORBIT 1.2 /spl mu/m technology with double polysilicon capacitors.
为RHIC加速器的STAR粒子探测器设计了一种16通道低噪声放大整形器。STAR放大器整形器(SAS)包括一个极点/零网络,可以消除时间投影室(TPC)信号的长尾。尾部校正可以根据TPC中使用的气体类型进行调整。SAS等效噪声电荷为900 e/sub RMS//sup -/,检测器电容为25 pf(测试板寄生电容为7.7 pf),整形时间为80 ns(阶跃响应)。测量到的噪声斜率为13.7 e/sub RMS//sup -//pF。成形脉冲FWHM调节在180 ns(检测器响应),在整个动态范围内有/spl + usmn/4%的变化。整形时间和尾部校正是用MOS电阻器通过外部电压调节的。增益为16 mV/fC,线性度为4%。串扰约为0.36%,对位置分辨率的影响可以忽略不计。该电路还包括一个片上校准系统,其中测试输入电荷由直流电压控制。输出缓冲器在50pf输出负载下驱动2v摆幅,总功耗小于750 mW (/spl plusmn/5伏电源)。片上保护二极管也已集成。全定制芯片已集成在CMOS ORBIT 1.2 /spl mu/m技术中,具有双多晶硅电容器。
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引用次数: 11
A 3D navigational environment for specifying positron emission tomography volumes-of-interest 用于指定正电子发射断层扫描感兴趣体积的3D导航环境
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500275
G. Klein, X. Teng, B. Reutter, R. Huesman, W. Jagust, T. Budinger
Volume of interest extraction for radionuclide and anatomical measurements requires correct identification of the anatomical feature being studied. We have developed a toolset for specifying 3D volumes-of-interest (VOIs) on a multislice Positron Emission Tomography (PET) dataset. The software is particularly suited for specifying cerebral cortex VOIs that represent a particular gyrus or mid-brain structure. A registered 3D magnetic resonance image (MRI) dataset is used to provide high-resolution anatomical information, both as oblique 2D sections and as volume renderings of a segmented cortical surface. Because most clinicians can readily identify specific sulci from high-quality renderings of the cortical surface, a crucial step in quickly identifying sulci in 2D sectional data is providing a feedback mechanism between the renderings and the section data. Our toolkit provides this mechanism by calculating a full depth map and transformation matrix for volume renderings of the cortex. A region drawing environment is then possible where the position of a main drawing cursor on a 2D section can be simultaneously mirrored on the rendered views. The feedback is further enhanced by displaying the projection of the main cursor position on any number of auxiliary 2D sections oriented at orthogonal slicing angles with respect to the principal 2D section. Complete VOIs are specified by drawing a stack of 2D contours subsequently filed together to form closed triangular mesh surface models.
放射性核素和解剖测量的兴趣体积提取需要正确识别所研究的解剖特征。我们开发了一个工具集,用于在多层正电子发射断层扫描(PET)数据集上指定3D感兴趣体积(VOIs)。该软件特别适合于指定大脑皮层的声音,代表一个特定的脑回或中脑结构。注册的3D磁共振图像(MRI)数据集用于提供高分辨率的解剖信息,既可以作为斜2D切片,也可以作为分割皮质表面的体效果图。由于大多数临床医生可以很容易地从高质量的皮层表面渲染图中识别出特定的脑沟,因此在二维断层数据中快速识别脑沟的关键一步是在渲染图和断层数据之间提供反馈机制。我们的工具包通过计算皮质体渲染的完整深度图和转换矩阵来提供这种机制。区域绘制环境是可能的,其中2D部分上的主绘制光标的位置可以同时镜像到渲染视图上。通过显示主光标位置在任意数量的相对于主2D切片的正交切片角度的辅助2D切片上的投影,反馈进一步增强。完整的voi是通过绘制一堆二维轮廓来指定的,这些轮廓随后被归档在一起,形成封闭的三角形网格表面模型。
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引用次数: 1
Truncation artifact correction of attenuation map with iterative and model based reconstruction 基于迭代和模型重建的衰减图截断伪影校正
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510479
R. Guillemaud, P. Hugonnard, R. Sauze, P. Grangeat
Attenuation compensation is an important issue for SPECT imaging. For this purpose transmission measurements can be acquired on a gamma, but the acquisitions are usually truncated. The truncation results in large artifacts in the attenuation map when reconstructed with usual filtered-backprojection algorithms. These artifacts prevents good attenuation correction of emission map. The authors propose a new efficient method for truncation correction which is based on an iterative reconstruction/reprojection algorithm using extended projections and constraints on the reconstructed map. Extended projections are a combination of truncated and reprojected projections with a continuity constraint at the truncation edge. The constraints on the attenuation map are based on object model. The first one is a large elliptical model, with positivity constraints. During the iterative reconstruction process, the model is refined to a have geometric shape closer to the patient's outline. The refining is an active contour segmentation technique. Additional constraints on the attenuation factors can finally be incorporated. Results on truncation correction obtained for simulated and experimental data are presented and the effect on attenuation compensation in emission reconstruction is discussed.
