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1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record最新文献

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Evaluation of silicon micro strip detectors with large read-out pitch 大读出节距硅微带探测器的评价
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504279
M. Hazumi, T. Kawasaki, K. Senyo, Y. Nagashima, K. Yamamoto, K. Yamamura, T. Tsuboyama, J. Haba, H. Ikeda, H. Iwasaki, T. Matsuda, H. Ozaki, M. Tanaka, Y. Yamada, S. Okuno, S. Avrillon, Y. Asano, S. Mori, C. Fukunaga, T. Hirose, H. Miyata, K. Miyano, E. Banas, A. Bozek, Z. Natkaniec, H. Palka, M. Różańska, K. Rybicki
For the development of the silicon micro strip detector with the pitch of the readout strips as large as 250 /spl mu/m on ohmic side, we made samples with different structures. Charge collection was evaluated to optimize the width of implant strips, aluminum read-out strips, and/or the read-out scheme among strips.
为了研制读出条带欧姆侧节距可达250 /spl mu/m的硅微带探测器,我们制作了不同结构的样品。评估电荷收集以优化植入条的宽度,铝读出条,和/或条带之间的读出方案。
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引用次数: 3
A comparison of WLS and LS reconstruction for PET PET的WLS与LS重建比较
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510485
G. Chinn, S. Huang
The realizable advantages from statistical reconstruction of positron emission tomography (PET) images remains an unsettled issue. Different iterative reconstruction schemes and convergence effects can lead to different levels of regularization in images. To assess the performance, an analytic approach was used to examine the noise levels of weighted least squares (WLS) and least squares (LS) image reconstruction under the same regularization. For certain non-trivial conditions on the error covariance (weighting) matrix, it was shown that WLS is equivalent to LS reconstruction in a mean square error sense, even when the sinogram noise is not uniform. Also, an approach was proposed for matching the regularization between WLS and LS iterative reconstruction. Computer simulations showed that WLS leads to only a marginally small reduction in noise compared to LS reconstruction at the same resolution.
正电子发射断层扫描(PET)图像统计重建的优势是一个有待解决的问题。不同的迭代重建方案和收敛效果会导致图像的正则化程度不同。为了评估该算法的性能,采用解析方法对相同正则化条件下加权最小二乘(WLS)和最小二乘(LS)图像重构的噪声水平进行了分析。对于误差协方差(加权)矩阵的某些非平凡条件,证明了即使在正弦图噪声不均匀的情况下,WLS在均方误差意义上等价于LS重构。同时,提出了一种匹配WLS和LS迭代重建正则化的方法。计算机模拟表明,在相同分辨率下,与LS重建相比,WLS只能略微降低噪声。
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引用次数: 1
Parallel readout of a photodiode array in a scintillating fibre calorimeter 闪烁光纤量热计中光电二极管阵列的并行读出
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.504325
M. Keller, A. Stellberger, K. Meier, K. Schmitt, A. Holscher
In this paper results from a prototype calorimeter built in connection with the development of a new calorimeter for the H1 detector at the HERA collider are reported. The prototype was constructed as a lead-fibre calorimeter where the fibers were read out with an array of discrete photodiodes connected to conventional preamplifiers built with discrete electronics. Furthermore the first steps towards the design of the final detector setup are described. In particular the development of the integrated readout electronics for the calorimeter is considered.
本文报道了在HERA对撞机上为H1探测器研制一种新型量热计时所研制的一个量热计原型的结果。该原型是一个铅纤维量热计,其中光纤通过一组独立的光电二极管读出,这些光电二极管连接到由分立电子元件构成的传统前置放大器。此外,还描述了最终探测器装置设计的第一步。特别考虑了量热计的集成读出电子器件的发展。
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引用次数: 0
Design study simulations of a Compton camera for radioactive waste container imaging 用于放射性废物容器成像的康普顿相机的设计研究模拟
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510401
J. McKisson, D. Henderson, K.E. Neelands, P. Haskins
Continued research and development efforts are being pursued to improve accuracy, minimize costly overestimates, and increase analysis throughput for non-destructive analysis (NDA) of radioactive waste containers. An imaging detector capable of locating and identifying source distributions in a waste container can improve the estimates obtained from an NDA system. This paper presents the approach taken to data handling and analysis for a simulation-based system design study. Simulations were first performed to sample a large, multiparameter design space and were then refined to focus on candidate geometries that proved to have acceptable performance. To handle the anticipated volume of data and to allow efficient search and analysis, a system was devised to organize the simulation and analysis effort, track data files, and construct a data base. Data were evaluated to determine functional relationships between design parameters and performance. A set of performance metrics were developed and applied to compare the results of the simulations.
