Pub Date : 2008-12-01DOI: 10.1163/2213-2139_bema_com_034028
Han-Mo Chiu, Andrew Schepmyer
{"title":"Preface from the Editors","authors":"Han-Mo Chiu, Andrew Schepmyer","doi":"10.1163/2213-2139_bema_com_034028","DOIUrl":"https://doi.org/10.1163/2213-2139_bema_com_034028","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75592226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-04-01DOI: 10.1146/annurev.an.14.010185.100001
S. Dugani, Jonathan So
{"title":"Preface from the Editors","authors":"S. Dugani, Jonathan So","doi":"10.1146/annurev.an.14.010185.100001","DOIUrl":"https://doi.org/10.1146/annurev.an.14.010185.100001","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80631286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-03-01DOI: 10.1146/annurev.so.22.010196.100001
J. Kwan, J. Chan
{"title":"Preface from the Editors","authors":"J. Kwan, J. Chan","doi":"10.1146/annurev.so.22.010196.100001","DOIUrl":"https://doi.org/10.1146/annurev.so.22.010196.100001","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90800923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-01DOI: 10.1146/annurev-ma-3-120710-100001
Diana C. Anderson, Fiona Menzies
{"title":"Preface from the Editors","authors":"Diana C. Anderson, Fiona Menzies","doi":"10.1146/annurev-ma-3-120710-100001","DOIUrl":"https://doi.org/10.1146/annurev-ma-3-120710-100001","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76509314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1146/annurev-ma-4-121211-100001
A. Deonarine, Andrea Rowe
More than 20 years after having being written, a manuscript by Edoardo Amaldi comes to the publication. It is about the ‘‘adventurous life’’ of a colleague, Friedrich ‘‘Fritz’’ Georg Houtermans that shared with him a turbulent and dramatic time, starting in the first half of last century. A time, which has undoubtedly influenced the way physics developed, and even more dramatically the private life of men and scientists. Among them, Fritz Houtermans. Why a manuscript Edoardo Amaldi was working on just before his sudden death in 1989 becomes public more than 20 years later? Indeed, recently some lucky circumstances met that came to a full circle within the Physics Institute of the University of Berne, and more particularly within the Laboratory for High Energy Physics (LHEP) and the Albert Einstein Center for Fundamental Physics (AEC). Research activities on particle physics started in Berne, and in Switzerland, thanks to Fritz Houtermans, along with his predecessor, Heinrich Greinacher. Houtermans was an essential promoter and protagonist for the development of physics in Berne, with the introduction of a series of activities in the field of elementary particles and important contributions in applied physics. During the Bernese phase, Houtermans was especially devoted to the physics of cosmic rays, using an experimental activity carried out with nuclear emulsion detectors and particle accelerators. Research with nuclear emulsion detectors and particle accelerators—what a coincidence!—have recently experienced a rebirth in Berne: among some consolidated research activities in physics, a renewed interest on nuclear emulsions characterizes the present time of the LHEP, together with the study of new particle detectors. All this and the recent installation of a cyclotron for medical applications the University Hospital in Berne (Inselspital) have naturally led to a new line of research: the application of particle physics to medicine. Hence, the circumstances that recently met in Berne are: elementary particle physics, physics applied to medicine, Amaldi’s family. In fact, to promote the new research field in Berne, Ugo Amaldi was invited to give a seminar on Physics and Medicine, namely ‘‘Hadrontherapy in the world and its recent developments’’.
{"title":"Preface from the Editors","authors":"A. Deonarine, Andrea Rowe","doi":"10.1146/annurev-ma-4-121211-100001","DOIUrl":"https://doi.org/10.1146/annurev-ma-4-121211-100001","url":null,"abstract":"More than 20 years after having being written, a manuscript by Edoardo Amaldi comes to the publication. It is about the ‘‘adventurous life’’ of a colleague, Friedrich ‘‘Fritz’’ Georg Houtermans that shared with him a turbulent and dramatic time, starting in the first half of last century. A time, which has undoubtedly influenced the way physics developed, and even more dramatically the private life of men and scientists. Among them, Fritz Houtermans. Why a manuscript Edoardo Amaldi was working on just before his sudden death in 1989 becomes public more than 20 years later? Indeed, recently some lucky circumstances met that came to a full circle within the Physics Institute of the University of Berne, and more particularly within the Laboratory for High Energy Physics (LHEP) and the Albert Einstein Center for Fundamental Physics (AEC). Research activities on particle physics started in Berne, and in Switzerland, thanks to Fritz Houtermans, along with his predecessor, Heinrich Greinacher. Houtermans was an essential promoter and protagonist for the development of physics in Berne, with the introduction of a series of activities in the field of elementary particles and important contributions in applied physics. During the Bernese phase, Houtermans was especially devoted to the physics of cosmic rays, using an experimental activity carried out with nuclear emulsion detectors and particle accelerators. Research with nuclear emulsion detectors and particle accelerators—what a coincidence!—have recently experienced a rebirth in Berne: among some consolidated research activities in physics, a renewed interest on nuclear emulsions characterizes the present time of the LHEP, together with the study of new particle detectors. All this and the recent installation of a cyclotron for medical applications the University Hospital in Berne (Inselspital) have naturally led to a new line of research: the application of particle physics to medicine. Hence, the circumstances that recently met in Berne are: elementary particle physics, physics applied to medicine, Amaldi’s family. In fact, to promote the new research field in Berne, Ugo Amaldi was invited to give a seminar on Physics and Medicine, namely ‘‘Hadrontherapy in the world and its recent developments’’.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77712751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It’s 1659. A woman in Boston, Massachusetts is in labour. She rushes to get out her birthing linens and sets up her birthing room. Her husband ventures out to collect the midwife and the neighbouring women. She proceeds to have her child with the care and coaching of the midwife and neighbourly women at the bedside, while her husband waits anxiously outside. He might fetch a minister and go pray for her during her ‘travail’.
