Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.111115
E.N.J. Al-Obaidy, M.M. Ismail, M.Z. Muhi
The aim of present study was to compare the effect of Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical parameters at room temperature 25℃ and extreme temperatures -18℃and 50℃ for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23G needle) into four tubes contain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25℃, waterbath50℃ and refrigerator -18 ℃, for 1hr then put in centrifuge at 3000rpm for 15min. From total examined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) after 1hr under in 25c℃ , -18℃ and 50℃. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochemical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25C; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18C and 50C as compare with antithrombin anticoagulant. In conclusion; heparin was more effective than Ca chelating anticoagulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition.
{"title":"The Effect of Some Different Blood Anticoagulants on Rabbits Plasma Biochemical Parameters under Different Temperatures","authors":"E.N.J. Al-Obaidy, M.M. Ismail, M.Z. Muhi","doi":"10.18137/cardiometry.2023.29.111115","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.111115","url":null,"abstract":"The aim of present study was to compare the effect of Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical parameters at room temperature 25℃ and extreme temperatures -18℃and 50℃ for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23G needle) into four tubes contain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25℃, waterbath50℃ and refrigerator -18 ℃, for 1hr then put in centrifuge at 3000rpm for 15min. From total examined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) after 1hr under in 25c℃ , -18℃ and 50℃. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochemical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25C; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18C and 50C as compare with antithrombin anticoagulant. In conclusion; heparin was more effective than Ca chelating anticoagulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139302152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.6266
A.V. Yarovoy, M.P. Deberdeev, A.O. Chepiga, I. M. Borodyansky
This review examines the role of bioinspired methods in medicine and their potential for improving human health, as well as in the treatment of various diseases. The authors highlight the genetic algorithm and recommendation systems as one of the main tools used in bioinspired methods. This methodology is considered in various aspects of medical practice, such as diagnosis, therapy, prognosis, sports medicine and selection of the correct treatment. Various areas of application of bioinspired methods in medicine are considered. The authors provide an overview of research and development based on the principles of evolutionary modeling. In addition, ethical, economic, and legal aspects of the use of bioinspired methods in medicine are discussed. An integrated approach and a unique view on the role of bioinspired methods and means in medical practice is presented, which reflects modern views on the prospects for research and development of this area.
{"title":"Application of bioinspired methods and means in medicine","authors":"A.V. Yarovoy, M.P. Deberdeev, A.O. Chepiga, I. M. Borodyansky","doi":"10.18137/cardiometry.2023.29.6266","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.6266","url":null,"abstract":"This review examines the role of bioinspired methods in medicine and their potential for improving human health, as well as in the treatment of various diseases. The authors highlight the genetic algorithm and recommendation systems as one of the main tools used in bioinspired methods. This methodology is considered in various aspects of medical practice, such as diagnosis, therapy, prognosis, sports medicine and selection of the correct treatment. Various areas of application of bioinspired methods in medicine are considered. The authors provide an overview of research and development based on the principles of evolutionary modeling. In addition, ethical, economic, and legal aspects of the use of bioinspired methods in medicine are discussed. An integrated approach and a unique view on the role of bioinspired methods and means in medical practice is presented, which reflects modern views on the prospects for research and development of this area.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139291305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.99102
M. Shaheen, M. Afzal, M. Mukhtar
Triage is a French word meaning to sort or to choose. Triage is therefore a process whereby each patient is prioritized amongst the randomly approaching patients in the Accident & Emergency Department/rescue area for emergency care ( Zachariasse et al., 2021). Sorting of patients into priority categories is often performed by an experienced doctor/surgeon or a senior health professional/nurse. The triage nurse/health professional shall quickly assess the patient’s condition, interpret the clinical features and then exercise interventions in the early phase to prevent deterioration and death (Soler‐Sanchis, Martínez‐Arnau, Sánchez‐Frutos, & Pérez‐Ros, 2022). The objective of the triage is to defer a patient who can wait, while give priority to those who are in imminent danger, and whose life can be saved by a timely intervention (Costa, Nicolaidis, Gonçalves, Souza, & Blatt, 2020). The Manchester Triage System is used to maintain a consistent method of prioritising and assessing patients, allowing for thorough audits and improved patient safety. Emergency departments (EDs) are seeing more difficulties globally as a result of an increase in patients and an inability to adjust capacity to meet demand. This is against a background of decreasing hospital resources. Consequently, ED crowding has become a great, international phenomenon (Zachariasse et al., 2021). The Manchester Triage System is one of Europe's most widely used triage systems, considering five levels to prioritise patients in the ED: level 1 (red), immediate; level 2 (orange), very urgent; level 3 (yellow), urgent; level 4 (green), standard; and level 5 (blue), non-urgent (Brutschin, Kogej, Schacher, Berger, & Gräff, 2021) Patient flow model refers to the movement of patients through health care settings involves the medical care, physical resources, and internal systems needed to get patients from the point of admission to the point of discharge while maintaining quality and patient/provider satisfaction (Tlapa et al., 2020). The major facility for urgent medical difficulties is a hospital emergency department (ED), which is a complex system with erratic demands.