持续的研究和开发工作正在进行,以提高准确性,最大限度地减少昂贵的高估,并增加放射性废物容器的非破坏性分析(NDA)的分析吞吐量。能够定位和识别废物容器中源分布的成像探测器可以改进从NDA系统获得的估计。本文介绍了基于仿真的系统设计研究中所采用的数据处理和分析方法。首先进行模拟,对一个大的、多参数的设计空间进行采样,然后对候选几何形状进行细化,以证明其具有可接受的性能。为了处理预期的数据量,并允许有效的搜索和分析,设计了一个系统来组织模拟和分析工作,跟踪数据文件,并构建数据库。对数据进行评估,以确定设计参数与性能之间的函数关系。开发并应用了一组性能指标来比较模拟结果。
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引用次数: 1
A weighted least-squares method for PET PET的加权最小二乘法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510495
J. Anderson, B. Mair, Murali Rao, C.-H. Wu
In this paper, the authors present a reconstruction algorithm for positron emission tomography that minimizes a weighted least-squares (WLS) objective function. The weights are based on the covariance matrix of the model error and depend on the unknown parameters. The algorithm guarantees nonnegative estimates, and in simulation studies it converged faster and had significantly better resolution and contrast than the ML-EM algorithm. Although simulations suggest that the proposed algorithm is globally convergent, a proof of convergence has not been found yet. Nevertheless, the authors are able to show that it produces estimates that decrease the objective function monotonically with increasing iterations.
本文提出了一种加权最小二乘(WLS)目标函数最小化的正电子发射断层成像重建算法。权重基于模型误差的协方差矩阵,并依赖于未知参数。该算法保证了非负估计,在仿真研究中,它比ML-EM算法收敛得更快,具有明显更好的分辨率和对比度。尽管仿真结果表明该算法是全局收敛的,但尚未找到收敛的证明。然而,作者能够证明它产生的估计随着迭代的增加而单调地减小目标函数。
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引用次数: 8
Improved axial resolution in 2D PET with 3D reconstruction 通过三维重建提高了二维PET的轴向分辨率
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510490
K. Erlandsson, S. Strand
A 3D reconstruction method originally developed by the authors for 3D scanners has now been implemented for handling data from a 2D scanner. The scanner consists of 4 detector rings and gives 7 simultaneous planes including cross-planes. The axial sampling is improved by moving the patient couch. This will halve the plane separation, but there will be cross-talk between the planes. The axial sensitivity profile for each plane is, for the direct planes, fairly independent of radial position, but varies significantly for the cross-planes. The authors' 3D reconstruction technique is based on 2D reconstruction of transaxial planes and deconvolution of a position dependent axial spread function. The authors have tested two different methods for the deconvolution step; the iterative Landweber method and singular value decomposition. Evaluations were made with Monte Carlo simulations and phantom studies. The result of 3D reconstruction an improved axial resolution at the cost of a higher noise level. Iterative deconvolution gives the best compromise between resolution and noise.
