Cardiometry最新文献

{"title":"MicroRNA miR-204-5p IS A REGULATOR OF APOPTOSIS IN DACARBAZINE-RESISTANT MELANOMA CELLS","authors":"N.V. Palkina","doi":"10.18137/cardiometry.2023.29.conf.19","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.19","url":null,"abstract":"Therapy for skin melanoma in its disseminated form is ineffective, among other things, due to the development of tumor cell resistance, mediated by various mechanisms. The acquisition of a stable cell phenotype is associated both with genetic and epigenetic changes mediated by the regulatory non-coding microRNA molecules.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOLECULAR PROFILE OF METASTATIC COLON CANCER","authors":"T.A. Dronova, N. Babyshkina, D.N. Kostromitsky, D.A. Eremin, N. Cherdyntseva","doi":"10.18137/cardiometry.2023.29.conf.4","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.4","url":null,"abstract":"Metastatic colon cancer (mCC) is a heterogeneous disease, which significantly complicates its prognosis and the choice of an effective treatment strategy for patients. The use of mСС molecular profiling data will allow identifying an optimal approach to justify the choice of therapy and increase the patient’s survival rates.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRUCTURAL AND FUNCTIONAL DIFFERENCES IN CARDIAC AND BRAIN MITOCHONDRIA IN ANIMALS WITH DIFFERENT TOLERANCE TO OXYGEN DEFICIENCY","authors":"N. Khmil, V.V. Mironov, V.P. Medvedeva, L. Pavlik, E. Germanova, L. Lukyanova, G.D. Mironova","doi":"10.18137/cardiometry.2023.29.conf.11","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.11","url":null,"abstract":"Depending on the individual resistance to hypoxia, many cell-adaptive reactions are formed, but the mechanisms of their occurrence are still not clear. Hypoxia is associated with many biological processes, including pathogenic microbial infection, cancer, acute and chronic diseases, and more other. Hypoxia-inducible factors (HIFs) regulate the expression of a number of genes involved in cellular metabolism, cell growth/death, cell proliferation, glycolysis, immune response, tumorigenesis, and metastasis. The brain and the heart are the organs most sensitive to oxygen deficiency, and their mitochondria, as the primary consumers of cellular oxygen, help tune cellular and organismal responses to hypoxia through structural or functional modifications. To date, there have been no comparative studies of the ultrastructural features of brain and cardiac mitochondria in animals demonstrating different tolerance types to oxygen deficiency: low-resistance (LR) and high resistance (HR) to hypoxia, which influence the general resistance of the body to oxygen deficiency.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139302930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and epidemiological study of pseudomonas aeruginosa isolated from burn patients in Baghdad city-Iraq","authors":"H.A. Hilal","doi":"10.18137/cardiometry.2023.29.116121","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.116121","url":null,"abstract":"Pseudomonas aeruginosa is rod-shaped with Gram-negative pathogens. It causes disease in humans and animals. P. aeruginosa interferes with the burn cure rates and can lead to increased death among the patients. The current study aims to detect pseudomonas aeruginosa isolates using the classical biochemical methods and polymerase chain reaction technique after isolating pseudomonas aeruginosa from burns cases in Baghdad-Iraq. A sterile swab takes Fifty samples randomly from Al-Yarmouk Teaching Hospital and Kadhemia Hospital. All samples were inoculated on rich media and then submitted to staining by gram stain and the biochemical tests (lactose fermenter, oxidase, and catalase….). The positive samples for biochemical tests are submitted to the PCR test for confirmation diagnosis. All the data related to age and gender are recorded to determine the epidemiological aspects. The findings demonstrate that the percentage of p. aeruginosa in burn cases using biochemical testing was 17/50 (34%), and the percentage of p. aeruginosa isolates from burn samples using the PCR technique was 13/17 (76.4%). In addition, the percentage of P. aeruginosa isolates using PCR in the males was 8/13 (61.5%), while the percentage of p. aeruginosa isolates using PCR in the females was 5/13 (38.4%). The infection percentage in the age groups (1-10), (11-20), (21-30), (31-40), and (41-50) years were (7.6%), (7.6%), (7.6%), (30.7%), and (46.1%), respectively. The conclusion is that PCR is an accurate method for detecting Pseudomonas aeruginosa. Pseudomonas aeruginosa infection is occurring higher in burn males than in burn females. Pseudomonas aeruginosa infection occurs more in the elderly than in young children.