{"title":"Effectiveness of modified Manchester triage flow model regarding patients’ waiting time","authors":"M. Shaheen, M. Afzal, M. Mukhtar","doi":"10.18137/cardiometry.2023.29.99102","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.99102","url":null,"abstract":"Triage is a French word meaning to sort or to choose. Triage is therefore a process whereby each patient is prioritized amongst the randomly approaching patients in the Accident & Emergency Department/rescue area for emergency care ( Zachariasse et al., 2021). Sorting of patients into priority categories is often performed by an experienced doctor/surgeon or a senior health professional/nurse. The triage nurse/health professional shall quickly assess the patient’s condition, interpret the clinical features and then exercise interventions in the early phase to prevent deterioration and death (Soler‐Sanchis, Martínez‐Arnau, Sánchez‐Frutos, & Pérez‐Ros, 2022). The objective of the triage is to defer a patient who can wait, while give priority to those who are in imminent danger, and whose life can be saved by a timely intervention (Costa, Nicolaidis, Gonçalves, Souza, & Blatt, 2020). The Manchester Triage System is used to maintain a consistent method of prioritising and assessing patients, allowing for thorough audits and improved patient safety. Emergency departments (EDs) are seeing more difficulties globally as a result of an increase in patients and an inability to adjust capacity to meet demand. This is against a background of decreasing hospital resources. Consequently, ED crowding has become a great, international phenomenon (Zachariasse et al., 2021). The Manchester Triage System is one of Europe's most widely used triage systems, considering five levels to prioritise patients in the ED: level 1 (red), immediate; level 2 (orange), very urgent; level 3 (yellow), urgent; level 4 (green), standard; and level 5 (blue), non-urgent (Brutschin, Kogej, Schacher, Berger, & Gräff, 2021) Patient flow model refers to the movement of patients through health care settings involves the medical care, physical resources, and internal systems needed to get patients from the point of admission to the point of discharge while maintaining quality and patient/provider satisfaction (Tlapa et al., 2020). The major facility for urgent medical difficulties is a hospital emergency department (ED), which is a complex system with erratic demands.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.103110
A. Iqbal, S. Khursheed, M. Ibrahim, R. Ali, S.B. Munir, T.H. Khan, K. Lodhi
Skull base ENT (Ear, Nose, and Throat) pathologies present a diagnostic challenge due to their intricate location. Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scans are commonly used diagnostic tools for detecting these pathologies. This study aims to associate the diagnostic exactness of MRI and CT scans in detecting skull base ENT pathologies. Aim: The primary objective of our current research is to assess and associate the diagnostic accuracy of MRI and CT scans in detecting skull base ENT pathologies, including tumors, infections, and congenital anomalies. Methods: Researchers led the retrospective study of medical records from the cohort of patients with suspected skull base ENT pathologies who underwent both MRI and CT scans. Imaging reports were reviewed by experienced radiologists blinded to the clinical outcomes. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were calculated for each modality. McNemar's test was utilized to assess statistical significance of differences in diagnostic accuracy between MRI and CT. Results: An overall of 150 individuals were involved in our research. MRI demonstrated a sensitivity of 87%, specificity of 92%, PPV of 85%, and NPV of 93% in detecting skull base ENT pathologies. CT scans showed a sensitivity of 72%, specificity of 78%, PPV of 70%, and NPV of 80%. The diagnostic accuracy of MRI was significantly higher than that of CT for detecting these pathologies (p < 0.05). Subgroup analyses were performed for different types of pathologies, providing valuable insights into the strengths and limitations of each imaging modality. Conclusion: This comparative analysis highlights the superior diagnostic accuracy of MRI over CT scans in detecting skull base ENT pathologies. MRI offers higher sensitivity and specificity, making it a valuable tool for clinicians in the evaluation and management of individuals with these conditions. However, CT may still have a role in specific cases where MRI is contraindicated or for initial screening. Clinicians should consider these findings when selecting the most appropriate imaging modality for patients with suspected skull base ENT pathologies.