最初由作者为3D扫描仪开发的3D重建方法现已用于处理来自2D扫描仪的数据。该扫描仪由4个探测环组成,可同时给出包括交叉平面在内的7个平面。通过移动病人床,改善了轴向采样。这将使平面间隔减半,但平面之间会有串扰。对于直平面,每个平面的轴向灵敏度分布与径向位置无关,但对于交叉平面,轴向灵敏度分布变化很大。作者的三维重建技术是基于跨轴平面的二维重建和位置相关轴向扩展函数的反卷积。作者测试了反褶积步骤的两种不同方法;迭代Landweber法和奇异值分解。通过蒙特卡罗模拟和模拟研究进行了评估。三维重建的结果提高了轴向分辨率,但代价是更高的噪声水平。迭代反褶积给出了分辨率和噪声之间的最佳折衷。
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引用次数: 2
A Gamma Camera Probe with Hybrid Photodiode Readout 带有混合光电二极管读出的伽马照相机探头
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501935
P. Durrant, A. Truman, C. Datema, D. Ramsden
The application of newly emerging multi-pixel Hybrid Photodiode tubes as the basis for a compact clinical gamma camera is proposed. The characteristics of this camera system are discussed and an optimised design presented. Compared to existing clinical gamma cameras, this system is expected to offer an improved spatial resolution without a significant deterioration in the detection efficiency and energy resolution. A comparison is made of multi-pixel Hybrid Photodiodes and Position Sensitive Photomultiplier Tubes.
提出了新型多像素混合光电二极管管作为小型临床伽玛相机基础的应用。讨论了该摄像系统的特点,提出了优化设计方案。与现有的临床伽玛相机相比,该系统有望提供更高的空间分辨率,而不会显著降低检测效率和能量分辨率。对多像素混合光电二极管和位置敏感光电倍增管进行了比较。
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引用次数: 2
Image segmentation using circularly spread MR images 利用循环扩散的MR图像分割
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.500309
T. Ono, K. Ogawa
Describes a new segmentation method using an artificial neural network for brain magnetic resonance (MR) images. In the proposed method, the authors spread an MR image circularly to recognize several regions in the brain. In the spread image, the cerebral regions including white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) align in layers from bottom to top. The above regions are segment by the following procedures: First, the contour of the whole cerebral region including CSF is detected from the spread image by using a Gaussian filter and a differential operator. The region outside the contour is then eliminated. Cerebral regions WM, GM, and CSF are eliminated by an artificial neural network which has three layers. The inputs of the neural network are a pixel value and its normalized vertical and horizontal locations in the spread image. The proposed method was examined using the T2-weighted images, and it was able to segment WM, GM, and CSF regions accurately.
介绍了一种基于人工神经网络的脑磁共振图像分割方法。在提出的方法中,作者循环传播磁共振图像以识别大脑中的几个区域。在扩散图像中,包括白质(WM)、灰质(GM)和脑脊液(CSF)在内的大脑区域从下往上排列成行。上述区域的分割步骤如下:首先,利用高斯滤波和微分算子从扩散图像中检测出包括脑脊液在内的整个大脑区域的轮廓。然后消除轮廓外的区域。采用三层人工神经网络消除脑区WM、GM和CSF。神经网络的输入是像素值及其在扩散图像中的标准化垂直和水平位置。使用t2加权图像对所提出的方法进行了检验,该方法能够准确地分割WM, GM和CSF区域。
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引用次数: 0
Methods for the correction of vascular artifacts in PET O-15 water brain mapping studies PET O-15水脑成像中血管伪影的校正方法
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.510498
Kewei Chen, E. Reiman, M. Lawson, L. Yun, D. Bandy, Anita Palant
While positron emission tomographic (PET) measurements of regional cerebral blood flow (CBF) can be used to map regions of the brain that are involved in normal and pathological human behaviors, measurements in the anteromedial temporal lobe can be confounded by the combined effects of radiotracer activity in neighboring arteries and partial volume averaging. The authors now describe two alternative methods for addressing this potential confound. One method utilizes the early frames of a dynamic PET study, while the other method utilizes a coregistered magnetic resonance image (MRI) to characterize the vascular region-of-interest (ROI). Both methods subsequently assign a common value to each pixel in the vascular ROI. To simulate the vascular artifact, four dynamically acquired PET, O-15 water scans in the same subject during the same behavioral state were used to compute 4 vascular images (0-60 s after radiotracer administration) which included vascular activity and 4 control images (20-80 s after radiotracer administration) which did not. t-score maps were used to characterize regional blood flow differences related to vascular activity before and after the application of each vascular artifact-correction method. Both methods eliminated the observed differences in vascular activity, as well as the vascular artifact observed in the anteromedial temporal lobes.
