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1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record最新文献

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Effects of head movements measured during PET scans 在PET扫描中测量的头部运动的影响
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501929
Michael S. Atkins, M. Menke
The authors have measured the head movements of patients during PET scans, using two cameras fixed above the bed. The cameras observe motion of infra-red reflectors attached to a mouthpiece attached to the patient's upper jaw by a tooth splint. The entire assembly is completely rigid, both for patients with dentures and for patients with their own teeth. Most patients were able to tolerate the extra inconvenience of the mouthpiece, although some refused to try it. The effects of head motion arise both in re-positioning the patient between scans (e.g. between a raclopride and a fluorodopa scan) and during the scans. Typically the authors measure uptake over a 30-minute period for raclopride, and during 10-minute intervals for fluorodopa. Patient repositioning errors of up to 7-10 mm were observed between scans, and even during a short 10-minute scan, the patients may slip 7-10 mm within their face masks. Experiences with measuring the motion are explored.
作者使用固定在床上的两台摄像机测量了患者在PET扫描期间的头部运动。摄像机观察红外反射器的运动,红外反射器通过牙夹板连接在患者上颌的口腔上。整个组装是完全刚性的,无论是对病人的假牙和病人自己的牙齿。尽管有些病人拒绝尝试,但大多数病人都能忍受这种牙套带来的额外不便。头部运动的影响出现在两次扫描之间(例如,在一次氯吡唑啉和一次氟多巴扫描之间)和扫描期间重新定位患者时。通常,作者在30分钟的时间内测量雷氯pride的摄取,在10分钟的时间间隔内测量氟多巴的摄取。在两次扫描之间观察到患者重新定位误差高达7-10毫米,即使在短暂的10分钟扫描期间,患者也可能在口罩内滑动7-10毫米。探讨了测量运动的经验。
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引用次数: 2
A low-noise, wide-band CMOS charge-sensitive preamplifier for use with APD/LSO PET detectors 一种低噪声,宽带CMOS电荷敏感前置放大器,用于APD/LSO PET探测器
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504238
M. Paulus, J. M. Rochelle, M. Andreaco, D. Binkley
The recent emergence of LSO as a potential scintillator for positron emission tomography (PET) and recent improvements in avalanche photodiode (APD) technology offer encouragement that an APD/LSO based PET detector may be commercially viable in the near future. An important component of any APD/LSO based PET detector will be the preamplifier used to read out the low-level detector signals. Due to the large number of detectors (>18,000) in a high-resolution PET scanner, the preamplifier must be implemented as a monolithic integrated circuit. Additionally, in order to achieve the timing resolution required for high resolution PET, the preamplifier must have a large band-width and a low equivalent input noise voltage. This paper presents a CMOS charge-sensitive preamplifier design which uses local feedback to improve the performance of the common gate transistor. The modified cascode circuit is analyzed and compared with a previously reported simple folded cascode circuit. A prototype circuit was fabricated in a 2 /spl mu/m NWELL CMOS process. The prototype amplifier has a measured 10-90% rise-time of 7 ns with an external input capacitance of /spl sim/6 pF and has an equivalent input noise voltage of /spl sim/1.1 nV/rt-Hz above the flicker noise corner. A pulse height resolution of 14.3% FWHM and a timing resolution of 1.57 ns FWHM (vs. plastic) were obtained with the preamplifier, an Advanced Photonix 5 mm diameter beveled-edge APD and 3.5/spl times/3.5/spl times/22 mm/sup 3/ Teflon wrapped LSO crystal.