{"title":"Comparative analysis of diagnostic accuracy between MRI and CT scans in detecting skull base ENT pathologies","authors":"A. Iqbal, S. Khursheed, M. Ibrahim, R. Ali, S.B. Munir, T.H. Khan, K. Lodhi","doi":"10.18137/cardiometry.2023.29.103110","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.103110","url":null,"abstract":"Skull base ENT (Ear, Nose, and Throat) pathologies present a diagnostic challenge due to their intricate location. Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scans are commonly used diagnostic tools for detecting these pathologies. This study aims to associate the diagnostic exactness of MRI and CT scans in detecting skull base ENT pathologies. Aim: The primary objective of our current research is to assess and associate the diagnostic accuracy of MRI and CT scans in detecting skull base ENT pathologies, including tumors, infections, and congenital anomalies. Methods: Researchers led the retrospective study of medical records from the cohort of patients with suspected skull base ENT pathologies who underwent both MRI and CT scans. Imaging reports were reviewed by experienced radiologists blinded to the clinical outcomes. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were calculated for each modality. McNemar's test was utilized to assess statistical significance of differences in diagnostic accuracy between MRI and CT. Results: An overall of 150 individuals were involved in our research. MRI demonstrated a sensitivity of 87%, specificity of 92%, PPV of 85%, and NPV of 93% in detecting skull base ENT pathologies. CT scans showed a sensitivity of 72%, specificity of 78%, PPV of 70%, and NPV of 80%. The diagnostic accuracy of MRI was significantly higher than that of CT for detecting these pathologies (p < 0.05). Subgroup analyses were performed for different types of pathologies, providing valuable insights into the strengths and limitations of each imaging modality. Conclusion: This comparative analysis highlights the superior diagnostic accuracy of MRI over CT scans in detecting skull base ENT pathologies. MRI offers higher sensitivity and specificity, making it a valuable tool for clinicians in the evaluation and management of individuals with these conditions. However, CT may still have a role in specific cases where MRI is contraindicated or for initial screening. Clinicians should consider these findings when selecting the most appropriate imaging modality for patients with suspected skull base ENT pathologies.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.10
A. Kasatova, Y. Taskaeva, I. Razumov, S. Taskaev, N.P. Bgatova
Boron neutron capture therapy (BNCT) is a binary radiation therapy modality based on the high capability of the non-radioactive isotope 10B to absorb thermal neutrons. The use of alternative isotope 6Li for lithium neutron capture therapy (LiNCT) may be a promising area in the treatment of oncological diseases, but at present the data on the possibilities of lithium accumulation in tumor cells are limited to some sporadic studies.
{"title":"COMPARATIVE ASSESSMENT OF CYTOTOXICITY AND ACCUMULATION OF LITHIUM AND BORON IN SKIN MELANOMA CELLS IN VITRO","authors":"A. Kasatova, Y. Taskaeva, I. Razumov, S. Taskaev, N.P. Bgatova","doi":"10.18137/cardiometry.2023.29.conf.10","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.10","url":null,"abstract":"Boron neutron capture therapy (BNCT) is a binary radiation therapy modality based on the high capability of the non-radioactive isotope 10B to absorb thermal neutrons. The use of alternative isotope 6Li for lithium neutron capture therapy (LiNCT) may be a promising area in the treatment of oncological diseases, but at present the data on the possibilities of lithium accumulation in tumor cells are limited to some sporadic studies.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article is devoted to the most pressing issues of studying the clinical and epidemiological features concerning the detection and course of tuberculosis infection in patients with concomitant pathologies. Such pathologies include cancer, diseases of the endocrine system, of the respiratory system (chronic bronchitis, pneumoconiosis), gastric ulcer, pathology of the urinary system, exhaustion due to insufficient nutrition, smoking. Using genetically engineered biological drugs (GEBPs) in practice reduces the activity of inflammatory phenomena due to suppression of the immune response, but increases the risk of developing infectious diseases, primarily tuberculosis. Immunosuppressive therapy in organ transplant patients is also associated with the risk of developing tuberculosis. A special nature of immune disorders develops during HIV infection, a comorbid disease in patients with tuberculosis. The diseases listed above create a medical risk group in patients with immunocompromise, which is the basis for the development of tuberculosis. In addition to the risk of developing infection, patients with concomitant diseases have unfavorable results from treatment of tuberculosis, which does not allow achieving abacillation in a short time, thereby maintaining a reservoir of infection in society. In this regard, the purpose of our research was to study the clinical and epidemiological features of the detection and course of tuberculosis infection in patients with concomitant pathology A study was conducted using a continuous sampling method for the period from December 2020 to August 2021. 67 medical records of an inpatient at the state budgetary healthcare institution “Republican Clinical Anti-TB Dispensary” (Ufa) were analyzed. The groups were formed based on the detection of concomitant pathology (main, n=33) and its absence (control, n=34). To achieve the goal of the study, a comparative analysis of methods for detecting tuberculosis and clinical manifestations of tuberculosis was performed; prevalence of the process, detection of the fact of bacterial excretion and drug sensitivity from December 2020 to August 2021. 67 case histories of Mycobacterium tuberculosis (MBT) in patients of the studied groups were analyzed. Statistical data processing was performed using licensed software Statistica 6.0 when calculating two types of data: discrete and interval. To assess the chances of detecting the studied factor in both groups, the indicator (OR) was used to calculate the 95% confidence interval (CI). Interval indicators were studied by t-test for independent samples, with Livigne's correction.