衰减补偿是SPECT成像中的一个重要问题。为此目的,可以在伽玛射线上获得传输测量,但采集通常被截断。当用通常的滤波反投影算法重建衰减图时,截断会导致大量的伪影。这些伪影妨碍了发射图的良好衰减校正。提出了一种基于扩展投影和约束的迭代重建/重投影算法的截断校正新方法。扩展投影是截断投影和重投影的组合,在截断边具有连续性约束。衰减图的约束是基于对象模型的。第一个是一个大的椭圆模型,带有正约束。在迭代重建过程中,模型被细化为更接近患者轮廓的几何形状。细化是一种主动轮廓分割技术。最后可以加入对衰减因子的附加约束。给出了模拟和实验数据的截断校正结果,并讨论了衰减补偿对发射重建的影响。
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引用次数: 3
A fully automated algorithm for estimating attenuation length in 3D from projection data 从投影数据估计三维衰减长度的全自动算法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500265
M.X.H. Yan, J. Karp
An algorithm is described for estimating attenuation length in 3D from sinogram or projection data, by which 3D attenuation correction can be performed in brain PET imaging for given attenuation coefficients. The algorithm begins with the estimation of scalp contours from sinogram data, based on optimal thresholding, spline smoothing and interpolation and backprojection. A cubic B-spline surface is then introduced to accurately describe the scalp surface by the least squares fitting to the stacked 2D estimated scalp contours. Due to the use of this surface model, an efficient and accurate technique is developed for estimation of a distance between two intersecting points formed by an arbitrary projection ray and the scalp surface. This fully automated and fast algorithm has been applied to sinogram and projection data collected using PENN-PET scanners. It has the potential to be used in routine clinical PET imaging.
描述了一种从正弦图或投影数据估计三维衰减长度的算法,通过该算法可以在给定衰减系数的脑PET成像中进行三维衰减校正。该算法首先基于最优阈值分割、样条平滑、插值和反向投影,从正弦图数据中估计头皮轮廓。然后引入三次b样条曲面,通过最小二乘拟合叠加的二维估计头皮轮廓来精确描述头皮表面。由于该表面模型的使用,开发了一种高效准确的技术来估计由任意投影光线形成的两个相交点与头皮表面之间的距离。这种全自动和快速算法已应用于使用PENN-PET扫描仪收集的正弦图和投影数据。它具有应用于常规临床PET成像的潜力。
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引用次数: 1
The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity 动物PET的设计:灵活的几何形状,实现最佳的空间分辨率或高灵敏度
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510435
S. Weber, A. Terstegge, H. Halling, H. Herzog, R. Reinartz, P. Reinhart, F. Rongen, H. Muller-Gartner
A positron emission tomograph (PET) for small animals, e.g. rabbits or rats, is under development at the KFA Juelich as a cooperative effort between the Institute of Medicine which includes a PET center, the Central Laboratory for Electronics and the Institute for Thin Film and Ion Technology (ISI). The first version of the scanner uses arrays of small individual Yttrium Aluminium Perovskit (YAP) scintillator crystals coupled to position sensitive photomultiplier tubes. Special hardware has been built for coincidence detection, position detection and real time data acquisition, which is performed by a PC. The single event data are transfered to workstations, where the radioactivity distribution is reconstructed. The fundamental design features have extensively been simulated. Preliminary studies were carried out by using single NaI:Tl crystals coupled to position sensitive photomultiplier tubes. For the reconstruction of the simulated source configurations and measured data a 3D EM-algorithm has been implemented. The main advantage of the animal PET scanner is its high flexibility, allowing the realization of various detector system configurations. The system is capable of either providing good spatial resolution or high sensitivity for dynamic studies of pharmacokinetics. The reconstruction software is flexible and matches the different choices.
KFA Juelich正在开发一种用于小动物(如兔子或老鼠)的正电子发射断层扫描(PET),这是医学研究所(包括PET中心)、电子中心实验室和薄膜与离子技术研究所(ISI)之间的合作。第一个版本的扫描仪使用小型单个钇铝钙钛矿(YAP)闪烁晶体阵列耦合来定位敏感的光电倍增管。设计了符合检测、位置检测和实时数据采集的专用硬件,由PC机完成。单个事件的数据被传送到工作站,在那里重建放射性分布。基本的设计特征已经被广泛地模拟。初步的研究是利用单一的NaI:Tl晶体偶联来定位敏感的光电倍增管。为了重建模拟源结构和测量数据,实现了一种三维电磁算法。动物PET扫描仪的主要优点是灵活性高,可实现各种检测系统配置。该系统能够为药代动力学的动态研究提供良好的空间分辨率和高灵敏度。重建软件是灵活的,并匹配不同的选择。
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引用次数: 7
Multiscale Bayesian image reconstruction in positron emission tomography 正电子发射断层成像中的多尺度贝叶斯图像重建
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501913
B. Xu, C. Chen, J. Aarsvold, C. Kao, J. Chen, X. Pan
In recent years, various approaches to overcome the problems associated with iterative statistical image reconstruction methods have been investigated, including issues such as slow convergence rate, costly computational time and nonuniform correction efficiency. A multiscale Bayesian image reconstruction algorithm based on a 1-D wavelet technique is proposed. In this approach, the authors first apply a wavelet transform to the sinogram measurements, which yields a multiresolution object representation. The image is reconstructed at the corresponding grid by the Bayesian image reconstruction algorithm for each scale level in the frequency space; the backprojector is also modified to match each corresponding resolution scale. After the low-frequency components of the image have been recovered sufficiently on the coarser scale level, the resulted image is used as the starting point for the finer level at a new iteration. An important feature in the authors' new approach is that the wavelet decomposition is carried out in the sinogram space, while multiple grids are also used in the reconstructed image space.