最近LSO作为正电子发射断层扫描(PET)的潜在闪烁体的出现,以及雪崩光电二极管(APD)技术的最新改进,都鼓励了基于APD/LSO的PET探测器在不久的将来可能具有商业可行性。任何基于APD/LSO的PET检测器的一个重要组成部分将是用于读出低电平检测器信号的前置放大器。由于高分辨率PET扫描仪中有大量的检测器(>18,000),前置放大器必须作为单片集成电路实现。此外,为了达到高分辨率PET所需的时序分辨率,前置放大器必须具有较大的带宽和较低的等效输入噪声电压。本文提出了一种采用局部反馈的CMOS电荷敏感前置放大器设计方案,以提高共栅晶体管的性能。对改进的级联电路进行了分析,并与先前报道的简单折叠级联电路进行了比较。采用2 /spl mu/m NWELL CMOS工艺制作了原型电路。该原型放大器的测量上升时间为10-90%,为7 ns,外部输入电容为/spl sim/6 pF,在闪烁噪声角上方的等效输入噪声电压为/spl sim/1.1 nV/rt-Hz。使用前置放大器、Advanced Photonix 5 mm直径的斜边APD和3.5/spl倍/3.5/spl倍/22 mm/sup / Teflon包裹的LSO晶体,获得了14.3% FWHM的脉冲高度分辨率和1.57 ns FWHM的时序分辨率(相对于塑料)。
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引用次数: 19
High rate large dynamic range analog circuitry and digitizers for fast calorimetry 用于快速量热的高速率大动态范围模拟电路和数字化仪
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504258
B. Hallgren, F. Bal, G. Barr, P. Buchholz, F. Formenti, W. Funk, Y. Kozhevnikov, A. Lacourt, G. Laverriere, M. Martini, A. Papi, P. Ponting, M. Sozzi, O. Vossnack, H. Wahl
This paper describes the issues encountered in the design of a large dynamic range digitizer for calorimetry. A gain switching technology developed for the liquid krypton calorimeter of the NA48 CP-violation experiment at CERN is described in detail. 14 bit dynamic range and better than 300 ps time resolution were achieved in beam tests with an 8 channel prototype. A mixed analog/digital ASIC has been developed. A 13500 channel system is being produced which will be put into operation in 1996.
本文介绍了大动态范围量热仪设计中遇到的问题。详细介绍了一种用于欧洲核子研究中心NA48 cp破坏实验的液体氪量热计的增益开关技术。在8通道样机的波束测试中,实现了14位动态范围和300ps以上的时间分辨率。研制了一种模拟/数字混合专用集成电路。目前正在制作一个13500频道系统,将于1996年投入使用。
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引用次数: 12
Iterative reconstruction with attenuation compensation from cone-beam projections acquired via non-planar orbit 基于非平面轨道锥束投影的衰减补偿迭代重建
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510489
Y. Weng, G. L. Zeng, G. Gullberg
Single photon emission computed tomography (SPECT) imaging with cone-beam collimators provides improved sensitivity and spatial resolution for imaging small objects with large field-of-view detectors. It is known that Tuy's (1983) cone-beam data sufficiency condition must be met in order to obtain artifact-free reconstructions. Even though Tuy's condition was derived for attenuation-free situation, the authors hypothesize that an artifact-free reconstruction can be obtained even if the cone-beam data are attenuated, provided the imaging orbit satisfies Tuy's condition and the exact attenuation map. In the authors' studies, emission data are acquired using nonplanar orbit such as circle-and-line orbit to acquire sufficient data for cone-beam tomographic reconstruction. An iterative conjugate gradient reconstruction algorithm is used to reconstruct projection data with a pre-acquired attenuation map. Quantitative accuracy of the attenuation corrected emission reconstruction is significantly improved. The authors observe that the cone-beam iterative algorithms are very sensitive to the projection and backprojection models, because each voxel is sampled anisotropically. Sampling artifacts (i.e., aliasing artifacts) sometimes are very severe for non-planar orbit data acquisition geometries. Better voxel models and sampling geometries are required in further investigations.
单光子发射计算机断层扫描(SPECT)成像与锥束准直器提供了改进的灵敏度和空间分辨率成像的小目标与大视场探测器。众所周知,要获得无伪影重建,必须满足Tuy(1983)的锥束数据充要条件。尽管在无衰减情况下导出了Tuy条件,但作者假设,只要成像轨道满足Tuy条件和精确的衰减图,即使锥束数据被衰减,也可以获得无伪影重构。在作者的研究中,发射数据的获取采用非平面轨道,如圆-线轨道,以获得足够的数据进行锥束层析重建。采用迭代共轭梯度重构算法,利用预获取的衰减图重构投影数据。衰减校正发射重建的定量精度显著提高。作者观察到锥束迭代算法对投影和反投影模型非常敏感,因为每个体素都是各向异性采样的。采样伪影(即混叠伪影)有时对非平面轨道数据采集几何非常严重。在进一步的研究中需要更好的体素模型和采样几何。
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引用次数: 22
SVX/silicon detector studies SVX/硅探测器研究
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504270
L. Bagby, M. Johnson, R. Lipton, W. Gu
AC coupled silicon detectors, being used for the D/spl phi/ upgrade, may have substantial voltage across the coupling capacitor. Failed capacitors can present /spl sim/50 V to the input of the SVX, Silicon Vertex, device. We measured the effects that failed detector coupling capacitors have on the SVXD (rad soft 3 /spl mu/m), SVXH (rad hard 1.2 /spl mu/m), and SVXIIb (rad soft 1.2 /spl mu/m) amplifier/readout devices. The test results show that neighboring channels saturate when an excessive voltage is applied directly to a SVX channel. We believe that the effects are due to current diffusion within the SVX substrate rather than surface currents on the detectors. This paper discusses the magnitude of the saturation and a possible solution to the problem.
