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1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record最新文献

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An application of the maximum entropy method for assessments of residual radioactivity at contaminated sites 最大熵法在污染场地残余放射性评价中的应用
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504293
M. Reginatto, P. Shebell, K. M. Miller
An important requirement in surveying for residual radioactivity is the detection of localized areas of elevated contamination, sometimes referred to as hot spots. In the present work we have developed a computer code that searches for distributions of surface activity (possibly many) that are consistent with a series of in situ measurements on a grid indicating the possible presence of hot spots. The algorithm makes use of a maximum entropy deconvolution of the data, followed by further analysis. The algorithm is quite general and could be modified for use in other types of measurements. Properties of the algorithm are demonstrated using data from actual field measurements.
残留放射性测量的一个重要要求是检测局部高污染区域,有时称为热点。在目前的工作中,我们开发了一种计算机代码,用于搜索表面活动的分布(可能很多),这些分布与网格上的一系列现场测量相一致,表明可能存在热点。该算法利用数据的最大熵反卷积,然后进行进一步分析。该算法是相当通用的,可以修改用于其他类型的测量。通过现场实测数据验证了该算法的性能。
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引用次数: 3
Using IEEE standard 1057 for testing analog-to-digital converters 使用IEEE 1057标准测试模数转换器
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504224
H. Crawley, R. Mckay, W. Meyer, E. Rosenberg, W. D. Thomas
We have used IEEE Trial Use Standard 1057 since 1989 for testing and evaluating analog-to-digital converters for use in high energy physics experiments. This standard primarily covers waveform digitizers, such as digital oscilloscopes, but much of it is applicable to testing ADCs. Using DC levels and sine, triangle, and specialized waveforms, we measure parameters such as integral and differential nonlinearity, number of effective bits, word error rate, short term settling time, and overvoltage recovery. We summarize the tests performed and describe our experience in using the standard.
自1989年以来,我们一直使用IEEE试用标准1057来测试和评估用于高能物理实验的模数转换器。该标准主要涵盖波形数字化仪,如数字示波器,但大部分适用于测试adc。使用直流电平和正弦、三角形和专用波形,我们测量诸如积分和微分非线性、有效位数、字错误率、短期稳定时间和过电压恢复等参数。我们总结了所进行的测试,并描述了我们使用该标准的经验。
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引用次数: 4
A method for calibrating 3D PET without scatter correction 一种无需散射校正的三维PET标定方法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510444
D. Bailey, T. Jones
Calibration for 3D PET using a uniform cylinder and cross-calibration with aliquots requires correction for scatter and attenuation. Thus the accuracy of the calibration is dependent on the scatter correction method, and on the applicability of the scatter correction for different regions of the body. A method has been developed which provides a calibration which does not require correction for scatter or attenuation, making it generally applicable and independent of the scatter correction. The method has been previously described for measurement of the absolute sensitivity of tomographic devices. This approach has been extended to give a calibration of the PET camera 'in air' in units of kBq/pixel. The reconstructed images are multiplied by this factor to give accurate activity concentrations, after attenuation and scatter correction. The method has been used with a fully 3D filtered-backprojection (reprojection) algorithm and iterative convolution-subtraction scatter correction on data from an ECAT 953B. Using this method 3D PET images have been calibrated to within 5% accuracy, but this is highly dependent on the accuracy of the scatter correction. The method described here is practical and provides a means of calibrating a 3D PET system without needing correction for scatter or attenuation of the calibration data.