{"title":"Clinical and epidemiological features of the detection and course of the infectious disease tuberculosis depending on the presence of concomitant pathology","authors":"N.V. Davletbaeva, R.A. Sharipov, E.A. Daminov, R.N. Davletbaev, T.E. Tyulkova","doi":"10.18137/cardiometry.2023.29.7479","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.7479","url":null,"abstract":"The article is devoted to the most pressing issues of studying the clinical and epidemiological features concerning the detection and course of tuberculosis infection in patients with concomitant pathologies. Such pathologies include cancer, diseases of the endocrine system, of the respiratory system (chronic bronchitis, pneumoconiosis), gastric ulcer, pathology of the urinary system, exhaustion due to insufficient nutrition, smoking. Using genetically engineered biological drugs (GEBPs) in practice reduces the activity of inflammatory phenomena due to suppression of the immune response, but increases the risk of developing infectious diseases, primarily tuberculosis. Immunosuppressive therapy in organ transplant patients is also associated with the risk of developing tuberculosis. A special nature of immune disorders develops during HIV infection, a comorbid disease in patients with tuberculosis. The diseases listed above create a medical risk group in patients with immunocompromise, which is the basis for the development of tuberculosis. In addition to the risk of developing infection, patients with concomitant diseases have unfavorable results from treatment of tuberculosis, which does not allow achieving abacillation in a short time, thereby maintaining a reservoir of infection in society. In this regard, the purpose of our research was to study the clinical and epidemiological features of the detection and course of tuberculosis infection in patients with concomitant pathology A study was conducted using a continuous sampling method for the period from December 2020 to August 2021. 67 medical records of an inpatient at the state budgetary healthcare institution “Republican Clinical Anti-TB Dispensary” (Ufa) were analyzed. The groups were formed based on the detection of concomitant pathology (main, n=33) and its absence (control, n=34). To achieve the goal of the study, a comparative analysis of methods for detecting tuberculosis and clinical manifestations of tuberculosis was performed; prevalence of the process, detection of the fact of bacterial excretion and drug sensitivity from December 2020 to August 2021. 67 case histories of Mycobacterium tuberculosis (MBT) in patients of the studied groups were analyzed. Statistical data processing was performed using licensed software Statistica 6.0 when calculating two types of data: discrete and interval. To assess the chances of detecting the studied factor in both groups, the indicator (OR) was used to calculate the 95% confidence interval (CI). Interval indicators were studied by t-test for independent samples, with Livigne's correction.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.13
N. V. Khunderyakova, V.P. Medvedeva, T.V. Polyakova, V.V. Mironov, I.V. Bulgin, G.R. Mikhailova, N.V. Penkov, G.D. Mironova
It is known that Parkinson’s disease (PD) being a neurodegenerative disease is accompanied by increased levels of reactive oxygen species, oxidative stress and impaired mitochondrial activity. It has been shown that the development of malignant tumors can be accompanied by disorders that mimic PD. In this regard, shifts in cellular metabolism associated with the development of true PD are of interest.
{"title":"CHANGES IN THE ENERGY ACTIVITY OF BLOOD LYMPHOCYTES AND MORPHOMETRIC PARAMETERS OF THE BRAIN IN A MODEL OF BRAIN DAMAGE IN RATS","authors":"N. V. Khunderyakova, V.P. Medvedeva, T.V. Polyakova, V.V. Mironov, I.V. Bulgin, G.R. Mikhailova, N.V. Penkov, G.D. Mironova","doi":"10.18137/cardiometry.2023.29.conf.13","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.13","url":null,"abstract":"It is known that Parkinson’s disease (PD) being a neurodegenerative disease is accompanied by increased levels of reactive oxygen species, oxidative stress and impaired mitochondrial activity. It has been shown that the development of malignant tumors can be accompanied by disorders that mimic PD. In this regard, shifts in cellular metabolism associated with the development of true PD are of interest.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.24
S. V. Timofeeva, S.Yu. Filippova, A. Sitkovskaya, I. A. Novikova, O.I. Kit, S.S. Mezentsev, L.N. Vashchenko, E. Kechedzhieva, I. Dashkova, T. V. Ausheva
Over the past decade, the use of adoptive immunotherapy has emerged as a promising approach to treatment of various malignancies, including breast cancer. Cytokines are involved in the development, differentiation and homeostasis of the T cells. Despite the similarities in signaling pathways, the γc cytokines shape the T cell responses differently: IL-2 plays a major role in the development and maintenance of the regulatory T cells, while IL15 stimulates the proliferation and cytotoxic functions of the CD8+ T cells and NK- cells that leads to an enhanced antitumor response. It is of interest to study the combined effect of these cytokines in an experiment.