近年来,人们研究了各种方法来克服迭代统计图像重建方法相关的问题,包括收敛速度慢、计算时间长和校正效率不均匀等问题。提出了一种基于一维小波技术的多尺度贝叶斯图像重建算法。在这种方法中,作者首先将小波变换应用于正弦图测量,从而产生多分辨率对象表示。在频率空间中,采用贝叶斯图像重构算法在相应的网格上对图像进行重构;背投机也被修改以匹配每个相应的分辨率尺度。在较粗的尺度上充分恢复图像的低频分量后,在新的迭代中将得到的图像作为较细的尺度的起点。该方法的一个重要特点是在正弦图空间中进行小波分解,同时在重构图像空间中使用多个网格。
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引用次数: 1
Enable++: a general-purpose L2 trigger processor 启用++:一个通用的L2触发处理器
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510359
H. Hogl, A. Kugel, J. Ludvig, R. Manner, K. Noffz, R. Zoz
Two years of experience with the two prototype FPGA processors Enable-1 and DecPeRLe-1 reveal that field programmable processors are the best choice for realizing a data-driven second level (L2) trigger for ATLAS. This paper presents Enable++, a modular and thus scalable 2nd generation FPGA processor that offers several substantial enhancements to the previous systems: In order to meet the varying demands of all ATLAS subdetectors Enable++ is structured into three different state-of-the-art modules for providing computing power, flexible and high-speed I/O communication and powerful intermodule communication with a raw bandwidth of 3.2 GByte/s by an active backplane. The computing core offers scalable computing power by virtue of a configurable processor topology, a 4/spl times/4 FPGA array and 12 MByte of distributed RAM. For building new applications the system provides a comfortable programming and debugging environment consisting of a compiler for the C-like hardware description language spC, a simulator and a source level debugger for hardware design. The most computing intensive tasks in L2 triggering are the feature extraction algorithms. From experience with Enable-1 we expect that Enable++ surpasses modern RISC processors by a factor of 100 to 1000.
对两个FPGA原型处理器Enable-1和DecPeRLe-1的两年经验表明,现场可编程处理器是实现ATLAS数据驱动的二级(L2)触发器的最佳选择。本文介绍了一种模块化的、可扩展的第二代FPGA处理器,它对以前的系统提供了几个实质性的增强:为了满足所有ATLAS子探测器的不同需求,使能++被结构成三个不同的最先进的模块,以提供计算能力、灵活和高速的I/O通信和强大的模块间通信,通过有源背板提供3.2 GByte/s的原始带宽。计算核心通过可配置的处理器拓扑、4/spl times/4 FPGA阵列和12mbyte的分布式RAM提供可扩展的计算能力。为了构建新的应用程序,该系统提供了一个舒适的编程和调试环境,包括用于类c硬件描述语言spC的编译器、用于硬件设计的模拟器和源代码级调试器。L2触发中计算量最大的任务是特征提取算法。从Enable-1的经验来看,我们预计Enable++将比现代RISC处理器高出100到1000倍。
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引用次数: 0
Microgap gas chamber studies 微隙毒气室研究
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504197
H. Cho, W. Hong, N. Palaio, J. Kadyk, K. Luk, V. Perez-mendez
Hydrogenated amorphous silicon carbide (a-Si:C:H) has been used as an insulating support pedestal for the anode strip in microgap gas chambers (MGCs) in an attempt to make a thicker high quality insulating layer. MGCs having 2.3 or 4.6 /spl mu/m thick a-Si:C:H and 2.0 /spl mu/m thick SiO/sub 2/ insulating layers have been built and tested. In this paper, the results of gas gains, strip damage by discharges, and preliminary aging studies are presented.
采用氢化非晶碳化硅(a- si:C:H)作为微隙气室阳极带的绝缘支撑基座,试图获得更厚的高质量绝缘层。已经建立并测试了具有2.3或4.6 /spl mu/m厚的a-Si:C:H和2.0 /spl mu/m厚的SiO/sub 2/绝缘层的MGCs。本文介绍了气体增益、放电对带钢的损伤和老化的初步研究结果。
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引用次数: 13
期刊
1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record
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