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139291857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of uremic and tuberculous pleuritis having exudative lymphocytic pleural effusion in patients with advanced renal disease","authors":"S.N. Tahir, M. Shaheen, T. Mahmood, N.R. Rajput, M. Saqib, M. Ahmed, H. Ishtiaq","doi":"10.18137/cardiometry.2023.29.122126","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.122126","url":null,"abstract":"Pleural effusion is a common occurrence in patients with late-stage chronic kidney disease. In developing countries like Pakistan, many effusions remain undiagnosed after pleural fluid analysis and patients are empirically treated with anti-tubercular therapy. Objective: To determine the frequency of uremic and tuberculosis pleuritis in patients with advanced renal disease. Study Design: Cross-sectional study Study Duration: The study was conducted within 6 months after approval of synopsis i.e. from 2nd December, 2020 till 1st June, 2021. Methodology:150 patients who fulfilled the inclusion criteria were enrolled Informed consent was taken from each patient. Demographic information (name, age, sex, BMI and duration of renal disease) was noted. Then diagnostic pleural tap was done and exudates sample was taken. All exudative samples were further assessed by pleural 2 biopsy and sample was sent to the laboratory of the hospital for histological assessment of uremic or tuberculous pleuritis Results: The mean age (in years), BMI (kg/m2) and duration of disease (in months) of the patients was 39.5±14.2, 27.6±4.19 and 35.8±14.6. There were 55.3% males and 44.7% females. Uremic pleuritis was present in 69.4% and tuberculous pleuritis was seen in 30.6% patients. Age, gender and duration of disease was significantly associated with uremic and tuberculous pleuritis as indicated by a p value of 0.026, 0.048 and 0.007 respectively. Conclusion:Uremic pleuritis was more frequently seen as compared to tuberculous pleuritis in patients with advanced renal disease.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological basis of the relationship between art and medicine","authors":"V. Polikarpov, E.V. Polikarpova","doi":"10.18137/cardiometry.2023.29.6773","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.6773","url":null,"abstract":"The aim of the article is to show the importance of methodological foundations in the relationship between art and medicine, whose source is the sacral core of the syncretic complex of primitive society, which includes the principles of harmony and beauty, the use of which makes it possible to have a therapeutic effect on human health under conditions where modern art of the West and East is characterized by the use of many new technologies that cancel the lines between abstract thinking and artistic activity. All this is directly related to the functioning of medicine III, which combines the methods of Eastern and technology and the instrument base of Western medicine, as well as new concepts and paradigms in the context of such trends of the modern world as aestheticization and technization. Materials and methods. This article uses the followingg theoretical tools: the idea by C. Jung, quite widely used in modern research, that a person’s psychological impulses (archetypes) lie dormant in his collective unconscious (self), which contains the golden ratio; a new approach to the relationship between art and medicine, when the Universe is a masterpiece of Baroque art, and medicine has a quantum character; the paradigm of the fractal nature of the world; the concept of the relationship between the synergetics of the human brain and the synergetics of art; the relationship between art and medicine in the aspect of disaster theory; the paradigms of “integration of the model of healing and healing according the traditions of the East and West; mythological and ritual source of the unity of arts and medicine; the model of digital art and human consciousness. The analytical psychology of K. Jung was chosen as the methodology and logic of scientific research into the relationship between art and medicine, which makes it possible to show the significance of their deep connections in adapting to the complex world of uncertainty and extremity. Results. For the first time in philosophical literature, the philosophical and methodological significance of the relationship between art and medicine is shown from the position of depth psychology by C. Jung in the development of the unconscious of civilizations and cultures of our planet, which makes it possible to adequately assess the degree of their significance in the context of an increasing number of extreme situations. For the first time, a hypothesis has been put forward, according to which art therapy gives a person’s life high meaning. Conclusions. It is proposed to use methodological problems of the relationship between art and medicine based on the depth psychology by C. Jung to overcome the cultural savagery of humanity so that it can survive in the extreme situation of the modern world.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF BIOCHEMICAL HOMEOSTASIS IN RATS WITH ANTI-TUMOR EFFECT PRODUCED BY IRON NANOPARTICLES","authors":"P. Kachesova, I. Goroshinskaya, G. V. Zhukova, I. Kaplieva, I. Neskubina, N.S. Golomeeva, E.A. Andreyko","doi":"10.18137/cardiometry.2023.29.conf.9","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.9","url":null,"abstract":"Overloading a tumor with iron (Fe) is a promising strategy for cancer therapy. A number of papers have demonstrated a self-dependent anti-tumor effect of Fe nanoparticles (NPs) in vivo. However, an excessive amount of this trace metal can produce a negative effect on the organism.