虽然区域脑血流(CBF)的正电子发射断层扫描(PET)测量可用于绘制与正常和病理人类行为有关的大脑区域,但在前内侧颞叶的测量可能会被邻近动脉的放射性示踪剂活性和部分体积平均的综合影响所混淆。作者现在描述了两种解决这种潜在混淆的替代方法。一种方法利用动态PET研究的早期帧,而另一种方法利用共注册磁共振图像(MRI)来表征血管感兴趣区域(ROI)。这两种方法随后为血管ROI中的每个像素分配一个共同的值。为了模拟血管伪影,使用同一受试者在相同行为状态下的4张动态获取的PET, O-15水扫描图,计算了4张血管图像(给药后0-60秒),其中包括血管活动,以及4张对照图像(给药后20-80秒),其中不包括血管活动。t评分图用于描述应用每种血管伪影校正方法前后与血管活动相关的区域血流差异。两种方法都消除了观察到的血管活动差异,以及在前内侧颞叶观察到的血管伪影。
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引用次数: 5
OPTIMIZING LIGHT COLLECTION FROM THIN SCINTILLATORS USED IN A BETA-RAY CAMERA FOR SURGICAL USE 优化外科用β射线相机中使用的薄闪烁体的光收集
Pub Date : 1995-10-21 DOI: 10.1109/NSSMIC.1995.501933
Craig S. Levin, L. R. MacDonald, M. Tornai, Edward J. Hoffman, J. Park
The authors are developing a 1-2 cm/sup 2/ area camera for imaging the distribution of beta-emitting radiopharmaceuticals at the surface of tissue exposed during surgery. The front end consists of a very thin continuous or segmented scintillator sensitive to betas (positrons or electrons) of a few hundred keV, yet insensitive to gamma rays. The light from the scintillator is piped through clear fibers to the photon detector (PD). This approach requires that a sufficient number of scintillation photons be transported from the scintillator, through the fibers to the PD. The scintillator, reflector, surface treatments, geometry, fiber light guides, and optical couplings must be optimized. The authors report here on efforts made to optimize the light collection from <3 mm thick plastic and CaF/sub 2/(Eu) scintillators into clear fibers using experimental measurements and computer simulations. The authors measured that with a 1.25 cm diameter, 0.5 mm thick optimized CaF/sub 2/(Eu) disk coupled to a 5 cm long bundle of clear optical fibers, on average, /spl sim/250 photoelectrons are produced at a PMT photocathode for a /sup 204/Tl beta flood source (E/sub max/=763 keV). This corresponds to a sufficient number of photoelectrons for <1 mm resolution imaging capabilities for the proposed camera.
作者正在开发一种1- 2cm /sup / area相机,用于成像手术中暴露的组织表面β -放射药物的分布。前端由一个非常薄的连续或分段闪烁体组成,对几百keV的β(正电子或电子)敏感,但对伽马射线不敏感。来自闪烁体的光通过透明光纤输送到光子探测器(PD)。这种方法要求足够数量的闪烁光子从闪烁体通过光纤传输到PD。闪烁体、反射器、表面处理、几何形状、光纤光导和光耦合必须优化。作者在此报告了利用实验测量和计算机模拟优化从< 3mm厚的塑料和CaF/sub 2/(Eu)闪烁体到透明纤维的光收集的努力。作者测量了一个直径1.25 cm,厚度0.5 mm的优化CaF/sub 2/(Eu)磁盘与一个5 cm长的透明光纤束耦合,在PMT光电阴极上平均产生/spl sim/250个光电子,用于/sup 204/Tl β流源(E/sub max/=763 keV)。这对应于足够数量的光电子,用于建议的相机的<1毫米分辨率成像能力。
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引用次数: 27
期刊
1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record
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