{"title":"Preface from the Editors","authors":"M. Landis, J. Gabor","doi":"10.3828/bj.1990.1","DOIUrl":"https://doi.org/10.3828/bj.1990.1","url":null,"abstract":"It’s 1659. A woman in Boston, Massachusetts is in labour. She rushes to get out her birthing linens and sets up her birthing room. Her husband ventures out to collect the midwife and the neighbouring women. She proceeds to have her child with the care and coaching of the midwife and neighbourly women at the bedside, while her husband waits anxiously outside. He might fetch a minister and go pray for her during her ‘travail’.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86506303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson’s disease (PD) and Huntington’s disease (HD) are the paradigms of opposite movement disorders originating in the basal ganglia. On one hand, poverty and slowness of movement (hypokinesia and bradykinesia) are pathognomic to PD and related conditions. On the other hand, excessive and uncontrolled movements are a hallmark of HD. Indeed, the latter condition is the most common genetic cause of involuntary, fleeting and writhing movements (chorea), which is why the disease used to be called ‘Huntington’s chorea’. Both PD and HD are not only disorders of movement, however. In both conditions, mental processing and mood are affected, and metabolic or autonomic dysfunction cause a range of non-neurological symptoms. From both etiological and epidemiological standpoints, PD and HD appear as two widely different conditions. PD is the second most common neurodegenerative disease after Alzheimer’s and currently affects about 6.3 million people worldwide. It is an age-related disorder lacking an identifiable cause (‘idiopathic’) in 90 % of the cases. By contrast, HD is a relatively rare familial disease caused by an autosomal dominant mutation in the HTT gene. Symptoms of HD commonly become manifest between the ages of 35 and 50 years, but they can begin at virtually any age depending on the CAG repeat length (see below). The genetic basis of HD was discovered in 1993 by an international collaborative effort spearheaded by the Hereditary Disease Foundation. Since then, several other neurological diseases were found to depend on a similar genetic defect, consisting in the expansion of a CAG (cytosine-adenine-guanine) triplet repeat stretch within the disease-causing gene. During the past 17 years, it has become increasingly clear that PD has a strong genetic component, too. Since 1997, several genetic mutations have been positively associated with PD in affected families. Beside these monogenic cases, genetic susceptibility has been suggested to underlie the common idiopathic forms of PD. Indeed, recent genome-wide association studies have established that certain common gene variants occur with an increased frequency in people with idiopathic PD. It is however clear that environmental factors, such as exposure to certain toxins, may underlie many cases of idiopathic PD.
{"title":"Preface from the Editors","authors":"R. Kim, P. Stotland","doi":"10.2307/j.ctt2204s9x.4","DOIUrl":"https://doi.org/10.2307/j.ctt2204s9x.4","url":null,"abstract":"Parkinson’s disease (PD) and Huntington’s disease (HD) are the paradigms of opposite movement disorders originating in the basal ganglia. On one hand, poverty and slowness of movement (hypokinesia and bradykinesia) are pathognomic to PD and related conditions. On the other hand, excessive and uncontrolled movements are a hallmark of HD. Indeed, the latter condition is the most common genetic cause of involuntary, fleeting and writhing movements (chorea), which is why the disease used to be called ‘Huntington’s chorea’. Both PD and HD are not only disorders of movement, however. In both conditions, mental processing and mood are affected, and metabolic or autonomic dysfunction cause a range of non-neurological symptoms. From both etiological and epidemiological standpoints, PD and HD appear as two widely different conditions. PD is the second most common neurodegenerative disease after Alzheimer’s and currently affects about 6.3 million people worldwide. It is an age-related disorder lacking an identifiable cause (‘idiopathic’) in 90 % of the cases. By contrast, HD is a relatively rare familial disease caused by an autosomal dominant mutation in the HTT gene. Symptoms of HD commonly become manifest between the ages of 35 and 50 years, but they can begin at virtually any age depending on the CAG repeat length (see below). The genetic basis of HD was discovered in 1993 by an international collaborative effort spearheaded by the Hereditary Disease Foundation. Since then, several other neurological diseases were found to depend on a similar genetic defect, consisting in the expansion of a CAG (cytosine-adenine-guanine) triplet repeat stretch within the disease-causing gene. During the past 17 years, it has become increasingly clear that PD has a strong genetic component, too. Since 1997, several genetic mutations have been positively associated with PD in affected families. Beside these monogenic cases, genetic susceptibility has been suggested to underlie the common idiopathic forms of PD. Indeed, recent genome-wide association studies have established that certain common gene variants occur with an increased frequency in people with idiopathic PD. It is however clear that environmental factors, such as exposure to certain toxins, may underlie many cases of idiopathic PD.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81316442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral anticoagulants--a review.","authors":"D NAIBERG","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"1961-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23994993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent developments in diuretic agents.","authors":"R O DAVIES","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"1961-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23472808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous manifestations of drug reactions.","authors":"W A YORZYK","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23380400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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