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139300521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORPHOLOGICAL ASPECTS OF DEVELOPMENT OF MALIGNANT TUMORS UNDER THE CONDITIONS OF COMORBID PATHOLOGY AND MITOCHONDRIAL THERAPY","authors":"O. I. Kit, A. Shikhlyarova, E. Frantsiyants, I. Kaplieva, I. Neskubina, G. V. Zhukova, V. A. Bandovkina, E. Surikova, L. K. Trepitaki","doi":"10.18137/cardiometry.2023.29.conf.14","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.14","url":null,"abstract":"Morphological studies represent the most important part of evidence-based medicine, and in oncology they are an essential attribute in the diagnostics of malignant neoplasms. In experimental oncology, current models of the tumor growth are developed to be as close as possible to the actual biological life conditions. There is a need to study the pathogenesis of tumors in various variants of their orthotopic growth, the formation of bi-model systems with a combination of the malignant growth and comorbid conditions (chronic neurogenic pain, diabetes mellitus, hypothyroidism, obesity), the use of subcellular substrates for the induction of carcinogenesis and biotherapy. Among the important methods for studying the pathogenesis of tumors, morphology is on a par with advanced molecular genetic and biochemical methods, as well as radioimmunoassay techniques.Morphological studies represent the most important part of evidence-based medicine, and in oncology they are an essential attribute in the diagnostics of malignant neoplasms. In experimental oncology, current models of the tumor growth are developed to be as close as possible to the actual biological life conditions. There is a need to study the pathogenesis of tumors in various variants of their orthotopic growth, the formation of bi-model systems with a combination of the malignant growth and comorbid conditions (chronic neurogenic pain, diabetes mellitus, hypothyroidism, obesity), the use of subcellular substrates for the induction of carcinogenesis and biotherapy. Among the important methods for studying the pathogenesis of tumors, morphology is on a par with advanced molecular genetic and biochemical methods, as well as radioimmunoassay techniques.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPONENTS OF ANTITUMOR EXTRACT OF GRATIOLA OFFICINALIS LEAD TO TUMOR CELL DEATH BY APOPTOSIS DUE TO NEGATIVE REGULATION OF MCL-1 PROTEIN","authors":"N. Polukonova, A.G. Demin, A. Polukonova","doi":"10.18137/cardiometry.2023.29.conf.20","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.20","url":null,"abstract":"Escape from cell death is one of the most prominent features of tumor cells and is closely related to the dysregulation of Bcl-2 family proteins. Among them, the anti-apoptotic protein Mcl-1 (myeloid cell leukaemia-1) acts as a master regulator of apoptosis in various human malignancies. The Mcl-1 -1 protein, whose main function is to protect tumor cells from apoptosis, is not the only product of the anti-apoptotic gene MCL1. On the contrary, another product of this gene, the shortened Mcl-1S protein, formed by alternative splicing, serves as a negative regulator of Mcl-1. Increased levels of Mcl-1S lead to inhibition of apoptosis-protective Mcl-1 and, consequently, tumor cell death by apoptosis (Senichkin, 2018). Mcl-1 inhibitors are currently being developed, which opens new perspectives to fight the hitherto untreatable addiction of cancer cells (Bolomsky et al., 2020).","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Manchester triage flow model regarding patients’ waiting time in Bahria international hospital Lahore, Pakistan","authors":"M. Shaheen, M. Afzal, M. Mukhtar","doi":"10.18137/cardiometry.2023.29.9598","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.9598","url":null,"abstract":"The triage system is meant to be implemented in all (Accidental & Emergency Departments) so as to help and determine the relative priority of individual patient needs. Emergency patients are to be given immediate treatment, while those with non-acute symptoms may have to wait longer (Lucke et al., 2021). Assessment process during the triage need to be balanced with the extent of patient flow, as expanding the assessment process during triage may slow down the patient flow and may lead to delay in emergency service provision (Lucke et al., 2021).Through the use of computer-generated reports, archival data records for two months from the ED of the Bahria International Hospital in Lahore, Pakistan to assess the effectiveness of patients triage flow model. The results of this quantitative study showed that the patient flow model had a considerable temporal effect. Including 16 females, 25 were male and 25% average waiting was more than 240 mints. The ability to decrease patient wait times while enhancing patients quality of care and health outcomes is one of the social change implications. A quantitative study would produce data that would assist medical staff by shortening the wait times for patients.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}