在过去十年中，采用免疫疗法已成为治疗包括乳腺癌在内的各种恶性肿瘤的一种前景广阔的方法。细胞因子参与 T 细胞的发育、分化和平衡。尽管信号通路相似，但γc 细胞因子对 T 细胞反应的影响却各不相同：IL-2 在调节性 T 细胞的发育和维持中起主要作用，而 IL15 则刺激 CD8+ T 细胞和 NK- 细胞的增殖和细胞毒性功能，从而增强抗肿瘤反应。我们有兴趣在实验中研究这些细胞因子的综合效应。
{"title":"THE EFFECT PRODUCED BY IL-2 AND IL-15 ON THE PROLIFERATION OF T CELLS IN VITRO IN PATIENTS DIAGNOSED WITH BREAST CANCER","authors":"S. V. Timofeeva, S.Yu. Filippova, A. Sitkovskaya, I. A. Novikova, O.I. Kit, S.S. Mezentsev, L.N. Vashchenko, E. Kechedzhieva, I. Dashkova, T. V. Ausheva","doi":"10.18137/cardiometry.2023.29.conf.24","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.24","url":null,"abstract":"Over the past decade, the use of adoptive immunotherapy has emerged as a promising approach to treatment of various malignancies, including breast cancer. Cytokines are involved in the development, differentiation and homeostasis of the T cells. Despite the similarities in signaling pathways, the γc cytokines shape the T cell responses differently: IL-2 plays a major role in the development and maintenance of the regulatory T cells, while IL15 stimulates the proliferation and cytotoxic functions of the CD8+ T cells and NK- cells that leads to an enhanced antitumor response. It is of interest to study the combined effect of these cytokines in an experiment.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.8
T. Inui
One in Four Deaths in Japan Caused by Cancer. Cancer is the most common cause of death for Japanese people who are 40 and over, while suicide is the leading cause among young people.
{"title":"SONODYNAMIC THERAPY (SDT) AND GENE THERAPY","authors":"T. Inui","doi":"10.18137/cardiometry.2023.29.conf.8","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.8","url":null,"abstract":"One in Four Deaths in Japan Caused by Cancer. Cancer is the most common cause of death for Japanese people who are 40 and over, while suicide is the leading cause among young people.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.23
A. Shikhlyarova
The 20th century was skeptical about magnetobiology. But the early experiments conducted by the American couple Barnothy, M. F., & Barnothy, J. M, who presented their data on the possibility of inhibiting the growth of tumors using strong magnetic fields, excited the world, and in the 60s last century, 3 international symposiums were held in Chicago, Rome, and Moscow to discuss that topical issue.
20 世纪的人们对磁生物学持怀疑态度。但美国夫妇巴诺西（Barnothy, M. F.）和巴诺西（Barnothy, J. M）进行的早期实验，提出了利用强磁场抑制肿瘤生长的可能性的数据，令世界为之振奋，并于上世纪 60 年代在芝加哥、罗马和莫斯科召开了 3 次国际研讨会，讨论这一热点问题。
{"title":"HISTORY OF DEVELOPMENT OF ACTIVATION MAGNETIC THERAPY OF TUMORS AND MODERN WAVE TECHNOLOGIES. DEDICATED TO THE MEMORY OF E. B. KVAKINA AND THE 90TH ANNIVERSARY OF HER BIRTH","authors":"A. Shikhlyarova","doi":"10.18137/cardiometry.2023.29.conf.23","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.23","url":null,"abstract":"The 20th century was skeptical about magnetobiology. But the early experiments conducted by the American couple Barnothy, M. F., & Barnothy, J. M, who presented their data on the possibility of inhibiting the growth of tumors using strong magnetic fields, excited the world, and in the 60s last century, 3 international symposiums were held in Chicago, Rome, and Moscow to discuss that topical issue.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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