使用均匀圆柱体和等分交叉校准3D PET需要校正散射和衰减。因此,校准的精度取决于散射校正方法,以及散射校正对身体不同区域的适用性。已经开发了一种方法,该方法提供了一种不需要对散射或衰减进行校正的校准,使其普遍适用并且独立于散射校正。该方法已被先前描述为测量层析设备的绝对灵敏度。该方法已被扩展到以kBq/像素为单位对PET相机“在空中”进行校准。经过衰减和散射校正后,将重建图像乘以该因子以得到准确的活度浓度。该方法已用于全三维滤波-反投影(重投影)算法和迭代卷积-减去散射校正从ECAT 953B的数据。使用这种方法,3D PET图像的校准精度在5%以内,但这高度依赖于散射校正的精度。这里描述的方法是实用的,并且提供了一种校准3D PET系统而无需校正校准数据的散射或衰减的方法。
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引用次数: 2
Reducing the effect of non-stationary resolution on activity quantitation with the frequency distance relationship in SPECT 利用SPECT的频率距离关系降低非平稳分辨率对活度定量的影响
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510497
P. H. Pretorius, Matt A. King, S. Glick, Tin-Su Pan, D. Luo
The determination of quantitative parameters such as the maximum and total counts in a volume are influenced by the partial volume effect. The magnitude of this effect varies with the non-stationary spatial resolution inherent in SPECT imaging compared to the size and shape of the object, and the relative concentration of the object to its background. The objective of this investigation was to determine if the FDR (Frequency Distance Relationship) restoration filtering can reduce the impact of distance dependent spatial resolution on the quantitation of activity. An analytical projector which incorporates attenuation and distance dependent blurring was used to simulate small hot spherical objects in an cylindrical attenuator as imaged with a LEUHR collimator. FDR restoration filtering regularized using different Gaussian and parametric Wiener filters, was employed after attenuation correction with Bellini's method. Projections were also processed using Bellini's attenuation correction method followed by filtered backprojection and 3D Butterworth filtering with different cut-off frequencies. CCR's (Center Count Ratios) and TCR's (Total Count Ratios) were determined as the observed counts over true counts. Results show that after FDR restoration the CCR and TCR become approximately position invariant. However, when regularizing the FDR inverse filter with a Gaussian function, CCR's become highly unstable as the standard deviation (/spl sigma/) decreased below that at the center of rotation. The use of the Gaussian and parametric Wiener filters to regularize FDR filtering introduce noise in the CCR's but improve recovery of TCR's over that of the center of rotation.
定量参数的确定,如体积中的最大计数和总数,受部分体积效应的影响。这种影响的程度随SPECT成像中固有的非平稳空间分辨率、物体的大小和形状以及物体相对于其背景的相对浓度而变化。本研究的目的是确定FDR(频率距离关系)恢复滤波是否可以减少距离依赖的空间分辨率对活动定量的影响。结合衰减和距离依赖模糊的分析投影仪被用来模拟小热球形物体在一个圆柱形衰减器成像与LEUHR准直器。采用不同的高斯滤波器和参数维纳滤波器进行正则化的FDR恢复滤波,并采用Bellini方法进行衰减校正。采用Bellini衰减校正法对投影进行处理,然后进行滤波后的反向投影和不同截止频率的三维巴特沃斯滤波。中心计数比(CCR’s)和总计数比(TCR’s)以观察计数比真实计数确定。结果表明,经过FDR恢复后,CCR和TCR近似位置不变。然而,当用高斯函数正则化FDR逆滤波器时,随着标准偏差(/spl sigma/)减小到旋转中心以下,CCR变得高度不稳定。使用高斯滤波器和参数维纳滤波器对FDR滤波进行正则化,在CCR中引入了噪声,但提高了TCR的恢复速度。
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引用次数: 25
A refined mathematical model for positron emission tomography 正电子发射层析成像的精细数学模型
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510482
B. Mair, M. Rao, J. Anderson
The authors introduce a refined version of the mathematical model introduced by Shepp and Vardi (1982) for positron emission tomography. This model replaces the finite-dimensional Shepp-Vardi linear system by a nonstandard integral equation in which the data-space is finite-dimensional, but the unknown emission intensities are represented by a mathematical measure on the region of interest. As in the finite-dimensional model, the authors obtain an iterative procedure which generates a sequence of functions. Such a functional iteration has already been proposed by other researchers for solving a general class of linear inverse problems. However, unlike the finite-dimensional version, to date, the convergence of this infinite-dimensional version has not been established. This paper discusses issues relating to computer data simulation and present examples which suggest that this refined model should eventually lead to more accurate reconstruction algorithms. The authors also present a mathematical approach for proving convergence.
作者介绍了由Shepp和Vardi(1982)为正电子发射断层扫描引入的数学模型的改进版本。该模型用非标准积分方程代替有限维的Shepp-Vardi线性系统,其中数据空间是有限维的,但未知的发射强度由感兴趣区域上的数学度量表示。与有限维模型一样,作者得到了生成一系列函数的迭代过程。这种泛函迭代已经被其他研究者提出用于求解一类一般的线性逆问题。然而,与有限维版本不同的是,到目前为止,这个无限维版本的收敛性还没有得到证实。本文讨论了与计算机数据模拟有关的问题,并提出了实例,表明这种改进的模型最终应该导致更准确的重建算法。作者还提出了证明收敛性的数学方法。
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引用次数: 2
Modified convolution-subtraction scattering correction technique for 3D PET 三维PET的改进卷积-减散射校正技术
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500270
L. Shao, J. Karp
A modified convolution-subtraction (CS) scatter correction technique in 3D PET imaging has been proposed and evaluated. It can compensate for the shortcomings with the conventional CS techniques, which are commonly used in 2D PET data. The shortcomings include requiring the position-dependent scatter-kernel calibration, the non-standard convolution and long processing time. The modified CS technique assumes that the position-dependent scatter response function (SRF) can be modeled by a product of an average SRF, an adjustable parameter and a relative scatter fraction function. The relative scatter fraction function is a function of source position. The technique was applied to both simulated and measured data. The preliminary results indicate that the modified CS scattering correction technique is practical and robust to the sizes of objects. It provides more accurate scatter estimates than the conventional CS techniques, especially for highly nonuniform distributed sources.