用于D/spl phi/升级的交流耦合硅检测器可能在耦合电容器上具有较大的电压。失效电容可以提供/spl sim/50 V到SVX, Silicon Vertex器件的输入端。我们测量了失效检测器耦合电容对SVXD (rad soft 3 /spl mu/m)、SVXH (rad hard 1.2 /spl mu/m)和SVXIIb (rad soft 1.2 /spl mu/m)放大器/读出器件的影响。测试结果表明,当过高电压直接施加到SVX通道时,相邻通道饱和。我们认为这种影响是由于SVX衬底内的电流扩散而不是探测器上的表面电流。本文讨论了饱和度的大小和可能的解决方法。
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引用次数: 2
Analysis of trabecular patterns using fractal dimensions 用分形维数分析小梁图案
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500310
E. Inoue, K. Ogawa
The authors analyse trabecular patterns which appear in the X-ray bone images using fractal geometry. The trabecular structures contain the information about the bone strength or the inner minerals. Fractal dimensions are useful for analyzing of these trabecular structures because they can express complex patterns quantitatively. The authors calculated the fractal dimensions of the trabecular structures by using the surface area method which treats the structures as a three-dimensional "mountain". More precisely, the method uses the surface areas of the structures and the basis rulers. To study the relationship between a fractal dimension and patient's age or diseases, the authors used 38 radiographic images in which the trabecular structures appeared. As a result, the authors found that the fractal dimension of the trabecular bone structure was related to the age of the patients.
作者分析小梁模式出现在x射线骨图像使用分形几何。小梁结构包含有关骨骼强度或内部矿物质的信息。分形维数可以定量地表达复杂的结构,对分析这些小梁结构非常有用。将小梁结构视为一座三维的“山”,采用表面积法计算了小梁结构的分形维数。更准确地说,该方法利用了结构的表面积和基尺。为了研究分形维数与患者年龄或疾病之间的关系,作者使用了38张出现小梁结构的放射图像。结果发现,骨小梁结构分形维数与患者年龄有关。
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引用次数: 5
Energy resolution of xenon proportional counters: Monte Carlo and experimental results for 5.9 keV X-rays 氙比例计数器的能量分辨率:蒙特卡罗和5.9 keV x射线的实验结果
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504183
P. Rachinhas, T. Dias, F. Santos, A. Stauffer, C. Conde
The energy resolution, R, of xenon filled cylindrical proportional counters is investigated experimentally for 5.9 keV X-rays and 10 and 47.5 /spl mu/m anode wires, and calculated theoretically using a Monte Carlo simulation technique based on first principles with no adjustable parameters. The gas multiplication factor, M, is also measured experimentally and calculated using the same Monte Carlo technique. Good agreement is in general found between the experimental and the calculated values for R and M. It is shown that better energy resolutions are achieved for the thinner anode wire. The Monte Carlo results for R are expressed in terms of a parameter that characterizes the statistical fluctuations in the number of electrons in single-electron initiated avalanches, the parameter f. These calculations have given evidence that f depends mainly on the critical reduced electric field, S/sub 0/, at the onset of multiplication.