提出并评价了一种改进的卷积-减法(CS)散射校正技术在三维PET成像中的应用。它可以弥补传统CS技术的不足,传统CS技术通常用于二维PET数据。缺点是需要位置相关的散射核校准,非标准卷积和处理时间长。改进的CS技术假设位置相关散射响应函数(SRF)可以由平均SRF、可调参数和相对散射分数函数的乘积来建模。相对散射分数函数是源位置的函数。该技术应用于模拟数据和实测数据。初步结果表明,改进的CS散射校正技术具有实用性和对目标尺寸的鲁棒性。它提供了比传统CS技术更准确的散射估计,特别是对于高度不均匀分布的源。
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引用次数: 5
Application of lead and tungsten pinhole inserts to I-131 SPECT tumor imaging: a Monte Carlo investigation 应用铅和钨针孔插入到I-131 SPECT肿瘤成像:蒙特卡罗研究
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500317
M. Smith, R. Jaszczak, H. Wang, J. Li
The potential use of lead and tungsten pinhole inserts for high resolution SPECT imaging of intratumor activity in I-131 radioimmunotherapy is investigated using experimental point source measurements, and raytracing and Monte Carlo simulations. I-131 imaging is challenging because the primary photon emission is at 364 keV and penetration through the insert near the pinhole aperture is significant. Point source response functions (PSRFs) for Pb and W pinhole inserts are measured and are modeled using raytracing simulations. More accurate simulation of the PSRFs may require the modeling of scatter within the pinhole insert and of higher energy emissions at 637 and 723 keV. A numerical study of geometrically identical pinhole inserts made of Pb and W shows narrower point source response functions for the W insert due to reduced penetration. Monte Carlo modeling was used to compare these inserts for SPECT pinhole imaging of 3 cm diameter tumors with a central core and 3-5 mm thick shells. The shell:core activity concentration ratio was 5:1. The tumor shells are resolved for the W insert but not for the Pb insert. As a result, shell:core activity ratios are more accurate with the use of the W pinhole insert. Experimental SPECT acquisitions are needed to confirm the potential advantages of a W insert over a Pb insert suggested by this study.
利用实验点源测量、射线追踪和蒙特卡罗模拟,研究了铅和钨针孔插入物在I-131放射免疫治疗中用于肿瘤内活动的高分辨率SPECT成像的潜在用途。I-131成像具有挑战性,因为主光子发射在364 keV,并且通过针孔孔径附近的插入物的穿透力很大。测量了Pb和W针孔嵌件的点源响应函数(psrf),并利用射线追踪模拟对其进行了建模。更精确的psrf模拟可能需要对针孔内的散射和637和723 keV的高能量发射进行建模。对几何形状相同的铅和钨针孔嵌件的数值研究表明,由于侵深减少,W嵌件的点源响应函数更窄。使用蒙特卡罗模型比较这些插入物对直径3cm、中心核和3- 5mm厚壳的肿瘤的SPECT针孔成像。壳核活性浓度比为5:1。W插入物可以分解肿瘤壳,而Pb插入物则不能。因此,使用W针孔嵌套时,壳芯活度比更加准确。需要实验SPECT采集来确认本研究提出的W插入物比Pb插入物的潜在优势。
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引用次数: 1
Design of a variable field prototype PET camera 可变场PET相机样机的设计
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510429
W. Wong, J. Uribe, WeiZhao Lu, Guoji Hu, K. Hicks
A prototype PET camera has been designed and is being constructed to test the concept, and develop the engineering design and production methodology for a variable field PET camera. The long term goal of the design is to develop a lower cost, high resolution PET camera. The camera has eight detector heads which form a closely packed octagon detector ring with an average diameter of 44 cm for brain/breast and animal model imaging. The heads can be translated radially to a maximum ring diameter of 70 cm for whole body imaging. In the larger diameter modes, the camera rotates 45/spl deg/ during imaging. The camera heads can be set to intermediate positions to fit the camera to the subject size to maximize detection sensitivity and sampling uniformity. The detector design implemented is the quadrant sharing photomultiplier (PMT) design using circular 19 mm PMT. The camera images 27 slices simultaneously. The BGO detector pitch size is 27/spl times/2.7 mm. Preliminary simulation studies have been performed to evaluate the resolution, sensitivity, and sampling uniformity.
一个原型PET相机已经设计并正在建造中,以测试这一概念,并为可变场PET相机开发工程设计和生产方法。设计的长期目标是开发一种低成本、高分辨率的PET相机。该相机有8个检测器头,它们形成一个紧密排列的八角形检测器环,平均直径为44厘米,用于脑/乳房和动物模型成像。头部可以径向平移至最大直径70厘米的环形,用于全身成像。在大直径模式下,相机在成像过程中旋转45/spl度/。相机头可以设置在中间位置,以使相机适合主体尺寸,以最大限度地提高检测灵敏度和采样均匀性。探测器设计是采用圆形19mm光电倍增管的四象限共享光电倍增管(PMT)设计。摄像机同时拍摄27个切片。BGO探测器螺距尺寸为27/spl倍/2.7 mm。已经进行了初步的模拟研究,以评估分辨率、灵敏度和采样均匀性。
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引用次数: 38
A class of analytical methods that compensate for attenuation and spatially-variant resolution in 2D SPECT 一类补偿二维SPECT中衰减和空间变分辨率的分析方法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501915
X. Pan, C. Metz, C.-T. Chen
An infinite class of closed-form methods was developed by the authors in 1994 for image reconstruction in 2D SPECT with uniform attenuation. In the work reported here, the authors extended their approach to develop a class of closed-form methods that compensate for the effects of both photon attenuation and distance-dependent spatial resolution in 2D SPECT. These methods, which are characterized by an index n that can be assigned any real number, are exact in the absence of noise but propagate noise differently. The authors implemented this class of methods for SPECT image reconstruction in both computer-simulation and real-data studies. The results demonstrate that this class of methods corrects effectively for the aforementioned effects. Extensive computer simulation studies indicate that the method obtained with n=2, which the authors had proved to be the optimal choice of n in 2D SPECT when only attenuation is present, also provides the smallest global image variance among the methods in the class when compensation for both uniform attenuation and distance-dependent spatial resolution is performed.
作者于1994年提出了一种无限类的封闭方法,用于二维SPECT均匀衰减图像的重建。在这里报告的工作中,作者扩展了他们的方法,开发了一类封闭形式的方法,以补偿二维SPECT中光子衰减和距离相关空间分辨率的影响。这些方法的特点是指标n可以被指定为任何实数,在没有噪声的情况下是精确的,但传播噪声的方式不同。作者在计算机模拟和实际数据研究中实现了这类SPECT图像重建方法。结果表明,这类方法可以有效地修正上述影响。大量的计算机模拟研究表明,当n=2时获得的方法(作者已经证明,当仅存在衰减时,该方法是二维SPECT中n的最佳选择)在对均匀衰减和距离相关空间分辨率进行补偿时,也提供了同类方法中最小的全局图像方差。
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引用次数: 14
An application of microstrip gas proportional counter for a X-ray polarimeter 微带气体比例计数器在x射线偏振计中的应用
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504216
T. Tamura, H. Sugeno, H. Sakurai, M. Noma, S. Gunji, Gertenbort
An application of a microstrip gas proportional counter to a X-ray polarimeter was investigated. Primary electron clouds produced by photoelectric absorption extend to the direction of electric vector of incident polarized X-ray and the direction of electron clouds to the microstrip plate (MS plate) affects the rise time of signal from MSGC. By using a test counter which mounted a MS plate, the characteristics of the rise time distributions of pulses from MSGC were investigated. The difference of the rise times between X-rays of /sup 55/Fe and /sup 241/Am sources was 71 nsec in Xe+methane (10%) with 0.4 atm. It reflects the difference of length of the trajectory between 5.9 keV X-rays and 29.8 keV photoelectrons ejected by photoabsorption. The detection of the rise time due to MSGC is available to a X-ray polarimeter.
研究了微带气体比例计数器在x射线偏振计中的应用。光电吸收产生的初级电子云向入射偏振x射线的电矢量方向延伸,电子云向微带板(MS板)的方向影响MSGC信号的上升时间。利用安装在质谱板上的测试计数器,研究了质谱脉冲的上升时间分布特性。在0.4 atm的Xe+甲烷(10%)中,/sup 55/Fe源和/sup 241/Am源x射线的上升时间差为71 nsec。它反映了5.9 keV x射线与29.8 keV光电子在光吸收作用下的轨迹长度之差。由于MSGC的上升时间的检测是可用的x射线偏振计。
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引用次数: 0
期刊
1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record
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