实验研究了5.9 keV x射线和10和47.5 /spl mu/m阳极线下氙填充圆柱形比例计数器的能量分辨率R,并采用基于第一性原理的蒙特卡罗模拟技术进行了理论计算。气体倍增系数M也用同样的蒙特卡罗技术进行了实验测量和计算。R和m的实验值与计算值基本一致,表明阳极线越细,能量分辨率越高。R的蒙特卡罗结果用表征单电子引发的雪崩中电子数量的统计波动的参数f来表示。这些计算提供的证据表明,f主要取决于乘法开始时的临界简化电场S/sub 0/。
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引用次数: 1
Surface horizontal logging for radon at a Superfund site 在一个超级基金站点进行氡的地面水平测井
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510398
L. Gadeken, W. Madigan
The Department of Energy sponsored an Expedited Site Characterization study performed by Ames Laboratory at the St. Louis (Missouri) Airport Site during August-September, 1994. Uranium processing occurred there during the Cold War and significant residual radioactive contamination now exists on site. This paper reports on continuous gamma ray spectroscopy measurements to identify the emitting isotopes and to quantify the amount of radioactivity present for each. An oilfield wireline gamma ray spectrometry-sonde (the Compensated Spectral Natural Gamma instrument) was adapted to perform horizontal measurements with the detector section 3 ft above the soil surface. The results of the gamma ray spectroscopy measurements will be discussed.
能源部赞助了1994年8月至9月期间由Ames实验室在圣路易斯(密苏里)机场场址进行的快速场址特征研究。冷战期间在那里进行了铀加工,现在现场存在大量残留的放射性污染。本文报告了连续的伽马射线光谱测量,以确定发射同位素和量化每一个存在的放射性量。采用油田电缆伽马射线能谱探空仪(补偿谱自然伽马仪器)进行水平测量,探测器距离土壤表面3英尺。本文将讨论伽马能谱测量的结果。
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引用次数: 0
Accurate attenuation correction in SPECT without transmission measurements 准确的衰减校正在SPECT没有传输测量
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510422
A. Welch, R. Clack, G. Gullberg, F. Natterer
The current trend in attenuation correction for SPECT is to measure and reconstruct the attenuation coefficient map using a transmission scan, performed either sequentially or simultaneously with the emission scan. This approach requires dedicated hardware and increases the cost (and in some cases the scanning time) required to produce a clinical SPECT image. Furthermore, if short focal length fan-beam collimators are used for transmission imaging, the projection data may be truncated, leading to errors in the attenuation coefficient map. Our goal is to obtain information about the attenuation distribution from only the measured emission data by exploiting the fact that only certain attenuation distributions are consistent with a given emission dataset. Ultimately this consistency information will either be used directly to compensate for attenuation or combined with the incomplete information from fan-beam transmission measurements to produce a more accurate attenuation coefficient map. The simulations and phantom studies performed in this investigation show that, in certain circumstances, the consistency conditions of the SPECT data can be used to produce an accurate estimate of the attenuation map without performing any transmission measurements.
目前SPECT衰减校正的趋势是使用透射扫描测量和重建衰减系数图,与发射扫描顺序或同时进行。这种方法需要专用硬件,并且增加了产生临床SPECT图像所需的成本(在某些情况下还增加了扫描时间)。此外,如果使用短焦距扇形光束准直器进行透射成像,则投影数据可能被截断,导致衰减系数图出现误差。我们的目标是通过利用只有某些衰减分布与给定发射数据集一致的事实,仅从测量的发射数据中获得有关衰减分布的信息。最终,这种一致性信息要么直接用于补偿衰减,要么与来自扇波束传输测量的不完整信息相结合,以产生更准确的衰减系数图。在本研究中进行的模拟和模拟研究表明,在某些情况下,SPECT数据的一致性条件可用于产生衰减图的准确估计,而无需执行任何传输测量。
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引用次数: 7
An image reconstruction method for dynamic PET 一种动态PET图像重建方法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501917
M. Wernick, G. Wang, C. Kao, J. Yap, J. Mukherjee, M. Cooper, C. Chen
In PET, SPECT, and other tomographic imaging modalities, dynamic image sequences are typically obtained by reconstructing the individual time frames independently. This frame-by-frame reconstruction approach can be highly suboptimal because it fails to take into account the temporal correlations in the signal. The authors propose an alternative approach, based on a Karhunen-Loeve transformation of the dynamic-image reconstruction problem, that can offer both significant improvement of the reconstructed images and a substantial reduction in the computation required to reconstruct an image sequence.
在PET、SPECT和其他层析成像模式中,动态图像序列通常是通过独立重建单个时间帧来获得的。这种逐帧重建方法可能非常不理想,因为它没有考虑到信号中的时间相关性。作者提出了一种基于动态图像重建问题的Karhunen-Loeve变换的替代方法,该方法既可以显著改善重建图像,又可以大大减少重建图像序列所需的计算。
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引用次数: 14
期刊
1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record
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